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Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression
Abstract
Depressive disorders, including major depression, are serious and disabling. However, the exact pathophysiology of depression is not clearly understood. Life stressors contribute in some fashion to depression and are an extension of what occurs normally. In this context, chronic stress has been used as an animal model of depression. Based on the hypothesis that metabolism impairment might be involved in the pathophysiology of depression, in the present work we evaluated the activities of mitochondrial respiratory chain complexes and creatine kinase in brain of rats subjected to chronic stress. After 40 days of mild stress, a reduction in sweet food ingestion was observed, as well as increased adrenal gland weight, when compared to control group. We also verified that control group gained weight after 40 days, but stressed group did not. Moreover, our findings showed that complex I, III and IV were inhibited in stress group only in cerebral cortex and cerebellum. On the other hand, complex II and creatine kinase were not affected in stressed group. Although it is difficult to extrapolate our findings to the human condition, the inhibition of mitochondrial respiratory chain by chronic stress may be one mechanism in the pathophysiology of depressive disorders.
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“Preclinical models of MDD suppress mitochondrial function223.”
From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [223]
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Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Wallimann, T., Wyss, M., Brdiczka, D., Nicolay, K., & Eppenberger, H. M. (1992) · Biochemical Journal · doi:10.1042/bj2810021 · Cited by 2,011
Willner, P., Towell, A., Sampson, D., Sophokleous, S., & Muscat, R. (1987) · Psychopharmacology · doi:10.1007/bf00187257 · Cited by 1,993
Biochemical and molecular investigations in respiratory chain deficiencies
Rustin, P., Chrétien, D., Bourgeron, T., Gérard, B., Rötig, A., Saudubray, J., & Münnich, A. (1994) · Clinica Chimica Acta · doi:10.1016/0009-8981(94)90055-8 · Cited by 1,265
Prabakaran, S., SWATTON, J. E., Ryan, M. M., Huffaker, S. J., Huang, J.-J., Griffin, J. L., Wayland, M. T., Freeman, T., Dudbridge, F., Lilley, K. S., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001511 · Cited by 985
THE CREATINE-CREATINE PHOSPHATE ENERGY SHUTTLE
Bessman, S. P., & Carpenter, C. L. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.54.070185.004151 · Cited by 776
Differential Inhibitory Action of Nitric Oxide and Peroxynitrite on Mitochondrial Electron Transport
Cassina, A., & Radí, R. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0178 · Cited by 721
The mitochondrial energy transduction system and the aging process
Navarro, A., & Boveris, A. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00213.2006 · Cited by 646
Hughes, B. P. (1962) · Clinica Chimica Acta · doi:10.1016/0009-8981(62)90137-7 · Cited by 550
Papp, M., Willner, P., & Muscat, R. (1991) · Psychopharmacology · doi:10.1007/bf02244188 · Cited by 542
Neuroimaging studies of the cerebellum: language, learning and memory
Desmond, J. E., & Fiez, J. A. (1998) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(98)01211-x · Cited by 526
Animal model of depression: Pharmacological sensitivity of a hedonic deficit
Katz, R. J. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90053-3 · Cited by 480
Nitric oxide, mitochondria and neurological disease
Heales, S., Bolaños, J. P., Stewart, V. C., Brookes, P. S., Land, J. M., & Clark, J. B. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00168-6 · Cited by 473
Differential investigation of the capacity of succinate oxidation in human skeletal muscle
Fischer, J., Ruitenbeek, W., BERDEN, J. A., Trijbels, J. M. F., Veerkamp, J. H., Stadhouders, A. M., Sengers, R. C. A., & Janssen, A. J. M. (1985) · Clinica Chimica Acta · doi:10.1016/0009-8981(85)90135-4 · Cited by 471
Adam-Vizi, V. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.1140 · Cited by 439
Endophenotypes in the Genetic Analyses of Mental Disorders
Cannon, T. D., & Keller, M. C. (2006) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.2.022305.095232 · Cited by 399
Madrigal, J. L. M. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00208-6 · Cited by 381
Prabakaran, S., SWATTON, J. E., Ryan, M. M., Huffaker, S. J., Huang, J. T.-J., Griffin, J. L., Wayland, M. T., Freeman, T., Dudbridge, F., Lilley, K. S., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001532 · Cited by 375
Konarski, J. Z., McIntyre, R. S., Kennedy, S. H., Rafi‐Tari, S., Soczynska, J. K., & Ketter, T. A. (2008) · Bipolar Disorders · doi:10.1111/j.1399-5618.2008.00435.x · Cited by 311
Oxidative Modification of Creatine Kinase BB in Alzheimer’s Disease Brain
Aksenov, M. Y., Aksenova, M. V., Butterfield, D. A., & Markesbery, W. R. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0742520.x · Cited by 286
Gardner, A. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00067-8 · Cited by 272
Regional Mitochondrial Respiratory Activity in Huntington's Disease Brain
Brennan, W. A., Bird, E. D., & Aprille, J. R. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb07192.x · Cited by 265
The cerebellum on the rise in human emotion
Schutter, D. J. L. G., & Van Honk, J. (2005) · The Cerebellum · doi:10.1080/14734220500348584 · Cited by 261
The Molecular Neurobiology of Depression
Shelton, R. C. (2007) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2006.12.005 · Cited by 244
Reversal of stress-induced anhedonia by the atypical antidepressants, fluoxetine and maprotiline
Muscat, R., Papp, M., & Willner, P. (1992) · Psychopharmacology · doi:10.1007/bf02247719 · Cited by 237
Is the cerebellum relevant in the circuitry of neuropsychiatric disorders?
