Cytokine Signaling Modulates Blood-Brain Barrier Function

Structure and function of the blood–brain barrier

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THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

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Transport of brain-derived neurotrophic factor across the blood–brain barrier

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Revitalizing membrane rafts: new tools and insights

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Leptin enters the brain by a saturable system independent of insulin

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Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

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Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice.

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Physiological response to long-term peripheral and central leptin infusion in lean and obese mice.

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Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation.

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Blood–brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions

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IL-15Rα Recycles and Presents IL-15 In trans to Neighboring Cells

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The multidrug transporter, a double-edged sword.

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Diet-induced obese mice develop peripheral, but not central, resistance to leptin.

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Caveolae/raft-dependent endocytosis

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Role of leptin in hypothalamic–pituitary function

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GPI-Anchored Proteins Are Delivered to Recycling Endosomes via a Distinct cdc42-Regulated, Clathrin-Independent Pinocytic Pathway

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Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases

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Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF

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Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis

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Murine tumor necrosis factor alpha is transported from blood to brain in the mouse

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Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific.

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Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms

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ABC Transporters and the Blood-Brain Barrier

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Caveolin-Stabilized Membrane Domains as Multifunctional Transport and Sorting Devices in Endocytic Membrane Traffic

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Blood-brain barrier transport of cytokines: a mechanism for neuropathology

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Choroid plexus epithelial expression of MDR 1 P glycoprotein and multidrug resistance-associated protein contribute to the blood–cerebrospinal-fluid drug-permeability barrier

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Interleukin 2 Receptors and Detergent-Resistant Membrane Domains Define a Clathrin-Independent Endocytic Pathway

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The blood-brain barrier and immune function and dysfunction

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Triglycerides Induce Leptin Resistance at the Blood-Brain Barrier

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Penetration of interleukin-6 across the murine blood-brain barrier

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Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism.

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SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier

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Dynamics of CNS Barriers: Evolution, Differentiation, and Modulation

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Modulation of PPAR activity via phosphorylation

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Clathrin-independent endocytosis: New insights into caveolae and non-caveolar lipid raft carriers

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Endocytosis without clathrin coats

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Modulation of P-Glycoprotein at the Blood-Brain Barrier: Opportunities to Improve Central Nervous System Pharmacotherapy

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Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae

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The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity

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Impaired transport of leptin across the blood-brain barrier in obesity☆

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Orexin A but Not Orexin B Rapidly Enters Brain from Blood by Simple Diffusion

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Bidirectional transport of interleukin-1 alpha across the blood-brain barrier

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Mechanisms of Disease: The Blood-Brain Barrier

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Inflammatory Mediators of Cerebral Endothelium: A Role in Ischemic Brain Inflammation

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Endocytic regulation of TGF-β signaling

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Tumor Necrosis Factor α and Endothelin-1 Increase P-Glycoprotein Expression and Transport Activity at the Blood-Brain Barrier

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Release of cytokines by brain endothelial cells: A polarized response to lipopolysaccharide

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Dual Roles for Perivascular Macrophages in Immune-to-Brain Signaling

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P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain

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p38 Mitogen-Activated Protein Kinase (MAPK) Is a Key Mediator in Glucocorticoid-Induced Apoptosis of Lymphoid Cells: Correlation between p38 MAPK Activation and Site-Specific Phosphorylation of the Human Glucocorticoid Receptor at Serine 211

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Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation

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22R-Hydroxycholesterol and 9-cis-Retinoic Acid Induce ATP-binding Cassette Transporter A1 Expression and Cholesterol Efflux in Brain Cells and Decrease Amyloid β Secretion

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Estrogen Receptors and Endothelium

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Permeability of the blood–brain and blood–spinal cord barriers to interferons

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Chemokine receptor internalization and intracellular trafficking

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Differential BBB interactions of three ingestive peptides: obestatin, ghrelin, and adiponectin.

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Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor alpha, beta, and gamma chains.

