Developmental changes in dopamine neurotransmission in adolescence: Behavioral implications and issues in assessment
Open accessAbstract
Adolescence is characterized by increased risk-taking, novelty-seeking, and locomotor activity, all of which suggest a heightened appetitive drive. The neurotransmitter dopamine is typically associated with behavioral activation and heightened forms of appetitive behavior in mammalian species, and this pattern of activation has been described in terms of a neurobehavioral system that underlies incentive-motivated behavior. Adolescence may be a time of elevated activity within this system. This review provides a summary of changes within cortical and subcortical dopaminergic systems that may account for changes in cognition and affect that characterize adolescent behavior. Because there is a dearth of information regarding neurochemical changes in human adolescents, models for assessing links between neurochemical activity and behavior in human adolescents will be described using molecular genetic techniques. Furthermore, we will suggest how these techniques can be combined with other methods such as pharmacology to measure the impact of dopamine activity on behavior and how this relation changes through the lifespan.
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Childhood and adolescence are sensitive periods in which these neurobiological systems develop and change, making young people particularly vulnerable to insult.
“Childhood and adolescence are sensitive periods in which these systems develop and change [26–29], making them particularly vulnerable to insult.”
From Psychological impacts of “screen time” and “green time” for children and adolescents: A systematic scoping review (2020) · cites this paper as [26]
The Introduction describes widespread neurobiological changes during adolescence, supporting that part of the cited sentence. The passages do not establish childhood as a sensitive period or say that these changes make young people particularly vulnerable to insult; the vulnerability discussed in Section II concerns negative consequences of adolescent risk-seeking. (LLM, conf=0.85)
Experimental — accuracy not yet measuredThe brain mechanisms of interest here show a distinctive pattern of development: subcortical regions involved in incentive motivation develop faster than the prefrontal regions that exert inhibition in the interests of long-term consequences.
“The brain mechanisms of interest here show a distinctive pattern of development: subcortical regions involved in incentive motivation develop faster than the prefrontal regions that exert inhibition in the interests of long-term consequences (Gladwin et al., 2011;Wahlstrom et al., 2010).”
From A motivation model of sex addiction – Relevance to the controversy over the concept (2022) · cites this paper as Wahlstrom et al., 2010
Section V describes heightened adolescent incentive motivation alongside slower prefrontal structural development and potentially weaker behavioral inhibition. But it presents their interaction as a hypothesis, not an established finding that subcortical regions develop faster than prefrontal regions; it also says there is no clear cortical–subcortical difference in overall dopamine activity. Page numbers were not available in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe DA system undergoes marked developmental changes through adolescence and into adulthood.
“Marked developmental alterations are seen in the DA system through adolescence and into adulthood, as reviewed recently elsewhere (Ernst et al, 2009; Galvan, 2010; Wahlstrom et al, 2010).”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Wahlstrom et al, 2010
Marked developmental alterations occur in the DA system through adolescence and into adulthood.
“Marked developmental alterations are seen in the DA system through adolescence and into adulthood, as reviewed recently elsewhere (Ernst et al, 2009; Galvan, 2010; Wahlstrom et al, 2010).”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Wahlstrom et al, 2010
An adolescent-limited increase in IM confers evolutionary advantages and promotes learning, encouraging a sense of agency as youth transition to adult independence.
“An adolescent-limited increase in IM is a positive development that may confer evolutionary advantages and that serves ultimately--through the promotion of learning--to encourage a sense of agency as youth make the transition to adult independence (Spear, 2000; Wahlstrom et al., 2010).”
From Incentive Motivation, Cognitive Control, and the Adolescent Brain: Is It Time for a Paradigm Shift? (2012) · cites this paper as Wahlstrom et al., 2010
Biologically determined trait-based individual differences very likely interact with age-based trends to determine developmental outcomes.
“Importantly, biologically determined trait-based individual differences very likely interact with these age-based trends to determine developmental outcomes (Wahlstrom et al. 2010).”
From Incentive Motivation, Cognitive Control, and the Adolescent Brain: Is It Time for a Paradigm Shift? (2012) · cites this paper as Wahlstrom et al. 2010
Dopamine receptor expression peaks around the age of puberty, though only for specific receptor subtypes in specific neuronal populations.
“Dopamine receptor expression also peaks around the age of puberty, though only for specific receptor subtypes in specific neuronal populations (reviewed in (Wahlstrom et al., 2010)).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Wahlstrom et al., 2010
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“Similar models have been proposed to account for decrements in working memory and other fluid abilities that are associated with normal aging (Lindenberger et al., 2008; Backman et al., 2006; Nagel et al., 2008).”
Effects of bromocriptine on human subjects depend on working memory capacity
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“making, planning, working memory, and inhibitory control (Asato et al., 2006; Crone et al., 2004; Hooper et al., 2004; Luciana et al., 2005; Luciana et al., 2009; Luna et al., 2004).”
BackgroundSelf-citationHuman brain dopamine receptors in children and aging adults
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“D1 and D2 receptor densities appear to be heightened during adolescence compared to adulthood in both cortical and subcortical regions, though peaks in receptor density occur in childhood (Lidow & Rakic, 1992; Seeman et al., 1987).”
BackgroundDopaminergic modulation of cortical function in patients with Parkinson's disease
Mattay, V. S., Tessitore, A., Callicott, J. H., Bertolino, A., Goldberg, T. E., Chase, T. N., Hyde, T. M., & Weinberger, D. R. (2002) · Annals of Neurology · doi:10.1002/ana.10078 · Cited by 402 · cited 1× · see citing works
“In addressing these issues, the monoamines have been of specific interest because of extensive data linking their activity to multiple domains of affect, cognition, and motor behaviors (Depue & Spoont, 1986; Mattay et al., 2002; Sawaguchi & Goldman-Rakic, 1994; Wise, 2004), as well as psychiatric disorders such as dep…”
BackgroundOlesen, P. J., Nagy, Z., Westerberg, H., & Klingberg, T. (2003) · Cognitive Brain Research · doi:10.1016/j.cogbrainres.2003.09.003 · Cited by 397 · see citing works
The Cortical Dopamine System: Role in Memory and Cognition
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“Age-related sources of variation in structure–function relations are relatively small in magnitude (Olson et al., 2009; Schmithorst et al., 2005; Shaw et al., 2006), and some structure– function relations are not easily attributable to maturational processes (Olesen, Nagy, Westerberg, & Klingberg,…”
BackgroundVariation in dopamine genes influences responsivity of the human reward system
Dreher, J.-C., Kohn, P., Kolachana, B., Weinberger, D. R., & Berman, K. F. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805517106 · Cited by 376 · cited 1× · see citing works
“Finally, individuals whose genetic predispositions result in higher levels of dopamine in neural synapses, particularly in circuits involved in reward processing, demonstrate increased levels of brain activation in response to rewards (Dreher et al., 2009; Hariri, 2009).”
