The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression
Abstract
Depressive disorders, including major depression, are serious and disabling. However, the exact pathophysiology of depression is not clearly understood. Life stressors contribute in some fashion to depression and are an extension of what occurs normally. In this context, chronic stress has been used as an animal model of depression. Based on the hypothesis that metabolism impairment might be involved in the pathophysiology of depression, in the present work we evaluated the activities of mitochondrial respiratory chain complexes and creatine kinase in brain of rats subjected to chronic stress. After 40 days of mild stress, a reduction in sweet food ingestion was observed, as well as increased adrenal gland weight, when compared to control group. We also verified that control group gained weight after 40 days, but stressed group did not. Moreover, our findings showed that complex I, III and IV were inhibited in stress group only in cerebral cortex and cerebellum. On the other hand, complex II and creatine kinase were not affected in stressed group. Although it is difficult to extrapolate our findings to the human condition, the inhibition of mitochondrial respiratory chain by chronic stress may be one mechanism in the pathophysiology of depressive disorders.
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“Preclinical models of MDD suppress mitochondrial function223.”
From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [223]
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Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
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THE CREATINE-CREATINE PHOSPHATE ENERGY SHUTTLE
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Differential Inhibitory Action of Nitric Oxide and Peroxynitrite on Mitochondrial Electron Transport
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The mitochondrial energy transduction system and the aging process
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Impaired mitochondrial function in psychiatric disorders
Manji, H. K., Kato, T., Prospero, N. A. D., Ness, S. L., Beal, M. F., Krams, M., & Chen, G. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3229 · Cited by 493
Alcocer-Gómez, E., de Miguel, M., Casas-Barquero, N., Núñez-Vasco, J., Sánchez-Alcazar, J. A., Fernández-Rodríguez, A., & Cordero, M. D. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.10.017 · Cited by 443
Mitochondrial Dysfunction and Psychiatric Disorders
Rezin, G. T., Amboni, G., Zugno, A. I., Quevedo, J., & STRECK, E. L. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9865-8 · Cited by 453
“It has also been recently reported inhibition of mitochondrial respiratory chain complexes I, III and IV activities after chronic variate stress for 40 days [ 59 ].”
BackgroundSelf-citationMitochondrial allostatic load puts the 'gluc' back in glucocorticoids
Picard, M., Juster, R.-P., & McEwen, B. S. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.22 · Cited by 405
“69 72 Chronic administration of corticosterone also contributes to dampen mitochondrial function in the context of partial dysfunction.”
BackgroundMitochondrial Dysfunction in Depression
Bansal, Y., & Kuhad, A. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160229114755 · Cited by 360
“Studies have shown that chronic mild stress inhibits mitochondrial OXPHOS, dissipates mitochondrial membrane potential and damages mitochondrial ultrastructure in various brain regions including hippocampus, cortex and hypothalamus of mice [77, 78].”
Metadata
- Authors
- Rezin, G. T., Cardoso, M. R., Gonçalves, C. L., Scaini, G., Fraga, D. B., Riegel, R. E., Comim, C. M., Quevedo, J., & Streck, E. L.
- Affiliations
- Universidade do Extremo Sul Catarinense (BR)
- Corresponding author
- Streck, Emilio L.
- ORCID
- Venue
- Neurochemistry International
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 53
- Issue
- 6-8
- Pages
- 395-400
- ISSN
- 0197-0186 (ISSN-L)
- OpenAlex
- W1996982207
- Cited by
- 197
- References
- 63
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 9 · 2020: 19 · 2019: 21 · 2018: 20 · 2017: 11 · 2016: 14 · 2015: 7 · 2014: 12 · 2013: 9 · 2012: 7
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurochemistry International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- depression, chronic stress, mitochondrial respiratory chain, mitochondrial complex I inhibition, complex III inhibition, complex IV inhibition, creatine kinase, brain energy metabolism, cerebral cortex, cerebellum, adrenal weight, sweets consumption, rat model of depression
- MeSH terms
- Adrenal Glands, Animals, Appetite Regulation, Body Weight, Brain, Brain Diseases, Metabolic, Chronic Disease, Creatine Kinase, Depressive Disorder, Disease Models, Animal, Electron Transport, Energy Metabolism, Male, Mitochondria, Organ Size, Oxidative Phosphorylation, Stress, Psychological, Biomarkers, Down-Regulation, Rats, Wistar, Rats
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