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Occludin as direct target for glucocorticoid‐induced improvement of blood–brain barrier properties in a murinein vitrosystem

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TNFα Transport across the Blood–Brain Barrier Is Abolished in Receptor Knockout Mice

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Product ion of the cytokines interleukin 1 and 6 by murine brain microvessel endothelium and smooth muscle pericytes

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Pathological Expression of CXCL12 at the Blood-Brain Barrier Correlates with Severity of Multiple Sclerosis

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Decreased transport of leptin across the blood–brain barrier in rats lacking the short form of the leptin receptor☆

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ABCA1 and Scavenger Receptor Class B, Type I, Are Modulators of Reverse Sterol Transport at an in Vitro Blood-Brain Barrier Constituted of Porcine Brain Capillary Endothelial Cells

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Blood-Spinal Cord and Brain Barriers in Health and Disease

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Interactions of IGF-1 with the Blood-Brain Barrier in vivo and in situ

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Regulation of BCRP (ABCG2) and P-Glycoprotein (ABCB1) by Cytokines in a Model of the Human Blood–Brain Barrier

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Drug metabolizing enzymes in the brain and cerebral microvessels

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Obesity induces functional astrocytic leptin receptors in hypothalamus

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Permeability of the blood–brain barrier to neurotrophins

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Blood-borne interleukin-1 receptor antagonist crosses the blood-brain barrier

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Differential Regulation of Leptin Transport by the Choroid Plexus and Blood-Brain Barrier and High Affinity Transport Systems for Entry into Hypothalamus and Across the Blood-Cerebrospinal Fluid Barrier

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Partial saturation and regional variation in the blood-to-brain transport of leptin in normal weight mice

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Caveolae and transcytosis in endothelial cells: role in atherosclerosis

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Regulating Actin Dynamics at Membranes: A Focus on Dynamin

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Rapid endocytosis of interleukin 2 receptors when clathrin-coated pit endocytosis is inhibited

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Permeation of Growth Hormone across the Blood-Brain Barrier

Pan, W., Yu, Y., Cain, C. M., Nyberg, F., Couraud, P. O., & Kastin, A. J. (2005) · Endocrinology · doi:10.1210/en.2005-0587 · Cited by 149 · see citing works

Altered energy balance causes selective changes in melanocortin-4(MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: further evidence that activation of MC4-R is a physiological inhibitor of feeding.

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Subcellular Localization and Internalization of the Four Human Leptin Receptor Isoforms

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Transforming Growth Factor-β Signaling Alters Substrate Permeability and Tight Junction Protein Expression at the Blood-Brain Barrier during Inflammatory Pain

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Peptides crossing the blood–brain barrier: some unusual observations

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Cerebral malaria: role of microparticles and platelets in alterations of the blood–brain barrier

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Brain endothelial cell production of a neuroprotective cytokine, interleukin-6, in response to noxious stimuli

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Cortactin and dynamin are required for the clathrin-independent endocytosis of γc cytokine receptor

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Distinct Mechanisms of Clathrin-independent Endocytosis Have Unique Sphingolipid Requirements

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Interleukin‐1 receptors on rat brain endothelial cells: a role in neuroimmune interaction?

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IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Rα in T cells

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Astrocyte Leptin Receptor (ObR) and Leptin Transport in Adult-Onset Obese Mice

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The Biochemistry Of P-Glycoprotein-Mediated Multidrug Resistance

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Endothelial transcytosis in health and disease

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Differential permeability of the BBB in acute EAE: enhanced transport of TNT-alpha

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Claudin-5 as a Novel Estrogen Target in Vascular Endothelium

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Interleukin-1β-mediated Suppression of RXR:RAR Transactivation of the Ntcp Promoter Is JNK-dependent

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Passage of peptides across the blood-brain barrier: Pathophysiological perspectives

Banks, W. A., & Kastin, A. J. (1996) · Life Sciences · doi:10.1016/s0024-3205(96)00380-3 · Cited by 120 · see citing works

Unidirectional Specific and Modulated Brain to Blood Transport of Corticotropin-Releasing Hormone