BackgroundCostello, E. J., Erkanli, A., Federman, E. B., & Angold, A. C. (1999) · Journal of Clinical Child Psychology · doi:10.1207/s15374424jccp280302 · Cited by 368 · cited 1× · see citing works
“These associations may be especially relevant to adolescence, given the broad changes in cognition and affect that occur during this time as well as increased rates of psychiatric disorders (Costello et al., 1999; Kessler et al., 2005; Paus, Keshaven & Giedd, 2008; Shedler & Block, 1990, Szymanski et al., 1995).”
BackgroundMultivariate analysis and psychological theory
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“…such as shifts in brain matter composition (see papers by Paus, Gogtay, Thompson, and Schmithorst (this issue)), modifications of neural synchrony (Uhlhaas et al., 2009), increased hormonal release (Styne, 1994), and neurochemical alterations (Doremus-Fitzwater et al., this issue; Spear, 2000).”
BackgroundPsychoactive drug use in evolutionary perspective
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The role of noradrenaline in tuning and dopamine in switching between signals in the CNS
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Self-citationThe neuropsychology of emotion and personality.
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A critical role for "affective neuroscience" in resolving what is basic about basic emotions.
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Postnatal development of monoamine content and synthesis in the cerebral cortex of rhesus monkeys
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Connectivity-based segregation of the human striatum predicts personality characteristics
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“More direct conclusions could also be drawn through the use of acute psychopharmacological challenge paradigms, which have provided important and useful information regarding the impact of dopamine manipulations on adult cognition (Cools et al., 2007; Floresco & Magyar, 2006; Luciana & Collins, 1997).”
BackgroundModels of information processing in the basal ganglia
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The neurobiology of individual differences in complex behavioral traits
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A Behavioral Dimension of Constraint
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High Impulsivity Predicts Relapse to Cocaine-Seeking After Punishment-Induced Abstinence
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“These animals are also more vulnerable to drug reinstatement after extinction (Economidou et al., 2009; Robinson et al., 2009).”
BackgroundAge-related decline in brain resources magnifies genetic effects on cognitive functioning
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Neuroleptic-induced attenuation of brain stimulation reward in rats.
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Functional magnetic resonance imaging of facial affect recognition in children and adolescents
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Cocaine sensitization in periadolescent and adult rats.
Giovanni Laviola, A., Wood, R. D., Kuhn, C. M., Francis, R., & SPEAR, L. P. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12056-9 · Cited by 195 · cited 1× · see citing works
“In animal models, periadolescent rodents exhibit heightened novelty seeking, risk-taking, locomotor activity, and grooming as compared to adults (Adriani, Chiarotti, & Laviola, 1998; Laviola et al., 1995; Macri, Adriani, Chiarotti, & Laviola, 2002; Spear & Brake, 1983), all of which are argued to be roughly analogous…”
BackgroundHaycock, J. W., Becker, L. E., Ang, L. C., Furukawa, Y., Hornykiewicz, O., & Kish, S. J. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02017.x · Cited by 195 · see citing works
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“For example, numerous groups have used functional MRI techniques to document developmental differences in neural systems during the completion of reward-related tasks, which implicate differences in regions innervated by dopamine such as the OFC and ventral striatum (Van Leijenhorst, Zanolie1, Van Meel, Westenberg, Ro…”
BackgroundO’Donnell, P., & Grace, A. A. (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033325 · Cited by 191 · see citing works
Ventral Tegmental Area BDNF Induces an Opiate-Dependent–Like Reward State in Naïve Rats
Vargas-Pérez, H., Ting‐A‐Kee, R. A., Walton, C. H., Hansen, D. M., Razavi, R., Clarke, L., Bufalino, M. R., Allison, D. W., Steffensen, S. C., & van der Kooy, D. (2009) · Science · doi:10.1126/science.1168501 · Cited by 187 · cited 1× · see citing works
“(2006) study, though based on a small sample and not replicated, indicates that adolescents exhibit hyperresponsivity of the ventral striatum in response to reward compared to adults, which could reflect hyperactivity of the modulatory dopamine system or of other neurochemicals involved in reward processing, such as o…”
BackgroundOlson, E. A., Collins, P. F., Hooper, C. J., Muetzel, R., Lim, K. O., & Luciana, M. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21107 · Cited by 185 · cited 1× · see citing works
“Age-related sources of variation in structure–function relations are relatively small in magnitude (Olson et al., 2009; Schmithorst et al., 2005; Shaw et al., 2006), and some structure– function relations are not easily attributable to maturational processes (Olesen, Nagy, Westerberg, & Klingberg,…”
BackgroundSelf-citationTarazi, F. I., Tomasini, E. C., & Baldessarini, R. J. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00644-2 · Cited by 179 · see citing works
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“Several groups have demonstrated that DA tissue concentrations increase postnatally until adulthood (Giorgi et al., 1987; Ungethüm et al., 1996), though other data indicate that dopamine synthesis peaks during adolescence relative to both childhood and adulthood (Andersen, Dumont, & Teicher, 1997).”
BackgroundDopamine Increases Excitability of Pyramidal Neurons in Primate Prefrontal Cortex
Henze, D. A., González‐Burgos, G., Urban, N. N., Lewis, D. A., & Barrionuevo, G. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.6.2799 · Cited by 171 · cited 1× · see citing works
“Dopamine decreases the voltage threshold required for cell firing in these pyramidal cells (Henze et al., 2000); thus, adolescence may by characterized by increased excitability of the neural networks underlying prefrontally Wahlstrom et al.”
BackgroundTarazi, F. I., Tomasini, E. C., & Baldessarini, R. (1999) · Developmental Neuroscience · doi:10.1159/000017365 · Cited by 169 · see citing works
Dopaminergic Modulation of Working Memory for Spatial but Not Object Cues in Normal Humans
Luciana, M. M., & Collins, P. F. (1997) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1997.9.3.330 · Cited by 168 · see citing works
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“Others have indicated that dopamine receptor density stabilizes beginning in periadolescence, but these findings might relate to a lack of measurement in the time points defining that period (as opposed to directly prior to and following periadolescence) (Leslie et al., 1991; Rao et al., 1991).”
