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A Novel RNA In Situ Hybridization Assay for the Long Noncoding RNA SChLAP1 Predicts Poor Clinical Outcome After Radical Prostatectomy in Clinically Localized Prostate Cancer
Open accessAbstract
Long noncoding RNAs (lncRNAs) are an emerging class of oncogenic molecules implicated in a diverse range of human malignancies. We recently identified SChLAP1 as a novel lncRNA that demonstrates outlier expression in a subset of prostate cancers, promotes tumor cell invasion and metastasis, and associates with lethal disease. Based on these findings, we sought to develop an RNA in situ hybridization (ISH) assay for SChLAP1 to 1) investigate the spectrum of SChLAP1 expression from benign prostatic tissue to metastatic castration-resistant prostate cancer and 2) to determine whether SChLAP1 expression by ISH is associated with outcome after radical prostatectomy in patients with clinically localized disease. The results from our current study demonstrate that SChLAP1 expression increases with prostate cancer progression, and high SChLAP1 expression by ISH is associated with poor outcome after radical prostatectomy in patients with clinically localized prostate cancer by both univariate (hazard ratio = 2.343, P = .005) and multivariate (hazard ratio = 1.99, P = .032) Cox regression analyses. This study highlights a potential clinical utility for SChLAP1 ISH as a novel tissue-based biomarker assay for outcome prognostication after radical prostatectomy.
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The prostate tumor microarray with correlated clinical information from 120 clinically localized PCa patients was constructed by the University of Michigan Center for Translational Pathology.
“The prostate tumor microarray (TMA) with correlated clinical information from 120 clinically localized PCa patients was constructed by the University of Michigan Center for Translational Pathology as previously reported65.”
From Genome-scale CRISPR screens identify PTGES3 as a direct modulator of androgen receptor function in advanced prostate cancer (2025) · cites this paper as [65]
The Tissue Microarray (TMA) Construction section describes TMAs from patients with clinically localized prostate cancer and says detailed clinicopathologic data were maintained for the cohort. It gives 208 patients, not 120, and identifies the University of Michigan Prostate Cancer SPORE Tissue Core rather than the Center for Translational Pathology. (LLM, conf=0.87)
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Li, H., Melnyk, J. E., Fu, B. X. H., Shrestha, R., Zhang, M., Sjöström, M., Feng, S., Anderson, J. A., Han, W., Chesner, L. N., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02388-8 · Cited by 10
“The prostate tumor microarray (TMA) with correlated clinical information from 120 clinically localized PCa patients was constructed by the University of Michigan Center for Translational Pathology as previously reported 65 .”
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Metadata
- Authors
- Mehra, R., Shi, Y., Udager, A. M., Prensner, J. R., Sahu, A., Iyer, M. K., Siddiqui, J., Cao, X., Wei, J., Jiang, H., Feng, F. Y., & Chinnaiyan, A. M.
- Affiliations
- University of Michigan (US)
- Michigan Medicine (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Mehra, Rohit
- Chinnaiyan, Arul M.
- ORCID
- Venue
- Neoplasia
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 16
- Issue
- 12
- Pages
- 1121-1127
- ISSN
- 1476-5586 (ISSN-L)
- PMC
- PMC4309259
- OpenAlex
- W2052750768
- Cited by
- 95
- References
- 28
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 4 · 2020: 3 · 2019: 10 · 2018: 16 · 2017: 14 · 2016: 18 · 2015: 8 · 2014: 1
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Neoplasia (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- Funders
- Howard Hughes Medical Institute
- American Cancer Society
- Prostate Cancer Foundation
- Evans Medical Foundation
- National Institutes of Health (UO1 CA113913)
- National Cancer Institute (P50-CA-69568, F30CA180376, P50CA069568, P50CA186786, U01CA113913)
- National Institute of General Medical Sciences (T32GM007863)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
- Health Sciences › Medicine › Urology › Prostate Cancer Diagnosis and Treatment
- Keywords
- SChLAP1, long non-coding RNA, RNA in situ hybridization, localized prostate cancer, radical prostatectomy, prognostic factors, disease progression, castration-resistant prostate cancer, metastasis, tumor invasion, clinical outcomes
- MeSH terms
- Humans, Male, Neoplasm Proteins, Prostatectomy, Prostatic Neoplasms, RNA, Biomarkers, Tumor, In Situ Hybridization, RNA, Long Noncoding
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