The DOI matches its Crossref record; 224 of the 226 references it cites were found in a registry or an index.
Early life stress, air pollution, inflammation, and disease: An integrative review and immunologic model of social-environmental adversity and lifespan health
Open accessAbstract
Socially disadvantaged individuals are at greater risk for simultaneously being exposed to adverse social and environmental conditions. Although the mechanisms underlying joint effects remain unclear, one hypothesis is that toxic social and environmental exposures have synergistic effects on inflammatory processes that underlie the development of chronic diseases, including cardiovascular disease, diabetes, depression, and certain types of cancer. In the present review, we examine how exposure to two risk factors that commonly occur with social disadvantage-early life stress and air pollution-affect health. Specifically, we identify neuroimmunologic pathways that could link early life stress, inflammation, air pollution, and poor health, and use this information to propose an integrated, multi-level model that describes how these factors may interact and cause health disparity across individuals based on social disadvantage. This model highlights the importance of interdisciplinary research considering multiple exposures across domains and the potential for synergistic, cross-domain effects on health, and may help identify factors that could potentially be targeted to reduce disease risk and improve lifespan health.
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In the citing paper
“SCI during pregnancy and childhood can have serious developmental consequences that include elevating the risk of non-communicable diseases over the life span7,8,26,27.”
From Chronic inflammation in the etiology of disease across the life span (2019) · cites this paper as [27]
In the citing paper
“childhood circumstances significantly impact metabolic and immune responses later in life, which in turn promote SCI in adulthood8,26,27,168,169”
From Chronic inflammation in the etiology of disease across the life span (2019) · cites this paper as [27]
In the citing paper
“exposure to psychological stress early in life—for example, in the form of abuse, neglect, maltreatment, bullying or living in a low socioeconomic environment—can heighten neural responses to threat that can upregulate inflammatory activity170, alter immuno-competence and lead to SCI throughout the lifecycle27,169”
From Chronic inflammation in the etiology of disease across the life span (2019) · cites this paper as [27]
In the citing paper
“Early life and childhood exposure to antibiotics, vaccination, diet, smoke, and psychosocial stress seems to lead to a long-term adverse influence throughout life.”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [72]
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Items 201–225 of 225
Wolitzky-Taylor, K., Sewart, A., Vrshek-Schallhorn, S., Zinbarg, R., Mineka, S., Hammen, C., Bobova, L., Adam, E. K., & Craske, M. G. (2017) · Journal of Youth and Adolescence · doi:10.1007/s10964-016-0566-3 · Cited by 51 · cited 2×
“Indeed, several psychiatric disorders including substance abuse, post-traumatic stress disorder, depression, and schizophrenia have been linked to both early adversity exposure and inflammation, as have many somatic conditions, such as metabolic, cardiovascular, neoplastic, and rheumatic diseases (Anda et al., 2008, 2…”
Kipen, H. M., Gandhi, S. K., Rich, D. Q., Ohman‐Strickland, P., Laumbach, R. J., Fan, Z. T., Chen, L., Laskin, D. L., Zhang, J. J., & Madura, K. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.1002784 · Cited by 50
Kristiansson, M., Sörman, K., Tekwe, C. D., & Calderón‐Garcidueñas, L. (2015) · Environmental Research · doi:10.1016/j.envres.2015.05.013 · Cited by 50
Cardiovascular reactivity as a mechanism linking child trauma to adolescent psychopathology
Heleniak, C., McLaughlin, K. A., Ormel, J., & Riese, H. (2016) · Biological Psychology · doi:10.1016/j.biopsycho.2016.08.007 · Cited by 46 · cited 10×
“Notably, NF-κB signaling is central to the human inflammatory machinery and can also be activated by toll-like receptor ligands of LPS (some of which can be attached to PM), hypoxic condition, and TNF-α.”
InfluentialDobreva, Z. G., Kostadinova, G., Popov, B. N., Petkov, G. S., & Stanilova, S. A. (2013) · Toxicology and Industrial Health · doi:10.1177/0748233713491812 · Cited by 46
Mechanisms linking traffic-related air pollution and atherosclerosis
Campen, M. J., Lund, A. K., & Rosenfeld, M. E. (2011) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e32834f210a · Cited by 45 · cited 1×
“…atherosclerosis, as well as poor neurodevelopment and cognitive function (Table 4) (Bobak, 2000; Bowatte et al., 2017; Calderón-Garcidueñas et al., 2015; Campen et al., 2012; Esposito et al., 2016; Malmqvist et al., 2011; Morgenstern et al., 2007; Thiering and Heinrich, 2015; Wang et al., 2016).”
