Cited by 468Prenatal Substance Exposure EffectsMaternal Mental Health During Pregnancy and PostpartumSubstance Abuse Treatment and Outcomes

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Maternal smoking, drinking or cannabis use during pregnancy and neurobehavioral and cognitive functioning in human offspring

Huizink, Anja C., Mulder, Eduard J.H.·2006·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2005.04.005

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Abstract

Teratological investigations have demonstrated that agents that are relatively harmless to the mother may have significant negative consequences to the fetus. Among these agents, prenatal alcohol, nicotine or cannabis exposure have been related to adverse offspring outcomes. Although there is a relatively extensive body of literature that has focused upon birth and behavioral outcomes in newborns and infants after prenatal exposure to maternal smoking, drinking and, to a lesser extent, cannabis use, information on neurobehavioral and cognitive teratogenic findings beyond these early ages is still quite limited. Furthermore, most studies have focused on prenatal exposure to heavy levels of smoking, drinking or cannabis use. Few recent studies have paid attention to low or moderate levels of exposure to these substances. This review endeavors to provide an overview of such studies, and includes animal findings and potential mechanisms that may explain the mostly subtle effects found on neurobehavioral and cognitive outcomes. It is concluded that prenatal exposure to either maternal smoking, alcohol or cannabis use is related to some common neurobehavioral and cognitive outcomes, including symptoms of ADHD (inattention, impulsivity), increased externalizing behavior, decreased general cognitive functioning, and deficits in learning and memory tasks.

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Connor, 2001, A preliminary study of working memory in fetal alcohol damage using fMRI, Journal of the Neuropsychological Society, 7, 206
Olson, 1997, Association of prenatal alcohol exposure with behavioral and learning problems in early adolescence, Journal of the American Academy of Child and Adolescent Psychiatry, 36, 1187, 10.1097/00004583-199709000-00010 · DOI

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Authors: Huizink, A. C., & Mulder, E. J. H.
Affiliations: Erasmus MC (NL)
Corresponding author: Huizink, Anja C.
ORCID: Huizink, Anja C.
Mulder, Eduard J.H.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2006-01
Volume: 30
Issue: 1
Pages: 24-41
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2005.04.005
OpenAlex: W2079050247
Cited by: 468
References: 163
Citations by year: 2026: 6 · 2025: 12 · 2024: 9 · 2023: 9 · 2022: 11 · 2021: 20 · 2020: 19 · 2019: 25 · 2018: 19 · 2017: 29 · 2016: 15 · 2015: 28 · 2014: 31 · 2013: 31 · 2012: 33
FWCI: 4.06
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Radboud Repository (Radboud University) (submittedVersion)
VU Research Portal (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: prenatal exposure, maternal smoking, prenatal alcohol exposure, prenatal cannabis exposure, neurobehavioral outcomes, cognitive function, ADHD symptoms, externalizing problems, learning and memory impairment, teratogenicity, low-dose exposure
MeSH terms: Alcohol Drinking, Animals, Cannabis, Cognition, Female, Humans, Maternal Behavior, Pregnancy, Prenatal Exposure Delayed Effects, Smoking

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Maternal smoking, drinking or cannabis use during pregnancy and neurobehavioral and cognitive functioning in human offspring

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