Martins, M., Kastin, A. J., & Banks, W. A. (2008) · Neuroendocrinology · doi:10.1159/000126974 · Cited by 119 · see citing works

Nonsaturable entry of neuropeptide Y into brain

Kastin, A. J., & Akerstrom, V. L. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.3.e479 · Cited by 119 · see citing works

Lipid Rafts and Caveolin-1 Coordinate Interleukin-1β (IL-1β)-dependent Activation of NFκB by Controlling Endocytosis of Nox2 and IL-1β Receptor 1 from the Plasma Membrane

Oakley, F. D., Smith, R. L., & Engelhardt, J. F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.042127 · Cited by 118 · see citing works

Adipokines and the blood-brain barrier

Pan, W., & Kastin, A. J. (2007) · Peptides · doi:10.1016/j.peptides.2007.04.023 · Cited by 118 · see citing works

Leptin transport across the blood–brain barrier of the Koletsky rat is not mediated by a product of the leptin receptor gene

Banks, W. A., Niehoff, M. L., Martin, D., & Farrell, C. L. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03013-5 · Cited by 118 · see citing works

Clathrin-independent endocytosis: New insights into caveolae and non-caveolar lipid raft carriers

Kirkham, M., & Parton, R. G. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.11.007 · Cited by 118 · see citing works

Liver X receptor and retinoid X receptor agonists inhibit inflammatory responses of microglia and astrocytes

Zhang-Gandhi, C. X., & Drew, P. D. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.007 · Cited by 117 · see citing works

Cytokines Stimulate the CRH but Not the Vasopressin Neuronal System: Evidence for a Median Eminence Site of Interleukin-6 Action

Spinedi, E., Hadid, R., Daneva, T., & Gaillard, R. C. (2008) · Neuroendocrinology · doi:10.1159/000126207 · Cited by 115 · see citing works

Passage of human amyloid β-protein 1–40 across the murine blood-brain barrier

Maness, L. M., Banks, W. A., Podlisny, M. B., Selkoe, D. J., & Kastin, A. J. (1994) · Life Sciences · doi:10.1016/0024-3205(94)00331-9 · Cited by 113 · see citing works

Involvement of the Ubiquitin/Proteasome System in Sorting of the Interleukin 2 Receptor β Chain to Late Endocytic Compartments

Rocca, A., Lamaze, C., Subtil, A., & Dautry‐Varsat, A. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.5.1293 · Cited by 113 · see citing works

Get Off My Back! Rapid Receptor Internalization through Circular Dorsal Ruffles

Orth, J. D., & McNiven, M. A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-3397 · Cited by 112 · see citing works

Site-specific Androgen Receptor Serine Phosphorylation Linked to Epidermal Growth Factor-dependent Growth of Castration-recurrent Prostate Cancer

Ponguta, L. A., Gregory, C. W., French, F. S., & Wilson, E. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802392200 · Cited by 112 · see citing works

Distribution of 3H-α-MSH in rat brain

Kastin, A. J., Nissen, C., Nikolics, K., Medzihradszky, K., Coy, D. H., Teplán, I., & Schally, A. V. (1976) · Brain Research Bulletin · doi:10.1016/0361-9230(76)90045-9 · Cited by 112 · see citing works

Physiological Pathway for Low-Density Lipoproteins across the Blood-Brain Barrier: Transcytosis through Brain Capillary Endothelial Cells In Vitro

Candela, P., Gosselet, F., Miller, F., Buée‐Scherrer, V., Torpier, G., Cecchelli, R., & Fénart, L. (2008) · Endothelium · doi:10.1080/10623320802487759 · Cited by 111 · see citing works

Filamin A Regulates Caveolae Internalization and Trafficking in Endothelial Cells

Sverdlov, M. S., Shinin, V., Place, A. T., Castellon, M., & Minshall, R. D. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-10-0997 · Cited by 110 · see citing works

MyD88 signaling in brain endothelial cells is essential for the neuronal activity and glucocorticoid release during systemic inflammation

