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Cited by 271Neurotransmitter Receptor Influence on BehaviorRegulation of Appetite and ObesityEating Disorders and Behaviors

The DOI matches its Crossref record; 388 of the 398 references it cites were found in a registry or an index.

The impact of sugar consumption on stress driven, emotional and addictive behaviors

Open access
Jacques, Angela, Chaaya, Nicholas, Beecher, Kate, Ali, Syed Aoun, Belmer, Arnauld, Bartlett, Selena·2019·Neuroscience & Biobehavioral Reviews
DOI 10.1016/j.neubiorev.2019.05.021
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Abstract

In 2016 the World Health Organization reported 39% of the world's adult population (over 18 y) was overweight, with western countries such as Australia and the United States of America at 64.5% and 67.9% respectively. Overconsumption of high fat/sugar containing food and beverages contribute to the development of obesity. Neural plasticity that occurs as a result of long term sugar consumption has been shown to reduce impulse control and therefore lower the ability to resist the high fat/sugar foods contributing to the obesity epidemic. There is significant overlap between the neural pathways involved in emotions that guide behavioural responses to survival situations with those regulating overconsumption of highly palatable food. This suggests that having a clearer understanding of the role of stress and emotions in the development of obesity will lead to the development of novel therapeutic strategies. Sucrose consumption activates the mesocorticolimbic system in a manner synonymous with substances of abuse. There is overwhelming evidence to support the hypothesis that sucrose consumption results in pathophysiological consequences such as morphological neuronal changes, altered emotional processing and modified behaviour in rodent and human models. In this comprehensive review, we examined >300 studies investigating the interaction between sugar consumption, stress and emotions. Preclinical and clinical trials investigating highly palatable foods and stress, anxiety, depression and fear are reviewed. Importantly, the synergy between sugar consumption and neurobiology is addressed. This review summarizes the neurochemical changes and neural adaptations ö including changes in the dopaminergic system ö that influence emotion and behaviour following sugar consumption.

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Crossref · 10.1016/j.neubiorev.2019.05.021

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Research works printed but not linked: 4

  1. Bonin, 2018, Systems, methods and apparatus for rodent behavioural monitoring, Google Patents,.
  2. Knolle, 2018, Altered cingulate and substantia nigra/ventral tegmental activation to novelty and emotional salience in antipsychotic naive first episode psychosis patients, bioRxiv, 263020
  3. Shearrer, 2018, Adolescents at high risk of obesity show greater striatal response to increased sugar content in milkshakes, Am. J. Clin. Nutr., 107, 859, 10.1093/ajcn/nqy050 · DOI
  4. Smith, 1960, 1, 246

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Metadata

Authors
Jacques, A., Chaaya, N., Beecher, K., Ali, S. A., Belmer, A., & Bartlett, S.
Affiliations
Translational Research Institute (AU)
Corresponding author
Bartlett, Selena
ORCID
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2019-08
Volume
103
Pages
178-199
ISSN
0149-7634 (ISSN-L)
DOI
10.1016/j.neubiorev.2019.05.021
OpenAlex
W2945345480
Cited by
271
References
398
Citations by year
2026: 40 · 2025: 44 · 2024: 47 · 2023: 53 · 2022: 42 · 2021: 26 · 2020: 17 · 2019: 2
FWCI
2.90
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • QUT ePrints (Queensland University of Technology) (submittedVersion, cc-by)
Funders
National Health and Medical Research Council
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords
sugar consumption, sucrose, obesity, stress, emotional processing, addictive behavior, mesocorticolimbic system, dopaminergic system, neuroplasticity, impulse control, anxiety, depression, fear, highly palatable food
MeSH terms
Diet, Carbohydrate Loading, Dietary Sugars, Affective Symptoms, Animals, Mental Disorders, Brain, Feeding Behavior, Humans, Impulsive Behavior, Obesity, Stress, Psychological, Behavior, Addictive, Cognitive Dysfunction

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