BackgroundMacrı̀, S., Adriani, W., Chiarotti, F., & Giovanni Laviola, A. (2002) · Animal Behaviour · doi:10.1006/anbe.2002.4004 · Cited by 165 · see citing works
Developmental differences in dopamine synthesis inhibition by (±)-7-OH-DPAT
Andersen, S. L., Dumont, N. L., & Teicher, M. H. (1997) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/pl00005038 · Cited by 159 · see citing works
Investigating the dopaminergic basis of extraversion in humans: A multilevel approach.
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Pubertal changes in gonadal hormones do not underlie adolescent dopamine receptor overproduction
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“However, D1 and D2 densities do appear to peak in subcortical structures such as the striatum and nucleus accumbens, as do the densities of D2-like D3 and D4 receptors (Andersen et al., 2002; Tarazi, Tomasini, & Baldessarini, 1998b).”
BackgroundCognitive processes in the development of TOL performance
Asato, M. R., Sweeney, J. A., & Luna, B. (2006) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.05.010 · Cited by 149 · cited 1× · see citing works
“making, planning, working memory, and inhibitory control (Asato et al., 2006; Crone et al., 2004; Hooper et al., 2004; Luciana et al., 2005; Luciana et al., 2009; Luna et al., 2004).”
BackgroundSelf Regulatory Behavior and Risk Taking: Causes and Consequences
Lipsitt, L. P., & Mitnick, L. L. (1991) · Medical Entomology and Zoology · Cited by 148 · see citing works
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Reward-related processing in the human brain: developmental considerations
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Genetic contributions to avoidance-based decisions: striatal D2 receptor polymorphisms
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Postnatal development of dopamine D1 and D2 receptor sites in rat striatum
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Amygdala response to facial expressions in children and adults
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“Similar studies have found that adolescents exhibit a unique pattern of amygdaloid activation in response to emotional facial expressions (Baird et al., 2001; Thomas et al., 2001).”
ResultThe Dynamics of Self-Esteem and Delinquency
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Aging and the nigrostriatal dopamine system: a non-human primate study.
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“making, planning, working memory, and inhibitory control (Asato et al., 2006; Crone et al., 2004; Hooper et al., 2004; Luciana et al., 2005; Luciana et al., 2009; Luna et al., 2004).”
BackgroundSelf-citationCatecholamines in neocortex of rhesus monkeys: regional distribution and ontogenetic development
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“The D4 dopamine receptor and the dopamine transporter genes are also likely candidates for analysis, because individual differences in SNPs associated with these genes have been linked to variations in personality traits, externalizing behaviors, and higherorder cognition (DeYoung et al., 2006; Durston et al., 2008; M…”
BackgroundDevelopment and Ageing of the Rat Nigrostriatal Dopamine System Studied with Fast Cyclic Voltammetry
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Cellular and subcellular localization of the dopamine transporter in rat cortex
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“This latter interpretation seems possible given that the PFC dopamine system is less rigorously regulated in terms of autoreceptor and dopamine transporter activity (Bannon & Roth, 1983; Sesack et al., 1998).”
BackgroundDistribution of Dopamine in the rat cerebral cortex
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Differential expression of autoreceptors in the ascending dopamine systems of the human brain.
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“Prefrontal synapses have received a maximal amount of empirical assessment and are characterized by low activity of the dopamine transporter, by relatively low numbers of DA autoreceptors, by catechol-O-methyltransferase (COMT) versus monoamine oxidase (MAO) activity in DA catabolism, and by a relative abundance of D1…”
BackgroundSerotonergic mechanisms in anxiety
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NEURODEVELOPMENTAL MECHANISMS IN PSYCHOPATHOLOGY
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Mesoprefrontal dopaminergic neurons: Can tyrosine availability influence their functions?
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CSF dopamine levels correlate with extraversion in depressed patients
King, R., Mefford, I. N., Wang, C., Murchison, A., Caligari, E. J., & Berger, P. A. (1986) · Psychiatry Research · doi:10.1016/0165-1781(86)90123-x · Cited by 72 · cited 1× · see citing works
“Eysenck’s extraversion modulates the impact of dopamine antagonists on cognitive performance in humans (Wacker, Chavanon, & Stemmler, 2006), and levels of dopamine in cerebrospinal fluid are positively correlated with trait levels of extraversion (King et al., 1986).”
BackgroundBerger, B., Verney, C., Febvret, A., Vigny, A., & Helle, K. B. (1985) · Developmental Brain Research · doi:10.1016/0165-3806(85)90021-5 · Cited by 71 · see citing works
Ontogeny of dopamine D1 receptors in rat forebrain: a quantitative autoradiographic study
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Self-citationNeurodevelopmental Mechanisms in Psychopathology
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Textbook of pediatric neuropsychiatry
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Developmental Regulation of the Dopamine D1 Receptor in Human Caudate and Putamen
Montague, D. C. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00062-7 · Cited by 61 · cited 1× · see citing works
“Few studies have assessed the ontogeny of dopamine receptor density in humans, but those that have indicate that densities decrease between childhood and adulthood (Montague et al., 1999; Seeman et al., 1987).”
BackgroundDeYoung, C. G., Peterson, J. B., Séguin, J. R., Mejia, J. M., Pihl, R. O., Beitchman, J. H., Jain, U., Tremblay, R. E., Kennedy, J. L., & Palmour, R. M. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.12.1410 · Cited by 60 · cited 1× · see citing works
“The D4 dopamine receptor and the dopamine transporter genes are also likely candidates for analysis, because individual differences in SNPs associated with these genes have been linked to variations in personality traits, externalizing behaviors, and higherorder cognition (DeYoung et al., 2006; Durston et al., 2008; M…”
BackgroundElements of the Intrinsic Organization and Information Processing in the Neostriatum
Groves, P. M., Garcia-Munoz, M., Linder, J. C., Manley, M. S., Martone, M. E., & Young, S. J. (1994) · The MIT Press eBooks · doi:10.7551/mitpress/4708.003.0007 · Cited by 59 · see citing works
Neurodevelopment During Adolescence
SPEAR, L. P. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546365.005 · Cited by 58 · see citing works
Pre- and postnatal development of dopaminergic neuron numbers in the male and female mouse midbrain
Lieb, K., Andersen, C., Lazarov, N., Zienecker, R., Urban, I., Reisert, I., & Pilgrim, C. (1996) · Developmental Brain Research · doi:10.1016/0165-3806(96)00063-6 · Cited by 52 · cited 1× · see citing works
“Other evidence suggests that changes in dopamine receptors are similar in males and females (Lieb et al., 1996); however, rates of change during adolescence were not directly compared.”