Gosselin, D., & Rivest, S. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002122 · Cited by 109 · see citing works

PPARα and PPARγ attenuate HIV‐induced dysrégulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities

Huang, W., Eum, S. Y., Andras, I. E., Hennig, B., & Toborek, M. J. (2009) · The FASEB Journal · doi:10.1096/fj.08-121624 · Cited by 109 · see citing works

Caveolae Participate in Tumor Necrosis Factor Receptor 1 Signaling and Internalization in a Human Endothelial Cell Line

D’Alessio, A., Al‐Lamki, R. S., Bradley, J. R., & Pober, J. S. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62346-2 · Cited by 108 · see citing works

Clathrin‐independent endocytosis used by the IL‐2 receptor is regulated by Rac1, Pak1 and Pak2

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Blood–Brain Barrier Permeability to Ebiratide and TNF in Acute Spinal Cord Injury

Pan, W., Banks, W. A., & Kastin, A. J. (1997) · Experimental Neurology · doi:10.1006/exnr.1997.6533 · Cited by 106 · see citing works

Activation of Peroxisome Proliferator-Activated Receptor γ (PPARγ) Suppresses Rho GTPases in Human Brain Microvascular Endothelial Cells and Inhibits Adhesion and Transendothelial Migration of HIV-1 Infected Monocytes

Ramirez, S. H., Heilman, D., Morsey, B., Potula, R., Haorah, J., & Persidsky, Y. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.3.1854 · Cited by 105 · see citing works

Regulation of major efflux transporters under inflammatory conditions at the blood‐brain barrierin vitro

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Entry of EGF into brain is rapid and saturable

Pan, W., & Kastin, A. J. (1999) · Peptides · doi:10.1016/s0196-9781(99)00094-7 · Cited by 104 · see citing works

Functional and morphological studies of protein transcytosis in continuous endothelia

Predescu, D. N., Vogel, S. M., & Malik, A. B. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00075.2004 · Cited by 102 · see citing works

Dexamethasone induces the expression of metalloproteinase inhibitor TIMP‐1 in the murine cerebral vascular endothelial cell line cEND

Förster, C. Y., Kahles, T., Kietz, S., & Drenckhahn, D. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.129007 · Cited by 102 · see citing works

Effect of endotoxin on expression of TNF receptors and transport of TNF-α at the blood-brain barrier of the rat

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P-glycoprotein on astrocyte foot processes of unfixed isolated human brain capillaries

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Glucocorticoid effects on mouse microvascular endothelial barrier permeability are brain specific

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Soluble receptor inhibits leptin transport

Tu, H., Kastin, A. J., Hsuchou, H., & Pan, W. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21195 · Cited by 96 · see citing works

The Blood-Brain Barrier in NeuroAIDS

Banks, W. A., Nuran Ercal, A., & Price, T. O. (2006) · Current HIV Research · doi:10.2174/157016206777709447 · Cited by 95 · see citing works

Rate of 59Fe Uptake into Brain and Cerebrospinal Fluid and the Influence Thereon of Antibodies Against the Transferrin Receptor

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Urocortin and the brain

Pan, W., & Kastin, A. J. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.10.008 · Cited by 92 · see citing works

Steroid receptor phosphorylation: Assigning function to site‐specific phosphorylation

Ward, R. D., & Weigel, N. L. (2009) · BioFactors · doi:10.1002/biof.66 · Cited by 92 · see citing works

Ethanol mimics ligand‐mediated activation and endocytosis of IL‐1RI/TLR4 receptors via lipid rafts caveolae in astroglial cells

Blanco, A. M. A., Pérez-Aragó, A., Fernández‐Lizarbe, S., & Guerri, C. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05425.x · Cited by 92 · see citing works

Studies of the slow bidirectional transport of iron and transferrin across the blood-brain barrier

Banks, W. A., Kastin, A. J., Fasold, M. B., Barrera, C. M., & Augereau, G. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90021-4 · Cited by 91 · see citing works

