The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
A glycogen synthase kinase 3-β promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression
Abstract
The molecular mechanisms driving the biological clock in the suprachiasmatic nucleus of the hypothalamus may play a role in mood disorders. A single nucleotide polymorphism (SNP) (-50T/C) falling into the effective promoter region (nt -171 to +29) of the gene coding for glycogen synthase kinase 3-beta (GSK3-beta) has been linked with different age at onset of bipolar illness. GSK3-beta codes for an enzyme which is a target for the action of lithium and valproic acid, and the inhibition of which causes antidepressant-like behaviors in a preclinical model. We studied the effect of this polymorphism on the acute response to total sleep deprivation of 60 depressed bipolar type I inpatients. Homozygotes for the mutant allele of GSK3-beta promoter (-50T/C) SNP showed a later onset of bipolar illness, and better acute effects of TSD treatment on perceived mood (as rated on VAS). Overall, these observations suggest a protective role for this genotype in respect to bipolar illness. Results warrant interest for the variants of genes pertaining to the molecular clock as possible endophenotypes of bipolar disorder, and for GSK3-beta as a target of a new class of antidepressant drugs, but caution ought to be taken in interpreting these preliminary results and future replication studies must be awaited because of the low frequency of the GSK3-beta*C/C genotype in the studied populations.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“other studies failed to show a general association between these SNPs and BPD”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Benedetti et al., 2004
In the citing paper
“one of these SNPs (−50 T to C) is linked to a later age of onset of BPD and a greater response to total sleep deprivation (TSD) and long-term lithium treatment (Benedetti et al., 2004; Benedetti et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Benedetti et al., 2004
In the citing paper
“one of these SNPs (−50 T to C) is linked to a later age of onset of BPD and a greater response to total sleep deprivation (TSD) and long-term lithium treatment (Benedetti et al., 2004; Benedetti et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Benedetti et al., 2004
In the citing paper
“one of these SNPs (−50 T to C) is linked to a later age of onset of BPD and a greater response to total sleep deprivation (TSD) and long-term lithium treatment (Benedetti et al., 2004; Benedetti et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Benedetti et al., 2004
Citations
Cites
A molecular mechanism for the effect of lithium on development.
Klein, P. S., & Melton, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8455 · Cited by 2,334
The glamour and gloom of glycogen synthase kinase-3
Jope, R. S., & Johnson, G. V. W. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2003.12.004 · Cited by 1,535
The multifaceted roles of glycogen synthase kinase 3β in cellular signaling
Grimes, C. A., & Jope, R. S. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00011-9 · Cited by 1,440
A Role for the Segment Polarity Gene shaggy/GSK-3 in the Drosophila Circadian Clock
Martinek, S., Inonog, S., Manoukian, A. S., & Young, M. W. (2001) · Cell · doi:10.1016/s0092-8674(01)00383-x · Cited by 512
Chen, A. C. H., Shirayama, Y., Shin, K.-H., Neve, R. L., & Duman, R. S. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01114-8 · Cited by 316
Newton, S. S., Thome, J., Wallace, T. L., Shirayama, Y., Schlesinger, L., Sakai, N., Chen, J., Neve, R., Nestler, E. J., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10883.2002 · Cited by 313
Kaidanovich‐Beilin, O., Milman, A., Weizman, A., Pick, C. G., & Eldar-Finkelman, H. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.01.008 · Cited by 276
Endophenotypes in bipolar disorder
Lenox, R. H., Gould, T. D., & Manji, H. K. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10360 · Cited by 264
BDNF‐mediated signal transduction is modulated by GSK3β and mood stabilizing agents
Mai, L., Jope, R. S., & Li, X. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00939.x · Cited by 197
Benedetti, F., Serretti, A., Colombo, C., Campori, E., Barbini, B., di Bella, D., & Smeraldi, E. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.9.1450 · Cited by 167
Benedetti, F., Bernasconi, A., Lorenzi, C., Pontiggia, A., Serretti, A., Colombo, C., & Smeraldi, E. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.10.021 · Cited by 162
Rhythms and the pharmacology of lithium
Klemfuss, H. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90037-z · Cited by 134
Expression analysis of glycogen synthase kinase‐3 in human tissues
Lau, K., Miller, C. C. J., Anderton, B. H., & Shaw, P. C. (1999) · Journal of Peptide Research · doi:10.1034/j.1399-3011.1999.00083.x · Cited by 114
Retraction of an Interpretation
Zhang, L., Lopez, P., Tian, H., Yu, W., & Ho, D. D. (2004) · Science · doi:10.1126/science.303.5657.467b · Cited by 112
Gasparini, P., Estivill, X., Volpini, V., Totaro, A., Castellvı́-Bel, S., Govea, N., Milà, M., Monica, M. D., Ventruto, N. V., Benedetto, M. D., et al. (1997) · PubMed · Cited by 108
