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The Epidemiology, Burden, and Comorbidities of Migraine
Abstract
We describe the epidemiology and comorbidities of migraine, which affects 12% of adults in occidental countries. Prevalence is three times higher in women, but 6% of men are affected, making it the most prevalent neurologic disorder in men. Although migraine is a remarkably common cause of temporary disability, many migraineurs have never consulted a physician for the problem. Many disorders are comorbid with migraine. For some such as depression, the association has been well described, but for others, the relationship has been recently suggested, such as in the case of clinical and subclinical vascular brain lesions and coronary heart disease.
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“Depression, in particular, is three times more common among migraineurs than in the general population; and this rate is even higher in migraine patients presenting to clinical settings [1 -3].”
From One-Day Acceptance and Commitment Therapy Compared to Support for Depressed Migraine Patients: a Randomized Clinical Trial. (2020) · cites this paper as [1]
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Migraine: Multiple Processes, Complex Pathophysiology
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“It frequently starts in childhood, particularly around puberty, and affects women more than men (3:1 female-to-male ratio; Leonardi et al., 2005; Bigal and Lipton, 2009).”
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“A recognized public health problem (10), migraine ranks 19th among all single causes for years lived with disability according to theWorldHealthOrganization (WHO) (2).”
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“Both in general population studies of migraine,(32) and our population with frequent headache, headache prevalence was most common in younger adults and declined with age.(36) We found that prevalence was higher in those with low educational attainment, a condition that has been found to be associated with increased r…”
BackgroundThe association between migraine and physical exercise
Amin, F. M., Aristeidou, S., Baraldi, C., Czapińska-Ciepiela, E., Daponte, A., Lenola, D. D., Fenech, C., Kampouris, K., Karagiorgis, G., Braschinsky, M., et al. (2018) · The Journal of Headache and Pain · doi:10.1186/s10194-018-0902-y · Cited by 228
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“The striking well-known female preponderance in patients with migraine which is also evident in our study is more consistent across studies than the overall prevalence figures of migraine [1, 5, 14].”
ResultContributions of Epidemiology to Our Understanding of Migraine
Merikangas, K. R. (2013) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12038 · Cited by 191
“Children with migraine have been consistently shown to have more recurrrent illnesses,(114) school absences, decreased academic performance, social stigma, and impaired ability to establish and maintain peer relationships.(8,35,55,65,76) In fact, the quality of life in children with migraine is impaired to a degree si…”
BackgroundBond, D. S., Roth, J. L., Nash, J. M., & Wing, R. R. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00791.x · Cited by 144
“Both disorders are prevalent, particularly in the USA where 12% of individuals are migraineurs and onethird of persons are obese (1,2).”
BackgroundInfluentialMigraine, migraine aura, and cervical artery dissection: A systematic review and meta-analysis
Rist, P. M., Diener, H., Kurth, T., & Schürks, M. (2011) · Cephalalgia · doi:10.1177/0333102411401634 · Cited by 138
“Migraine is a common disorder affecting approximately 18% of the female population and 6% of the male population (1).”
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Mitsikostas, D. D., Mantonakis, L., & Chalarakis, N. (2011) · Cephalalgia · doi:10.1177/0333102410391485 · Cited by 131
Aerobic Exercise for Reducing Migraine Burden: Mechanisms, Markers, and Models of Change Processes
Irby, M. B., Bond, D. S., Lipton, R. B., Nicklas, B. J., Houle, T. T., & Penzien, D. B. (2015) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12738 · Cited by 128
Self-citationOpioid Use and Dependence Among Persons With Migraine: Results of the AMPP Study
Buse, D. C., Pearlman, S. H., Reed, M. L., Serrano, D., Ng‐Mak, D., & Lipton, R. B. (2012) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2011.02050.x · Cited by 123
Self-citationPropranolol Blocks Cardiac and Neuronal Voltage-Gated Sodium Channels
Wang, D. W., Mistry, A. M., Kahlig, K. M., Kearney, J. A., Xiang, J., & George, A. L. (2010) · Frontiers in Pharmacology · doi:10.3389/fphar.2010.00144 · Cited by 117
“Migraine is a significant public health problem affecting about 18% of the women and 6% of the men in the United States (Bigal and Lipton, 2009).”
Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonists in the Treatment of Migraine
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Methodological Issues in Studying Trigger Factors and Premonitory Features of Migraine
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Self-citationPathophysiological Bases of Comorbidity in Migraine
Altamura, C., Corbelli, I., de Tommaso, M., Lorenzo, C. D., Lorenzo, G. D., Renzo, A. D., Filippi, M., Jannini, T. B., Messina, R., Parisi, P., et al. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.640574 · Cited by 112
“As these two conditions are often comorbid, they can both lead to a higher degree of social life, family life, and career disability (Rossi et al., 2005; Bigal and Lipton, 2009).”
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“Migraine is among the most common neurological diseases, reportedly occurring in at least 12% of the population.(1,2) The true burden of the disease is compounded by debilitation and losses in productivity.”
BackgroundMethodMedical and Psychological Risks and Consequences of Long-Term Opioid Therapy in Women
Darnall, B. D., Stacey, B. R., & Chou, R. (2012) · Pain Medicine · doi:10.1111/j.1526-4637.2012.01467.x · Cited by 98
Targeting TRP Channels For Novel Migraine Therapeutics
Dussor, G. O., Yan, J., Xie, J. Y., Ossipov, M. H., Dodick, D. W., & Porreca, F. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn500083e · Cited by 95
Headaches, Quality of Life, and Academic Performance in Schoolchildren and Adolescents
Rocha‐Filho, P. A. S., & dos Santos, P. V. (2014) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12394 · Cited by 91
“There are various reasons for this, such as the presence of physical and emotional limitations, the damage to social and family life, and academic activities due to a greater number of absences and lower productivity as a result of pain or related symptoms.(12) From the Department of Neuropsychiatry, Universidade Fede…”
BackgroundNonpharmacologic Treatments for Migraine and Tension-Type Headache: How to Choose and When to Use
Nicholson, R. A., Buse, D. C., Andrasik, F., & Lipton, R. B. (2011) · Current Treatment Options in Neurology · doi:10.1007/s11940-010-0102-9 · Cited by 88
Self-citationMigraine exacerbation during Ramadan fasting
Abu‐Salameh, I., Plakht, Y., & Ifergane, G. (2010) · The Journal of Headache and Pain · doi:10.1007/s10194-010-0242-z · Cited by 86
“Migraine prevalence is estimated [ 2 ] to be approximately 12% of adults.”
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Migraine and cognitive decline in the population-based EVA study
Rist, P. M., Dufouil, C., Glymour, M. M., Tzourio, C., & Kurth, T. (2011) · Cephalalgia · doi:10.1177/0333102411417466 · Cited by 85
“Approximately 20% of the female population and 6% of the male population suffer from migraine (1).”
Clinical Outcomes following Supraorbital Foraminotomy for Treatment of Frontal Migraine Headache
Chepla, K. J., Oh, E., & Guyuron, B. (2012) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e3182450b64 · Cited by 77
Migraine and cognitive decline among women: prospective cohort study
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Depression comorbidity in migraine
Amoozegar, F. (2017) · International Review of Psychiatry · doi:10.1080/09540261.2017.1326882 · Cited by 73
“Migraine is comorbid with a number of conditions, including psychiatric, neurologic, vascular, and cardiac conditions (Bigal & Lipton, 2009).”
BackgroundMigraine: treatments, comorbidities, and quality of life, in the USA
Malone, C., Wachholtz, A., & Bhowmick, A. (2015) · Journal of Pain Research · doi:10.2147/jpr.s88207 · Cited by 73
“disorders, especially depression and anxiety, have been found to be prevalent among migraineurs.(2) Chronic pain, stroke, gastrointestinal disorders, cardiovascular disease, and other medical conditions have also been found to be more prevalent in migraineurs compared with the general population.”
