CoChat
Sign Up
Cited by 196Bipolar Disorder and TreatmentCircadian rhythm and melatoninTreatment of Major Depression

A glycogen synthase kinase 3-β promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression

Benedetti, Francesco, Serretti, Alessandro, Colombo, Cristina, Lorenzi, Cristina, Tubazio, Viviana, Smeraldi, Enrico·2004·Neuroscience Letters
DOI 10.1016/j.neulet.2004.06.050
Open this paper in CoChat — free account

Abstract

The molecular mechanisms driving the biological clock in the suprachiasmatic nucleus of the hypothalamus may play a role in mood disorders. A single nucleotide polymorphism (SNP) (-50T/C) falling into the effective promoter region (nt -171 to +29) of the gene coding for glycogen synthase kinase 3-beta (GSK3-beta) has been linked with different age at onset of bipolar illness. GSK3-beta codes for an enzyme which is a target for the action of lithium and valproic acid, and the inhibition of which causes antidepressant-like behaviors in a preclinical model. We studied the effect of this polymorphism on the acute response to total sleep deprivation of 60 depressed bipolar type I inpatients. Homozygotes for the mutant allele of GSK3-beta promoter (-50T/C) SNP showed a later onset of bipolar illness, and better acute effects of TSD treatment on perceived mood (as rated on VAS). Overall, these observations suggest a protective role for this genotype in respect to bipolar illness. Results warrant interest for the variants of genes pertaining to the molecular clock as possible endophenotypes of bipolar disorder, and for GSK3-beta as a target of a new class of antidepressant drugs, but caution ought to be taken in interpreting these preliminary results and future replication studies must be awaited because of the low frequency of the GSK3-beta*C/C genotype in the studied populations.

Integrity signals

Registry

Crossref · 10.1016/j.neulet.2004.06.050

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Other studies failed to show a general association between the GSK3β SNPs and bipolar disorder.

    “other studies failed to show a general association between these SNPs and BPD”

    From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Benedetti et al., 2004

  • The GSK3β −50 T to C SNP is linked to a later age of onset of bipolar disorder.

    “one of these SNPs (−50 T to C) is linked to a later age of onset of BPD and a greater response to total sleep deprivation (TSD) and long-term lithium treatment (Benedetti et al., 2004; Benedetti et al., 2005).”

    From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Benedetti et al., 2004

  • The GSK3β −50 T to C SNP is linked to a greater response to total sleep deprivation in bipolar patients.

    “one of these SNPs (−50 T to C) is linked to a later age of onset of BPD and a greater response to total sleep deprivation (TSD) and long-term lithium treatment (Benedetti et al., 2004; Benedetti et al., 2005).”

    From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Benedetti et al., 2004

  • The GSK3β −50 T to C SNP is linked to a greater response to long-term lithium treatment in bipolar patients.

    “one of these SNPs (−50 T to C) is linked to a later age of onset of BPD and a greater response to total sleep deprivation (TSD) and long-term lithium treatment (Benedetti et al., 2004; Benedetti et al., 2005).”

    From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Benedetti et al., 2004

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Benedetti, F., Serretti, A., Colombo, C., Lorenzi, C., Tubazio, V., & Smeraldi, E.
Affiliations
  • Vita-Salute San Raffaele University (IT)
  • IRCCS Ospedale San Raffaele (IT)
Corresponding author
Benedetti, Francesco
ORCID
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2004-09
Volume
368
Issue
2
Pages
123-126
ISSN
0304-3940 (ISSN-L)
DOI
10.1016/j.neulet.2004.06.050
OpenAlex
W2080758948
Cited by
195
References
26
Citations by year
2026: 3 · 2025: 2 · 2023: 2 · 2022: 4 · 2021: 27 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 13 · 2014: 11 · 2013: 9 · 2012: 15
FWCI
5.01
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
  • Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
glycogen synthase kinase-3β, single nucleotide polymorphisms, total sleep deprivation, bipolar depression, bipolar I disorder, age of onset, genetic susceptibility, circadian clock, suprachiasmatic nucleus, mood disorders, antidepressant targets, endophenotypes
MeSH terms
Glycogen Synthase Kinase 3 beta, Adult, Alleles, Analysis of Variance, Bipolar Disorder, DNA Mutational Analysis, Female, Genotype, Humans, Male, Middle Aged, Mutation, Promoter Regions, Genetic, Sleep Deprivation, Age of Onset, Genetic Predisposition to Disease, Reverse Transcriptase Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Glycogen Synthase Kinase 3

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review