The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Selenium: Biochemical Role as a Component of Glutathione Peroxidase
Abstract
When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H 2 O 2 , added glutathione failed to protect the hemoglobin from oxidative damage. This occurred because the erythrocytes were practically devoid of glutathione-peroxidase activity. Extensively purified preparations of glutathione peroxidase contained a large part of the 75 Se of erythrocytes labeled in vivo. Many of the nutritional effects of selenium can be explained by its role in glutathione peroxidase.
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Citations
Cites
Glutathione Peroxidase: The Primary Agent for the Elimination of Hydrogen Peroxide in Erythrocytes*
Cohen, G., & Hochstein, P. (1963) · Biochemistry · doi:10.1021/bi00906a038 · Cited by 666
Cited by
Organoselenium and Organotellurium Compounds: Toxicology and Pharmacology
Nogueira, C. W., Zeni, G., & Rocha, J. B. T. (2004) · Chemical Reviews · doi:10.1021/cr0406559 · Cited by 1,926
Brigelius-Flohé, R., & Maiorino, M. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.11.020 · Cited by 1,904
Glutathione and its role in cellular functions
Sies, H. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00177-x · Cited by 1,735
A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding
Perron, N. R., & Brumaghim, J. L. (2009) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-009-9043-x · Cited by 1,370
Terry, N., Zayed, A. M., de Souza, M. P., & Tarun, A. S. (2000) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.51.1.401 · Cited by 1,328
Metadata
- Authors
- Rotruck, J. T., Pope, A. L., Ganther, H. E., Swanson, A. B., Hafeman, D. G., & Hoekstra, W. G.
- Venue
- Science
- Published
- 1973-02-09
- Volume
- 179
- Issue
- 4073
- Pages
- 588-590
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2060194897
- Cited by
- 7,809
- References
- 1
- FWCI
- 48.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Selenium: Biochemical Role as a Component of Glutathione Peroxidase. https://app.cochat.ai/papers/10.1126/science.179.4073.588
- The paper
- Rotruck, J. T., Pope, A. L., Ganther, H. E., Swanson, A. B., Hafeman, D. G., & Hoekstra, W. G. (1973). Selenium: Biochemical Role as a Component of Glutathione Peroxidase. Science. https://doi.org/10.1126/science.179.4073.588
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