Konarski, J. Z., McIntyre, R. S., Grupp, L. A., & Kennedy, S. H. (2005) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0526 · Cited by 224
Supramolecular Structure of the Mitochondrial Oxidative Phosphorylation System
Boekema, E. J., & Braun, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r600031200 · Cited by 224
Review of the Literature on Major Mental Disorders in Adult Patients With Mitochondrial Diseases
Fattal, O., Budur, K., Vaughan, A. J., & Franco, K. (2006) · Psychosomatics · doi:10.1176/appi.psy.47.1.1 · Cited by 209
Nitric oxide inhibits creatine kinase and regulates rat heart contractile reserve.
Gross, W. L., Bak, M. I., Ingwall, J. S., Arstall, M. A., Smith, T. W., Balligand, J., & Kelly, R. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.11.5604 · Cited by 199
Gamaro, G. D. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(02)00080-3 · Cited by 197
Repeated Restraint Stress Induces Oxidative Damage in Rat Hippocampus
Fontella, F. U., Siqueira, I. R., de Vasconcellos, A. P. S., Tabajara, Â. S., Netto, C. A., & Dalmaz, C. (2005) · Neurochemical Research · doi:10.1007/s11064-004-9691-6 · Cited by 195
Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes
Moreira, P. I., Santos, M. S., Seiça, R. M. F., & Oliveira, C. R. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.017 · Cited by 190
Petrosillo, G., Matera, M. G., Casanova, G., Ruggiero, F. M., & Paradies, G. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.07.001 · Cited by 171
Neuroendocrinological mechanisms of actions of antidepressant drugs
Schüle, C. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01516.x · Cited by 167
Evidence for Decreased DARPP-32 in the Prefrontal Cortex of Patients With Schizophrenia
Albert, K. A., Hemmings, H. C., Adamo, A. I. B., Potkin, S. G., Akbarian, S., Sandman, C. A., Cotman, C. W., Bunney, W. E., & Greengard, P. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.8.705 · Cited by 166
Blass, J. P. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.10087 · Cited by 165
Alzheimer's Disease: A Lesson from Mitochondrial Dysfunction
Moreira, P. I., Santos, M. S., & Oliveira, C. R. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1703 · Cited by 155
Effect of Restraint Stress on Feeding Behavior of Rats
Ely, D. R., Dapper, V. D., Marasca, J. A., Correa, J. B. B., Gamaro, G. D., Xavier, M., Michalowski, M. B., Catelli, D. H., Rosat, R. M., & Ferreira, M. B. C. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00450-7 · Cited by 143
David, S. S. M., Shoemaker, M. T., & Haley, B. E. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00343-4 · Cited by 141
Harro, J., Tõnissaar, M., Eller, M., Kask, A., & Oreland, L. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02256-9 · Cited by 124
Lee, B.-T., Seok, J.-H., Lee, B.-C., Cho, S. W., Yoon, B.-J., Lee, K.-U., Chae, J.-H., Choi, I.-G., & Ham, B.-J. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.12.009 · Cited by 123
Gamaro, G. D., STRECK, E. L., Matté, C., Prediger, M. E., Wyse, Â. T. D. S., & Dalmaz, C. (2003) · Neurochemical Research · doi:10.1023/a:1024988113978 · Cited by 115
Self-citationOctamers of Mitochondrial Creatine Kinase Isoenzymes Differ in Stability and Membrane Binding
Schlattner, U., & Wallimann, T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001919200 · Cited by 113
Inhibition of the creatine kinase reaction decreases the contractile reserve of isolated rat hearts
Hamman, B. L., Bittl, J. A., Jacobus, W. E., Allen, P. D., Spencer, R. G. S., Tian, R., & Ingwall, J. S. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.269.3.h1030 · Cited by 109
Energy metabolism, stress hormones and neural recovery from cerebral ischemia/hypoxia
Schurr, A. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(01)00142-5 · Cited by 86
Tomimoto, H., Yamamoto, K., Homburger, H. A., & Yanagihara, T. (1993) · Acta Neuropathologica · doi:10.1007/bf00228579 · Cited by 79
Mitochondrial dysfunction in human pathologies
Monsalve, M. (2006) · Frontiers in bioscience · doi:10.2741/2132 · Cited by 75
Torres, R. L., Torres, I. L. D. S., Gamaro, G. D., Fontella, F. U., Silveira, P. P., Moreira, J. S. R., Lacerda, M., Amoretti, J. R., Rech, D. L., Dalmaz, C., et al. (2004) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2004000200004 · Cited by 69
Khuchua, Z. A., Qin, W., Boero, J., Cheng, J. M., Payne, R. M., Saks, V. A., & Strauss, A. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.36.22990 · Cited by 68
Theory of active antidepressants: A nonsynaptic approach to the treatment of depression
Kiss, J. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.04.006 · Cited by 68
de Vasconcellos, A. P. S., Nieto, F., Crema, L. M., Diehl, L. A., de Almeida, L. M., Prediger, M. E., da Rocha, E. R., & Dalmaz, C. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9139-2 · Cited by 63
