The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
The forgotten APOE allele: A review of the evidence and suggested mechanisms for the protective effect of APOE ɛ2
Abstract
Ongoing efforts to improve survival, and enhance quality of life have led biomedical research to focus on disease and the mechanisms that increase risk for disease. The other side of that coin may be as important, i.e. examining the protective factors that allow some individuals to enjoy long, healthy lives. One of the best examples of a gene that positively influences cognitive health is the apolipoprotein (APOE) ɛ2 allele. The APOE ɛ4 allele is a well-established risk factor for Alzheimer's disease (AD) and has thus dominated the APOE literature, with the putative protective role of ɛ2 receiving little attention. This review describes the effects of APOE ɛ2 on the structure and function of the brain. With a focus on neurodegeneration, we discuss evidence for APOE ɛ2's protective effects, explore some key mechanisms through which this protection may be conferred, and address a few inconsistencies in the literature. Understanding the mechanisms that underlie the association between APOE ɛ2, cognition and longevity may provide new targets for research on promoting life-long health.
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“This finding is consistent with recent research,62 and suggests that PSEN1 and APOE may interact to modify ADAOO in these patients.”
From APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer’s disease (2016) · cites this paper as [62]
Citations
Cites
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The Amyloid-β Pathway in Alzheimer’s Disease
Hampel, H., Hardy, J., Blennow, K., Chen, C., Perry, G., Kim, S. H., Villemagne, V. L., Aisen, P., Vendruscolo, M., Iwatsubo, T., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01249-0 · Cited by 1,952
Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia: A Meta-analysis
Jansen, W. J., Ossenkoppele, R., Knol, D. L., Tijms, B. M., Scheltens, P., Verhey, F. R. J., Visser, P. J., Aalten, P., Aarsland, D., Alcolea, D., et al. (2015) · JAMA · doi:10.1001/jama.2015.4668 · Cited by 1,610
Chin-Chan, M., Navarro-Yepes, J., & Quintanilla‐Vega, B. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00124 · Cited by 746
Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis
Neu, S. C., Pa, J., Kukull, W., Beekly, D., Kuzma, A., Gangadharan, P., Wang, L.-S., Romero, K., Arneric, S. P., Redolfi, A., et al. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2017.2188 · Cited by 674
ApoE4: an emerging therapeutic target for Alzheimer’s disease
Safieh, M., Korczyn, A. D., & Michaelson, D. M. (2019) · BMC Medicine · doi:10.1186/s12916-019-1299-4 · Cited by 449
Metadata
- Authors
- Suri, S., Heise, V., Trachtenberg, A. J., & Mackay, C. E.
- Affiliations
- John Radcliffe Hospital (GB)
- Corresponding author
- Mackay, Clare E.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 37
- Issue
- 10
- Pages
- 2878-2886
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2067079625
- Cited by
- 183
- References
- 126
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 14 · 2023: 15 · 2022: 15 · 2021: 24 · 2020: 26 · 2019: 14 · 2018: 11 · 2017: 14 · 2016: 18 · 2015: 14 · 2014: 3
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Oxford Clarendon scholarship
- Alzheimer's Research UK studentship
- Rhodes scholarship
- National Institute for Health Research (NIHR), UK
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- APOE ε2 allele, APOE ε4, apolipoprotein E, Alzheimer's disease, neuroprotection, cognitive health, longevity, neurodegeneration, brain structure and function, protective genetic factor
- MeSH terms
- Alleles, Cognition Disorders, Genotype, Humans, Longevity, Risk Factors, Neurodegenerative Diseases, Apolipoprotein E2
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