ResultD2 dopamine receptor gene polymorphism discriminates two kinds of novelty seeking
Berman, S. M., Ozkaragoz, T. Z., Young, R. M., & Noble, E. P. (2002) · Personality and Individual Differences · doi:10.1016/s0191-8869(01)00197-0 · Cited by 50 · see citing works
DeYoung, C. G., Getchell, M., Koposov, R. A., Yrigollen, C. M., Haeffel, G. J., af Klinteberg, B., Oreland, L., Ruchkin, V. V., PAKSTIS, A. J., & Grigorenko, E. L. (2009) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32833511e4 · Cited by 48 · see citing works
Beyer, C. E., & Steketee, J. D. (2000) · Psychopharmacology · doi:10.1007/s002139900345 · Cited by 48 · see citing works
Evaluation of Unconditioned Novelty-Seeking and d-Amphetamine–Conditioned Motivation in Mice
Giovanni Laviola, A., & Adriani, W. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00531-5 · Cited by 40 · see citing works
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“…such as shifts in brain matter composition (see papers by Paus, Gogtay, Thompson, and Schmithorst (this issue)), modifications of neural synchrony (Uhlhaas et al., 2009), increased hormonal release (Styne, 1994), and neurochemical alterations (Doremus-Fitzwater et al., this issue; Spear, 2000).”
BackgroundUngeth�m, U., Chen, Y., Gross, J. P., Bjelke, B., Bolme, P., Eneroth, P. H. E., Heldt, J., Loidl, C. F., Herrera‐Marschitz, M., & Andersson, K. (1996) · Experimental Brain Research · doi:10.1007/bf00227946 · Cited by 34 · see citing works
Vadász, C., Smiley, J. F., Figarsky, K., Saito, M., Tóth, R., Gyetvai, B. M., Oros, M., Kovacs, K. K., Mohan, P. S., & Wang, R. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.06.049 · Cited by 33 · cited 1× · see citing works
“The synthesis of tyrosine hydryxylase is under genetic control (Vadasz et al., 2007), and genes also regulate the activity of catabolic enzymes (MAO, COMT: Lachman et al.”
BackgroundICTAL SYMPTOMS RELATING TO THE NATURE OF AFFECTS AND THEIR CEREBRAL SUBSTRATE
MASLEAN, P. D. (1986) · Elsevier eBooks · doi:10.1016/b978-0-12-558703-7.50009-7 · Cited by 30 · see citing works
Kalaria, R. N., Fiedler, C., Hunsaker, J. C., & Sparks, D. L. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03494.x · Cited by 22 · see citing works
Number of dopamine neurons predicts prolactin levels in two inbred mouse strains
Sved, A. F., Baker, H. A., & Reis, D. J. (1985) · Cellular and Molecular Life Sciences · doi:10.1007/bf02007700 · Cited by 18 · cited 1× · see citing works
“Animal studies have revealed plasticity in the coupling that emerges over time between neurons that synthesize dopamine and receptors in target regions, such that higher cell numbers are associated with higher numbers of receptors in target regions as well as the increased expression of behaviors that are DA-modulated…”
BackgroundOn the constructive role of problem behavior in adolescence further evidence on alcohol use
Silbereisen, R. Κ., & Reitzle, M. (. U. B. (1987) · OpenGrey (Institut de l'Information Scientifique et Technique) · Cited by 2 · see citing works
Andersen (2000) · doi:10.1002/1098-2396(200008)37:2
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Maturation of the adolescent brain
SHARMA, S. K., Arain, Mathur, Rais, Nel, Sandhu, Haque, & Johal (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s39776 · Cited by 1,339 · see citing works
“These changes, which are the consequence of puberty, occur primarily in the brain regions closely linked to emotions, arousal, motivation, as well as to appetite and sleep patterns.”
BackgroundAdolescence as a neurobiological critical period for the development of higher-order cognition
Larsen, B., & Luna, B. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.005 · Cited by 853 · see citing works
“This behavior is thought to be linked to the development of the DA system (for Reviews see: (Luciana et al., 2012; Padmanabhan and Luna, 2014; Sturman and Moghaddam, 2011; Telzer, 2016; Wahlstrom et al., 2010)).”
<scp>N</scp> icotine and the adolescent brain
Yuan, M., Cross, S. J., Loughlin, S. E., & Leslie, F. M. (2015) · The Journal of Physiology · doi:10.1113/jp270492 · Cited by 582 · see citing works
“During adolescence, there are also major functional changes in the dopamine system that parallel changes in emotional regulation and cognitive function (Wahlstrom et al. 2010; Naneix et al. 2012; Garske et al. 2013; Spear, 2013).”
BackgroundAn Integrative Model of the Maturation of Cognitive Control
Luna, B., Marek, S., Larsen, B., Tervo-Clemmens, B., & Chahal, R. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-034054 · Cited by 550 · see citing works
Impulsivity-related personality traits and adolescent alcohol use: a meta-analytic review.
Stautz, K., & Cooper, A. (2013) · Clinical Psychology Review · doi:10.1016/j.cpr.2013.03.003 · Cited by 491 · see citing works
Beyond stereotypes of adolescent risk taking: Placing the adolescent brain in developmental context
Römer, D., Reyna, V. F., & Satterthwaite, T. D. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.07.007 · Cited by 421 · see citing works
“This rather striking pattern is regarded as a marker of rising dopaminergic activation during adolescence (Chambers et al., 2003; Wahlstrom et al., 2010) and may reflect activity in the midbrain dopamine pathway ascending from the ventral tegmental region (Ikemoto, 2007; Previc, 2009).”
Oswald, T. K., Rumbold, A. R., Kedzior, S. G. E., & Moore, V. M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237725 · Cited by 367 · see citing works
Adolescent alcohol exposure: Are there separable vulnerable periods within adolescence?
SPEAR, L. P. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.01.027 · Cited by 364 · see citing works
“, [83]) suggested that elevated PFC DA activity might lead to a functional DA “overdose” there during adolescence and hence a preponderance of subcortical DA activity, although they did not detail when during adolescence such changes might take place.”
Unraveling the Miswired Connectome: A Developmental Perspective
Martino, A. D., Fair, D. A., Kelly, C. A. M., Satterthwaite, T. D., Castellanos, F. X., Thomason, M. E., Craddock, R. C., Luna, B., LEVENTHAL, B. L., Zuo, X., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.050 · Cited by 346 · see citing works
“Schizophrenia research provides a useful example: recent models suggest that frontoparietal dysfunction may in part result from low-level abnormalities in the visual system (Butler et al., 2001).”
