The DOI matches its Crossref record; 173 of the 175 references it cites were found in a registry or an index.
The reciprocal interaction between serotonin and social behaviour
Abstract
Serotonin (5-HT) is an ancient molecule directing behavioural responses to environmental stimuli. The social environment is the most powerful environmental factor. It is well recognized that 5-HT plays a key role in shaping social responses, and that the serotonergic system itself is highly responsive to social influences. This review aims to provide an overview of a selection of representative papers that significantly contribute to a coherent view on the role of serotonin in reciprocal social interactions. The studies here reviewed, selected using the pubmed search terms "social behaviour" and "serotonin", describe the effects of serotonergic gene variation and pharmacological manipulations in humans, monkeys, and rodents, and involve parental attachment and caregiving, social play, aggressiveness, cooperation, and sexual behaviour. We conclude that serotonin is positively correlated with sensitivity to social factors and modulates social behaviour in a 'for-better-and-for-worse' manner, depending on the nature of social factors. Simultaneously, these behavioural responses influence the serotonergic system, leading to highly complex bidirectional serotonin×environment interaction.
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In the citing paper
“For decades, 5-HT release in the central nervous system has been implicated in regulating a broad range of behaviors, including sociability [3,18,[44][45][46].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [44]
In the citing paper
“Mounting evidence suggests that the GM modulates the tryptophan and kynurenine pathways and is a humoral route through which the GM may influence cognition at the level of the CNS (206–210).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [207]
Citations
Cites
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162
Role of genotype in the cycle of violence in maltreated children
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002) · Science · doi:10.1126/science.1072290 · Cited by 4,842
Meeting of minds: the medial frontal cortex and social cognition
Amodio, D. M., & Frith, C. D. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1884 · Cited by 3,782 · cited 2×
“, 2006), hich collectively comprise a network believed to be involved n imitation, imitative learning, social cognition and communiation (Amodio and Frith, 2006;Carr et al., 2003).”
Serotonin transporter genetic variation and the response of the human amygdala.
Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M. F., & Weinberger, D. R. (2002) · Science · doi:10.1126/science.1071829 · Cited by 2,340
Allelic Variation of Human Serotonin Transporter Gene Expression
Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D., & Lesch, K. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66062621.x · Cited by 2,221
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980
Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas
Carr, L., Iacoboni, M., Dubeau, M.-C., Mazziotta, J. C., & Lenzi, G. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0935845100 · Cited by 1,978
Risch, N., Herrell, R., Lehner, T., Liang, K.-Y., Eaves, L., Hoh, J., Griem, A., Kovacs, M., Ott, J., & Merikangas, K. R. (2009) · JAMA · doi:10.1001/jama.2009.878 · Cited by 1,655
Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform
Walther, D. J., Peter, J., Bashammakh, S., Hörtnagl, H., Voits, M., Fink, H., & Bäder, M. (2003) · Science · doi:10.1126/science.1078197 · Cited by 1,576
Research works printed but not linked: 1
- Davidsdottir, 2010, Health anxiety—increased knowledge and treatment options, Laeknabladid, 96, 755
Cited by
Sorted by citations
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012
Discriminative and affective touch: Sensing and feeling.
McGlone, F., Wessberg, J., & Olausson, H. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.001 · Cited by 1,112
Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415
Probiotic modulation of the microbiota-gut-brain axis and behaviour in zebrafish
Borrelli, L., Aceto, S., Agnisola, C., De Paolo, S., Dipineto, L., Stilling, R. M., Dinan, T. G., Cryan, J. F., Menna, L. F., & Fioretti, A. (2016) · Scientific Reports · doi:10.1038/srep30046 · Cited by 225
“Furthermore, socio-emotional behaviour in vertebrates is heavily dependent on the serotonergic system 51,52 .”
Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning
Unger, E. K., Keller, J. P., Altermatt, M., Liang, R., Matsui, A., Dong, C., Hon, O. J., Yao, Z. W., Sun, J., Banala, S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.11.040 · Cited by 182
Metadata
- Authors
- Kiser, D., SteemerS, B., Branchi, I., & Homberg, J. R.
- Affiliations
- Donders Institute for Brain, Cognition and Behaviour (NL)
- Istituto Superiore di Sanità (IT)
- Corresponding author
- Homberg, Judith R.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 36
- Issue
- 2
- Pages
- 786-798
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2021060120
- Cited by
- 214
- References
- 175
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 25 · 2023: 21 · 2022: 12 · 2021: 13 · 2020: 23 · 2019: 13 · 2018: 11 · 2017: 6 · 2016: 19 · 2015: 13 · 2014: 11 · 2013: 13 · 2012: 4
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (86410003)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- serotonin, social behavior, serotonergic system, parental attachment, caregiving, social play, aggression, cooperation, sexual behavior, reciprocal social interaction
- MeSH terms
- Animals, Humans, Interpersonal Relations, Serotonin, Sexual Behavior, Social Behavior, Social Perception, Signal Transduction, Serotonin Agents
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