Efflux of human and mouse amyloid β proteins 1–40 and 1–42 from brain: impairment in a mouse model of alzheimer's disease

Banks, W. A., Robinson, S. M., Verma, S., & Morley, J. E. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00474-3 · Cited by 90 · see citing works

Expression of endothelial phosphorylated caveolin‐1 is increased in brain injury

Nag, S., Manias, J. L., & Stewart, D. J. (2009) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2008.01009.x · Cited by 90 · see citing works

Circulating Regulatory Factors and Neuroendocrine Function

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Linkage of progestin and epidermal growth factor signaling: Phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growth

Daniel, A. R., Qiu, M., Faivre, E. J., Ostrander, J. H., Skildum, A. J., & Lange, C. A. (2006) · Steroids · doi:10.1016/j.steroids.2006.11.009 · Cited by 87 · see citing works

Functional Expression of P-glycoprotein in Rat Brain Microglia

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Regulation of transendothelial permeability by Src Kinase

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Upregulation of Tumor Necrosis Factor α Transport across the Blood–Brain Barrier after Acute Compressive Spinal Cord Injury

Pan, W., Kastin, A. J., Bell, R. L., & Olson, R. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-09-03649.1999 · Cited by 85 · see citing works

Glucose and Insulin Increase the Transport of Leptin through the Blood-Brain Barrier in Normal Mice but Not in Streptozotocin-Diabetic Mice

Kastin, A. J., & Akerstrom, V. L. (2001) · Neuroendocrinology · doi:10.1159/000054640 · Cited by 85 · see citing works

Interleukin-1α in blood has direct access to cortical brain cells

Banks, W. A., Kastin, A. J., & Gutierrez, E. G. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90224-9 · Cited by 82 · see citing works

Leptin receptor mRNA in rat brain astrocytes

Hsuchou, H., Pan, W., Barnes, M. J., & Kastin, A. J. (2009) · Peptides · doi:10.1016/j.peptides.2009.08.023 · Cited by 78 · see citing works

Neuroinflammation facilitates LIF entry into brain: role of TNF

Pan, W., Yu, C., Hsuchou, H., Zhang, Y., & Kastin, A. J. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00489.2007 · Cited by 77 · see citing works

Validity of multiple-time regression analysis in measurement of tritiated and iodinated leptin crossing the blood-brain barrier: meaningful controls

Kastin, A. J., Akerstrom, V. L., & Pan, W. (2001) · Peptides · doi:10.1016/s0196-9781(01)00569-1 · Cited by 75 · see citing works

Opposite direction of transport across the blood-brain barrier for Tyr-MIF-1 and MIF-1: Comparison with morphine

Banks, W. A., & Kastin, A. J. (1994) · Peptides · doi:10.1016/0196-9781(94)90165-1 · Cited by 74 · see citing works

Oxysterol Activators of Liver X Receptor and 9-cis-Retinoic Acid Promote Sequential Steps in the Synthesis and Secretion of Tumor Necrosis Factor-α from Human Monocytes

Landis, M. S., Patel, H. V., & Capone, J. P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108807200 · Cited by 74 · see citing works

Diurnal variation of leptin entry from blood to brain involving partial saturation of the transport system

Pan, W., & Kastin, A. J. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01085-2 · Cited by 73 · see citing works

Pak1 Phosphorylation Enhances Cortactin–N‐WASP Interaction in Clathrin‐Caveolin‐Independent Endocytosis

Grassart, A., Meas-Yedid, V., Dufour, A., Olivo-Marin, J.-C., Dautry-Varsat, A., & Sauvonnet, N. (2010) · Traffic : the International Journal of Intracellular Transport · doi:10.1111/j.1600-0854.2010.01075.x · Cited by 73 · see citing works

Progesterone exerts neuroprotective effects by inhibiting inflammatory response after stroke

Jiang, C. Q., Wang, J., Li, X., Liu, C., Chen, N., & Hao, Y. (2009) · Inflammation Research · doi:10.1007/s00011-009-0032-8 · Cited by 73 · see citing works

