The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Light induced retinal degeneration activates a caspase-independent pathway involving cathepsin D
Abstract
Neuroprotection strategies in the retina aim at interference with regulatory mechanisms of cell death. To successfully target these mechanisms it is necessary to understand the molecular pathways activated in the degenerating retina. Induced retinal degeneration models, like the light damage model, give a synchronized response allowing their detailed investigation. In this study we exposed Fisher rats to a continuous white light. This induced a caspase-independent cell death in which the activation of cathepsin D has an important role via the activation of L-DNase II. Inhibition of this enzyme by intravitreal administration of pepstatin A protects photoreceptors indicating that this enzyme might be an interesting target for neuroprotection.
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“However, it is probably prudent to monitor both turnover of LC3-II and an autophagosome substrate in parallel, due to the fact that LC3 might be coupled to endosomal membranes and not just autophagosomes, and the levels of well-characterized autophagosome substrates such as SQSTM1/p62 can also be affected by proteasome inhibitors [342].”
From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [342]
Citations
Cites
Modulation of cathepsin D activity in retinal pigment epithelial cells
RAKOCZY, P. E., LAI, C. M., BAINES, M., GRANDI, S. D., FITTON, J. H., & CONSTABLE, I. J. (1997) · Biochemical Journal · doi:10.1042/bj3240935 · Cited by 64
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Sorted by citations
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894
Self-citationGuidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
Self-citationCuenca, N., Fernández-Sánchez, L., Campello, L., Maneu, V., De la Villa, P., Lax, P., & Pinilla, I. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.07.001 · Cited by 401
Metadata
- Authors
- Chahory, S., Keller, N., Martin, E., Omri, B., Crisanti, P., & Torriglia, A.
- Venue
- Neurochemistry International
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 57
- Issue
- 3
- Pages
- 278-287
- ISSN
- 0197-0186
- Cited by
- 33
- References
- 1
- Language
- en
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