The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson’s disease
Open accessAbstract
Parkinson's disease (PD) is a complex, chronic and progressive neurodegenerative disease. While the etiology of PD is likely multifactorial, the protein α-synuclein is a central component to the pathogenesis of the disease. However, the mechanism by which α-synuclein causes toxicity and contributes to neuronal death remains unclear. Mitochondrial dysfunction is also widely considered to play a major role in the underlying mechanisms contributing to neurodegeneration in PD. This review discusses evidence for the neuropathological role for α-synuclein in the dysfunction of dopamine neurons in PD. We also discuss insights into the structure, localization, and cellular roles for α-synuclein that may influence its aggregation properties, ultimately impacting its pathogenicity, role in lysosomal dysfunction and activation of the neuroimmune response. We further highlight recent evidence linking α-synuclein and mitochondrial dysfunction in neurodegeneration. Identifying the underlying mechanisms responsible for this bi-directional relationship between α-synuclein and mitochondrial dysfunction may provide new insights into the pathophysiology of PD.
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Cited by
Ageing as a risk factor for neurodegenerative disease
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The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders
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Targeting RNA structures with small molecules
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Metadata
- Authors
- Rocha, E. M., De Miranda, B., & Sanders, L. H.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 109
- Issue
- Pt B
- Pages
- 249-257
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2605252223
- Cited by
- 762
- References
- 24
- FWCI
- 28.15
- Type
- journal article
- Language
- en
- Open access
- green
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- Rocha, E. M., De Miranda, B., & Sanders, L. H. (2018). Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson’s disease. Neurobiology of Disease. https://doi.org/10.1016/j.nbd.2017.04.004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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