BackgroundThe attentive brain: insights from developmental cognitive neuroscience
Amso, D., & Scerif, G. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4025 · Cited by 333 · see citing works
Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior
Crews, F. T., Vetreno, R. P., Broadwater, M., & Robinson, D. L. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.012138 · Cited by 332 · see citing works
Spear, L. P. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.08.001 · Cited by 292 · see citing works
Matt, S. M., & Gaskill, P. J. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09851-4 · Cited by 286 · see citing works
“While this enables a more standardized comparison, it does not account for substantial variability resulting from differences in species, age, cell type or sex (Arvidsson et al. 2014; Bourque et al. 2011; Cosentino et al. 2000; Pilipović et al. 2008; Wahlstrom et al. 2010).”
Neurobehavioral evidence for changes in dopamine system activity during adolescence
Wahlstrom, D., White, T., & Luciana, M. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.12.007 · Cited by 277 · see citing works
“…this model predicts individual differences in neuroplasticity on the basis of genotype, and indeed, we observe that adolescents who carry the Met-Met genotype have a more protracted rate of working memory development than individuals with the Val-Met and Val-Val genotypes (Wahlstrom et al., 2010).”
BackgroundInfluentialSelf-citationSilverman, M. H., Jedd, K., & Luciana, M. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.07.083 · Cited by 277 · see citing works
“Wehypothesize that these structures will represent nodes of the ascending mesocorticolimbic dopamine system (Berridge and Robinson, 1998; Goto and Grace, 2005; Wahlstrom et al., 2010b).”
InfluentialSelf-citationTelzer, E. H. (2016) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2015.10.010 · Cited by 274 · see citing works
Adolescence as a vulnerable period to alter rodent behavior
Schneider, M. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1581-2 · Cited by 266 · see citing works
“1997) and considerable changes in dopaminergic signaling have also been reported to occur in human adolescents (Wahlstrom et al. 2010).”
BackgroundUrošević, S., Collins, P., Muetzel, R., Lim, K., & Luciana, M. (2012) · Developmental Psychology · doi:10.1037/a0027502 · Cited by 258 · see citing works
Self-citationThe triadic model perspective for the study of adolescent motivated behavior
Ernst, M. (2014) · Brain and Cognition · doi:10.1016/j.bandc.2014.01.006 · Cited by 240 · see citing works
Olson, E. A., Collins, P. F., Hooper, C. J., Muetzel, R., Lim, K. O., & Luciana, M. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21107 · Cited by 185 · see citing works
Self-citationDoes puberty mark a transition in sensitive periods for plasticity in the associative neocortex?
Piekarski, D. J., Johnson, C. M., Boivin, J. R., Thomas, A. W., Lin, W. C., Delevich, K., M. Galarce, E., & Wilbrecht, L. (2017) · Brain Research · doi:10.1016/j.brainres.2016.08.042 · Cited by 175 · see citing works
“Given that reward circuitry is also developing (Benes et al., 1996; Sinclair et al., 2014; Wahlstrom et al., 2010), it is not surprising that animal models of drug abuse reveal unique patterns of drug-related behaviors (Schramm-Sapyta et al., 2009) and heightened sensitivity to the long-term…”
BackgroundInfluentialBuecker, S., Luhmann, M., Haehner, P., Bühler, J. L., Dapp, L. C., Luciano, E. C., & Orth, U. (2023) · Psychological Bulletin · doi:10.1037/bul0000401 · Cited by 178 · see citing works
Silk, J. S., Davis, S., McMakin, D. L., Dahl, R. E., & Forbes, E. E. (2012) · Psychological Medicine · doi:10.1017/s0033291712000207 · Cited by 155 · see citing works
“…to changes in dopaminergic systems in adolescence, including changes in the firing rates, density and concentration of dopamine fibers and receptors and a shift in the balance of dopamine receptors across brain regions (see reviews by Ernst et al. 2009 ; Galvan, 2010 ; Wahlstrom et al. 2010).”
BackgroundLuciana, M., Wahlstrom, D., Porter, J. N., & Collins, P. F. (2012) · Developmental Psychology · doi:10.1037/a0027432 · Cited by 156 · see citing works
“Table 1, reprinted from Wahlstrom et al. (2010b), summarizes evidence of adolescentspecific changes in dopamine function.”
BackgroundSelf-citationAdolescent brain development in normality and psychopathology
Luciana, M. M. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000643 · Cited by 157 · see citing works
Self-citationStojan, R., & Voelcker‐Rehage, C. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050734 · Cited by 154 · see citing works
“The decrease in cognitive performance is associated with a variety of age-related brain changes, including the shrinkage in grey and white matter volume [11–13], region specific changes in brain connectivity [14,15], losses in brain vascularization and cerebral blood flow [16,17], higher rates of neuroinflammation [18…”
BackgroundDennison, M., Whittle, S., Yücel, M., Vijayakumar, N., Kline, A., Simmons, J., & Allen, N. B. (2013) · Developmental Science · doi:10.1111/desc.12057 · Cited by 146 · see citing works
Brain Development During Adolescence
Konrad, K., Firk, C., & Uhlhaas, P. J. (2013) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2013.0425 · Cited by 323 · see citing works
Salmanzadeh, H., Ahmadi‐Soleimani, S. M., Pachenari, N., Azadi, M., Halliwell, R. F., Rubino, T., & Azizi, H. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.01.007 · Cited by 146 · see citing works
Mesocorticolimbic Dopamine Pathways Across Adolescence: Diversity in Development
Reynolds, L. M., & Flores, C. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.735625 · Cited by 137 · see citing works
Adolescent brain maturation and smoking: What we know and where we’re headed
Lydon‐Staley, D. M., Wilson, S. J., Child, A. E., & Geier, C. F. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.003 · Cited by 133 · see citing works
Spontaneous blink rate as an index of attention and emotion during film clips viewing
Maffei, A., & Angrilli, A. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.02.037 · Cited by 133 · see citing works
Doremus-Fitzwater, T. L., & Spear, L. P. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.015 · Cited by 125 · see citing works
“Additionally, adolescent rodents have been reported to exhibit significant changes in motivational and reward-related behaviors (as reviewed below), as well as marked transformations in reward-relevant neural regions and related neurocircuitry, with similarity in these fundamental neural alterations again evident betw…”
BackgroundIncentive Motivation, Cognitive Control, and the Adolescent Brain: Is It Time for a Paradigm Shift?
Luciana, M., & Collins, P. F. (2012) · Child Development Perspectives · doi:10.1111/j.1750-8606.2012.00252.x · Cited by 123 · see citing works
“An adolescent-limited increase in IM is a positive development that may confer evolutionary advantages and that serves ultimately--through the promotion of learning--to encourage a sense of agency as youth make the transition to adult independence (Spear, 2000; Wahlstrom et al., 2010).”
