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Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter A1 at rat blood–brain barrier

Akanuma, Shin-ichi, Hori, Satoko, Ohtsuki, Sumio, Fujiyoshi, Masachika, Terasaki, Tetsuya·2008·Neurochemistry International
DOI 10.1016/j.neuint.2007.08.012
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Abstract

The aim of the present study was to investigate the expression of nuclear receptor mRNA and regulation of the expression of ATP-binding cassette (ABC) transporters by nuclear receptor agonists in rat brain capillary endothelial cells, which form the blood-brain barrier, by using rat brain capillary fraction from 8-week-old rats and a conditionally immortalized brain capillary endothelial cell line (TR-BBB13). RT-PCR analysis revealed that liver X receptor alpha and beta, retinoid X receptor alpha and beta and peroxisome proliferator-activating receptor alpha and beta mRNAs were expressed in the rat brain capillary endothelial cells and TR-BBB cells. In contrast, pregnane X receptor, farnesoid X receptor and constitutive androstane receptor were not detected. Furthermore, treatment with a liver X receptor agonist increased the ABCA1 mRNA level in TR-BBB13 cells, while ABCG2 mRNA expression was not affected. Treatment with a rat pregnane X receptor agonist did not affect the ABCB1 mRNA level in TR-BBB13 cells. These results demonstrate that the rat blood-brain barrier has an expressional regulation mechanism via sterol-related nuclear receptor, and indicate that the blood-brain barrier in 8-week-old rats lacks ABCB1 regulation via pregnane X receptor.

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Metadata

Authors
Akanuma, S.-I., Hori, S., Ohtsuki, S., Fujiyoshi, M., & Terasaki, T.
Venue
Neurochemistry International
Publisher
Elsevier BV
Published
2008-03
Volume
52
Issue
4-5
Pages
669-674
ISSN
0197-0186
DOI
10.1016/j.neuint.2007.08.012
Cited by
43
References
3
Language
en
Licence
Funders
  • New Energy and Industrial Technology Development Organization
  • Japan Society for the Promotion of Science
  • Ministry of Education, Culture, Sports, Science and Technology

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