Cited by 71Regulation of Appetite and ObesityCytokine Signaling Pathways and InteractionsHypothalamic control of reproductive hormones

Nuclear translocation of the transcription factor STAT5 in the rat brain after systemic leptin administration

Mütze, Jörg, Roth, Joachim, Gerstberger, Rüdiger, Hübschle, Thomas·2007·Neuroscience Letters

Abstract

Leptin binding to its functional receptor stimulates JAK-STAT-signaling pathway, which finally results in activation and nuclear translocation of transcription factors of the signal transducer and activator of transcription (STAT) family, namely of STAT3. Here we report for the first time that systemic treatment with leptin (5 mg/kg; intraperitoneal injection) also increased the number of nuclear STAT5 signals in the hypothalamus. In particular, the entire arcuate nucleus (ARC), the ventral premammilary nucleus (PMV), and the supraoptic nucleus (SO) showed an enhanced nuclear STAT5 translocation in response to leptin when compared to saline, 120 min after the respective injection. Co-localization studies revealed that a high percentage of those STAT5-responsive cells proved to be neurons. In addition, some astrocytes within the ARC showed nuclear STAT5 signals. The functional relevance of leptin-induced nuclear STAT5 activation in hypothalamic cells still has to be determined.

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Crossref · 10.1016/j.neulet.2007.02.074

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Authors
Mütze, J., Roth, J., Gerstberger, R., & Hübschle, T.
Affiliations
Justus-Liebig-Universität Gießen (DE)
Corresponding author
Roth, Joachim
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2007-05
Volume
417
Issue
3
Pages
286-291
ISSN
0304-3940 (ISSN-L)
OpenAlex
W1970705566
Cited by
71
References
23
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 9 · 2012: 2
FWCI
2.18
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
leptin, STAT5, nuclear translocation, hypothalamus, arcuate nucleus, ventral premammillary nucleus, supraoptic nucleus, JAK/STAT signaling, leptin receptor, astrocytes, neurons, rat brain
MeSH terms
Animals, Appetite Regulation, Arcuate Nucleus of Hypothalamus, Astrocytes, Body Weight, Cell Nucleus, Hypothalamus, Injections, Intraperitoneal, Male, Neurons, Supraoptic Nucleus, Signal Transduction, Rats, Wistar, Leptin, Active Transport, Cell Nucleus, STAT5 Transcription Factor, Rats

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