Developmental Changes of Leptin Receptors in Cerebral Microvessels: Unexpected Relation to Leptin Transport

Pan, W., Hsuchou, H., Tu, H., & Kastin, A. J. (2007) · Endocrinology · doi:10.1210/en.2007-0893 · Cited by 70 · see citing works

Changing the chemokine gradient: CINC1 crosses the blood–brain barrier

Pan, W., & Kastin, A. J. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00256-9 · Cited by 70 · see citing works

Fasting, but not adrenalectomy, reduces transport of leptin into the brain☆

Kastin, A. J., & Akerstrom, V. L. (2000) · Peptides · doi:10.1016/s0196-9781(00)00195-9 · Cited by 70 · see citing works

Functions of lipid raft membrane microdomains at the blood–brain barrier

Dodelet-Devillers, A., Cayrol, R., van Horssen, J., Haqqani, A. S., de Vries, H. E., Engelhardt, B., Greenwood, J., & Prat, A. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0488-6 · Cited by 70 · see citing works

Endocytic pathway of recombinant murine tumor necrosis factor in L-929 cells.

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Saturable entry of leukemia inhibitory factor from blood to the central nervous system

Pan, W., Kastin, A. J., & Brennan, J. M. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00241-1 · Cited by 68 · see citing works

HIV-1 infected monocyte-derived macrophages affect the human brain microvascular endothelial cell proteome: New insights into blood–brain barrier dysfunction for HIV-1-associated dementia

Ricardo-Dukelow, M., Kadiu, I., Rożek, W., Schlautman, J. D., Persidsky, Y., Ciborowski, P. S., Kanmogne, G. D., & Gendelman, H. E. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.01.004 · Cited by 68 · see citing works

Stroke upregulates TNFα transport across the blood–brain barrier

Pan, W., Ding, Y., Yu, Y., Ohtaki, H., Nakamachi, T., & Kastin, A. J. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2005.11.020 · Cited by 67 · see citing works

Chronic Inflammatory Pain and the Neurovascular Unit: A Central Role for Glia in Maintaining BBB Integrity?

Willis, C. L., & Davis, T. P. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208784705414 · Cited by 66 · see citing works

Selective increase in TNFα permeation across the blood–spinal cord barrier after SCI

Pan, W., Zhang, L., Liao, J., Csernus, B., & Kastin, A. J. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00426-5 · Cited by 65 · see citing works

Strategy and mechanism for the prevention of hepatocellular carcinoma: Phosphorylated retinoid X receptor α is a critical target for hepatocellular carcinoma chemoprevention

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Cloning and characterization of the murine claudin-5 promoter

Burek, M., & Förster, C. Y. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.09.041 · Cited by 64 · see citing works

Increase in TNFα Transport after SCI Is Specific for Time, Region, and Type of Lesion

Pan, W., & Kastin, A. J. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7702 · Cited by 64 · see citing works

Increased hippocampal uptake of tumor necrosis factor α and behavioral changes in mice

Pan, W., Kastin, A. J., Rigai, T., McLay, R. N., & Pick, C. G. (2003) · Experimental Brain Research · doi:10.1007/s00221-002-1355-7 · Cited by 64 · see citing works

Peroxisome Proliferator-Activated Receptor-α Activation Protects Brain Capillary Endothelial Cells from Oxygen-Glucose Deprivation-Induced Hyperpermeability in the Blood-Brain Barrier

Mysiorek, C., Culot, M., Dehouck, L., Derudas, B., Staels, B., Bordet, R., Cecchelli, R., Fénart, L., & Bérézowski, V. (2009) · Current Neurovascular Research · doi:10.2174/156720209788970081 · Cited by 64 · see citing works

TNF Activates P-Glycoprotein in Cerebral Microvascular Endothelial Cells

Yu, C., Kastin, A. J., Tu, H., Waters, S., & Pan, W. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000110445 · Cited by 64 · see citing works

Saturable entry of ciliary neurotrophic factor into brain

Pan, W., Kastin, A. J., Maness, L. M., & Brennan, J. M. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00083-x · Cited by 63 · see citing works

Blood‐borne interleukin‐1 alpha is transported across the endothelial blood‐spinal cord barrier of mice.

