Cited by 277Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesSchizophrenia research and treatment

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Neurobehavioral evidence for changes in dopamine system activity during adolescence

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Wahlstrom, Dustin, White, Tonya, Luciana, Monica·2010·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2009.12.007PMC PMC2845533

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Abstract

Human adolescence has been characterized by increases in risk-taking, emotional lability, and deficient patterns of behavioral regulation. These behaviors have often been attributed to changes in brain structure that occur during this developmental period, notably alterations in gray and white matter that impact synaptic architecture in frontal, limbic, and striatal regions. In this review, we provide a rationale for considering that these behaviors may be due to changes in dopamine system activity, particularly overactivity, during adolescence relative to either childhood or adulthood. This rationale relies on animal data due to limitations in assessing neurochemical activity more directly in juveniles. Accordingly, we also present a strategy that incorporates molecular genetic techniques to infer the status of the underlying tone of the dopamine system across developmental groups. Implications for the understanding of adolescent behavioral development are discussed.

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“, [85]) and dopamine activity peaks in adolescence (see [86]), studies using selective behavioral measures of food palatability suggest that DA does not play a crucial role in this aspect of reward processing [34].”
Background
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“…both child development and older age such as maturation of GABAergic and glutamatergic neurons during childhood and adolescence (10); dopaminergic (11) and hormonal changes that occur during adolescence; and decreased dopaminergic, serotoninergic, and cholinergic transmission later in life…”
Background
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“This system promotes reward-seeking behavior by activating limbic, striatal, and frontal networks, enhancing an individual ’ s capacity to transfer positive motives into adaptive actions (Wahlstrom et al., 2010).”
Background

Authors: Wahlstrom, D., White, T., & Luciana, M.
Affiliations: University of Minnesota (US)
Corresponding author: Luciana, Monica
ORCID: Wahlstrom, Dustin
White, Tonya
Luciana, Monica
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2010-04
Volume: 34
Issue: 5
Pages: 631-648
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2009.12.007
PMC: PMC2845533
OpenAlex: W2102081573
Cited by: 277
References: 263
Citations by year: 2026: 7 · 2025: 12 · 2024: 10 · 2023: 10 · 2022: 18 · 2021: 14 · 2020: 54 · 2019: 12 · 2018: 11 · 2017: 13 · 2016: 21 · 2015: 17 · 2014: 19 · 2013: 25 · 2012: 13
FWCI: 0.97
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (T32MH017069)
National Institute on Drug Abuse (R01DA017843)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: dopaminergic system, adolescence, neurobehavioral development, risk-taking, emotional lability, behavioral regulation, synaptic structure, striatum, frontal cortex, limbic system, white matter, gray matter, animal models, molecular genetics
MeSH terms: Adolescent, Animals, Behavior, Catechol O-Methyltransferase, Dopamine, Humans, Human Development, Models, Neurological

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Neurobehavioral evidence for changes in dopamine system activity during adolescence

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