Alzheimer's Disease: The Downside of a Highly Evolved Parietal Lobe?

Bruner, Emiliano; Jacobs, Heidi I.L.

doi:10.3233/jad-122299

Cited by 87Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Alzheimer's Disease: The Downside of a Highly Evolved Parietal Lobe?

Bruner, Emiliano, Jacobs, Heidi I.L.·2013·Journal of Alzheimer's Disease

DOI 10.3233/jad-122299

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Abstract

Clinical grade Alzheimer's disease (AD) is only described in humans. Recent imaging studies in early AD patients showed that the parietal areas display the most prominent metabolic impairments. So far, neuroimaging studies have not been able to explain why the medial parietal regions possess this hub characteristic in AD. Paleoneurological and neuroanatomical studies suggest that our species, Homo sapiens, has a unique and derived organization of the parietal areas, which are involved in higher cognitive functions. Combining evidence from neuroimaging, paleontology, and comparative anatomy, we suggest that the vulnerability of the parietal lobe to neurodegenerative processes may be associated with the origin of our species. The species-specific parietal morphology in modern humans largely influenced the brain spatial organization, and it involved changes in vascularization and energy management, which may underlie the sensitivity of these areas to metabolic impairment. Metabolic constraints and anatomical evolutionary changes in the medial parietal regions of modern humans may be important in early AD onset. Taking into account the species-specific adaptations of the modern human parietal areas and their association with AD, we hypothesize that AD can be the evolutionary drawback of the specialized structure of our parietal lobes. The cognitive advantage is associated with increased sensitivity to neurodegenerative processes which, being limited to the post-reproductive period, have a minor effect on the overall genetic fitness. The changes of energy requirements associated with form and size variations at the parietal areas may support the hypothesis of AD as a metabolic syndrome.