Self-citationMurphy, M. L. M., Slavich, G. M., Chen, E., & Miller, G. E. (2015) · Psychological Science · doi:10.1177/0956797614556320 · Cited by 43 · cited 1×
“, 2013) and downregulation of anti-inflammatory pathways (Murphy et al., 2015).”
Munjiza, A., Kostic, M., Pesic, D., Gajic, M., Markovic, I., & Tosevski, D. L. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.03.072 · Cited by 42 · cited 1×
“First, high levels of chronic peripheral inflammation, indexed by circulatory inflammatory markers, have been associated with experiences of early life stress in both crosssectional (Carroll et al., 2011; Dixon et al., 2009; Gouin et al., 2012; Grosse et al., 2016; Hartwell et al., 2013; Lacey et al., 2013; Lehto et a…”
Okello, J., Nakimuli-Mpungu, E., Musisi, S., Broekaert, E., & Derluyn, I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088494 · Cited by 42 · cited 1×
“There is evidence for instance that positive parental attachment could protect children against some of the outcomes associated with early life stress exposure (Cameron et al., 2017; Okello et al., 2014), but this research has generally not considered the potential role of air pollution or inflammatory processes.”
Cohen‐Woods, S., Fisher, H. L., Ahmetspahic, D., Douroudis, K., Stacey, D., Hosang, G. M., Korszun, A., Owen, M. J., Craddock, N. J., Arolt, V., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.08.023 · Cited by 40 · cited 1×
“In one case-control study of 262 cases of depression and 288 controls, childhood maltreatment interacted with single nucleotide polymorphisms in genes that regulate inflammation—namely, IL-6 [rs1818879] and CRP [rs3093077]—to predict increased risk of depression (Cohen-Woods et al., 2018).”
Cortisol Stress Response Variability in Early Adolescence: Attachment, Affect and Sex
Cameron, C. A., McKay, S. L., Susman, E. J., Wynne‐Edwards, K. E., Wright, J. M., & Weinberg, J. (2016) · Journal of Youth and Adolescence · doi:10.1007/s10964-016-0548-5 · Cited by 39
Monroe, S. M., & Slavich, G. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800951-2.00013-3 · Cited by 38 · cited 1×
“The notion that early life stress can affect health has been around for centuries (Monroe and Slavich, 2016; Slavich, 2016).”
BackgroundSelf-citationMoreira, F. P., Wiener, C. D., Jansen, K., Portela, L. V., Lara, D. R., Souza, L. D. D. M., da Silva, R. A., & Oses, J. P. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.02.018 · Cited by 37 · cited 1×
“First, high levels of chronic peripheral inflammation, indexed by circulatory inflammatory markers, have been associated with experiences of early life stress in both crosssectional (Carroll et al., 2011; Dixon et al., 2009; Gouin et al., 2012; Grosse et al., 2016; Hartwell et al., 2013; Lacey et al., 2013; Lehto et a…”
Pusalkar, M., Suri, D., Kelkar, A., Bhattacharya, A., Galande, S., & Vaidya, V. A. (2015) · Developmental Psychobiology · doi:10.1002/dev.21365 · Cited by 36
C-Reactive Protein Levels Among U.S. Adults Exposed to Parental Incarceration
Boch, S. J., & Ford, J. L. (2014) · Biological Research For Nursing · doi:10.1177/1099800414564011 · Cited by 33
Wang, F., Jia, X., Wang, X., Zhao, Y., & Hao, W. (2016) · BMC Public Health · doi:10.1186/s12889-016-3015-z · Cited by 31 · cited 1×
“5), has also been associated with increased risk of adverse birth outcomes, respiratory disease, diabetes, and atherosclerosis, as well as poor neurodevelopment and cognitive function (Table 4) (Bobak, 2000; Bowatte et al., 2017; Calderón-Garcidueñas et al., 2015; Campen et al., 2012; Esposito et al., 2016; Malmqvist…”
Dixon, D. A., Meng, H., Goldberg, R. B., Schneiderman, N., & Delamater, A. M. (2008) · Journal of Pediatric Nursing · doi:10.1016/j.pedn.2008.02.034 · Cited by 28 · cited 1×
“First, high levels of chronic peripheral inflammation, indexed by circulatory inflammatory markers, have been associated with experiences of early life stress in both crosssectional (Carroll et al., 2011; Dixon et al., 2009; Gouin et al., 2012; Grosse et al., 2016; Hartwell et al., 2013; Lacey et al., 2013; Lehto et a…”
Serum adipokine levels in adults with a history of childhood maltreatment
Lehto, S. M., Elomaa, A.-P., NISKANEN, L. K., Herzig, K., Tolmunen, T., Viinamäki, H. T., Koivumaa-Honkanen, H. T., Huotari, A., Honkalampi, K. M., Valkonen‐Korhonen, M., et al. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.01.016 · Cited by 24
Psychological Stressors, Overview
Monroe, S. M., & Slavich, G. M. (2007) · Elsevier eBooks · doi:10.1016/b978-012373947-6.00317-2 · Cited by 23 · cited 1×
“The notion that early life stress can affect health has been around for centuries (Monroe and Slavich, 2016; Slavich, 2016).”