BackgroundResultHajihashemi, P., Askari, G., Khorvash, F., Maracy, M. R., & Nourian, M. (2019) · Cephalalgia · doi:10.1177/0333102418821661 · Cited by 71
Migraine is associated with better cognition in the middle‐aged and elderly: the Rotterdam Study
Wen, K., Nguyen, N. T., Albert Hofman, D., Ikram, M. A., & Franco, O. H. (2016) · European Journal of Neurology · doi:10.1111/ene.13066 · Cited by 69
“Migraine headache is ranked among the top 10 debilitating diseases worldwide, largely affecting women [1,2].”
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“Patients with migraine also report an impact on their ability to work, perform household tasks, and take part in social activities [20].”
BackgroundEffect of Different Meditation Types on Migraine Headache Medication Use
Wachholtz, A. B., Malone, C. D., & Pargament, K. I. (2017) · Behavioral Medicine · doi:10.1080/08964289.2015.1024601 · Cited by 65
“In the United States, approximately 18% of women and 6% ofmen suffer frommigraine headaches every year.(2) For individuals withmigraines, over a third (37%) experience frequent migraine attacks of five or more migraine headaches per month.”
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Optimising migraine treatment: from drug-drug interactions to personalized medicine
Pomes, L. M., Guglielmetti, M., Bertamino, E., Simmaco, M., Borro, M., & Martelletti, P. (2019) · The Journal of Headache and Pain · doi:10.1186/s10194-019-1010-3 · Cited by 66
“The disorder is more frequent in female (3,1 = F:M) with a peak of prevalence between ages of 22 and 55 years old [4].”
BackgroundOne-day behavioral treatment for patients with comorbid depression and migraine: a pilot study
Dindo, L., Recober, A., Marchman, J. N., Turvey, C., & O'Hara, M. W. (2012) · Behaviour Research and Therapy · doi:10.1016/j.brat.2012.05.007 · Cited by 64
“In addition, this study showed that a 1-day intervention based on Acceptance and Commitment Training plus migraine education resulted in significant improvement in depression relative to WL/TAU based on (1) reduction in depressive symptom levels as measured by the HRSD and the IDAS-General Depression scale; (2) the pr…”
BackgroundMethodMigraine Surgery: A Plastic Surgery Solution for Refractory Migraine Headache
Kung, T. A., Guyuron, B., & Cederna, P. S. (2010) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e3181f95a01 · Cited by 65
Prevalence of migraine in the Canadian household population.
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“3 million [137] [138] Developmental disorders Autism [139] Attention deficit hyperactivity disorder 4.”
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“Migraine is a common disorder that affects 10%–12% of the adult population, with approximately two to three times more women than men being affected [3].”
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Silva, H. R. D. S. E., & Rocha‐Filho, P. A. S. (2011) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2011.02012.x · Cited by 63
“The migraine prevalence is highest from 25 to 55 years old, and is greater among women.(2) The majority of the interviewed students were women and they were close to the age group of greatest migraine prevalence, which could have influenced the prevalence demonstrated in this study.”
BackgroundMigraine, headache, and the risk of depression: Prospective cohort study
Rist, P. M., Schürks, M., Buring, J. E., & Kurth, T. (2013) · Cephalalgia · doi:10.1177/0333102413483930 · Cited by 61
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A Socioeconomic Analysis of Surgical Treatment of Migraine Headaches
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Hormonal contraception in women with migraine: is progestogen-only contraception a better choice?
Nappi, R. E., Merki‐Feld, G. S., Terreno, E., Pellegrinelli, A., & Viana, M. (2013) · The Journal of Headache and Pain · doi:10.1186/1129-2377-14-66 · Cited by 59
“In fact during migraine attacks most migraineurs reported severe impairment or the need of the bed rest and almost 40% of migraine patients have five or more headache days monthly [1].”
