The DOI matches its Crossref record; 190 of the 190 references it cites were found in a registry or an index.
Role of oxidative stress in epileptic seizures
Open accessAbstract
Oxidative stress resulting from excessive free-radical release is likely implicated in the initiation and progression of epilepsy. Therefore, antioxidant therapies aimed at reducing oxidative stress have received considerable attention in epilepsy treatment. However, much evidence suggests that oxidative stress does not always have the same pattern in all seizures models. Thus, this review provides an overview aimed at achieving a better understanding of this issue. We summarize work regarding seizure models (i.e., genetically epilepsy-prone rats, kainic acid, pilocarpine, pentylenetetrazol, and trimethyltin), oxidative stress as an etiologic factor in epileptic seizures (i.e., impairment of antioxidant systems, mitochondrial dysfunction, involvement of redox-active metals, arachidonic acid pathway activation, and aging), and antioxidant strategies for seizure treatment. Combined, this review highlights pharmacological mechanisms associated with oxidative stress in epileptic seizures and the potential for neuroprotection in epilepsy that targets oxidative stress and is supported by effective antioxidant treatment.
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Cites
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Cited by
Excitatory Amino Acid Transporters in Physiology and Disorders of the Central Nervous System
Malik, A. R., & Willnow, T. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225671 · Cited by 170
Interweaving epilepsy and neurodegeneration: Vitamin E as a treatment approach
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Metadata
- Authors
- Shin, E.-J., Jeong, J. H., Chung, Y. H., Kim, W.-K., Ko, K.-H., Bach, J.-H., Hong, J.-S., Yoneda, Y., & Kim, H.-C.
- Venue
- Neurochemistry International
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 59
- Issue
- 2
- Pages
- 122-137
- ISSN
- 0197-0186 (ISSN-L)
- OpenAlex
- W2068078405
- Cited by
- 422
- References
- 190
- FWCI
- 13.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Shin, E.-J., Jeong, J. H., Chung, Y. H., Kim, W.-K., Ko, K.-H., Bach, J.-H., Hong, J.-S., Yoneda, Y., & Kim, H.-C. (2011). Role of oxidative stress in epileptic seizures. Neurochemistry International. https://doi.org/10.1016/j.neuint.2011.03.025
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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