The DOI matches its Crossref record; 183 of the 183 references it cites were found in a registry or an index.
GABA system dysfunction in autism and related disorders: From synapse to symptoms
Open accessAbstract
Autism Spectrum Disorders (ASDs) are neurodevelopmental syndromes characterised by repetitive behaviours and restricted interests, impairments in social behavior and relations, and in language and communication. These symptoms are also observed in a number of developmental disorders of known origin, including Fragile X Syndrome, Rett syndrome, and Fetal Anticonvulsant Syndrome. While these conditions have diverse etiologies, and poorly understood pathologies, emerging evidence suggests that they may all be linked to dysfunction in particular aspects of GABAergic inhibitory signalling in the brain. We review evidence from genetics, molecular neurobiology and systems neuroscience relating to the role of GABA in these conditions. We conclude by discussing how these deficits may relate to the specific symptoms observed.
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Cites
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Cited by
Ferguson, B. R., & Gao, W.-J. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00037 · Cited by 594
Gao, R., & Penzes, P. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150303003028 · Cited by 516
“Around 20% of those with FXS meet formal criteria for an ASD [239-242] and 25% exhibit epileptic symptoms [243], thus implicating FMR1 both as an autism susceptibility gene and a regulator of cortical inhibitory function.”
BackgroundCosta, L. G., Cole, T. B., Dao, K., Chang, Y.-C., Coburn, J., & Garrick, J. M. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107523 · Cited by 484
Influence of maternal thyroid hormones during gestation on fetal brain development
Moog, N. K., Entringer, S., Heim, C., Wadhwa, P. D., Kathmann, N., & Buss, C. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.070 · Cited by 474
Gephyrin: a master regulator of neuronal function?
Tyagarajan, S. K., & Fritschy, J.-M. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3670 · Cited by 425
Metadata
- Authors
- Coghlan, S., Horder, J., Inkster, B., Mendez, M. A., Murphy, D. G., & Nutt, D. J.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 36
- Issue
- 9
- Pages
- 2044-2055
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2038596292
- Cited by
- 446
- References
- 183
- FWCI
- 13.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Coghlan, S., Horder, J., Inkster, B., Mendez, M. A., Murphy, D. G., & Nutt, D. J. (2012). GABA system dysfunction in autism and related disorders: From synapse to symptoms. Neuroscience & Biobehavioral Reviews. https://doi.org/10.1016/j.neubiorev.2012.07.005
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