The DOI matches its Crossref record; 214 of the 214 references it cites were found in a registry or an index.
Resting-state fMRI functional connectivity and mindfulness in clinical and non-clinical contexts: A review and synthesis
Open accessAbstract
This review synthesizes relations between mindfulness and resting-state fMRI functional connectivity of brain networks. Mindfulness is characterized by present-moment awareness and experiential acceptance, and relies on attention control, self-awareness, and emotion regulation. We integrate studies of functional connectivity and (1) trait mindfulness and (2) mindfulness meditation interventions. Mindfulness is related to functional connectivity in the default mode (DMN), frontoparietal (FPN), and salience (SN) networks. Specifically, mindfulness-mediated functional connectivity changes include (1) increased connectivity between posterior cingulate cortex (DMN) and dorsolateral prefrontal cortex (FPN), which may relate to attention control; (2) decreased connectivity between cuneus and SN, which may relate to self-awareness; (3) increased connectivity between rostral anterior cingulate cortex region and dorsomedial prefrontal cortex (DMN) and decreased connectivity between rostral anterior cingulate cortex region and amygdala region, both of which may relate to emotion regulation; and lastly, (4) increased connectivity between dorsal anterior cingulate cortex (SN) and anterior insula (SN) which may relate to pain relief. While further study of mindfulness is needed, neural signatures of mindfulness are emerging.
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“Studies have shown that trait anxiety is associated with pathological eating behaviors2”
From Neural correlates of a mindfulness-based intervention in anorexia nervosa (2023) · cites this paper as [2]
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Items 201–214 of 214
Campos, D., Modrego-Alarcón, M., López-del-Hoyo, Y., González-Panzano, M., Van Gordon, W., Shonin, E., Navarro-Gil, M., & García-Campayo, J. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00809 · Cited by 45 · cited 1×
“…in cognitive processes (Chiesa et al., 2011; Gallant, 2016; Malinowski, 2013), stress-management (Chiesa and Serretti, 2009), social cognition (Campos et al., 2019; Tan et al., 2014), and general well-being (Campanella et al., 2014; Howell et al., 2008; Smith et al., 2015) in healthy…”
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“…in cognitive processes (Chiesa et al., 2011; Gallant, 2016; Malinowski, 2013), stress-management (Chiesa and Serretti, 2009), social cognition (Campos et al., 2019; Tan et al., 2014), and general well-being (Campanella et al., 2014; Howell et al., 2008; Smith et al., 2015) in healthy populations.”
Pain Perception Can Be Modulated by Mindfulness Training: A Resting-State fMRI Study
Su, I.-W., Wu, A. F.-W., Liang, K., Cheng, K.-Y., Hsieh, S., Sun, W., & Chou, T. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00570 · Cited by 39
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“…advantages over other functional connectivity methods (including its relative simplicity and efficiency), it may also introduce unwanted variability due to inconsistencies in individual-level seed placements that are based on group-level information (Venkataraman et al., 2009; Wang et al., 2015).”
BackgroundWinnebeck, E., Fißler, M., Gärtner, M., Chadwick, P., & Barnhofer, T. (2017) · Behaviour Research and Therapy · doi:10.1016/j.brat.2017.10.005 · Cited by 37
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“This region could be involved in a more mindful self-focus (Freton et al., 2014), shifting away from negative ruminations occurring in MDD.”
BackgroundKajimura, S., Masuda, N., Lau, J. K. L., & Murayama, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-75396-9 · Cited by 31 · cited 1×
“Given this role, and taking all of this into account, the FPN is sometimes theorized to facilitate mindful present-moment interactions with the environment (Hasenkamp et al., 2012; Kajimura et al., 2020; Taren et al., 2017; Vago and Zeidan, 2016).”
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Tang, Y.-Y. (2017) · The Neuroscience of Mindfulness Meditation · doi:10.1007/978-3-319-46322-3_4 · Cited by 30
Mindfulness-Based Therapy Regulates Brain Connectivity in Major Depression
Lifshitz, M., Sacchet, M. D., Huntenburg, J. M., Thiery, T., Fan, Y., Gärtner, M., Grimm, S., Winnebeck, E., Fißler, M., Schroeter, T. A., et al. (2019) · Psychotherapy and Psychosomatics · doi:10.1159/000501170 · Cited by 28 · cited 9×
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“…coupling to rACC are aberrant in MDD (Disner et al., 2011), and connectivity dysfunctions of rACC and the amygdala component of limbic circuitry are prevalent in mood disorders (Alexander et al., 2020; Connolly et al., 2013; Hakamata et al., 2020; Kamphausen et al., 2012; Scharnowski et al., 2020).”
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“PCC-dlPFC coupling seems, at first glance, contradictory to a generally reported FPN-DMN decoupling associated with mindfulness (Shen et al., 2020) but could be explained by more detailed examination of specific PCC subregions (see section 3.2.”
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“Disruption of amygdala and ventrolateral prefrontal cortex (vlPFC) circuitry has been extensively highlighted in populations with symptoms of anxiety and depression, especially in younger participants (Fowler et al., 2017; Greenberg et al., 2017; Guyer et al., 2008).”
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The Effects of Mindfulness Meditation on Emotion Regulation, Cognition and Social Skills
Jones, T. M. (2018) · European Scientific Journal ESJ · doi:10.19044/esj.2018.v14n14p18 · Cited by 10 · cited 1×
“Emotional distancing cultivated by mindfulness meditation seems to be an effective mechanism of adaptive coping strategy for processing emotions with negative valence (Grecucci et al., 2015; Guendelman et al., 2017; Jones, 2018; Ortner et al., 2007).”
Background
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Cited by
Sorted by citations
Gkintoni, E., Vassilopoulos, S. P., & Νικολάου, Γ. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14051703 · Cited by 117
Mulder, D., Aarts, E., Vásquez, A. A., & Bloemendaal, M. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02146-4 · Cited by 70
“Multiple studies have reported changes in connectivity strength following a mindfulness training, both in structural [15] and functional connectivity [16].”
BackgroundInfluentialEsch, T., & Stefano, G. B. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.913573 · Cited by 64
Yang, W. F. Z., Chowdhury, A., Bianciardi, M., van Lutterveld, R., Sparby, T., & Sacchet, M. D. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad408 · Cited by 46
Self-citationHan, Y. M. Y., Chan, M. M. Y., Choi, C. X. T., Law, M. C. H., Ahorsu, D. K., & Tsang, H. W. H. (2023) · Scientific Reports · doi:10.1038/s41598-023-37309-4 · Cited by 55
Metadata
- Authors
- Sezer, I., Pizzagalli, D. A., & Sacchet, M. D.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Harvard University (US)
- Corresponding author
- Sacchet, Matthew D.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2022-04
- Volume
- 135
- Pages
- 104583
- ISSN
- 0149-7634 (ISSN-L)
- PMC
- PMC9083081
- OpenAlex
- W4213207397
- Cited by
- 214
- References
- 214
- Citations by year
- 2026: 52 · 2025: 66 · 2024: 53 · 2023: 38 · 2022: 5
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 337 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuroscience & Biobehavioral Reviews (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH095809, R37MH068376)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Keywords
- mindfulness, resting-state functional connectivity, trait mindfulness, mindfulness meditation, default mode network, frontoparietal network, salience network, posterior cingulate cortex, dorsolateral prefrontal cortex, rostral anterior cingulate cortex, amygdala, anterior insula, attentional control, self-awareness, emotion regulation, analgesia
- MeSH terms
- Brain, Brain Mapping, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Prefrontal Cortex, Mindfulness
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