Rhythms and the pharmacology of lithium

Klemfuss, Harry

doi:10.1016/0163-7258(92)90037-z

Cited by 134Circadian rhythm and melatoninBipolar Disorder and TreatmentTreatment of Major Depression

Rhythms and the pharmacology of lithium

Klemfuss, Harry·1992·Pharmacology & Therapeutics

DOI 10.1016/0163-7258(92)90037-z

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Abstract

Lithium is the treatment of choice for bipolar affective disorder (manic-depression) and is useful in other recurrent affective and nonaffective illnesses. This review discusses lithium's actions on period, phase, amplitude and coupling of biological rhythms that may relate to its therapeutic effectiveness. Alternatively, lithium might interact with environmental light to influence circadian rhythms by an action on the retina. The mechanisms responsible for lithium's chronopharmacological actions are not known, but cellular cations, phosphoinositide or adenylate cyclase second messenger systems, hormones and neurotransmitters may all be involved.

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Lithium and valproate have been repeatedly shown to alter the circadian period, leading to a long period in Drosophila, non-human primates, rodents, and humans.
“Interestingly, both of these drugs have been repeatedly shown to alter the circadian period, leading to a long period in Drosophila, non-human primates, rodents and humans (Johnsson et al., 1983; Welsh and Moore-Ede, 1990; Klemfuss, 1992; Hafen and Wollnik, 1994; Dokucu et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Klemfuss, 1992

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Lithium chloride changes sensitivity of hamster rhythm to light pulses
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Lithium effects on selected circadian rhythms in rats.
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Disk-shedding in the rat retina: lithium dampens the circadian rhythm but potentiates the light response
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Aluminum fluoride reveals a phosphoinositide system within the suprachiasmatic region of rat hypothalamus
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Dietary calcium blocks lithium toxicity in hamsters without affecting circadian rhythms
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Retinal pigment epithelium response and the use of the EOG and arden ratio in depression
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THE CHRONOPHARMACOLOGY OF ANTIDEPRESSANT DRUGS
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Lithium and rhythms of beta-adrenergic ([3H]CGP-12177) binding in intact rat retina, pineal gland, and hypothalamus
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Lithium and the Endocrine System
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Adaptation to dim light in depressed patients with seasonal affective disorder
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Bipolar Patients Taking Lithium have Increased Dark Adaptation Threshold Compared with Controls
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GABA and circadian timekeeping: Implications for manic-depression and sleep disorders
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Diurnal Variations in Serum Lithium and Renal Lithium Clearance in Rats given Lithium as a Single Small Dose or as Multiple High Doses
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An endogenous circadian rhythm of transpiration in Tamarix aphylla
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Gene-Dependent Effect of Lithium on Circadian Rhythms in Mice (Mus Musculus)
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The effect of chronic lithium treatment on rat pineal N-acetyltransferase rhythm.
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Effects of lithium salts on the behaviour and the orcadian system ofMesocricetus auratusW.
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Sodium-potassium, magnesium, and calcium ATPase activities in erythrocyte membranes from manic-depressive patients responding to lithium
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Psychosis, lithium-induced antipsychotic response, and seasonality
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Splitting of circadian rhythm ofmusca domesticaflies with azadirachtin
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Effects of chronic lithium, clorgyline, imipramine, fluphenazine and constant darkness on the α-melanotropin content and circadian rhythm in rat brain
O’Donohue, T. L., Wirz‐Justice, A., Kafka, M. S., Naber, D., Campbell, I. C., & Wehr, T. A. (1982) · European Journal of Pharmacology · doi:10.1016/0014-2999(82)90417-4 · Cited by 14 · see citing works
The Pharmacokinetics of Lithium in Normal Humans: Expected and Unexpected Observations in View of Basic Kinetic Principles
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Prophylactic Therapy of Cluster Headaches
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Chronopharmacokinetics and Chronotoxicity of Lithium in Mice Eating Normal and Low-Sodium Diets
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Regular 48-hour cycling of sleep duration and mood in a 35-year-old woman: Use of lithium in time isolation
Welsh, D. K., Nino‐Murcia, G., Gander, P. H., Keenan, S. A., & Dement, W. C. (1986) · Biological Psychiatry · doi:10.1016/0006-3223(86)90195-2 · Cited by 14 · see citing works
Seasonal affective disorder and visual impairment: two case studies.
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Rhythms in second messenger mechanisms
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Effects of Li+, Rb+and tetraethylammoniumchloride on the locomotor activity rhythm ofMusca domestica
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Lithium-potassium interaction in acutely treated cortical neurons and astrocytes
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Early Physiological Effects of Lithium Treatment: Electrooculographic and Adaptometric Findings in Patients with Affective and Schizoaffective Psychoses
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Effect of Lithium Chloride on the Circadian Rhythm in the Flight Activity of the Microchiropteran Bat, Taphozous melanopogon
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Melatonin the retinal hypothalamic pineal axis and circadian rhythm regulation
Seggie, J. A. (1988) · Cited by 13 · see citing works
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Lithium and rubidium: Effects on the rhythmic swimming movement of jellyfish (Aurelia aurita)
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Low salt mimics effects of dark pulses on circadian pacemaker in cultured chick pineal cells
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Lithium in biology and medicine; new applications and developments
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Clinical implications of research on the mechanism of action of lithium
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The effect of lithium on pupillary response to pulses of light in sheep
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Effects of alkali ions on the circadian leaf movements of Oxalis regnellii
Rinnan, T., & Johnsson, A. (1986) · Physiologia Plantarum · doi:10.1111/j.1399-3054.1986.tb01246.x · Cited by 11 · see citing works
Lithium augments GM-CSA generation in canine cyclic hematopoiesis
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The effect of potassium on some nephrotoxic actions of lithium in rats.
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Lithium in the Cellular Environment
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Behavior of Rats Given Lithium Salts. A Review
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Lithium lengthens circadian period but fails to counteract behavioral helplessness in rats
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Some Aspects of Lithium in Living Systems
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The Interaction of Lithium with Magnesium-Dependent Enzymes
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Lithium and melatonin in pigmented eye rats: Effects of dose and time of day
Seggie, J. A., Werstiuk, E. S., Grota, L. J., Joshi, M., & Brown, G. M. (1984) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(84)90048-4 · Cited by 9 · see citing works