Banks, W. A., Kastin, A. J., & Ehrensing, C. A. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020293 · Cited by 63 · see citing works

Activation of urocortin transport into brain by leptin

Kastin, A. J., Akerstrom, V. L., & Pan, W. (2000) · Peptides · doi:10.1016/s0196-9781(00)00349-1 · Cited by 61 · see citing works

Differential Interactions of Urocortin/Corticotropin-Releasing Hormone Peptides with the Blood-Brain Barrier

Kastin, A. J., & Akerstrom, V. L. (2002) · Neuroendocrinology · doi:10.1159/000059433 · Cited by 58 · see citing works

HIV-1-induced production of endothelin-1 in an in vitro model of the human blood???brain barrier

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Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells

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Biphasic cytoarchitecture and functional changes in the BBB induced by chronic inflammatory pain

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Drug Delivery to Brain and the Role of Carrier-Mediated Transport

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Phosphorylation of the Retinoid X Receptor at the Omega loop, modulates the expression of retinoic-acid-target genes with a promoter context specificity

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Entry of CART into brain is rapid but not inhibited by excess CART or leptin

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Convergent trafficking pattern of leptin after endocytosis mediated by ObRa–ObRd

Tu, H., Pan, W., Feucht, L., & Kastin, A. J. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21020 · Cited by 50 · see citing works

ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-β peptide (1–40) at the blood–brain barrier

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Agouti-related protein(83-132) aggregates and crosses the blood-brain barrier slowly

Kastin, A. J., Akerstrom, V. L., & Hackler, L. (2000) · Metabolism · doi:10.1053/meta.2000.16556 · Cited by 50 · see citing works

Neuroinflammation Activates Mdr1b Efflux Transport Through NFκB: Promoter Analysis in BBB Endothelia

Yu, C., Argyropoulos, G. A., Zhang, Y., Kastin, A. J., Hsuchou, H., & Pan, W. (2008) · Cellular Physiology and Biochemistry · doi:10.1159/000185558 · Cited by 49 · see citing works

Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter A1 at rat blood–brain barrier

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Decreased blood–brain leptin transfer in an ovine model of obesity and weight loss: resolving the cause of leptin resistance

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Peptides and the Blood–Brain Barrier: The Status of Our Understanding

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In vitro demonstration of a saturable transport system for leptin across the blood-brain barrier

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Cytokine Transport Across the Injured Blood-Spinal Cord Barrier

Pan, W., & Kastin, A. J. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208784705450 · Cited by 44 · see citing works

Receptor-mediated transport of LIF across blood–spinal cord barrier is upregulated after spinal cord injury

Pan, W., Cain, C. M., Yu, Y., & Kastin, A. J. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.02.006 · Cited by 44 · see citing works

LIVER X RECEPTOR AGONIST GW3965 DOSE-DEPENDENTLY REGULATES LPS-MEDIATED LIVER INJURY AND MODULATES POSTTRANSCRIPTIONAL TNF-α PRODUCTION AND P38 MITOGEN-ACTIVATED PROTEIN KINASE ACTIVATION IN LIVER MACROPHAGES

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Upregulation of the Transport System for TNFa at the Blood-Brain Barrier

Pan, W., & Kastin, A. J. (2001) · Archives of Physiology and Biochemistry · doi:10.1076/apab.109.4.350.4238 · Cited by 43 · see citing works

Upregulation of p55 and p75 Receptors Mediating TNF-α Transport Across the Injured Blood-Spinal Cord Barrier

Pan, W., Csernus, B., & Kastin, A. J. (2003) · Journal of Molecular Neuroscience · doi:10.1385/jmn:21:2:173 · Cited by 41 · see citing works

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