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Visual Association Pathology in Preclinical Alzheimer Disease
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“Furthermore, parietal lobe alterations could also have an impact on clinical practice, as hypometabolism in the medial parietal areas is more accurate in differentiating cognitively healthy older people from early AD patients than metabolic changes in other brain regions [34, 61–63].”
Numerical Modeling of Temperature Distributions within the Neonatal Head
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Morphological Differences in the Parietal Lobes within the Human Genus
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Selective brain cooling in humans: “fancy” or fact?
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The amyloid cascade hypothesis
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Neuronal and morphological bases of cognitive decline in aged rhesus monkeys
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Obesity, leptin, and Alzheimer's disease
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Middle Cranial Fossa Anatomy and the Origin of Modern Humans
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Neuropathology of Pick’s disease
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Numerosity, Abstraction, and the Emergence of Symbolic Thinking
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A bivariate approach to the widening of the frontal lobes in the genus Homo
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Frontoparietal Network Involved in Successful Retrieval from Episodic Memory. Spatial and Temporal Analyses Using fMRI and ERP
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Theoretical model of temperature regulation in the brain during changes in functional activity
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Specialized brain cooling in humans?
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Vascular and metabolic dysfunction in Alzheimer’s disease: a review
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Alzheimer's disease: Pathogenesis and prevention
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How the body controls brain temperature: the temperature shielding effect of cerebral blood flow
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Functional MRI Assessment of Task-Induced Deactivation of the Default Mode Network in Alzheimer’s Disease and At-Risk Older Individuals
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Disconnection of Frontal and Parietal Areas Contributes to Impaired Attention in Very Early Alzheimer's Disease
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Qualitative magnetic resonance imaging findings in geriatric depression. Possible link between later-onset depression and Alzheimer's disease?
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Temporoparietal MR Imaging Measures of Atrophy in Subjects with Mild Cognitive Impairment That Predict Subsequent Diagnosis of Alzheimer Disease
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Understanding the parietal lobe syndrome from a neurophysiological and evolutionary perspective
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Functional MRI assessment of task-induced deactivation of the default mode network in Alzheimer's disease and at-risk older individuals.
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Cerebral perfusion correlates of conversion to Alzheimer's disease in amnestic mild cognitive impairment
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Increasing Required Neural Response to Expose Abnormal Brain Function in Mild Versus Moderate or Severe Alzheimer's Disease: PET Study Using Parametric Visual Stimulation
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The cortical network for eye–hand coordination and its relevance to understanding motor disorders of parietal patients
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Hominoid visual brain structure volumes and the position of the lunate sulcus
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Atrophy of the parietal lobe in preclinical dementia
Jacobs, H. I. L., van Boxtel, M. P. J., Uylings, H. B. M., Gronenschild, E. H. B. M., Verhey, F. R. J., & Jolles, J. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2010.11.003 · Cited by 73 · see citing works
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Functional integration of parietal lobe activity in early Alzheimer disease
Jacobs, H. I. L., van Boxtel, M. P. J., Heinecke, A., Gronenschild, E. H. B. M., Backes, W. H., Ramakers, I. H. G. B., Jolles, J., & Verhey, F. R. J. (2012) · Neurology · doi:10.1212/wnl.0b013e318245287d · Cited by 71 · see citing works
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Distinctive alterations of the cingulum bundle during aging and Alzheimer’s disease
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Primate aging in the mammalian scheme: the puzzle of extreme variation in brain aging
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Morphology and histology of chimpanzee primary visual striate cortex indicate that brain reorganization predated brain expansion in early hominid evolution
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The middle meningeal artery: from clinics to fossils
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Visuospatial processing in early Alzheimer’s disease: A multimodal neuroimaging study
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The evolution of the meningeal vascular system in the human genus: From brain shape to thermoregulation
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Thermodynamic constraints on neural dimensions, firing rates, brain temperature and size
