Cited by 3,310Genetics, Aging, and Longevity in Model OrganismsAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Ageing as a risk factor for neurodegenerative disease

Hou, Yujun, Dan, Xiuli, Babbar, Mansi, Wei, Yong, Hasselbalch, Steen G., Croteau, Deborah L., Bohr, Vilhelm A.·2019·Nature Reviews Neurology

Abstract

Ageing is the primary risk factor for most neurodegenerative diseases, including Alzheimer disease (AD) and Parkinson disease (PD). One in ten individuals aged ≥65 years has AD and its prevalence continues to increase with increasing age. Few or no effective treatments are available for ageing-related neurodegenerative diseases, which tend to progress in an irreversible manner and are associated with large socioeconomic and personal costs. This Review discusses the pathogenesis of AD, PD and other neurodegenerative diseases, and describes their associations with the nine biological hallmarks of ageing: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellular senescence, deregulated nutrient sensing, stem cell exhaustion and altered intercellular communication. The central biological mechanisms of ageing and their potential as targets of novel therapies for neurodegenerative diseases are also discussed, with potential therapies including NAD+ precursors, mitophagy inducers and inhibitors of cellular senescence.

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Crossref · 10.1038/s41582-019-0244-7

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210 of 210 references verified0 citation errors · 0 not checkable

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Authors
Hou, Y., Dan, X., Babbar, M., Wei, Y., Hasselbalch, S. G., Croteau, D. L., & Bohr, V. A.
Affiliations
  • National Institute on Aging (US)
  • University of Copenhagen (DK)
Corresponding author
Bohr, Vilhelm A.
Venue
Nature Reviews Neurology
Published
2019-09-09
Volume
15
Issue
10
Pages
565-581
ISSN
  • 1759-4758 (ISSN-L)
  • 1759-4766
OpenAlex
W2972368830
Cited by
3,310
References
209
Citations by year
2026: 441 · 2025: 639 · 2024: 675 · 2023: 534 · 2022: 474 · 2021: 359 · 2020: 178 · 2019: 8
FWCI
22.06
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
National Institute on Aging
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
aging, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, genomic instability, telomere shortening, epigenetic modifications, proteostasis, mitochondrial dysfunction, cellular senescence, nutrient sensing, stem cell exhaustion, intercellular communication, NAD+ precursors, mitophagy, senolytics, therapeutic target
MeSH terms
Aging, Brain, DNA Damage, Humans, Risk Factors, Neurodegenerative Diseases, Epigenesis, Genetic, Mitophagy

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