BackgroundMigraine and risk of stroke: a national population-based twin study
Lantz, M., Sieurin, J., Sjölander, A., Waldenlind, E., Sjöstrand, C., & Wirdefeldt, K. (2017) · Brain · doi:10.1093/brain/awx223 · Cited by 59
“Migraine is a complex primary headache disorder, characterized by recurrent headache attacks, affecting 11% of the population, with a female predominance of 3:1 (Bigal and Lipton, 2009).”
BackgroundMigraine and Cognitive Decline: A Topical Review
Rist, P. M., & Kurth, T. (2012) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12046 · Cited by 60
Migraine incidence in 5 years: a population-based prospective longitudinal study in Turkey
Baykan, B. B., Ertaş, M., Karlı, N., Uludüz, D., Uygunoğlu, U., Ekizoğlu, E., Orhan, E. K., Saip, S., Zarifoğlu, M., & Sıva, A. (2015) · The Journal of Headache and Pain · doi:10.1186/s10194-015-0589-2 · Cited by 57
“The prevalence of migraine for Western countries is established as nearly between 5 and 9 % for men and between 12 and 25 % for women [3, 4].”
BackgroundMigraine Prevalence, Treatment and Impact: The Canadian Women and Migraine Study
Cooke, L., & Becker, W. J. (2010) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100010738 · Cited by 55
C-reactive protein and migraine. Facts or speculations?
Lippi, G., Mattiuzzi, C., & Cervellin, G. (2014) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2014-0011 · Cited by 54
Migraine and Functional Outcome From Ischemic Cerebral Events in Women
Rist, P. M., Buring, J. E., Kase, C. S., Schürks, M., & Kurth, T. (2010) · Circulation · doi:10.1161/circulationaha.110.977306 · Cited by 52
“From this information, we divided the women into 4 possible categories: (1) “no migraine history”; (2) “active migraine with aura,” which included those who reported migraine within the past year and who reported presence of aura or any indication that a migraine is coming; (3) “active migraine without aura”; and (4)…”
Buse, D. C., Yugrakh, M. S., Lee, L. K., Bell, J., Cohen, J. M., & Lipton, R. B. (2020) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2020.20100 · Cited by 50
“episodic migraine).(5,13,14,16,19,20,40,43-44) A study by Hawkins et al.”
Self-citationQuality of life of migraine patients followed in neurology clinics in Riyadh, Saudi Arabia
Al-Ateeq, M., & AlHarbi, F. (2020) · Journal of Family and Community Medicine · doi:10.4103/jfcm.jfcm_185_19 · Cited by 51
“Again, this is similar to what is known about the age predominance of migraine.[1,2,4,19,28]”
ResultThe Bowel and Migraine: Update on Celiac Disease and Irritable Bowel Syndrome
Cady, R. K., Farmer, K. U., Dexter, J., & Hall, J. (2012) · Current Pain and Headache Reports · doi:10.1007/s11916-012-0258-y · Cited by 49
Exercise in Treatment of Migraine Including Chronic Migraine
Song, T.-J., & Chu, M. (2021) · Current Pain and Headache Reports · doi:10.1007/s11916-020-00929-w · Cited by 41
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Martins, L. B., Teixeira, A. L., & Domingues, R. B. (2016) · Vitamins and hormones · doi:10.1016/bs.vh.2016.10.003 · Cited by 43
“The prevalence of migraine in the United States is about 18% in women and 6% in men (Bigal & Lipton, 2009) and CM prevalence rate is 1.3–5.1% of world population (Natoli et al., 2010).”
