Cited by 411Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeural and Behavioral Psychology Studies

Neurobiology of craving, conditioned reward and relapse

Weiss, Friedbert·2005·Current Opinion in Pharmacology

Abstract

Chronic vulnerability to relapse is a formidable challenge for the treatment of drug addiction. The neurobiological basis of relapse and its prevention has, therefore, attracted major attention in addiction research. Current conceptualizations of addiction recognize craving as a central driving force for ongoing drug use, as well as for relapse following abstinence. Progress has been made in understanding experiential factors, neurocircuitry components and signaling mechanisms that mediate conditioned drug-seeking behaviour, craving and long-lasting susceptibility to relapse. Importantly, stress contributes to drug craving, and there is evidence for overlap between the neural and neuroendocrine mechanisms implicated in drug desire evoked by drug cues and stress. Recent research has substantially advanced our understanding of the neurobiological factors responsible for drug craving and relapse, with promising therapeutic implications.

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Crossref · 10.1016/j.coph.2004.11.001

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  • Amygdala conditioning underlies cue-triggered craving that may precipitate relapse to drug seeking.

    “The product of such conditioning in the amygdala (AMG) is thought to underlie the craving triggered by people, places, and things associated with drug use, which may precipitate relapse to drug-seeking behavior (Weiss, 2005).”

    From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Weiss, 2005

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Authors
Weiss, F.
Affiliations
Scripps Research Institute (US)
Corresponding author
Weiss, Friedbert
Venue
Current Opinion in Pharmacology
Publisher
Elsevier BV
Published
2005-02
Volume
5
Issue
1
Pages
9-19
ISSN
1471-4892 (ISSN-L)
OpenAlex
W2054971111
Cited by
411
References
9
Citations by year
2026: 12 · 2025: 7 · 2024: 9 · 2023: 15 · 2022: 7 · 2021: 15 · 2020: 19 · 2019: 15 · 2018: 15 · 2017: 13 · 2016: 17 · 2015: 18 · 2014: 19 · 2013: 15 · 2012: 27
FWCI
8.09
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute on Alcohol Abuse and Alcoholism (AA 10531, AA014351, R01AA010531, AA-06420, R01AA014351)
  • National Institute on Drug Abuse (DA07348, DA-08467, R01DA017097, R01DA008467, DA017097)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
drug craving, relapse, drug addiction, conditioned reward, drug-seeking behavior, stress, neuroendocrine mechanisms, drug cues, neurocircuitry, relapse prevention
MeSH terms
Animals, Brain, Conditioning, Psychological, Conditioning, Classical, Humans, Neurobiology, Recurrence, Reward, Substance-Related Disorders

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