The complex roles of neurosteroids in depression and anxiety disorders
Longone, P., Rupprecht, R., Manieri, G. A., Bernardi, G., Romeo, E., & Pasini, A. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.10.001 · Cited by 62
Brain creatine kinase activity in an animal model of mania
STRECK, E. L., Amboni, G., Scaini, G., Di‐Pietro, P. B., Rezin, G. T., Valvassori, S. S., da Luz, G., Kapczinski, F. P., & Quevedo, J. (2008) · Life Sciences · doi:10.1016/j.lfs.2007.11.026 · Cited by 60
Self-citationKonarska, M., Stewart, R. E., & McCarty, R. (1990) · Behavioral and Neural Biology · doi:10.1016/0163-1047(90)90458-i · Cited by 53
Stanyer, L., Jørgensen, W., Hori, O., Clark, J. B., & Heales, S. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.06.004 · Cited by 51
Tretter, L., Mayer-Takacs, D., & Ádám‐Vizi, V. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.07.010 · Cited by 48
Antidepressant-like effect of nicotinamide adenine dinucleotide in the forced swim test in rats
Rex, A., Schickert, R., & Fink, H. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2003.11.001 · Cited by 48
Schnyder, T., Winkler, H., Gross, H., Eppenberger, H. M., & Wallimann, T. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)67790-2 · Cited by 43
Fontella, F. U., Cimarosti, H., Crema, L. M., Thomazi, A. P., Leite, M. C., Salbego, C. G., Gonçalves, C. A., Wofchuk, S. T., Dalmaz, C., & Netto, C. A. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.02.026 · Cited by 42
Self-citationMurua, V. S., & Molina, V. A. (1992) · Behavioral and Neural Biology · doi:10.1016/0163-1047(92)90790-b · Cited by 37
van Gemert, N. G., & Joëls, M. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01472.x · Cited by 34
Kanarik, M., Matrov, D., Kõiv, K., Eller, M., Tõnissaar, M., & Harro, J. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.08.003 · Cited by 30
Decreased Creatine Kinase Activity Caused by Electroconvulsive Shock
Búrigo, M., Roza, C. A., Bassani, C., Feier, G., Dal‐Pizzol, F., Quevedo, J., & STRECK, E. L. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9091-1 · Cited by 19
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Manji, H. K., Kato, T., Prospero, N. A. D., Ness, S. L., Beal, M. F., Krams, M., & Chen, G. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3229 · Cited by 493
Alcocer-Gómez, E., de Miguel, M., Casas-Barquero, N., Núñez-Vasco, J., Sánchez-Alcazar, J. A., Fernández-Rodríguez, A., & Cordero, M. D. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.10.017 · Cited by 443
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“It has also been recently reported inhibition of mitochondrial respiratory chain complexes I, III and IV activities after chronic variate stress for 40 days [ 59 ].”
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“69 72 Chronic administration of corticosterone also contributes to dampen mitochondrial function in the context of partial dysfunction.”
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“Studies have shown that chronic mild stress inhibits mitochondrial OXPHOS, dissipates mitochondrial membrane potential and damages mitochondrial ultrastructure in various brain regions including hippocampus, cortex and hypothalamus of mice [77, 78].”
Metadata
- Authors
- Rezin, G. T., Cardoso, M. R., Gonçalves, C. L., Scaini, G., Fraga, D. B., Riegel, R. E., Comim, C. M., Quevedo, J., & Streck, E. L.
- Affiliations
- Universidade do Extremo Sul Catarinense (BR)
- Corresponding author
- Streck, Emilio L.
- ORCID
- Venue
- Neurochemistry International
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 53
- Issue
- 6-8
- Pages
- 395-400
- ISSN
- 0197-0186 (ISSN-L)
- OpenAlex
- W1996982207
- Cited by
- 197
- References
- 63
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 9 · 2020: 19 · 2019: 21 · 2018: 20 · 2017: 11 · 2016: 14 · 2015: 7 · 2014: 12 · 2013: 9 · 2012: 7
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurochemistry International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- depression, chronic stress, mitochondrial respiratory chain, mitochondrial complex I inhibition, complex III inhibition, complex IV inhibition, creatine kinase, brain energy metabolism, cerebral cortex, cerebellum, adrenal weight, sweets consumption, rat model of depression
- MeSH terms
- Adrenal Glands, Animals, Appetite Regulation, Body Weight, Brain, Brain Diseases, Metabolic, Chronic Disease, Creatine Kinase, Depressive Disorder, Disease Models, Animal, Electron Transport, Energy Metabolism, Male, Mitochondria, Organ Size, Oxidative Phosphorylation, Stress, Psychological, Biomarkers, Down-Regulation, Rats, Wistar, Rats
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