BackgroundInfluentialVincenzo, A. D., Beghetto, M., Vettor, R., Tana, C., Rossato, M., Bond, D. S., & Pagano, C. (2020) · Obesity Surgery · doi:10.1007/s11695-020-04429-z · Cited by 41
Migraine headache: a review of the molecular genetics of a common disorder
Lorenzo, C. D., Grieco, G. S., & Santorelli, F. M. (2012) · The Journal of Headache and Pain · doi:10.1007/s10194-012-0478-x · Cited by 40
“The disease is more frequent in females (3:1 female-to-male ratio) and has its peak prevalence between the ages of 22 and 55 years [5, 6].”
BackgroundWhat Factors Contribute to Headache-Related Disability in Teens?
Kemper, K. J., Heyer, G. L., Pakalnis, A., & Binkley, P. F. (2015) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2015.10.024 · Cited by 43
“Factors Contribute to Headache-Related Disability in Teens? Kathi J Kemper, MD, MPH(1), Geoffrey Heyer, MD(1),(3),(4), Ann Pakalnis, MD(1),(3),(4), and Philip F.”
Frequency of pediatric migraine with aura in a clinic‐based sample
Genizi, J., Matar, A. K., Zelnik, N., Schertz, M., & Srugo, I. (2015) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12741 · Cited by 39
“In boys, he found peaks of 5 years vs 10-11 years of age for migraine with and without aura, respectively, while the corresponding figures in girls were 12-13 vs 14-17 years of age.(17,19) Mavromichalis also reported no influence of age on the prevalence of aura.”
ResultKleiboer, A., Sorbi, M., van Silfhout, M., Kooistra, L., & Passchier, J. (2014) · Behaviour Research and Therapy · doi:10.1016/j.brat.2014.07.009 · Cited by 37
“Migraine attacks can be highly debilitating and many patients report daily life problems such as disrupted family life, restricted social activities, and reduced work performance (Bigal & Lipton, 2009).”
BackgroundCho, S., Chung, Y. K., Kim, J.-M., & Chu, M. K. (2015) · The Journal of Headache and Pain · doi:10.1186/s10194-015-0554-0 · Cited by 37
“Migraine prevalence peaks from the 20s to 40s which is the most productive age in sufferers’ lives [1, 2, 4, 8].”
BackgroundBakhshayesh, B., Seyedsaadat, S. M., Rezania, K., Hatamian, H., & Hosseininezhad, M. (2013) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2012.10.014 · Cited by 36
Is there an Association between Migraine and Gastrointestinal Disorders?
Doulberis, M., Saleh, C., & Beyenburg, S. (2017) · Journal of Clinical Neurology · doi:10.3988/jcn.2017.13.3.215 · Cited by 35
Yang, X., Liu, B., Yang, B., Li, S., Wang, F., Li, K., Hu, F., Ren, H. J., & Xu, Z. (2018) · Neurological Sciences · doi:10.1007/s10072-018-3527-7 · Cited by 35
Obese children suffer more often from migraine
Verrotti, A., Fonzo, A. D., Agostinelli, S., Coppola, G., Margiotta, M., & Parisi, P. (2012) · Acta Paediatrica · doi:10.1111/j.1651-2227.2012.02768.x · Cited by 34
“Migraine occurs in 3–10% of children (1,4,28), and currently affects 50 ⁄ 1000 school-age children in the United Kingdom and an estimated 7.”
BackgroundHan, T. H., Blanchard, R. L., Palcza, J. S., McCrea, J. B., Laethem, T., Willson, K. J., Xu, Y., Ermlich, S. J., Boyle, J., Lines, C., et al. (2010) · The Journal of Clinical Pharmacology · doi:10.1177/0091270010361741 · Cited by 34
“It is estimated that 12% of the population in Western countries suffer from migraine symptoms, with the prevalence being 3 times higher in women than men.(2) Calcitonin generelated peptide (CGRP) is a neuropeptide that may play a key role in the pathophysiology of migraine.”
