The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
The Epidemiology, Burden, and Comorbidities of Migraine
Abstract
We describe the epidemiology and comorbidities of migraine, which affects 12% of adults in occidental countries. Prevalence is three times higher in women, but 6% of men are affected, making it the most prevalent neurologic disorder in men. Although migraine is a remarkably common cause of temporary disability, many migraineurs have never consulted a physician for the problem. Many disorders are comorbid with migraine. For some such as depression, the association has been well described, but for others, the relationship has been recently suggested, such as in the case of clinical and subclinical vascular brain lesions and coronary heart disease.
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“Depression, in particular, is three times more common among migraineurs than in the general population; and this rate is even higher in migraine patients presenting to clinical settings [1 -3].”
From One-Day Acceptance and Commitment Therapy Compared to Support for Depressed Migraine Patients: a Randomized Clinical Trial. (2020) · cites this paper as [1]
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“It has been estimated that the overall frequency of migraine attacks approximates 12 % in adults, with a prevalence that is nearly threefold higher in women than in men [1].”
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InfluentialAdvances in Exercise in the Clinical Trials of Migraine: A Scoping Review
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“Exercise benefits many aspects of health, including sleep, mood, body mass index, and cardiovascular function, with minimal side effects [4–6].”
Lagniappe: The Impact of Headache Disorders in America*
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“Migraine is highly comorbid with depression, anxiety, asthma, epilepsy, substance abuse, obesity, and multiple other disorders that compound disability and suffering.(26)”
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Recent advances in pediatric headaches
Suh, E. S. (2017) · Journal of Korean Medical Association · doi:10.5124/jkma.2017.60.2.109 · Cited by 2
Mas, M. T., Blanco, R. B., Núñez, C. G., Jiménez, N. R., Sánchez, J. J. A., & Buitrago, F. (2018) · Medicina de Familia SEMERGEN · doi:10.1016/j.semerg.2018.06.006 · Cited by 2
Traditional Medicine and its Use for Pain Management in Saudi Arabia
Shaikh, S. (2020) · Springer eBooks · doi:10.1007/978-3-319-74365-3_206-1 · Cited by 2
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Pathophysiology of migraine & triptan mechanism of action
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Diagnosis and Treatment of Common Headache Syndromes: A Guide for the Clinician
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“Given that there are estimated to be 45 million headache sufferers in the United States alone, one must ask themselves why it is that most clinicians approach the patient suffering from headache with a mixture of anxiety and dread? [1].”
BackgroundObesity and Migraine in Children
Parisi, P., Verrotti, A., Paolino, M. C., Ferretti, A., & Sabatino, F. D. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-410527-0.00023-5 · Cited by 1
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Real-World Healthcare Utilization and Costs in Migraine Patients in Ontario, Canada
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“Therefore, further meticulous research is required to explore the risk factors for migraine in addition to the well-manifested ones such as hypertension (9-12), diabetes (9-12), hyperlipidemia (9,10,12), stroke (4,911,13), CAD (14-16), depression (3,4,6,10-13), anxiety (3,4,6,12,13), sleep disorder (4,6,11-13), bipola…”
BackgroundInfluentialDifferences in personality traits between patients with episodic and chronic migraine
Compen, L., & Rojas, E. (2019) · Revista Médica de Trujillo · doi:10.17268/rmt.2019.v14i04.06 · Cited by 1
ERİTROSİT DAĞILIM GENİŞLİĞİ: MİGREN İLİŞKİLİ BEYİN MRG LEZYONLARI İÇİN YENİ BİR BELİRTEÇ Mİ?
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“Cross-sectional and prospective studies report higher incidence of musculoskeletal pain in those reporting all headaches, but no prospective trials have demonstrated an as sociation with migraine [2].”
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Reuck, J. D., Paemeleire, K., & Maele, G. V. (2010) · Neurologia i Neurochirurgia Polska · doi:10.1016/s0028-3843(14)60002-5 · Cited by 1
“As the one-year prevalence of migraine in the general population is estimated to be about 6% in males and 15 to 18% in females [21], it is probable that some admitted patients forgot to mention prior migraine attacks, considered by them as not relevant.”
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Florêncio, L. L. (2013) · doi:10.11606/d.17.2013.tde-02072015-043346 · Cited by 1
RE: Six novel rare non-synonymous mutations for migraine without aura identified by exome sequencing
Albury, C. L., Gerring, Z. F., Griffiths, L. R., Nyholt, D. R., & Rodriguez‐Acevedo, A. J. (2017) · Journal of Neurogenetics · doi:10.1080/01677063.2017.1382490 · Cited by 1
“The importance of the two variants UBE2NL T266G and EDAR2 G170A, located on the X chromosome is stressed as an endorsement to the observed sexual dimorphism in the presentation of migraine (i.e. females have up to three times higher risk than males) (Bigal & Lipton, 2009).”
BackgroundHeadache in Children and Adolescents
Gladstein, J., Jacobs, H. S., & Rothner, A. D. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800901-7.00017-3 · Cited by 1
Behavioral Factors in Headache Management
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SEX DIFFERENCES IN GENE EXPRESSION AND PAIN-RELATED BEHAVIORS IN A PRECLINICAL MODEL OF MIGRAINE
Stucky, N. L. (2010) · KU ScholarWorks (The University of Kansas)
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One person – Four different types of headache
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“There is some overlap in respect of epidemiology (both are more common in female) and pharmacology (some anti-migraine medication might trigger RCVS), but the prevalence of migraine appears similar in the general population (12–15%) and in RCVS.(8,9) Further controlled studies would be necessary to clarify this.”