Self-citationMirowsky, J. E., & Gordon, T. (2015) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2014.93 · Cited by 20 · cited 1×
“As a starting point, therefore, stress researchers are referred to a set of reviews summarizing air pollution exposure assessment methods (Krzyzanowski, 1997; Mirowsky and Gordon, 2015; Zhang and Lioy, 2002; Zou et al., 2009), as well as the USEPA’s online resources for human air pollution exposure.”
Human Exposure Assessment in Air Pollution Systems
Zhang, J. J., & Lioy, P. J. (2002) · The Scientific World JOURNAL · doi:10.1100/tsw.2002.119 · Cited by 18 · cited 1×
“As a starting point, therefore, stress researchers are referred to a set of reviews summarizing air pollution exposure assessment methods (Krzyzanowski, 1997; Mirowsky and Gordon, 2015; Zhang and Lioy, 2002; Zou et al., 2009), as well as the USEPA’s online resources for human air pollution exposure.”
Inflammation Through a Psychoneuroimmunological Lens
Bennett, J. M., Gillie, B. L., Lindgren, M. E., Fagundes, C. P., & Kiecolt-Glaser, J. K. (2013) · Handbook of Systems and Complexity in Health · doi:10.1007/978-1-4614-4998-0_19 · Cited by 15 · cited 2×
“1); (Bennett et al., 2012; Fiordelisi et al., 2017).”
Irwin, M. R., & Slavich, G. M. (2016) · Cambridge University Press eBooks · doi:10.1017/9781107415782.017 · Cited by 10
Self-citationHealth Disparities Related to Environmental Air Quality
Bose, S., & Diette, G. B. (2015) · Respiratory medicine · doi:10.1007/978-3-319-23675-9_3 · Cited by 6
Assessing the Extent of Human Exposure to Organics
Travis, C. C., & Hattemer‐Frey, H. A. (1988) · Springer eBooks · doi:10.1007/978-1-4684-5484-0_5 · Cited by 6
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Chronic inflammation in the etiology of disease across the life span
Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D. W., Fasano, A., Miller, G. W., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0675-0 · Cited by 4,915
Self-citationSlavich, G. M. (2020) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032816-045159 · Cited by 502
Self-citationLawrance, E. L., Thompson, R., Newberry Le Vay, J., Page, L., & Jennings, N. (2022) · International Review of Psychiatry · doi:10.1080/09540261.2022.2128725 · Cited by 500
Chen, P., Liu, H., Sun, Y., Li, J., Cui, W. Q., Liao, W., Zhang, W., Yuan, X., Wang, Z., Zhang, Y., et al. (2019) · Applied Catalysis B: Environmental · doi:10.1016/j.apcatb.2019.118545 · Cited by 334
Association of Air Pollution Exposure With Psychotic Experiences During Adolescence
Newbury, J. B., Arseneault, L., Beevers, S. D., Kitwiroon, N., Roberts, S., Pariante, C. M., Kelly, F. J., & Fisher, H. L. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.0056 · Cited by 210
Metadata
- Authors
- Olvera Alvarez, H. A., Kubzansky, L. D., Campen, M. J., & Slavich, G. M.
- Affiliations
- Harvard University (US)
- University of New Mexico (US)
- University of California, Los Angeles (US)
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 92
- Pages
- 226-242
- ISSN
- 0149-7634 (ISSN-L)
- PMC
- PMC6082389
- OpenAlex
- W2805640433
- Cited by
- 133
- References
- 226
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 19 · 2023: 16 · 2022: 24 · 2021: 19 · 2020: 10 · 2019: 14 · 2018: 3
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuroscience & Biobehavioral Reviews (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Branco Weiss Fellowship â Society in Science
- National Institute of Environmental Health Sciences (R01 ES014639, 3R01ES014639-09S1)
- National Alliance for Research on Schizophrenia and Depression (23958)
- Brain and Behavior Research Foundation (K08 MH103443)
- National Center on Minority Health and Health Disparities
- Topics
- Social Sciences › Health › Health disparities and outcomes
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Sociology and Political Science › Environmental Justice and Health Disparities
- Keywords
- early life stress, air pollution, inflammation, social deprivation, health disparities, neuroimmunology, chronic disease, cardiovascular disease, diabetes mellitus, depression, cancer, lifespan health, multi-level model
- MeSH terms
- Air Pollution, Humans, Inflammation, Longevity, Social Environment, Stress, Psychological, Models, Immunological
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