BackgroundThe prevalence of depression and the accuracy of depression screening tools in migraine patients
Amoozegar, F., Patten, S. B., Becker, W. J., Bulloch, A. G. M., Fiest, K. M., Davenport, W. J., Carroll, C. R., & Jetté, N. (2017) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2017.06.006 · Cited by 34
Kwok, Y. H., Swift, J. E., Gazerani, P., & Rolan, P. E. (2016) · Journal of Pain Research · doi:10.2147/jpr.s116968 · Cited by 35
“Introduction Chronic migraine (CM) is a disabling and undertreated disorder(1) which represents a clinically challenging problem that impacts significantly on the quality of life of affected individuals and imposes a large economic burden upon society due to lost productivity.(2,3) Despite this burden, the pathophysio…”
BackgroundRelationship Between Headaches and Neck Pain Characteristics With Neck Muscle Strength
Tolentino, G. D. A., Bevilaqua‐Grossi, D., Carvalho, G. F., Carnevalli, A. P. D. O., Dach, F., & Florêncio, L. L. (2018) · Journal of Manipulative and Physiological Therapeutics · doi:10.1016/j.jmpt.2018.04.003 · Cited by 33
The Risk of Headache Attributed to Surgical Treatment of Intracranial Aneurysms: A Cohort Study
Magalhães, J. E., Azevedo‐Filho, H. R. C., & Rocha‐Filho, P. A. S. (2013) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12165 · Cited by 32
“Psychiatric disorders are often associated with primary headaches(36,37) and other non-cranial painful conditions.(32) Moreover, a recent history of stressful events is an independent risk factor for chronic daily headache,(36) as well as the severity and frequency of everyday stress associated with recurrent headache…”
BackgroundMigraine and risk of incident diabetes in women: A prospective study
Burch, R. C., Rist, P. M., Winter, A. C., Buring, J. E., Pradhan, A. D., Loder, E., & Kurth, T. (2012) · Cephalalgia · doi:10.1177/0333102412453954 · Cited by 32
“Migraine is a primary headache disorder affecting approximately 6% of men and 18% of women (1).”
BackgroundPetrušić, I., & Zidverc-Trajkovic, J. J. (2014) · Europe PMC (PubMed Central) · Cited by 31
A Systematic Review of Behavioral Headache Interventions With an Aerobic Exercise Component
Baillie, L. E., Gabriele, J. M., & Penzien, D. B. (2013) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12204 · Cited by 30
“Recurrent headaches, most prevalent among females, negatively impact family functioning, work productivity, and absenteeism, and are associated with increased emergency room visits and use of prescription and non-prescription medications.(1) While From the Department of Psychology, G.”
BackgroundThe need for new acutely acting antimigraine drugs: moving safely outside acute medication overuse
van Hoogstraten, W. S., & MaassenVanDenBrink, A. (2019) · The Journal of Headache and Pain · doi:10.1186/s10194-019-1007-y · Cited by 30
“The neurovascular disorder migraine is one of the most common diseases worldwide [1, 2].”
BackgroundNguyen, B. N., McKendrick, A. M., & Vingrys, A. J. (2012) · Cephalalgia · doi:10.1177/0333102412453953 · Cited by 30
“People who experience aura are at slightly greater risk of subclinical brain lesion, stroke, cardiovascular disease and other ischaemic vascular events than are those who experience MO (for a review, see Schwedt and Dodick [1] and Bigal and Lipton [64]).”
BackgroundEarly Diagnosis of Migraine Necessary in Children: 10-Year Follow-Up
Galinski, M., Sidhoum, S., Cimerman, P., Perrin, O., Annequin, D., & Tourniaire, B. (2015) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2015.05.013 · Cited by 29
Carod-Artal, F. J., Ezpeleta, D., Martín-Barriga, M. L., & Peral, Á. L. G. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.02.027 · Cited by 29
“Headache and migraine burden have a worldwide distribution, and can be found in many urban and sub-urban, traditional and developed societies [1,2,8].”
