Very slow potential oscillations in locus coeruleus and dorsal raphe nucleus under different illumination in freely moving rats
Abstract
Recent findings have revealed very slow (<0.5 Hz) oscillatory phenomena in the structures of the brain visual system. It has been proposed that very slow brain potentials in an extremely slow domain, less than 0.1 Hz, recorded from the lateral geniculate complex and primary visual cortex are associated with periodic influences originating from the locus coeruleus and dorsal raphe nucleus. The present study was performed to test the hypothesis that extremely slow brain potential oscillatory patterns in the locus coeruleus and dorsal raphe nucleus during several types of visual stimulation--light exposure, darkness, and photostimulation--are similar to those in the primary visual cortex and lateral geniculate complex under the same conditions of illumination. The results support this hypothesis. Specifically, spectral patterns of multisecond oscillations in the range of 0.02-0.04 Hz and fluctuations in the domain of minutes (below 0.002 Hz) were present in both the locus coeruleus and dorsal raphe nucleus and were similar to those found in the primary visual cortex and lateral geniculate complex. Additionally, we detected significant increases in the power spectra of multisecond oscillations in both nuclei in response to photostimulation (P<0.05). Our tentative conclusion is that extremely slow potentials in the locus coeruleus and dorsal raphe nucleus contribute to the regulation of extremely slow activity in the brain visual system.
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Electrophysiological infraslow fluctuations have been shown in both cortical and subcortical tissues.
“eISFs have been shown in both cortical [65, 66, 77] and subcortical [76, 78–82] tissues”
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- Authors
- Filippov, I. V., Williams, W. C., & Frolov, V. A.
- Affiliations
- Yaroslavl State Medical Academy (RU)
- Eastern Washington University (US)
- Corresponding author
- Filippov, Igor V.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2004-06
- Volume
- 363
- Issue
- 1
- Pages
- 89-93
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2082011084
- Cited by
- 20
- References
- 27
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2018: 1 · 2017: 3 · 2015: 1 · 2013: 2
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- locus coeruleus, dorsal raphe nucleus, photostimulation, light exposure, darkness, primary visual cortex, power spectrum, freely moving rats
- MeSH terms
- Action Potentials, Animals, Lighting, Locus Coeruleus, Male, Photic Stimulation, Raphe Nuclei, Rats
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