No association of two common SNPs at position-1727 A/T,-50 C/T of GSK-3 beta polymorphisms with schizophrenia and bipolar disorder of Korean population
Abstract
Recent studies have suggested the involvement of Glycogen synthase kinase-3 beta (GSK-3 beta) in pathogenesis and treatment target of schizophrenia and bipolar disorder, which led to consider GSK-3 beta as one of the candidate genes for those disorders. However, the association analysis between GSK-3 beta and either schizophrenia or bipolar disorder is yet to be reported in Korean population. Along with 350 healthy individuals, a sample of 138 schizophrenia and 120 bipolar patients was analyzed for two common SNPs at position -1727 A/T and -50 C/T polymorphism localized in intron 1 of the gene. The results showed that allele, genotype and haplotype distributions for the two SNPs do not differ between the controls and neither schizophrenia nor bipolar disorder patients. We also analyzed the association between the controls and the combined samples of schizophrenia and bipolar disorder, but no association was found. In conclusion, these results suggest that the GSK-3 beta is not associated with the development of schizophrenia and bipolar disorder in Korean population.
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One genetic study failed to find any significant association between two SNPs (−1727 A to T, and −50 T to C) in GSK3β with bipolar disorder or schizophrenia in a Korean population.
“one genetic study failed to find any significant association between two SNPs (−1727 A to T, and −50 T to C) in GSK3β with BPD or schizophrenia in a Korean population (Lee et al., 2006).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Lee et al., 2006
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- Authors
- Lee, K. Y., Ahn, Y. M., Joo, E.-J., Jeong, S.-H., Chang, J. S., Kim, S.-C., & Kim, Y. S.
- Affiliations
- Seoul National University Hospital (KR)
- Seoul National University (KR)
- Eulji University (KR)
- Corresponding author
- Kim, Yong Sik
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 395
- Issue
- 2
- Pages
- 175-178
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2085356639
- Cited by
- 54
- References
- 22
- Citations by year
- 2023: 1 · 2020: 1 · 2018: 3 · 2016: 1 · 2015: 4 · 2014: 6 · 2013: 2 · 2012: 2
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- GSK3β, glycogen synthase kinase-3β, schizophrenia, bipolar disorder, single nucleotide polymorphisms, intron 1, candidate genes, genetic association, haplotypes, Korean population
- MeSH terms
- Glycogen Synthase Kinase 3 beta, Adult, Bipolar Disorder, Female, Humans, Male, Polymorphism, Genetic, Schizophrenia, Polymerase Chain Reaction, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Glycogen Synthase Kinase 3, Asian People
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