Metabolic syndrome and dementia risk in a multiethnic elderly cohort
Open accessAbstract
BACKGROUND/AIMS: The metabolic syndrome (MeSy) may be related to Alzheimer's disease (AD). Our aims were to investigate the association of the MeSy with incident dementia in a multiethnic elderly cohort in the United States. METHODS: We conducted cross-sectional and prospective analyses in 2,476 men and women aged 65 years and older and with data available on the MeSy and dementia diagnosis in Northern New York City. MeSy was defined by the National Cholesterol Education Program Adult Treatment Program III and the European Group for the Study of Insulin Resistance criteria. Dementia was diagnosed using standard criteria. RESULTS: No association was found between MeSy and prevalent dementia. After 4.4 years of follow-up, 236 individuals of the 1,833 without prevalent dementia developed dementia. MeSy was not associated with incident dementia. Of the components of the MeSy, diabetes and hyperinsulinemia were associated with an increased risk of incident AD [hazard ratio 1.4 (95% CI 1.0-2.1), and hazard ratio 1.4 (95% CI 0.9-2.7), respectively] and dementia associated with stroke [hazard ratio 1.9 (95% CI 1.1-3.1), and hazard ratio 2.3 (95% CI 1.1-4.7), respectively]. CONCLUSIONS: The MeSy was not associated with an increased dementia risk in a multiethnic elderly cohort, but diabetes and hyperinsulinemia were. In the elderly, examining diabetes and hyperinsulinemia separately may be preferable to using the MeSy as a risk factor.
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Two definitions of the metabolic syndrome, one including diabetes and one including hyperinsulinemia, are not related to Alzheimer's disease risk.
“We found that two definitions of the metabolic syndrome, one that included diabetes and one that included hyperinsulinemia, were not related to Alzheimer’s disease risk (Muller et al., 2007).”
From Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease (2008) · cites this paper as Muller et al., 2007
The individual components of hyperinsulinemia and diabetes as defined within the metabolic syndrome definition are associated with a higher risk of Alzheimer's disease.
“However, the individual components of hyperinsulinemia and diabetes as defined within the metabolic syndrome definition were associated with a higher risk of Alzheimer’s disease.”
From Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease (2008) · cites this paper as Muller et al., 2007
Hyperinsulinemia was associated with an increased incident Alzheimer's disease (hazard ratio = 1.4; 95% CI: 0.9-2.7).
“Of the components of the metabolic syndrome, diabetes and hyperinsulinemia were associated with an increased incident Alzheimer’s disease (hazard ratio; 95%CI respectively 1.4; 1.0–2.1 and 1.4; 0.9–2.7) and vascular dementia risk(hazard ratio; 95%CI respectively 1.9; 1.1–3.1 and 2.3; 1.1–4.7).”
From Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease (2008) · cites this paper as Muller et al., 2007
Hyperinsulinemia was associated with an increased incident vascular dementia risk (hazard ratio = 2.3; 95% CI: 1.1-4.7).
“Of the components of the metabolic syndrome, diabetes and hyperinsulinemia were associated with an increased incident Alzheimer’s disease (hazard ratio; 95%CI respectively 1.4; 1.0–2.1 and 1.4; 0.9–2.7) and vascular dementia risk(hazard ratio; 95%CI respectively 1.9; 1.1–3.1 and 2.3; 1.1–4.7).”
From Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease (2008) · cites this paper as Muller et al., 2007
Diabetes was associated with an increased incident vascular dementia risk (hazard ratio = 1.9; 95% CI: 1.1-3.1).
“Of the components of the metabolic syndrome, diabetes and hyperinsulinemia were associated with an increased incident Alzheimer’s disease (hazard ratio; 95%CI respectively 1.4; 1.0–2.1 and 1.4; 0.9–2.7) and vascular dementia risk(hazard ratio; 95%CI respectively 1.9; 1.1–3.1 and 2.3; 1.1–4.7).”
From Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease (2008) · cites this paper as Muller et al., 2007
Metabolic syndrome was not associated with incident dementia.
“metabolic syndrome was not associated with incident dementia.”
From Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease (2008) · cites this paper as Muller et al., 2007
Diabetes was associated with an increased incident Alzheimer's disease (hazard ratio = 1.4; 95% CI: 1.0-2.1).
“Of the components of the metabolic syndrome, diabetes and hyperinsulinemia were associated with an increased incident Alzheimer’s disease (hazard ratio; 95%CI respectively 1.4; 1.0–2.1 and 1.4; 0.9–2.7) and vascular dementia risk(hazard ratio; 95%CI respectively 1.9; 1.1–3.1 and 2.3; 1.1–4.7).”
From Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease (2008) · cites this paper as Muller et al., 2007
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- Authors
- Muller, M., Tang, M.-X., Schupf, N., Manly, J. J., Mayeux, R., & Luchsinger, J. A.
- Affiliations
- University Medical Center Utrecht (NL)
- Columbia University (US)
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2007
- Volume
- 24
- Issue
- 3
- Pages
- 185-192
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- PMC
- PMC2268640
- OpenAlex
- W2134834226
- Cited by
- 175
- References
- 43
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 5 · 2023: 5 · 2022: 3 · 2021: 15 · 2020: 11 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 6 · 2015: 8 · 2014: 15 · 2013: 13 · 2012: 14
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- PubMed Central (acceptedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Internationale Stichting Alzheimer Onderzoek
- National Institute on Aging (P01AG007232, K08AG20856-01, K08AG020856, AG 07702, AG 07232, P0L-AG07232)
- National Center for Research Resources (RR006451)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- metabolic syndrome, dementia risk, Alzheimer's disease, incident dementia, diabetes mellitus, hyperinsulinemia, stroke, older adults, multi-ethnic cohort, insulin resistance
- MeSH terms
- Aged, Blood Pressure, Cholesterol, Dementia, Diabetes Mellitus, Ethnicity, Female, Humans, Insulin, Longitudinal Studies, Male, Middle Aged, New York City, Risk, Triglycerides, Cohort Studies, Metabolic Syndrome, Waist-Hip Ratio
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