BackgroundCasucci, G., Villani, V., Cologno, D., & d’Onofrio, F. (2012) · Neurological Sciences · doi:10.1007/s10072-012-1047-4 · Cited by 29
Dahri, M., Hashemilar, M., Jafarabadi, M. A., & Tarighat‐Esfanjani, A. (2017) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2017.10.003 · Cited by 29
Zhang, Q., Han, X., Wu, H., Zhang, M., Hu, G., Dong, Z., & Yu, S. (2019) · Molecular Pain · doi:10.1177/1744806918820452 · Cited by 29
Sertel, M., Bakar, Y., & Şimşek, T. T. (2017) · African Journal of Traditional Complementary and Alternative Medicines · doi:10.21010/ajtcam.v14i2.31 · Cited by 33
Non-headache symptoms in migraine patients
Chen, P.-K., & Wang, S. (2018) · F1000Research · doi:10.12688/f1000research.12447.1 · Cited by 28
Cerami, C., Crespi, C., Bottiroli, S., Santi, G. C., Sances, G., Allena, M., Vecchi, T., & Tassorelli, C. (2021) · Cephalalgia · doi:10.1177/03331024211027568 · Cited by 28
“Additionally, we observed that a larger proportion of HHI compared to LHI patients indicated the decrease of physical activity as a possible cause of the worsening of their motor symptomatology (X(2)(1)1⁄4 6.”
BackgroundMethodResultInfluentialMaternal personality profile of children affected by migraine
Parisi, L., Esposito, M., Roccella, M., Gallai, B., Lavano, S. M., Marotta, R., & Carotenuto, M. (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s51554 · Cited by 27
“Children affected by migraine have been consistently shown to have more recurrent illnesses(2) and school absences, decreased academic performance, social stigma, and impaired ability to establish and maintain peer relationships.(3,4) In N eu ro ps yc hi at ric D is ea se a nd T re at m en t d ow nl oa de d fr om h tt…”
Ali, S. S., Bragin, I., Rende, E. K., Mejico, L. J., & Werner, K. (2019) · Cureus · doi:10.7759/cureus.4343 · Cited by 27
A comparison of outcome of medical and surgical treatment of migraine headache: In 1 year follow-up
Omranifard, M., Abdali, H., Ardakani, M. R., & Talebianfar, M. (2016) · Advanced Biomedical Research · doi:10.4103/2277-9175.186994 · Cited by 27
“[7‐9] The prevalence of migraine headache is highest in patients aged 25‐55 years, corresponding to the peak years of work productivity and childbearing.[2,7,9,14,15]”
Migraine and obesity: what is the real direction of their association?
Jahromi, S. R., Martami, F., Soltani, K. M., & Togha, M. (2023) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2023.2173575 · Cited by 27
“Migraine has several well-known cardiovascular, psychological and neurological comorbidities [103].”
BackgroundAdiponectin and leptin levels in migraineurs in the Atherosclerosis Risk in Communities Study
Dearborn, J. L., Schneider, A. L. C., Gottesman, R. F., Kurth, T., Pankow, J. S., Couper, D. J., Rose, K. M., Williams, M. A., & Peterlin, B. L. (2014) · Neurology · doi:10.1212/wnl.0000000000001067 · Cited by 26
“It is likely that this only occurred in a small number of participants, as migraine has the highest incidence in the second decade of life, with a very low incidence after age 50 years.(35,36) Another consideration is that adiponectin levels increase with age,(17) and are likely lower at visit 1 than would be projecte…”
BackgroundSorbi, M. J., Kleiboer, A. M., van Silfhout, H., Vink, G., & Passchier, J. (2014) · Cephalalgia · doi:10.1177/0333102414547137 · Cited by 26
“Migraine attacks of pounding headache impede work performance and family or social life (1) and are the seventh disabler worldwide according to the World Health Organization (WHO) Global Burden of Disease Survey 2010 (2).”
