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Cited by 51Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal PhysiologySubstance Abuse Treatment and Outcomes

Increased c-Fos expression in the medial part of the lateral habenula during cue-evoked heroin-seeking in rats

Zhang, Fuqiang, Zhou, Wenhua, Liu, Huifen, Zhu, Huaqiang, Tang, Shuaien, Lai, Miaojun, Yang, Guodong·2005·Neuroscience Letters
DOI 10.1016/j.neulet.2005.06.008
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Abstract

Conditioned environmental stimuli are known to be important determinants of drug seeking behavior. c-Fos, the protein product of the protooncogene c-Fos, is expressed in neurons when there are drug-associated cue-induced drug-seeking behaviour. Therefore, its expression could serve as a marker of regional neuronal activation. Using an extinction/reinstatement paradigm of relapse animal model, we trained Sprague-Dawley rats to nose-poke for i.v. heroin (0.05 mg/kg/infusion) either daily for 4h or 25 infusions for 14 consecutive days. We then tested these animals for cue-evoked heroin-seeking behavior after abstinence from self-administration of heroin for 14 days. Expression of c-Fos was examined in the lateral habenula (LHb), a region important for conveying information between the limbic forebrain and midbrain. Findings showed that heroin-associated conditioned stimuli could induce robust heroin-seeking behavior that was associated with increased c-Fos immunoreactivity in the medial part of the LHb. This observation suggests the involvement of the LHb in mediating drug cue-induced heroin-seeking behavior after abstinence from self-administration of heroin.

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Crossref · 10.1016/j.neulet.2005.06.008

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  • Activation of the habenula in animal models of cocaine addiction has been associated with relapse to drug taking upon cue exposure.

    “Indeed, activation of the habenula, in animal models of cocaine addiction, has been associated with relapse to drug taking upon cue exposure (153,154).”

    From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [153]

  • In animal models of cocaine or heroin addiction, activation of the lateral habenula is associated with relapse.

    “Indeed, activation of the lateral habenula, in animal models of cocaine or heroin addiction, has been associated with relapse (108,109).”

    From The Addictive Dimensionality of Obesity (2013) · cites this paper as [108]

  • Activation of the habenula in cocaine addicted subjects has been associated with behavioral relapse to drug taking upon cue exposure.

    “Indeed, activation of the habenula, in cocaine addicted subjects, has been associated with behavioral relapse to drug taking upon cue exposure (Brown et al 2011;Zhang et al 2005).”

    From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Zhang et al 2005

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Authors
Zhang, F., Zhou, W., Liu, H., Zhu, H., Tang, S., Lai, M., & Yang, G.
Corresponding author
  • Zhang, Fuqiang
  • Zhou, Wenhua
ORCID
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2005-09
Volume
386
Issue
2
Pages
133-137
ISSN
0304-3940 (ISSN-L)
DOI
10.1016/j.neulet.2005.06.008
OpenAlex
W1976855628
Cited by
51
References
23
Citations by year
2026: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 4 · 2018: 5 · 2017: 3 · 2015: 2 · 2014: 5 · 2013: 9 · 2012: 5
FWCI
0.24
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China
  • National Key Research and Development Program of China
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
c-fos, lateral habenula, heroin seeking, drug cue reactivity, conditioned stimulus, heroin self-administration, relapse, abstinence, neuronal activation, opioid use disorder
MeSH terms
Animals, Conditioning, Psychological, Heroin, Extinction, Psychological, Heroin Dependence, Male, Narcotics, Behavior, Addictive, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Habenula, Rats

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