Cited by 101Neural and Behavioral Psychology StudiesDementia and Cognitive Impairment ResearchCognitive Functions and Memory

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Neural correlates of apathy in patients with neurodegenerative disorders, acquired brain injury, and psychiatric disorders

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Kos, Claire, van Tol, Marie-José, Marsman, Jan-Bernard C., Knegtering, Henderikus, Aleman, André·2016·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2016.08.012

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Abstract

Apathy can be described as a loss of goal-directed purposeful behavior and is common in a variety of neurological and psychiatric disorders. Although previous studies investigated associations between abnormal brain functioning and apathy, it is unclear whether the neural basis of apathy is similar across different pathological conditions. The purpose of this systematic review was to provide an extensive overview of the neuroimaging literature on apathy including studies of various patient populations, and evaluate whether the current state of affairs suggest disorder specific or shared neural correlates of apathy. Results suggest that abnormalities within fronto-striatal circuits are most consistently associated with apathy across the different pathological conditions. Of note, abnormalities within the inferior parietal cortex were also linked to apathy, a region previously not included in neuroanatomical models of apathy. The variance in brain regions implicated in apathy may suggest that different routes towards apathy are possible. Future research should investigate possible alterations in different processes underlying goal-directed behavior, ranging from intention and goal-selection to action planning and execution.

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See all 101

Authors: Kos, C., van Tol, M.-J., Marsman, J.-B. C., Knegtering, H., & Aleman, A.
Affiliations: University Medical Center Groningen (NL)
Corresponding author: Kos, Claire
ORCID: van Tol, Marie-José
Marsman, Jan-Bernard C.
Knegtering, Henderikus
Aleman, André
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2016-10
Volume: 69
Pages: 381-401
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2016.08.012
OpenAlex: W2514186414
Cited by: 101
References: 130
Citations by year: 2026: 6 · 2025: 12 · 2024: 6 · 2023: 10 · 2022: 8 · 2021: 11 · 2020: 15 · 2019: 5 · 2018: 15 · 2017: 12 · 2016: 1
FWCI: 1.17
Type: journal article
Language: en
Open access: green
research.rug.nl
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
Funders: Nederlandse Organisatie voor Wetenschappelijk Onderzoek (312787, 453-11-004, 016156077)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords: apathy, neural correlates, neurodegenerative diseases, acquired brain injury, mental illness, frontostriatal circuits, inferior parietal cortex, goal-directed behavior, intention, goal selection, action planning
MeSH terms: Mental Disorders, Brain, Brain Injuries, Humans, Neurodegenerative Diseases, Apathy

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Neural correlates of apathy in patients with neurodegenerative disorders, acquired brain injury, and psychiatric disorders

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