BackgroundInfluentialSelf-citationHippocampal BDNF in physiological conditions and social isolation
Zaletel, I. V., Filipović, D., & Puškaš, N. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2016-0072 · Cited by 107 · see citing works
“The period of early adolescence during which this social isolation model was applied is an important period for the maturation of the dopaminergic and glutamatergic neurotransmitter system in which significant changes occur (Wahlstrom et al., 2010; Arain et al., 2013).”
BackgroundBauer, J. A., Devick, K. L., Bobb, J. F., Coull, B. A., Bellinger, D. C., Benedetti, C., Cagna, G., Fedrighi, C., Guazzetti, S., Oppini, M., et al. (2020) · Environmental Health Perspectives · doi:10.1289/ehp6803 · Cited by 110 · see citing works
Adolescent brain development: Implications for the juvenile criminal justice system.
Luna, B., & Wright, C. M. (2015) · American Psychological Association eBooks · doi:10.1037/14643-005 · Cited by 105 · see citing works
The impact of junk foods on the adolescent brain
Reichelt, A. C., & Rank, M. M. (2017) · Birth Defects Research · doi:10.1002/bdr2.1173 · Cited by 102 · see citing works
Ait-Bali, Y., Ba-M’hamed, S., & Bennis, M. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00146 · Cited by 98 · see citing works
“…in functional connectivity between regions of the prefrontal cortex and several areas of the limbic system, especially the dopaminergic and serotoninergic systems, concomitant with changes in emotional and cognitive function regulation (Wahlstrom et al., 2010; Naneix et al., 2012; Spear, 2013).”
BackgroundHo, T. C., Gifuni, A. J., & Gotlib, I. H. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01171-5 · Cited by 100 · see citing works
Adolescent brain development, risk-taking and vulnerability to addiction
Dayan, J., Bernard, A., Olliac, B., Mailhes, A.-S., & Kermarrec, S. (2010) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2010.08.007 · Cited by 101 · see citing works
“iour, and thus in reward-seeking, which cannot yet be controlled by the immature frontal regions (Wahlstrom et al., 2010).”
BackgroundFast dopamine release events in the nucleus accumbens of early adolescent rats
Robinson, D. L., Zitzman, D. L., Smith, K. J., & Spear, L. P. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2010.12.016 · Cited by 94 · see citing works
“…undergo dynamic changes during adolescence, it is not surprising that behavioral and neurochemical responses to rewards and novel stimuli that may well predict rewards are also dynamic (for reviews, see Chambers et al., 2003; Ernst et al., 2009; Wahlstrom et al., 2010b; Wahlstrom et al., 2010a).”
BackgroundWu, M., Minkowicz, S., Dumrongprechachan, V., Hamilton, P., & Kozorovitskiy, Y. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.022 · Cited by 93 · see citing works
“Because our experiments were carried out in young animals and neural plasticity dynamics are known to change across age (76 – 78), the ef fi cacy of ketamine treatment could vary in clinical populations as a function of age even if mechanisms of action are conserved.”
MethodReichelt, A. C. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00189 · Cited by 93 · see citing works
“Longitudinal neuroimaging studies have demonstrated that the brain, in particular the prefrontal cortex (PFC), continues to mature until ∼24 years old (Giedd et al., 1999; Sowell et al., 2001; Casey et al., 2008b; Wahlstrom et al., 2010; Mills et al., 2014).”
BackgroundOvarian Cycle Effects on Immediate Reward Selection Bias in Humans: A Role for Estradiol
Smith, C. T., Sierra, Y., Oppler, S. H., & Boettiger, C. A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0014-14.2014 · Cited by 91 · see citing works
“Measures of frontal DA neurotransmission decrease from adolescence to adulthood (Wahlstrom et al., 2010), including a rise in COMT expression with age (Tunbridge et al.”
BackgroundZisner, A. R., & Beauchaine, T. P. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000754 · Cited by 92 · see citing works
“…into adulthood (Lenroot & Giedd, 2006), combined with normal upregulation of DA functioning, lead to increased saliency of and motivation to seek rewards that then manifest as increased risk-taking and novelty-seeking behaviors (see Chambers, Taylor, & Potenza, 2003; Wahlstrom et al., 2010).”
BackgroundKendig, M. D., Boakes, R. A., Rooney, K. B., & Corbit, L. H. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.08.012 · Cited by 87 · see citing works
“Importantly, adolescence is also characterized by structural refinement to frontal and limbic brain systems involved in higher-order cognition [22,23], and a temporary spike in the activity of the dopaminergic system [24].”
BackgroundAdolescents are more vulnerable to cocaine addiction: behavioral and electrophysiological evidence
Wong, W. C., Ford, K. A., Pagels, N. E., McCutcheon, J. E., & Marinelli, M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1371-12.2013 · Cited by 87 · see citing works
“The adolescent brain undergoes extensive organizational and functional changes, including changes in the mesolimbic dopamine system (Andersen et al., 1997; Spear, 2000; Wahlstrom et al., 2010).”
Developmental imaging genetics: Linking dopamine function to adolescent behavior
Padmanabhan, A., & Luna, B. (2014) · Brain and Cognition · doi:10.1016/j.bandc.2013.09.011 · Cited by 87 · see citing works
Effects of reward sensitivity and regional brain volumes on substance use initiation in adolescence
Urošević, S., Collins, P. F., Muetzel, R. L., Schissel, A. M., Lim, K. O., & Luciana, M. M. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu022 · Cited by 83 · see citing works
“This DA-modulated network is implicated in adolescent brain development (Ernst et al., 2006b; Wahlstrom et al., 2010) and it contributes to rewarding aspects of abused substances (Koob and Volkow, 2010).”
BackgroundSelf-citationLongitudinal changes in white matter microstructure after heavy cannabis use
Becker, M. P., Collins, P. F., Lim, K. O., Muetzel, R. L., & Luciana, M. M. (2015) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2015.10.004 · Cited by 76 · see citing works
Self-citationKhurana, A., Römer, D., Betancourt, L. M., & Hurt, H. (2018) · Journal of Youth and Adolescence · doi:10.1007/s10964-018-0891-9 · Cited by 74 · see citing works
“This finding is consistent with the interpretation of sensation seeking as an indicator of rising dopamine expression that leads to heightened reward sensitivity (Wahlstrom et al., 2010) but that is also a critical modulator of working memory performance (Cools & D’Esposito, 2011).”
ResultAlloy, L. B., & Nusslock, R. (2019) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2019.1567347 · Cited by 73 · see citing works
“Dopamine expression also increases in adolescence underlying such traits as sensation seeking and reward sensitivity (Wahlstrom, Collins, White, & Luciana, 2010).”
