Relationship between Central Obesity and the incidence of Cognitive Impairment and Dementia from Cohort Studies Involving 5,060,687 Participants
Abstract
Central obesity, measured by the waist circumference (WC) or waist-to-hip ratio, has been linked with metabolic dysfunction and structural abnormalities in the brain, two risk factors for cognitive impairment and dementia. The current analysis was performed to understand the influence of central obesity on the incidence of cognitive impairment and dementia. It included 21 studies involving 5,060,687 participants and showed that a high WC was associated with a greater risk of cognitive impairment and dementia (HR = 1.10, 95 % CI: 1.05-1.15), compared with a low WC. Sub-group analysis showed that a high WC increased the likelihood of developing cognitive impairment and dementia in individuals older than 65 years of age (HR = 1.13, 95 % CI: 1.08-1.19), whereas no association was observed in individuals younger than 65 years of age (HR = 1.04, 95 % CI: 0.93-1.16). Furthermore, dose-response meta-analysis confirmed that a high WC was a risk factor for cognitive impairment and dementia. In conclusion, central obesity, as measured by WC, was associated with a risk of cognitive impairment and dementia.
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Higher waist circumference is associated with greater risk of cognitive impairment and dementia (HR 1.10, 95% CI 1.05-1.15), and the risk is greater in those aged >65 years.
“Another study on central obesity, measured through waist circumference or waist to hip ratio, included 5,060,687 participants from 16 studies, and showed that higher versus lower waist circumference was associated with a greater risk of cognitive impairment and dementia (HR 1.10, 1.05-1.15) and the risk was greater in those aged >65 years.(199)”
From Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission (2024) · cites this paper as [199]
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Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission
Livingston, G., Huntley, J., Liu, K. Y., Costafreda, S. G., Selbæk, G., Alladi, S., Ames, D., Banerjee, S., Burns, A., Brayne, C., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01296-0 · Cited by 3,860 · see citing works
- Authors
- Tang, X., Zhao, W., Lu, M., Zhang, X., Zhang, P., Xin, Z., Sun, R., Tian, W., Cardoso, M. A., Yang, J., Simó, R., Zhou, J.-B., & Stehouwer, C. D. A.
- Affiliations
- Beijing Tongren Hospital (CN)
- Universidade de São Paulo (BR)
- Universitat Autònoma de Barcelona (ES)
- Maastricht University Medical Centre (NL)
- ORCID
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 130
- Pages
- 301-313
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W3197523634
- Cited by
- 154
- References
- 10
- Citations by year
- 2026: 36 · 2025: 50 · 2024: 28 · 2023: 29 · 2022: 11
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Funders
- Beijing Municipal Administration of Hospitals (QML20170204)
- National Natural Science Foundation of China (82070851, 81870556, 81930019)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- abdominal obesity, waist circumference, waist-to-hip ratio, cognitive impairment, dementia, dementia risk factors, older adults, dose-response relationship, metabolic dysfunction, structural brain abnormalities
- MeSH terms
- Aged, Dementia, Humans, Risk Factors, Cohort Studies, Body Mass Index, Incidence, Obesity, Abdominal, Cognitive Dysfunction
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