The DOI matches its Crossref record; 203 of the 203 references it cites were found in a registry or an index.
Parietal cortex matters in Alzheimer's disease: An overview of structural, functional and metabolic findings
Abstract
Atrophy of the medial temporal lobe, especially the hippocampus and the parahippocampal gyrus, is considered to be the most predictive structural brain biomarker for Alzheimer's Dementia (AD). However, recent neuroimaging studies reported a possible mismatch between structural and metabolic findings, showing medial temporal lobe atrophy and medial parietal hypoperfusion as biomarkers for AD. The role of the parietal lobe in the development of AD is only recently beginning to attract attention. The current review discusses parietal lobe involvement in the early stages of AD, viz. mild cognitive impairment, as reported from structural, functional, perfusion and metabolic neuroimaging studies. The medial and posterior parts of the parietal lobe seem to be preferentially affected, compared to the other parietal lobe parts. On the basis of the reviewed literature we propose a model showing the relationship between the various pathological events, as measured by different neuroimaging techniques, in the development of AD. In this model myelin breakdown is a beginning of the chain of pathological events leading to AD pathology and an AD diagnosis.
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“given the impact of AD on parietal cortex 30”
From Alzheimer's disease and its progression reduce pyramidal cell gain and connectivity (2025) · cites this paper as [30]
Citations
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Memory loss in Alzheimer's disease
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The cerebellum in Alzheimer’s disease: evaluating its role in cognitive decline
Jacobs, H. I. L., Hopkins, D. A., Mayrhofer, H. C., Bruner, E., van Leeuwen, F. W., Raaijmakers, W., & Schmahmann, J. D. (2017) · Brain · doi:10.1093/brain/awx194 · Cited by 349
Self-citationBrickman, A. M., Provenzano, F. A., Muraskin, J., Manly, J. J., Blum, S., Apa, Z. L., Stern, Y., Brown, T. R., Luchsinger, J. A., & Mayeux, R. P. (2012) · Archives of Neurology · doi:10.1001/archneurol.2012.1527 · Cited by 258
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A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain
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Metadata
- Authors
- Jacobs, H. I. L., Van Boxtel, M. P. J., Jolles, J., Verhey, F. R. J., & Uylings, H. B. M.
- Affiliations
- Maastricht University (NL)
- Corresponding author
- Jacobs, Heidi I.L.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 36
- Issue
- 1
- Pages
- 297-309
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2119341498
- Cited by
- 293
- References
- 202
- Citations by year
- 2026: 16 · 2025: 40 · 2024: 28 · 2023: 28 · 2022: 25 · 2021: 21 · 2020: 15 · 2019: 15 · 2018: 11 · 2017: 17 · 2016: 9 · 2015: 12 · 2014: 21 · 2013: 22 · 2012: 12
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- VU Research Portal (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Alzheimer's disease, parietal lobe, medial temporal lobe atrophy, hippocampus, parahippocampal gyrus, mild cognitive impairment, brain metabolism, myelin breakdown, neuroimaging biomarkers
- MeSH terms
- Alzheimer Disease, Cognition Disorders, Humans, Models, Biological, Parietal Lobe, Radionuclide Imaging, Retrospective Studies, PubMed, Neuroimaging
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