Cited by 214Neurotransmitter Receptor Influence on BehaviorNeuroendocrine regulation and behaviorTryptophan and brain disorders

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The reciprocal interaction between serotonin and social behaviour

Kiser, Dominik, SteemerS, Ben, Branchi, Igor, Homberg, Judith R.·2012·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2011.12.009

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Abstract

Serotonin (5-HT) is an ancient molecule directing behavioural responses to environmental stimuli. The social environment is the most powerful environmental factor. It is well recognized that 5-HT plays a key role in shaping social responses, and that the serotonergic system itself is highly responsive to social influences. This review aims to provide an overview of a selection of representative papers that significantly contribute to a coherent view on the role of serotonin in reciprocal social interactions. The studies here reviewed, selected using the pubmed search terms "social behaviour" and "serotonin", describe the effects of serotonergic gene variation and pharmacological manipulations in humans, monkeys, and rodents, and involve parental attachment and caregiving, social play, aggressiveness, cooperation, and sexual behaviour. We conclude that serotonin is positively correlated with sensitivity to social factors and modulates social behaviour in a 'for-better-and-for-worse' manner, depending on the nature of social factors. Simultaneously, these behavioural responses influence the serotonergic system, leading to highly complex bidirectional serotonin×environment interaction.

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Authors: Kiser, D., SteemerS, B., Branchi, I., & Homberg, J. R.
Affiliations: Donders Institute for Brain, Cognition and Behaviour (NL)
Istituto Superiore di Sanità (IT)
Corresponding author: Homberg, Judith R.
ORCID: Branchi, Igor
Homberg, Judith R.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2012-02
Volume: 36
Issue: 2
Pages: 786-798
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2011.12.009
OpenAlex: W2021060120
Cited by: 214
References: 175
Citations by year: 2026: 13 · 2025: 16 · 2024: 25 · 2023: 21 · 2022: 12 · 2021: 13 · 2020: 23 · 2019: 13 · 2018: 11 · 2017: 6 · 2016: 19 · 2015: 13 · 2014: 11 · 2013: 13 · 2012: 4
FWCI: 0.85
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Funders: Nederlandse Organisatie voor Wetenschappelijk Onderzoek (86410003)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: serotonin, social behavior, serotonergic system, parental attachment, caregiving, social play, aggression, cooperation, sexual behavior, reciprocal social interaction
MeSH terms: Animals, Humans, Interpersonal Relations, Serotonin, Sexual Behavior, Social Behavior, Social Perception, Signal Transduction, Serotonin Agents

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The reciprocal interaction between serotonin and social behaviour

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