Lukie, C. N., Montazer-Hojat, S., & Holroyd, C. B. (2014) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2014.04.003 · Cited by 62 · see citing works
Adolescent peer interaction and trait surgency weaken medial prefrontal cortex responses to failure
Segalowitz, S. J., Santesso, D. L., Willoughby, T., Reker, D. L., Campbell, K., Chalmers, H., & Rose-Krasnor, L. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq090 · Cited by 58 · see citing works
Parr, A. C., Calabro, F., Larsen, B., Tervo-Clemmens, B., Elliot, S., Foran, W., Olafsson, V., & Luna, B. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.101997 · Cited by 60 · see citing works
Li, M., Du, W., Shao, F., & Wang, W. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.07.025 · Cited by 67 · see citing works
Saragosa‐Harris, N. M., Cohen, A. O., Reneau, T. R., Villano, W. J., Heller, A. S., & Hartley, C. A. (2022) · Psychological Science · doi:10.1177/09567976221102070 · Cited by 59 · see citing works
“, 1999; Philpot & Wecker, 2008; Stansfield & Kirstein, 2006), potentially reflecting reorganization of dopaminergic reward circuitry during adolescence (Crews et al., 2007; Doremus-Fitzwater et al., 2010; Galván, 2010; Spear, 2000a, 2011; Wahlstrom et al., 2010).”
BackgroundAge modulates the effect of COMT genotype on delay discounting behavior
Smith, C. T., & Boettiger, C. A. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2653-9 · Cited by 59 · see citing works
“As noted earlier, several measures of frontal DA signaling decrease from adolescence to adulthood (see (Wahlstrom et al. 2010) for recent review).”
BackgroundInfluentialUrošević, S., Collins, P. F., Muetzel, R. L., Lim, K. O., & Luciana, M. M. (2014) · Brain and Cognition · doi:10.1016/j.bandc.2014.01.007 · Cited by 59 · see citing works
Self-citationUse and abuse of dissociative and psychedelic drugs in adolescence
Bates, M. L. S., & Trujillo, K. A. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173129 · Cited by 58 · see citing works
“For a more detailed review of developmental differences in dopamine neurotransmission, see (Wahlstrom et al., 2010).”
Laviolette, S. R. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108411 · Cited by 57 · see citing works
Neuroimaging of the dopamine/reward system in adolescent drug use
Ernst, M., & Luciana, M. M. (2015) · CNS Spectrums · doi:10.1017/s1092852915000395 · Cited by 55 · see citing works
“For the purpose of this review, it is important to note that these behavioral patterns are influenced by ontogenic changes in neurotransmitter systems, including the dopamine (DA) system, which is fundamental in the neural coding of reward processes, and, more generally, in motivated approach behavior.(16,17) Reward s…”
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“, [59]) and changes in endocrinology and hormonal status (e.”
BackgroundDoumas, D. M., Miller, R., & Esp, S. M. (2016) · Addictive Behaviors · doi:10.1016/j.addbeh.2016.08.003 · Cited by 54 · see citing works
A Combination of Dopamine Genes Predicts Success by Professional Wall Street Traders
Sapra, S., Beavin, L. E., & Zak, P. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030844 · Cited by 54 · see citing works
“Levels of synaptic dopamine have an inverted-U relationship with several cognitive abilities as shown by both animal and human data [21].”
BackgroundPredictors of recurrent sprains after an index lateral ankle sprain: a longitudinal study
Pourkazemi, F., Hiller, C. E., Raymond, J., Black, D. A., Nightingale, E. J., & Refshauge, K. M. (2017) · Physiotherapy · doi:10.1016/j.physio.2017.10.004 · Cited by 54 · see citing works
On the normative advantages of dopamine and striatal opponency for learning and choice
Jaskir, A., & Frank, M. J. (2023) · eLife · doi:10.7554/elife.85107 · Cited by 53 · see citing works
Zhou, M., Rebholz, H., Brocia, C., Warner‐Schmidt, J. L., Fienberg, A. A., Nairn, A. C., Greengard, P., & Flajolet, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0915173107 · Cited by 51 · see citing works
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A longitudinal analysis of adolescent decision-making with the Iowa Gambling Task.
Almy, B., Kuskowski, M. A., Malone, S. M., Myers, E. J., & Luciana, M. M. (2017) · Developmental Psychology · doi:10.1037/dev0000460 · Cited by 51 · see citing works
Self-citationWu, M., Minkowicz, S., Dumrongprechachan, V., Hamilton, P., Xiao, L., & Kozorovitskiy, Y. (2021) · eLife · doi:10.7554/elife.64041 · Cited by 53 · see citing works
“One interesting possibility is that projections and activity profiles of DA neuron subgroups could be related to earlylife and adolescent experience (O’Donnell, 2010; Peña et al., 2019; Peña et al., 2017; Wahlstrom et al., 2010), resulting in variability of the overall low- dimensional activity pattern of the VTA DA p…”
van den Bos, R., Davies, W., Dellu-Hagedorn, F., Goudriaan, A. E., Granon, S., Homberg, J. R., Rivalan, M., Swendsen, J. D., & Adriani, W. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.07.005 · Cited by 49 · see citing works
Puberty Predicts Approach But Not Avoidance on the Iowa Gambling Task in a Multinational Sample
Icenogle, G., Steinberg, L. D., Olino, T. M., Shulman, E. P., Chein, J. M., Alampay, L. P., Al‐Hassan, S. M., Takash, H. M. S., Bacchini, D., Chang, L., et al. (2016) · Child Development · doi:10.1111/cdev.12655 · Cited by 48 · see citing works
Adolescent social defeat alters markers of adult dopaminergic function
Novick, A. M., Forster, G. L., Tejani‐Butt, S. M., & Watt, M. J. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.06.009 · Cited by 47 · see citing works
“Adolescence marks a period of critical change in which the mesocorticolimbic dopamine (DA) system undergoes substantial reorganization, enabling emotional and cognitive development that aids in the transition to adulthood [61, 70].”
BackgroundHämmerer, D., Müller, V., & Li, S. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.06.008 · Cited by 47 · see citing works
“With regard to neuromodulators, a protracted development in the cortical dopamine system is observed, which reaches adult levels only in late adolescence (Diamond et al., 2004; Wahlstrom et al., 2010; see Li, 2013 for review).”