BackgroundMethodInfluentialFamilial history of migraine influences habituation of visual evoked potentials
Martinez, M. L., Ruiz-Romagnoli, E., D’Ostilio, K., Piedrabuena, R., Giobellina, R., Schoenen, J. E., & Magis, D. (2016) · Cephalalgia · doi:10.1177/0333102416673207 · Cited by 26
Clinical features and risk factors for irritable bowel syndrome in Migraine patients
Li, C., Yu, S., Li, H., Zhou, J. F., Liu, J., Tang, W., & Zhang, L. (2017) · Pakistan Journal of Medical Sciences · doi:10.12669/pjms.333.12379 · Cited by 26
Migraine genetics: current findings and future lines of research
Persico, A. M., Verdecchia, M., Pinzone, V., & Guidetti, V. (2015) · neurogenetics · doi:10.1007/s10048-014-0433-x · Cited by 25
“Its peak incidence occurs between 25 and 55 years of age [2, 3].”
Pediatric Headache: Where Have We Been and Where Do We Need to Be
Singhi, S., Jacobs, H., & Gladstein, J. (2014) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12358 · Cited by 25
“In girls, migraine with aura peaks at 12-13 years of age, whereas migraines without aura reaches a peak at 14-17 years of age.(31) It has been well documented that one cannot adequately treat migraine without considering the comorbid psychological problems that are present in a large number of our patients.”
BackgroundIntraoperative anatomical variations during greater occipital nerve decompression
Junewicz, A., Katira, K. M., & Guyuron, B. (2013) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2013.06.016 · Cited by 25
Association of Migraine Headaches With Suicidal Ideation Among Pregnant Women in Lima, Peru
Friedman, L. E., Gelaye, B., Rondón, M. B., Sánchez, S. E., Peterlin, B. L., & Williams, M. A. (2016) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12793 · Cited by 26
Effects of Switching Acute Treatment on Disability in Migraine Patients Using Triptans
Serrano, D., Buse, D. C., Kori, S. H., Papapetropoulos, S., Cunanan, C. M., Manack, A. N., Reed, M. L., & Lipton, R. B. (2013) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12164 · Cited by 25
Self-citationGenizi, J., Bugdnoskya, V., Aboud, A., Segal, I., Assaf, N., Srugo, I., & Kerem, N. C. (2021) · Journal of Child Neurology · doi:10.1177/0883073820988417 · Cited by 24
“001 Light-moderate 114 (69) 6 (3) Moderate-severe 49 (31) 209 (97) Interferes with daily activity 4.”
Szabó, E., Ashina, S., Melo‐Carrillo, A., Bolo, N. R., Borsook, D., & Burstein, R. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103531 · Cited by 25
“…difference in sex be-tween the responder and non-responder groups, biological sex differences could not be assessed because of the female predominance in the sample (which is consistent with the literature: migraine has a female to male gender ratio of approximately 3:1) (Bigal and Lipton, 2009).”
Metadata
- Authors
- Bigal, M. E., & Lipton, R. B.
- Affiliations
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Albert Einstein College of Medicine (US)
- Corresponding author
- Bigal, Marcelo E.
- Venue
- Neurologic Clinics
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 27
- Issue
- 2
- Pages
- 321-334
- ISSN
- 0733-8619 (ISSN-L)
- OpenAlex
- W1996295044
- Cited by
- 285
- References
- 61
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 5 · 2023: 7 · 2022: 15 · 2021: 21 · 2020: 20 · 2019: 18 · 2018: 19 · 2017: 23 · 2016: 15 · 2015: 28 · 2014: 23 · 2013: 18 · 2012: 22
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurologic Clinics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
- Health Sciences › Medicine › Clinical Neurology › Intracranial Aneurysms: Treatment and Complications
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Keywords
- migraine, migraine epidemiology, migraine prevalence, sex differences, migraine comorbidity, depression, vascular brain lesions, coronary artery disease, underdiagnosis, disability burden
- MeSH terms
- Adult, Brain Injuries, Coronary Artery Disease, Depression, Female, Humans, Male, Migraine Disorders, Comorbidity, Prevalence, Cost of Illness, Headache Disorders
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