The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Individual differences in prefrontal cortex function and the transition from drug use to drug dependence
Open accessAbstract
Several neuropsychological hypotheses have been formulated to explain the transition to addiction, including hedonic allostasis, incentive salience, and the development of habits. A key feature of addiction that remains to be explored is the important individual variability observed in the propensity to self-administer drugs, the sensitivity to drug-associated cues, the severity of the withdrawal state, and the ability to quit. In this review, we suggest that the concept of self-regulation, combined with the concept of modularity of cognitive function, may aid in the understanding of the neural basis of individual differences in the vulnerability to drugs and the transition to addiction. The thesis of this review is that drug addiction involves a failure of the different subcomponents of the executive systems controlling key cognitive modules that process reward, pain, stress, emotion, habits, and decision-making. A subhypothesis is that the different patterns of drug addiction and individual differences in the transition to addiction may emerge from differential vulnerability in one or more of the subcomponents.
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Cites
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The Self-Medication Hypothesis of Substance Use Disorders: A Reconsideration and Recent Applications
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Drug Addiction, Dysregulation of Reward, and Allostasis
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Self-citationSex, gender, and pain: a review of recent clinical and experimental findings
Fillingim, R. B., King, C. D., Ribeiro-Dasilva, M. C., Rahim-Williams, B., & Riley, J. L. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2008.12.001 · Cited by 2,766
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Drug abuse: hedonic homeostatic dysregulation
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Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective
Bechara, A. (2005) · Nature Neuroscience · doi:10.1038/nn1584 · Cited by 2,149 · cited 2×
“This loss of control has often been attributed to a dysfunction of the frontal lobes or hypofrontality (Bechara, 2005; Mishkin, 1964; Pribram, 1956) and subsequent dysregulation of the different subcortical cognitive systems controlled by the prefrontal cortex.”
Background
Cited by
Relationship between Nonmedical Prescription-Opioid Use and Heroin Use
Compton, W. M., Jones, C. M., & Baldwin, G. T. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1508490 · Cited by 1,044
Decision making under stress: A selective review
Starcke, K., & Brand, M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.02.003 · Cited by 870
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Abnormal Brain Structure Implicated in Stimulant Drug Addiction
Ersche, K. D., Jones, P. S., Williams, G. B., Turton, A. J., Robbins, T. W., & Bullmore, E. T. (2012) · Science · doi:10.1126/science.1214463 · Cited by 546
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Nitsche, M. A., & Paulus, W. (2011) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2011-0618 · Cited by 544
Metadata
- Authors
- George, O., & Koob, G. F.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 35
- Issue
- 2
- Pages
- 232-247
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W1975600479
- Cited by
- 313
- References
- 84
- FWCI
- 9.83
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
