The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-β −50 T/C SNP
Abstract
The molecular mechanisms driving the biological clock in the suprachiasmatic nucleus of the hypothalamus may play a role in mood disorders. A single nucleotide polymorphism (SNP) (-50 T/C) falling into the effective promoter region (nt -171 to +29) of the gene coding for glycogen synthase kinase 3-beta (GSK3-beta) has been linked with different age at onset of bipolar illness and with different antidepressant effects of total sleep deprivation. GSK3-beta codes for an enzyme which is a target for the action of lithium and possibly of valproic acid. We studied the effect of this polymorphism on the therapeutic response to lithium salts of 88 bipolar type I patients. Data about recurrence rate of mood episodes were collected for at least 2 years before lithium and 2 years on lithium. Results showed that homozygotes for the wild variant did not change their recurrence index while carriers of the mutant allele improved, thus supporting the hypothesis that GSK is a target for the therapeutic action of lithium. Results warrant interest for the variants of genes pertaining to the molecular clock as possible endophenotypes of bipolar disorder, but caution ought to be taken in interpreting these preliminary results and future replication studies must be awaited because of the low frequency of the GSK3-beta*C/C genotype in the studied populations.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“one of these SNPs (−50 T to C) is linked to a later age of onset of BPD and a greater response to total sleep deprivation (TSD) and long-term lithium treatment (Benedetti et al., 2004; Benedetti et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Benedetti et al., 2005
In the citing paper
“other studies failed to show a general association between these SNPs and BPD”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Benedetti et al., 2005
In the citing paper
“one of these SNPs (−50 T to C) is linked to a later age of onset of BPD and a greater response to total sleep deprivation (TSD) and long-term lithium treatment (Benedetti et al., 2004; Benedetti et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Benedetti et al., 2005
In the citing paper
“one of these SNPs (−50 T to C) is linked to a later age of onset of BPD and a greater response to total sleep deprivation (TSD) and long-term lithium treatment (Benedetti et al., 2004; Benedetti et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Benedetti et al., 2005
Citations
Cites
A molecular mechanism for the effect of lithium on development.
Klein, P. S., & Melton, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8455 · Cited by 2,334
The glamour and gloom of glycogen synthase kinase-3
Jope, R. S., & Johnson, G. V. W. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2003.12.004 · Cited by 1,535
The multifaceted roles of glycogen synthase kinase 3β in cellular signaling
Grimes, C. A., & Jope, R. S. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00011-9 · Cited by 1,440
Beaulieu, J., Sotnikova, T. D., Yao, W., Kockeritz, L. K., Woodgett, J. R., Gainetdinov, R. R., & Caron, M. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307921101 · Cited by 815
A Role for the Segment Polarity Gene shaggy/GSK-3 in the Drosophila Circadian Clock
Martinek, S., Inonog, S., Manoukian, A. S., & Young, M. W. (2001) · Cell · doi:10.1016/s0092-8674(01)00383-x · Cited by 512
O'Brien, W. T., Harper, A. D., Jove, F. A., Woodgett, J. R., Maretto, S., Piccolo, S., & Klein, P. S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4753-03.2004 · Cited by 415
Chen, A. C. H., Shirayama, Y., Shin, K.-H., Neve, R. L., & Duman, R. S. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01114-8 · Cited by 316
Newton, S. S., Thome, J., Wallace, T. L., Shirayama, Y., Schlesinger, L., Sakai, N., Chen, J., Neve, R., Nestler, E. J., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10883.2002 · Cited by 313
Kaidanovich‐Beilin, O., Milman, A., Weizman, A., Pick, C. G., & Eldar-Finkelman, H. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.01.008 · Cited by 276
Endophenotypes in bipolar disorder
Lenox, R. H., Gould, T. D., & Manji, H. K. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10360 · Cited by 264
BDNF‐mediated signal transduction is modulated by GSK3β and mood stabilizing agents
Mai, L., Jope, R. S., & Li, X. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00939.x · Cited by 197
Benedetti, F., Serretti, A., Colombo, C., Lorenzi, C., Tubazio, V., & Smeraldi, E. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.06.050 · Cited by 195
Self-citationBenedetti, F., Bernasconi, A., Lorenzi, C., Pontiggia, A., Serretti, A., Colombo, C., & Smeraldi, E. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.10.021 · Cited by 162
Self-citationRhythms and the pharmacology of lithium
Klemfuss, H. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90037-z · Cited by 134
Search for a common mechanism of mood stabilizers
Harwood, A. J., & Agam, G. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00187-4 · Cited by 134
Expression analysis of glycogen synthase kinase‐3 in human tissues