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The Merits of FDDNP-PET Imaging in Alzheimer's Disease
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Exploring the dorsal surface of hominoid brain endocasts by stereoplotter and discriminant analysis
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A Bivariate Approach to the Variation of the Parietal Curvature in the Genus Homo
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Midsagittal cranial shape variation in the genus Homo by geometric morphometrics.
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Fractal dimension of the middle meningeal vessels: variation and evolution in Homo erectus , Neanderthals, and modern humans
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Discrimination of normal aging, MCI and AD with multimodal imaging measures on the medial temporal lobe
Jhoo, J. H., Lee, D. Y., Choo, I. H., Seo, E. H., Oh, J. S., Lee, J. S., Lee, D. S., Kim, S. G., Youn, J. C., Kim, K. W., et al. (2010) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2010.03.006 · Cited by 43 · see citing works
Brain temperature: heat production, elimination and clinical relevance
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Research Towards Tau Imaging
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Gender‐based differences in the shape of the human corpus callosum are associated with allometric variations
Bruner, E., de la Cuétara, J. M., Colom, R., & Martín‐Loeches, M. (2012) · Journal of Anatomy · doi:10.1111/j.1469-7580.2012.01476.x · Cited by 41 · see citing works
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Alzheimer's disease: an evolutionary approach.
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Successful vs. Unsuccessful Aging in the Rhesus Monkey
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Effects of neonatal amygdala or hippocampus lesions on resting brain metabolism in the macaque monkey: A microPET imaging study
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Relative size of the eye and orbit: An evolutionary and craniofacial constraint model for examining the etiology and disparate incidence of juvenile-onset myopia in humans
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Quantifying patterns of endocranial heat distribution: Brain geometry and thermoregulation
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Multimodal Imaging of Alzheimer Pathophysiology in the Brain′s Default Mode Network
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Anatomy of the parietal lobe: Mapping the individual pattern
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Is Alzheimer's disease amyloidosis the result of a repair mechanism gone astray?
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Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer’s Disease: Novel PET/SPECT Imaging Probes for Diagnosis of Alzheimer’s Disease
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From Blood Oxygenation Level Dependent (BOLD) Signals to Brain Temperature Maps
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Amyloid imaging of alzheimer’s disease using pittsburgh compound B
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Increasing the Diagnostic Accuracy of Medial Temporal Lobe Atrophy in Alzheimer's Disease
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Successful vs. Unsuccessful Aging in the Rhesus Monkey -- Brain Aging: Models, Methods, and Mechanisms
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A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain
Del-Aguila, J. L., Li, Z., Dube, U., Mihindukulasuriya, K. A., Budde, J. P., Fernandez, M. V., Ibanez, L., Bradley, J., Wang, F., Bergmann, K., et al. (2019) · Alzheimer's Research & Therapy · doi:10.1186/s13195-019-0524-x · Cited by 183 · see citing works
Evidence for expansion of the precuneus in human evolution
Bruner, E., Preuss, T. M., Chen, X., & Rilling, J. K. (2017) · Brain Structure and Function · doi:10.1007/s00429-015-1172-y · Cited by 172 · see citing works
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The shape of the human language-ready brain
Boeckx, C. A. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.00282 · Cited by 158 · see citing works
Rich club analysis in the Alzheimer's disease connectome reveals a relatively undisturbed structural core network
Daianu, M., Jahanshad, N., Nir, T. M., Jack, C. R., Weiner, M. W., Bernstein, M. A., Thompson, P. M., & Initiative, T. A. D. N. (2015) · Human Brain Mapping · doi:10.1002/hbm.22830 · Cited by 144 · see citing works
Extending mind, visuospatial integration, and the evolution of the parietal lobes in the human genus
Bruner, E., & Iriki, A. (2015) · Quaternary International · doi:10.1016/j.quaint.2015.05.019 · Cited by 140 · see citing works
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Dynamic functional connectivity changes in dementia with Lewy bodies and Alzheimer's disease
Schumacher, J., Peraza, L. R., Firbank, M., Thomas, A. J., Kaiser, M., Gallagher, P., O'Brien, J. T., Blamire, A. M., & Taylor, J. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101812 · Cited by 122 · see citing works
The effect of white matter hyperintensities on neurodegeneration in mild cognitive impairment
Tosto, G., Zimmerman, M. E., Hamilton, J. L., Carmichael, O. T., Brickman, A. M., & Initiative, A. D. N. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2015.05.014 · Cited by 112 · see citing works
Cognitive Archaeology and the Cognitive Sciences
Coolidge, F. L., Wynn, T., Overmann, K. A., & Hicks, J. M. (2014) · Springer series in bio-/neuroinformatics · doi:10.1007/978-3-319-08500-5_8 · Cited by 112 · see citing works
A catalog of single nucleotide changes distinguishing modern humans from archaic hominins
