The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Localized connectivity in depression: A meta-analysis of resting state functional imaging studies
Abstract
Resting-state fMRI studies investigating the pathophysiology of depression have identified prominent abnormalities in large-scale brain networks. However, it is unclear if localized dysfunction of specialized brain regions contribute to network-level abnormalities. We employed a meta-analytical procedure and reviewed studies conducted in China investigating changes in regional homogeneity (ReHo), a measure of localized intraregional connectivity, from resting-state fMRI in depression. Exploiting the statistical power gained from pooled analysis, we also investigated the effects of age, gender, illness duration and treatment on ReHo. The medial prefrontal cortex (MPFC) showed the most robust and reliable increase in ReHo in depression, with greater abnormality in medication-free patients with multiple episodes. Brain networks that relate to this region have been identified previously to show aberrant connectivity in depression, and we propose that the localized neuronal inefficiency of MPFC exists alongside wider network level disruptions involving this region.
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Cited by
Yan, C.-G., Chen, X., Li, L., Castellanos, F. X., Bai, T.-J., Bo, Q.-J., Cao, J., Chen, G.-M., Chen, N.-X., Chen, W., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1900390116 · Cited by 895
Brakowski, J., Spinelli, S., Dörig, N., Bosch, O. G., Manoliu, A., Holtforth, M. G., & Seifritz, E. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.04.007 · Cited by 328
Cheng, W., Rolls, E. T., Qiu, J., Liu, W., Tang, Y., Huang, C.-C., Wang, X., Zhang, J., Lin, W., Zheng, L., et al. (2016) · Brain · doi:10.1093/brain/aww255 · Cited by 294
A non-reward attractor theory of depression
Rolls, E. T. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.007 · Cited by 180
Wu, X., Lin, P., Yang, J., Song, H., Yang, R., & Yang, J. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.04.046 · Cited by 73
Metadata
- Authors
- Iwabuchi, S. J., Krishnadas, R., Li, C., Auer, D. P., Radua, J., & Palaniyappan, L.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 51
- Pages
- 77-86
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2078554065
- Cited by
- 255
- References
- 54
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
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