Kameda, S. R., Fukushiro, D. F., Trombin, T. F., Procópio‐Souza, R., Patti, C. L., Hollais, A. W., Calzavara, M. B., Abílio, V. C., Ribeiro, R. A., Tufik, S., et al. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.01.013 · Cited by 44 · see citing works
Karkhanis, A. N., Leach, A. C., Yorgason, J. T., Uneri, A., Barth, S. H., Niere, F., Alexander, N. J., Weiner, J. L., McCool, B. A., Raab‐Graham, K. F., et al. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00360 · Cited by 46 · see citing works
A Positive Affective Neuroendocrinology Approach to Reward and Behavioral Dysregulation
Welker, K. M., Gruber, J., & Mehta, P. H. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00093 · Cited by 43 · see citing works
Juvenile stress affects anxiety-like behavior and limbic monoamines in adult rats
Luo, X.-M., Yuan, S., Guan, X., Xie, X., Shao, F., & Wang, W. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.05.035 · Cited by 43 · see citing works
Overman, W., & Pierce, A. M. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00935 · Cited by 41 · see citing works
“Males as young as 7–15 years of age years perform significantly higher than females on a child-friendly variant of the IGT, the hungry donkey task (Crone et al., 2005).”
BackgroundMethodSuryanarayana, S. M., Kotaleski, J. H., Grillner, S. E., & GURNEY, K. N. (2018) · Neural Networks · doi:10.1016/j.neunet.2018.10.003 · Cited by 39 · see citing works
Meyer, B. M., Huemer, J., Rabl, U., Boubela, R. N., Kalcher, K., Berger, A., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Büchel, C., et al. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0895-5 · Cited by 39 · see citing works
“…adolescence such as increases of basal dopamine (DA) levels and changes of DA turnover resulting in a peak of prefrontal dopaminergic neurotransmission in early adolescence that declines thereafter (Andersen et al. 1997; Rosenberg and Lewis 1994, 1995; Teicher et al. 1993; Wahlstrom et al. 2010).”
BackgroundVan Beveren, M.-L., Mezulis, A., Wante, L., & Braet, C. (2019) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2016.1233499 · Cited by 38 · see citing works
Adolescent brain maturation and the neuropathological effects of binge drinking: A critical review
Tetteh-Quarshie, S., & Risher, M. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1040049 · Cited by 38 · see citing works
Binge drinking and illicit drug use among adolescent students
Raposo, J. C. D. S., Costa, A. C. D. Q., Valença, P. A. D. M., Zarzar, P. M., Diniz, A. D. S., Colares, V., & da Franca›, C. (2017) · Revista de Saúde Pública · doi:10.11606/s1518-8787.2017051006863 · Cited by 38 · see citing works
Fowler, J. A., Gullo, M. J., & Elphinston, R. A. (2020) · Personality and Individual Differences · doi:10.1016/j.paid.2020.109965 · Cited by 38 · see citing works
Role of Dopamine 2 Receptor in Impaired Drug-Cue Extinction in Adolescent Rats
Zbukvic, I., Ganella, D. E., Perry, C. J., Madsen, H. B., Bye, C. R., Lawrence, A. J., & Kim, J. H. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw051 · Cited by 37 · see citing works
“Adolescence constitutes a period of dramatic maturation of the mPFC, including alterations in dopamine receptor density (Andersen et al. 2000), fiber infiltration (Kalsbeek et al. 1988), and dopamine availability (Wahlstrom et al. 2010).”
BackgroundRocha, A., Hart, N., & Trujillo, K. A. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.04.007 · Cited by 37 · see citing works
“…parameters related to NMDA receptor/dopamine interactions in the forebrain are immature in early adolescence, and the adult pattern does not emerge until late adolescence (Flores-Barrera et al., 2014; O'Donnell, 2011; Tseng and O'Donnell, 2005; Tseng et al., 2007; Wahlstrom et al., 2010).”
Murty, V. P., Shah, H., Montez, D. F., Foran, W., Calabro, F. J., & Luna, B. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3508-17.2018 · Cited by 36 · see citing works
“Prior animal work has shown that dopamine receptor availability as well as baseline firing rate of dopamine neurons are enhanced in adolescent rodents (Wahlstrom et al., 2010a,b), both of which are putative neurobiological mechanisms of enhanced motivation (Lisman and Grace, 2005; Luo et al., 2011).”
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Adolescent morphine exposure induces immediate and long-term increases in impulsive behavior
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Adolescence is the starting point of sex-dichotomous COMT genetic effects
Sannino, S., Padula, M. C., Managò, F., Schaer, M., Schneider, M., Armando, M., Scariati, E., Bena, F. S., Mereu, M., Pontillo, M., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.109 · Cited by 34 · see citing works
Traumatic Brain Injury and Juvenile Offending
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A neuroscience perspective on sexual risk behavior in adolescence and emerging adulthood
Victor, E. C., & Hariri, A. R. (2015) · Development and Psychopathology · doi:10.1017/s0954579415001042 · Cited by 34 · see citing works
“…rewards, coding reward prediction in response to cues that signal reward delivery and providing cues to reward prediction fails (see in depth reviews of DA function and development and implications for adolescent behavior: Luciana et al., 2012; O’Donnell, 2010; Spear, 2000; Wahlstrom et al., 2010).”
BackgroundModulation of reward-related neural activation on sensation seeking across development
Hawes, S. W., Chahal, R., Hallquist, M. N., Paulsen, D. J., Geier, C. F., & Luna, B. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.12.020 · Cited by 32 · see citing works
“Participants were assessed for IQ using the Wechsler Abbreviated Scale of Intelligence (WASI; Wechsler, 1999), and demonstrated scores in the normal range (M=110.99, SD=11.64).”
Influential
- Authors
- Wahlstrom, D., Collins, P., White, T., & Luciana, M.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Luciana, Monica
- Venue
- Brain and Cognition
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 72
- Issue
- 1
- Pages
- 146-159
- ISSN
- 0278-2626 (ISSN-L)
- PMC
- PMC2815132
- OpenAlex
- W2168203121
- Cited by
- 311
- References
- 195
- Citations by year
- 2026: 14 · 2025: 20 · 2024: 15 · 2023: 28 · 2022: 24 · 2021: 21 · 2020: 15 · 2019: 18 · 2018: 19 · 2017: 17 · 2016: 25 · 2015: 18 · 2014: 15 · 2013: 29 · 2012: 11
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain and Cognition (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (T32MH017069)
- National Institute on Drug Abuse (DA017843, R01DA017843)
- National Center for Research Resources (M01RR000400, M01-RR00400)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- dopamine signaling, adolescence, appetitive behavior, risk-taking, novelty seeking, dopaminergic system, molecular genetics, pharmacological evaluation, lifespan development, cognitive and emotional development
- MeSH terms
- Adolescent, Animals, Behavior, Brain, Dopamine, Humans, Neural Pathways, Synaptic Transmission, Adolescent Development
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