BackgroundInfluentialA 40-Year-Old Woman with Chronic Recurrent Headache (Migraine)
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Genetic Basis of the Neurophysiological Findings
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The impact of trauma exposure on headache outcomes
Rittenberger, M., Ostrowski, S. A., & Woods, K. N. (2021) · Children s Health Care · doi:10.1080/02739615.2021.1913163
“Further, approximately 10% of youth experience recurrent headaches (Bigal & Lipton, 2009), and prevalence data suggests that migraine, specifically, negatively affects up to 30% of youth (Abu-Arafeh et al., 2010).”
BackgroundStępień, A., Domitrz, I., Kozubski, W. P., Rejdak, K., Rózniecki, J., Słowik, A., Woroń, J., Wachowska, K., & Gałecki, P. (2021) · Psychiatria Polska · doi:10.12740/pp/onlinefirst/136489
“It often leads to moderate or severe disability and disrupts family life, interpersonal relationships, and work life [2].”
Influentialİnce, H., Aydın, Ö. F., Alaçam, H., & Çetinoğlu, E. Ç. (2021) · MIDDLE BLACK SEA JOURNAL OF HEALTH SCIENCE · doi:10.19127/mbsjohs.908941
Soleimanian-Boroujeni, F., Badihian, N., Badihian, S., Shaygannejad, V., & Gorji, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-1143097/v1
Evaluation of the compatibility of visagism concept with natural teeth
Akmansoy, Ş. C., Abbasgholizadeh, Z. Ş., & Özkan, Y. (2022) · Yeditepe Dental Journal · doi:10.5505/yeditepe.2022.82621 · Cited by 1
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Cefalea en pediatría: tumor embrionario. Reporte de caso
Suescún-Vargas, J. M., Gaitán, J. A., Durán-Lara, A. L., Gaitán, M. P. G., Donoso-Samper, A., & Pinzón-Salamanca, J. Y. (2022) · Pediatría · doi:10.14295/rp.v55i1.297
“reportaron que la prevalencia de la cefalea aumenta de entre 3 % a 8 % en los niños de tres años a una prevalencia entre 57 % al 82% en los adolescentes de quince años y que inicialmente es más prevalente en hombres, pero luego de la pubertad, esta relación se invierte con mayor prevalencia en las mujeres (3).”
BackgroundClinical and Therapeutic Aspects of Migraine in Brazzaville
Boubayi, M. L. H. D., Diatewa, J. E., Bandzouzi, P. E. G. S., Mpandzou, G. A., Ikora, H. S. O., Aloba, K. L. O., & Ossou-Nguıet, P. M. (2024) · World Journal of Neuroscience · doi:10.4236/wjns.2024.141006
MIGRAINE AMONG PATIENTS AND PATIENT’S QUALITY OF LIFE: A CROSS-SECTIONAL STUY
Alshihri, R. A. A., Alalhareth, R. M. H., Alalhareth, M. S. A., Alalhareth, A. S. A., Leslom, A. M. A., Al-Hayani, A., Al-Hayani, A., & algrad, M. H. (2022) · doi:10.53555/jptcp.v29i04.4865
Frequency of Depression in Patients with Migraine Presenting to Services Hospital Lahore
Hassan, S., Khan, I. K., & Nauman, A. (2016) · Esculapio · doi:10.51273/esc16.71216
Epidemiology, Impact, and Disability
Idrovo, L. A., Villar‐Martínez, M. D., Moreno‐Ajona, D., & Hoffmann, J. (2025) · Springer eBooks · doi:10.1007/978-3-031-86923-5_2
Physical Activity, Exercise, and Migraine
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“The higher representation of female students in the present study is noteworthy, as migraine is consistently reported to be more common among women across different populations [2,8].”
InfluentialL'astrocyte un nouvel acteur dans la modulation ocytocinergique : du réseau au comportement
Kerspern, D. (2020) · theses.fr (ABES) · doi:10.70675/386e1bfbz661dz4336zb1e0zb5dbce3b6f10
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“It affects people across different age groups, but is especially common among young and middle-aged adults, often interfering with daily activities, work, and overall quality of life [2,3].”
Gupta, V. K. (2026) · Global Journal of Medical and Clinical Case Reports · doi:10.17352/gjmccr.000273
Metadata
- Authors
- Bigal, M. E., & Lipton, R. B.
- Affiliations
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Albert Einstein College of Medicine (US)
- Corresponding author
- Bigal, Marcelo E.
- Venue
- Neurologic Clinics
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 27
- Issue
- 2
- Pages
- 321-334
- ISSN
- 0733-8619 (ISSN-L)
- OpenAlex
- W1996295044
- Cited by
- 285
- References
- 61
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 5 · 2023: 7 · 2022: 15 · 2021: 21 · 2020: 20 · 2019: 18 · 2018: 19 · 2017: 23 · 2016: 15 · 2015: 28 · 2014: 23 · 2013: 18 · 2012: 22
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurologic Clinics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
- Health Sciences › Medicine › Clinical Neurology › Intracranial Aneurysms: Treatment and Complications
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Keywords
- migraine, migraine epidemiology, migraine prevalence, sex differences, migraine comorbidity, depression, vascular brain lesions, coronary artery disease, underdiagnosis, disability burden
- MeSH terms
- Adult, Brain Injuries, Coronary Artery Disease, Depression, Female, Humans, Male, Migraine Disorders, Comorbidity, Prevalence, Cost of Illness, Headache Disorders
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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