Totaro, A., P., G., Estivill, X., Volpini, V., Castellvı́-Bel, S., Govea, N., Milà, M., Monica, M. D., Ventruto, V., Benedetto, M. D., et al. (1997) · European Journal of Human Genetics · doi:10.1159/000484738 · Cited by 105
Benedetti, F., Colombo, C., Serretti, A., Lorenzi, C., Pontiggia, A., Barbini, B., & Smeraldi, E. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01894-2 · Cited by 90
Wirz‐Justice, A., Terman, M., Oren, D. A., Goodwin, F. K., Kripke, D. F., Whybrow, P. C., Wisner, K. L., Wu, J. C., Lam, R. W. M., Berger, T., et al. (2004) · Science · doi:10.1126/science.303.5657.467c · Cited by 81
Badenhop, R. F., Moses, M. J., Scimone, A., Mitchell, P. B., Ewen-White, K. R., Rosso, A., Donald, J. A., Adams, L. J., & Schofield, P. R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001025 · Cited by 73
Molecular Cloning and Characterization of the Human Glycogen Synthase Kinase-3β Promoter
Lau, K., Miller, C. C. J., Anderton, B. H., & Shaw, P. (1999) · Genomics · doi:10.1006/geno.1999.5875 · Cited by 67
Glycogen synthase kinase-3β, β-catenin, and tau in postmortem bipolar brain
Lesort, M. J., Greendorfer, A., Stockmeier, C. A., Johnson, G. V. W., & Jope, R. S. (1999) · Journal of Neural Transmission · doi:10.1007/s007020050235 · Cited by 62
Badenhop, R. F., Moses, M. J., Scimone, A., Mitchell, P. B., Ewen-White, K. R., Rosso, A., Donald, J. A., Adams, L. J., & Schofield, P. R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001114 · Cited by 61
Russ, C., Lovestone, S., & Powell, J. F. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000852 · Cited by 60
Effects of lithium ions on glycogen synthase and phosphorylase in rat hepatocytes.
Bosch, F., Gómèz‐Foix, A. M., Ariño, J., & Guinovart, J. J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75978-x · Cited by 50
Hansen, L., Arden, K. C., Rasmussen, S., Viars, C. S., Vestergaard, H., Hansen, T. F., Møller, A. M., Woodgett, J. R., & Pedersen, O. B. (1997) · Diabetologia · doi:10.1007/s001250050771 · Cited by 39
Antimanic drugs stabilize hamster circadian rhythms
Klemfuss, H., & Kripke, D. F. (1995) · Psychiatry Research · doi:10.1016/0165-1781(95)02687-r · Cited by 35
Flagged first, then by citations
Cited by
Sorted by citations
The physiology, signaling, and pharmacology of dopamine receptors
Beaulieu, J.-M., & Gainetdinov, R. R. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.002642 · Cited by 2,763
Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases
Beurel, E., Grieco, S. F., & Jope, R. S. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.11.016 · Cited by 1,768
“…particularly including links between GSK3β SNPs to susceptibility to mood disorders and to therapeutic responses to drugs used in mood disorders (Benedetti et al., 2004a; Benedetti et al., 2004b; Benedetti et al., 2005; Szczepankiewicz et al., 2006a; Adli et al., 2007; Tsai et al., 2008;…”
BackgroundCircadian genes, rhythms and the biology of mood disorders
McClung, C. A. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.02.003 · Cited by 666
“Similarly, other studies failed to show a general association between these SNPs and BPD, however, one of these SNPs (−50 T to C) is linked to a later age of onset of BPD and a greater response to total sleep deprivation (TSD) and long-term lithium treatment (Benedetti et al., 2004;Benedetti et al., 2005).”
ResultNuclear Receptor Rev-erbα Is a Critical Lithium-Sensitive Component of the Circadian Clock
Yin, L., Wang, J., Klein, P. S., & Lazar, M. A. (2006) · Science · doi:10.1126/science.1121613 · Cited by 563
Akt/GSK3 Signaling in the Action of Psychotropic Drugs
Beaulieu, J., Gainetdinov, R. R., & Caron, M. G. (2008) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.011008.145634 · Cited by 536
Metadata
- Authors
- Benedetti, F., Serretti, A., Colombo, C., Lorenzi, C., Tubazio, V., & Smeraldi, E.
- Affiliations
- Vita-Salute San Raffaele University (IT)
- IRCCS Ospedale San Raffaele (IT)
- Corresponding author
- Benedetti, Francesco
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 368
- Issue
- 2
- Pages
- 123-126
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2080758948
- Cited by
- 195
- References
- 26
- Citations by year
- 2026: 3 · 2025: 2 · 2023: 2 · 2022: 4 · 2021: 27 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 13 · 2014: 11 · 2013: 9 · 2012: 15
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- glycogen synthase kinase-3β, single nucleotide polymorphisms, total sleep deprivation, bipolar depression, bipolar I disorder, age of onset, genetic susceptibility, circadian clock, suprachiasmatic nucleus, mood disorders, antidepressant targets, endophenotypes
- MeSH terms
- Glycogen Synthase Kinase 3 beta, Adult, Alleles, Analysis of Variance, Bipolar Disorder, DNA Mutational Analysis, Female, Genotype, Humans, Male, Middle Aged, Mutation, Promoter Regions, Genetic, Sleep Deprivation, Age of Onset, Genetic Predisposition to Disease, Reverse Transcriptase Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Glycogen Synthase Kinase 3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