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Mania-like behavior induced by disruption of <i>CLOCK</i>
Roybal, K., Theobold, D., Graham, A., DiNieri, J. A., Russo, S. J., Krishnan, V., Chakravarty, S., Peevey, J., Oehrlein, N., Birnbaum, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609625104 · Cited by 803 · see citing works
Circadian genes, rhythms and the biology of mood disorders
McClung, C. A. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.02.003 · Cited by 666 · see citing works
Toward constructing an endophenotype strategy for bipolar disorders
Hasler, G., Drevets, W. C., Gould, T. D., Gottesman, I. I., & Manji, H. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.006 · Cited by 423 · see citing works
Glycogen Synthase Kinase-3: a Putative Molecular Target for Lithium Mimetic Drugs
Gould, T. D., & Manji, H. K. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300731 · Cited by 377 · see citing works
Novel melatonin-based therapies: potential advances in the treatment of major depression
Hickie, I. B., & Rogers, N. L. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60095-0 · Cited by 322 · see citing works
Endophenotypes in bipolar disorder
Lenox, R. H., Gould, T. D., & Manji, H. K. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10360 · Cited by 264 · see citing works
The feasibility of neuropsychological endophenotypes in the search for genes associated with bipolar affective disorder
Glahn, D. C., Bearden, C. E., Niendam, T. A., & Escamilla, M. A. (2004) · Bipolar Disorders · doi:10.1111/j.1399-5618.2004.00113.x · Cited by 258 · see citing works
Influence of sleep-wake and circadian rhythm disturbances in psychiatric disorders.
Boivin, D. B. (2000) · PubMed Central · Cited by 247 · see citing works
Knockdown of Clock in the Ventral Tegmental Area Through RNA Interference Results in a Mixed State of Mania and Depression-Like Behavior
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Authors: Klemfuss, H.
Affiliations: Veterans Health Administration (US)
Corresponding author: Klemfuss, Harry
Venue: Pharmacology & Therapeutics
Publisher: Elsevier BV
Published: 1992-01
Volume: 56
Issue: 1
Pages: 53-78
ISSN: 0163-7258 (ISSN-L)
DOI: 10.1016/0163-7258(92)90037-z
OpenAlex: W1987982071
Cited by: 134
References: 229
Citations by year: 2024: 2 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 2 · 2017: 5 · 2016: 9 · 2015: 6 · 2014: 6 · 2013: 7 · 2012: 4
FWCI: 0.74
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: lithium, circadian rhythm, chronopharmacology, bipolar disorder, biological rhythms, light exposure, retina, second messenger signaling, phosphoinositides, adenylate cyclase, neurotransmitters, hormones, mood disorders
MeSH terms: Animals, Chronobiology Phenomena, Circadian Rhythm, Humans, Lithium

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Rhythms and the pharmacology of lithium

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