The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.
Neural correlates of apathy in patients with neurodegenerative disorders, acquired brain injury, and psychiatric disorders
Open accessAbstract
Apathy can be described as a loss of goal-directed purposeful behavior and is common in a variety of neurological and psychiatric disorders. Although previous studies investigated associations between abnormal brain functioning and apathy, it is unclear whether the neural basis of apathy is similar across different pathological conditions. The purpose of this systematic review was to provide an extensive overview of the neuroimaging literature on apathy including studies of various patient populations, and evaluate whether the current state of affairs suggest disorder specific or shared neural correlates of apathy. Results suggest that abnormalities within fronto-striatal circuits are most consistently associated with apathy across the different pathological conditions. Of note, abnormalities within the inferior parietal cortex were also linked to apathy, a region previously not included in neuroanatomical models of apathy. The variance in brain regions implicated in apathy may suggest that different routes towards apathy are possible. Future research should investigate possible alterations in different processes underlying goal-directed behavior, ranging from intention and goal-selection to action planning and execution.
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“Concerning apathy, it is the case that limbic-frontal-subcortical circuits are frequently implicated in the pathophysiology of this condition in clinical populations (van Reekum et al., 2005; Kos et al., 2016).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Kos et al., 2016
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The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568
BrainNet Viewer: A Network Visualization Tool for Human Brain Connectomics
Xia, M., Wang, J., & He, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068910 · Cited by 4,106
Diffusion tensor imaging of the brain
Alexander, A. L., Lee, J. E., Lazar, M., & Field, A. S. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.05.011 · Cited by 2,747
Stereotaxic Display of Brain Lesions
Rorden, C., & Brett, M. (2000) · Behavioural Neurology · doi:10.1155/2000/421719 · Cited by 2,573
Reliability and validity of the apathy evaluation scale
Marin, R. S., Biedrzycki, R. C., & Firinciogullari, S. (1991) · Psychiatry Research · doi:10.1016/0165-1781(91)90040-v · Cited by 1,805
Apathy and the Functional Anatomy of the Prefrontal Cortex–Basal Ganglia Circuits
Levy, R., & Dubois, B. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhj043 · Cited by 1,285
Frontal–subcortical neuronal circuits and clinical neuropsychiatry
Tekin, S., & Cummings, J. L. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00428-2 · Cited by 1,240
Reliability, validity, and clinical correlates of apathy in Parkinson's disease
STARKSTEIN, S. E., Mayberg, H. S., Preziosi, T. J., Andrezejewski, P., Leiguarda, R. C., & Robinson, R. G. (1992) · Journal of Neuropsychiatry · doi:10.1176/jnp.4.2.134 · Cited by 1,224
Rémy, P., Doder, M., Lees, A. J., Turjanski, N., & Brooks, D. J. (2005) · Brain · doi:10.1093/brain/awh445 · Cited by 1,090
Apathy: a neuropsychiatric syndrome
Marin, R. S. (1991) · Journal of Neuropsychiatry · doi:10.1176/jnp.3.3.243 · Cited by 1,088
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Brain Stimulation as a Treatment for Apathy: A Scoping Review of Effects and Safety
Grewal, P., Seidman, M. B., Chasen, J., Lench, D. H., Dickens, I., Brennan, E. A., Rodriguez‐Porcel, F. E., Kindred, J. H., George, M. S., Kautz, S., et al. (2026) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.20250297
Metadata
- Authors
- Kos, C., van Tol, M.-J., Marsman, J.-B. C., Knegtering, H., & Aleman, A.
- Affiliations
- University Medical Center Groningen (NL)
- Corresponding author
- Kos, Claire
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 69
- Pages
- 381-401
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2514186414
- Cited by
- 101
- References
- 130
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 6 · 2023: 10 · 2022: 8 · 2021: 11 · 2020: 15 · 2019: 5 · 2018: 15 · 2017: 12 · 2016: 1
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- green
- research.rug.nl
- Licence
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (312787, 453-11-004, 016156077)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- apathy, neural correlates, neurodegenerative diseases, acquired brain injury, mental illness, frontostriatal circuits, inferior parietal cortex, goal-directed behavior, intention, goal selection, action planning
- MeSH terms
- Mental Disorders, Brain, Brain Injuries, Humans, Neurodegenerative Diseases, Apathy
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