Kuhlwilm, M., & Boeckx, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-44877-x · Cited by 108 · see citing works
Functional craniology and brain evolution: from paleontology to biomedicine
Bruner, E., de la CuÃ©tara, J. M., Masters, M., Amano, H., & Ogihara, N. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00019 · Cited by 87 · see citing works
“Beyond any possible coincidence, we should seriously evaluate the possibility that the vulnerability of the parietal areas, and the sensitivity to the processes of neurodegeneration associated with AD, could be a drawback of the complexity of our brain anatomy (Bruner and Jacobs, 2013).”
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Robust Identification of Alzheimer’s Disease subtypes based on cortical atrophy patterns
Park, J.-Y., Na, H. K., Kim, S. S., Kim, H., Kim, H. J., Seo, S. W., Na, D. L., Han, C. E., Seong, J., Initiative, A. D. N., et al. (2017) · Scientific Reports · doi:10.1038/srep43270 · Cited by 80 · see citing works
Egocentric versus allocentric spatial memory in behavioral variant frontotemporal dementia and Alzheimer's disease
Tu, S., Spiers, H. J., Hodges, J. R., Piguet, O., & Hornberger, M. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160592 · Cited by 70 · see citing works
Midsagittal brain variation and MRI shape analysis of the precuneus in adult individuals
Bruner, E., Lázaro, G. R., de la Cuétara, J. M., Martín‐Loeches, M., Colom, R., & Jacobs, H. I. L. (2014) · Journal of Anatomy · doi:10.1111/joa.12155 · Cited by 67 · see citing works
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Brain-derived neurotrophic factor and TrkB expression in the “oldest-old,” the 90+ Study: correlation with cognitive status and levels of soluble amyloid-beta
Michalski, B., Corrada, M. M., Kawas, C. H., & Fahnestock, M. L. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.08.022 · Cited by 55 · see citing works
Cognitive Improvement and Brain Changes after Real-Time Functional MRI Neurofeedback Training in Healthy Elderly and Prodromal Alzheimer’s Disease
Hohenfeld, C., Nellessen, N. D., Dogan, I., Kuhn, H., Müller, C., Papa, F., Ketteler, S. T., Goebel, R., Heinecke, A., Shah, N. J., et al. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00384 · Cited by 55 · see citing works
Possible functional links among brain- and skull-related genes selected in modern humans
Benítez‐Burraco, A., & Boeckx, C. A. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00794 · Cited by 54 · see citing works
Functional Craniology and Brain Evolution
Bruner, E. (2014) · Springer series in bio-/neuroinformatics · doi:10.1007/978-3-319-08500-5_4 · Cited by 52 · see citing works
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Malignant progression in parietal-dominant atrophy subtype of Alzheimer's disease occurs independent of onset age
Na, H. K., Kang, D. R., Kim, S. S., Seo, S. W., Heilman, K. M., Noh, Y., & Na, D. L. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.001 · Cited by 49 · see citing works
Parkinson's disease: Is it a consequence of human brain evolution?
Diederich, N. J., Surmeier, D. J., Uchihara, T., Grillner, S. E., & Goetz, C. G. (2019) · Movement Disorders · doi:10.1002/mds.27628 · Cited by 49 · see citing works
‘Evolutionary medicine’ perspectives on Alzheimer’s Disease: Review and new directions
Fox, M. M. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.008 · Cited by 46 · see citing works
Structural efficiency within a parieto-frontal network and cognitive differences
Pineda‐Pardo, J. A., Martínez, K., Román, F. J., & Colom, R. (2015) · Intelligence · doi:10.1016/j.intell.2015.12.002 · Cited by 47 · see citing works
Resilience to cognitive impairment in the oldest-old: design of the EMIF-AD 90+ study
Legdeur, N., Badissi, M., Carter, S. F., de Crom, S., van de Kreeke, A., Vreeswijk, R., Trappenburg, M. C., Oudega, M. L., Koek, H. L., van Campen, J. P., et al. (2018) · BMC Geriatrics · doi:10.1186/s12877-018-0984-z · Cited by 45 · see citing works
The Fossil Evidence of Human Brain Evolution
Bruner, E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804042-3.00105-6 · Cited by 42 · see citing works
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Visuospatial Integration: Paleoanthropological and Archaeological Perspectives
Bruner, E., Spinapolice, E. E., Burke, A. M., & Overmann, K. A. (2018) · Interdisciplinary evolution research · doi:10.1007/978-3-319-93776-2_19 · Cited by 43 · see citing works
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The Evolution-Driven Signature of Parkinson’s Disease
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Authors: Bruner, E., & Jacobs, H. I. L.
Affiliations: Centro Nacional de Investigación sobre la Evolución Humana (ES)
Forschungszentrum Jülich (DE)
Corresponding author: Bruner, Emiliano
ORCID: Bruner, Emiliano
Jacobs, Heidi I.L.
Venue: Journal of Alzheimer's Disease
Publisher: SAGE Publications
Published: 2013-04-17
Volume: 35
Issue: 2
Pages: 227-240
ISSN: 1387-2877 (ISSN-L)
1875-8908
DOI: 10.3233/jad-122299
OpenAlex: W118829763
Cited by: 87
References: 146
Citations by year: 2026: 2 · 2025: 7 · 2024: 5 · 2023: 6 · 2022: 9 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 7 · 2017: 8 · 2016: 6 · 2015: 9 · 2014: 8 · 2013: 3
FWCI: 6.13
Type: journal article
Language: en
Open access: closed
Locations: Journal of Alzheimer s Disease (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion)
Research Publications (Maastricht University) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, parietal lobe
MeSH terms: Alzheimer Disease, Brain, Biological Evolution, Humans, Parietal Lobe, Neuroimaging

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Alzheimer's Disease: The Downside of a Highly Evolved Parietal Lobe?

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