Lau, K., Miller, C. C. J., Anderton, B. H., & Shaw, P. C. (1999) · Journal of Peptide Research · doi:10.1034/j.1399-3011.1999.00083.x · Cited by 114
Early onset of lithium prophylaxis as a predictor of good long-term outcome
Franchini, L., Zanardi, R., Smeraldi, E., & Gasperini, M. (1999) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060050091 · Cited by 113
Self-citationGasparini, P., Estivill, X., Volpini, V., Totaro, A., Castellvı́-Bel, S., Govea, N., Milà, M., Monica, M. D., Ventruto, N. V., Benedetto, M. D., et al. (1997) · PubMed · Cited by 108
Totaro, A., P., G., Estivill, X., Volpini, V., Castellvı́-Bel, S., Govea, N., Milà, M., Monica, M. D., Ventruto, V., Benedetto, M. D., et al. (1997) · European Journal of Human Genetics · doi:10.1159/000484738 · Cited by 105
Iwahana, E., Akiyama, M., Miyakawa, K., Uchida, A., Kasahara, J., Fukunaga, K., Hamada, T., & Shibata, S. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03322.x · Cited by 103
Badenhop, R. F., Moses, M. J., Scimone, A., Mitchell, P. B., Ewen-White, K. R., Rosso, A., Donald, J. A., Adams, L. J., & Schofield, P. R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001025 · Cited by 73
Molecular Cloning and Characterization of the Human Glycogen Synthase Kinase-3β Promoter
Lau, K., Miller, C. C. J., Anderton, B. H., & Shaw, P. (1999) · Genomics · doi:10.1006/geno.1999.5875 · Cited by 67
Glycogen synthase kinase-3β, β-catenin, and tau in postmortem bipolar brain
Lesort, M. J., Greendorfer, A., Stockmeier, C. A., Johnson, G. V. W., & Jope, R. S. (1999) · Journal of Neural Transmission · doi:10.1007/s007020050235 · Cited by 62
Badenhop, R. F., Moses, M. J., Scimone, A., Mitchell, P. B., Ewen-White, K. R., Rosso, A., Donald, J. A., Adams, L. J., & Schofield, P. R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001114 · Cited by 61
Russ, C., Lovestone, S., & Powell, J. F. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000852 · Cited by 60
Vestergaard, P., Licht, R. W., Brodersen, A., Rasmussen, N. A., Christensen, H., Arngrim, T., Grønvall, B., Kristensen, E., & Poulstrup, I. (1998) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1998.tb10089.x · Cited by 59
Effects of lithium ions on glycogen synthase and phosphorylase in rat hepatocytes.
Bosch, F., Gómèz‐Foix, A. M., Ariño, J., & Guinovart, J. J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75978-x · Cited by 50
Hansen, L., Arden, K. C., Rasmussen, S., Viars, C. S., Vestergaard, H., Hansen, T. F., Møller, A. M., Woodgett, J. R., & Pedersen, O. B. (1997) · Diabetologia · doi:10.1007/s001250050771 · Cited by 39
Antimanic drugs stabilize hamster circadian rhythms
Klemfuss, H., & Kripke, D. F. (1995) · Psychiatry Research · doi:10.1016/0165-1781(95)02687-r · Cited by 35
Predicting Response to Lithium in Mood Disorders
Serretti, A., & Artioli, P. (2003) · American Journal of PharmacoGenomics · doi:10.2165/00129785-200303010-00004 · Cited by 29
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases
Beurel, E., Grieco, S. F., & Jope, R. S. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.11.016 · Cited by 1,768
Circadian genes, rhythms and the biology of mood disorders
McClung, C. A. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.02.003 · Cited by 666
Bauer, M., Pfennig, A., Severus, E., Whybrow, P. C., Angst, J., Möller, H.-J., & Šon behalf of the Task Force on Unipolar Depressive Disorders (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.804195 · Cited by 632
Glycogen Synthase Kinase-3: a Putative Molecular Target for Lithium Mimetic Drugs
Gould, T. D., & Manji, H. K. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300731 · Cited by 382
Clarifying the role of sleep in depression: A narrative review
Pandi-Perumal, S. R., Monti, J. M., Burman, D., Ramanujam, K., BaHammam, A. S., Spence, D. W., Brown, G. M., & Narashimhan, M. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.113239 · Cited by 351
Metadata
- Authors
- Benedetti, F., Serretti, A., Pontiggia, A., Bernasconi, A., Lorenzi, C., Colombo, C., & Smeraldi, E.
- Affiliations
- Vita-Salute San Raffaele University (IT)
- IRCCS Ospedale San Raffaele (IT)
- Corresponding author
- Benedetti, Francesco
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 376
- Issue
- 1
- Pages
- 51-55
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2078634434
- Cited by
- 184
- References
- 30
- Citations by year
- 2026: 3 · 2025: 3 · 2023: 3 · 2022: 7 · 2020: 8 · 2019: 9 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 8 · 2014: 15 · 2013: 16 · 2012: 13
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- lithium response, bipolar I disorder, glycogen synthase kinase-3β, promoter polymorphism, genetic susceptibility, mood episode recurrence, molecular clock, endophenotypes, valproic acid, age of onset
- MeSH terms
- Glycogen Synthase Kinase 3 beta, Adult, Analysis of Variance, Bipolar Disorder, DNA Mutational Analysis, Female, Humans, Lithium, Male, Middle Aged, Pharmacogenetics, Promoter Regions, Genetic, RNA, Messenger, Time, Time Factors, Reverse Transcriptase Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Glycogen Synthase Kinase 3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
