The DOI matches its Crossref record; 269 of the 269 references it cites were found in a registry or an index.
Neurobehavioral evidence for changes in dopamine system activity during adolescence
Open accessAbstract
Human adolescence has been characterized by increases in risk-taking, emotional lability, and deficient patterns of behavioral regulation. These behaviors have often been attributed to changes in brain structure that occur during this developmental period, notably alterations in gray and white matter that impact synaptic architecture in frontal, limbic, and striatal regions. In this review, we provide a rationale for considering that these behaviors may be due to changes in dopamine system activity, particularly overactivity, during adolescence relative to either childhood or adulthood. This rationale relies on animal data due to limitations in assessing neurochemical activity more directly in juveniles. Accordingly, we also present a strategy that incorporates molecular genetic techniques to infer the status of the underlying tone of the dopamine system across developmental groups. Implications for the understanding of adolescent behavioral development are discussed.
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“Childhood and adolescence are sensitive periods in which these systems develop and change [26–29], making them particularly vulnerable to insult.”
From Psychological impacts of “screen time” and “green time” for children and adolescents: A systematic scoping review (2020) · cites this paper as [27]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
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“These neurobiological changes underlie the profound maturation in motivational and cognitive domains across adolescence [30–34]”
From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [30]
In the citing paper
“recent studies have indicated changes in dopaminergic innervation to have more influence on circuitry development during adolescence”
From Developmental Changes in Organization of Structural Brain Networks (2013) · cites this paper as Wahlstrom et al. 2010
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Cited by
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Understanding adolescence as a period of social–affective engagement and goal flexibility
Crone, E. A., & Dahl, R. E. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3313 · Cited by 2,507
Extraordinary neoteny of synaptic spines in the human prefrontal cortex
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“The protracted postadolescent period of synaptic elimination and increase in dopaminergic innervation of the prefrontal cortex (61) may be linked to human-specific cognitive functions and circuitry specializations (58) that are a product of cooperation between genetic endowment and environment, as postulated by the se…”
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“Wehypothesize that these structures will represent nodes of the ascending mesocorticolimbic dopamine system (Berridge and Robinson, 1998; Goto and Grace, 2005; Wahlstrom et al., 2010b).”
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Metadata
- Authors
- Wahlstrom, D., White, T., & Luciana, M.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Luciana, Monica
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 34
- Issue
- 5
- Pages
- 631-648
- ISSN
- 0149-7634 (ISSN-L)
- PMC
- PMC2845533
- OpenAlex
- W2102081573
- Cited by
- 277
- References
- 263
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 10 · 2023: 10 · 2022: 18 · 2021: 14 · 2020: 54 · 2019: 12 · 2018: 11 · 2017: 13 · 2016: 21 · 2015: 17 · 2014: 19 · 2013: 25 · 2012: 13
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (T32MH017069)
- National Institute on Drug Abuse (R01DA017843)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- dopaminergic system, adolescence, neurobehavioral development, risk-taking, emotional lability, behavioral regulation, synaptic structure, striatum, frontal cortex, limbic system, white matter, gray matter, animal models, molecular genetics
- MeSH terms
- Adolescent, Animals, Behavior, Catechol O-Methyltransferase, Dopamine, Humans, Human Development, Models, Neurological
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