Cited by 43Asthma and respiratory diseasesStress Responses and CortisolDeath Anxiety and Social Exclusion

Targeted rejection predicts decreased anti-inflammatory gene expression and increased symptom severity in youth with asthma

Open access
Murphy, Michael L. M., Slavich, George M., Chen, Edith, Miller, Gregory E.·2015·Psychological Science

Abstract

Although responses to different stressors are sometimes assumed to be similar, recent research has demonstrated that certain types of stress, such as targeted rejection, are particularly potent. To test such associations in a chronic-disease model, we examined how noninterpersonal, interpersonal, and targeted-rejection major life events predicted changes in gene expression and symptom severity in 121 youths with asthma who were assessed every 6 months for 2 years. Youths who had recently experienced targeted rejection had lower messenger RNA expression for signaling molecules that control airway inflammation and obstruction (specifically, the glucocorticoid receptor and β2-adrenergic receptor) than youths who had not experienced targeted rejection. These associations were specific to targeted rejection and stronger for youths higher in subjective social status. Higher-status youths exposed to targeted rejection (but not other types of stress) also reported more asthma symptoms. These data demonstrate stressor-specific associations with molecular-signaling pathways and the severity of asthma, and they suggest that threats to the social self may be particularly deleterious.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1177/0956797614556320

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Murphy, M. L. M., Slavich, G. M., Chen, E., & Miller, G. E.
Affiliations
  • Northwestern University (US)
  • University of California, Los Angeles (US)
Venue
Psychological Science
Published
2015-01-06
Volume
26
Issue
2
Pages
111-121
ISSN
  • 0956-7976 (ISSN-L)
  • 1467-9280
OpenAlex
W2096528025
Cited by
43
References
41
Citations by year
2026: 2 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 8 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 1
FWCI
3.44
Type
journal article
Language
en
Open access
Locations
  • Psychological Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (R01HL108723, R01HL073975)
  • National Institute of Mental Health (K08MH103443)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD058502)
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Social Psychology › Death Anxiety and Social Exclusion
Keywords
childhood asthma, youth, major life events, stress, gene expression, glucocorticoid receptor, beta2-adrenergic receptor, airway inflammation, asthma symptom severity, subjective social status, social self, interpersonal stress, chronic disease
MeSH terms
Adolescent, Asthma, Child, Female, Humans, Male, Receptors, Glucocorticoid, Rejection, Psychology, Stress, Psychological, Signal Transduction, Down-Regulation, Gene Expression, Receptors, Adrenergic, beta-2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review