Nuclear translocation of the transcription factor STAT5 in the rat brain after systemic leptin administration
Abstract
Leptin binding to its functional receptor stimulates JAK-STAT-signaling pathway, which finally results in activation and nuclear translocation of transcription factors of the signal transducer and activator of transcription (STAT) family, namely of STAT3. Here we report for the first time that systemic treatment with leptin (5 mg/kg; intraperitoneal injection) also increased the number of nuclear STAT5 signals in the hypothalamus. In particular, the entire arcuate nucleus (ARC), the ventral premammilary nucleus (PMV), and the supraoptic nucleus (SO) showed an enhanced nuclear STAT5 translocation in response to leptin when compared to saline, 120 min after the respective injection. Co-localization studies revealed that a high percentage of those STAT5-responsive cells proved to be neurons. In addition, some astrocytes within the ARC showed nuclear STAT5 signals. The functional relevance of leptin-induced nuclear STAT5 activation in hypothalamic cells still has to be determined.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Leptin is capable of activating STAT5 in the hypothalamic arcuate nucleus in vivo.
“Recent evidence suggests that leptin is capable of activating STAT5 in the hypothalamic arcuate nucleus (ARC) in vivo (126)”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [126]
Cites
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405 · see citing works
Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice.
Vaisse, C., Halaas, J. L., Horvath, C. M., Darnell, J. E., Stoffel, M., & Friedman, J. M. (1996) · Nature Genetics · doi:10.1038/ng0996-95 · Cited by 1,086 · see citing works
Fei, H., Okano, H. J., Li, C., Lee, G.-H., Zhao, C., Darnell, R., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.7001 · Cited by 766 · see citing works
Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus
Håkansson, M., Brown, H., Ghilardi, N., Skoda, R. C., & Meister, B. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00559.1998 · Cited by 731 · see citing works
Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance
Sahu, A. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.10.001 · Cited by 351 · see citing works
Leptin Action in Intestinal Cells
Morton, N. M., Emilsson, V., Liu, Y.-L., & Cawthorne, M. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.26194 · Cited by 227 · see citing works
Brain Stem Is a Direct Target for Leptin’s Action in the Central Nervous System
Hosoi, T., Kawagishi, T., Okuma, Y., Tanaka, J., & Nomura, Y. (2002) · Endocrinology · doi:10.1210/en.2002-220077 · Cited by 205 · see citing works
Hübschle, T., Thom, E., Watson, A. M. D., Roth, J., Klaus, S., & Meyerhof, W. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-07-02413.2001 · Cited by 193 · see citing works
Self-citationMcCowen, K. C., Chow, J. C., & Smith, R. J. (1998) · Endocrinology · doi:10.1210/endo.139.11.6301 · Cited by 108 · see citing works
Carvalheira, J. B. C., Ribeiro, E. B., Folli, F. B., Velloso, L. A., & Saad, M. J. A. (2003) · Biological Chemistry · doi:10.1515/bc.2003.016 · Cited by 92 · see citing works
IL-1β-Mediated Innate Immunity Is Amplified in the <i>db/db</i> Mouse Model of Type 2 Diabetes
O’Connor, J. C., Satpathy, A., Hartman, M. E., Horvath, E. M., Kelley, K. W., Dantzer, R., Johnson, R. W., & Freund, G. G. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4991 · Cited by 86 · see citing works
Rummel, C. D., Voß, T., Matsumura, K., Korte, S., Gerstberger, R., Roth, J., & Hübschle, T. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20653 · Cited by 71 · see citing works
Self-citationRummel, C. D., Hübschle, T., Gerstberger, R., & Roth, J. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.058834 · Cited by 62 · see citing works
Self-citationLerant, A. A., Kanyicska, B., & Freeman, M. E. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02470-2 · Cited by 53 · see citing works
Steiner, A. A., Doğan, M. D., Ivanov, A. I., Patel, S., Rudaya, A. Y., Jennings, D. H., Orchinik, M., Pace, T. W. W., O’Connor, K., Watkins, L. R., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-2295fje · Cited by 49 · see citing works
Leptin induces cyclooxygenase‐2 via an interaction with interleukin‐1β in the rat brain
Inoue, W., Poole, S., Bristow, A. F., & Luheshi, G. N. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05105.x · Cited by 45 · see citing works
Leptin Signaling in the Hypothalamus of Normal Rats in Vivo
McCowen, K. (1998) · Endocrinology · doi:10.1210/en.139.11.4442 · Cited by 42 · see citing works
Mütze, J., Roth, J., Gerstberger, R., Matsumura, K., & Hübschle, T. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.10.031 · Cited by 40 · see citing works
Self-citationRehn, M., Hübschle, T., & Diener, M. (2004) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2004.01269.x · Cited by 37 · see citing works
Self-citationYamamoto, S., Morimoto, I., Kai, K., Arao, T., Fujihira, T., Morita, E., Kannan, H., & Eto, S. (1999) · Neuroendocrinology · doi:10.1159/000054478 · Cited by 36 · see citing works
Rizk, N. M., Stammsen, D., Preibisch, G., & Eckel, J. (2001) · Endocrinology · doi:10.1210/endo.142.7.8225 · Cited by 35 · see citing works
Rizk, N. M. (2001) · Endocrinology · doi:10.1210/en.142.7.3027 · Cited by 15 · see citing works
Elmquist (1998) · doi:10.1002/(sici)1096-9861(19980615)395:4
Flagged first, then by citations
Cited by
Sorted by citations
Recent advances in understanding leptin signaling and leptin resistance
Morris, D. L., & Rui, L. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00274.2009 · Cited by 467 · see citing works
Leptin signaling and leptin resistance
Zhou, Y., & Rui, L. (2013) · Frontiers of Medicine · doi:10.1007/s11684-013-0263-5 · Cited by 417 · see citing works
Leptin Indirectly Regulates Gonadotropin-Releasing Hormone Neuronal Function
Quennell, J. H., Mulligan, A. C., Tups, A., Liu, X., Phipps, S. J., Kemp, C. J., Herbison, A. E., Grattan, D. R., & Anderson, G. M. (2009) · Endocrinology · doi:10.1210/en.2008-1693 · Cited by 385 · see citing works
Leptin and the Central Nervous System Control of Glucose Metabolism
Morton, G. J., & Schwartz, M. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00007.2010 · Cited by 338 · see citing works
“Recent evidence suggests that leptin is capable of activating STAT5 in the hypothalamic arcuate nucleus (ARC) in vivo (126), in addition to cultured cells (71), raising the possibility that LepRb-STAT5 signaling contributes to the physiological actions of leptin.”
BackgroundCross-talk between estrogen and leptin signaling in the hypothalamus
Gao, Q., & Horváth, T. L. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00733.2007 · Cited by 249 · see citing works
Leptin receptor signaling and the regulation of mammalian physiology
Villanueva, E. C., & Myers, M. G. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.232 · Cited by 231 · see citing works
Molecular and neural mediators of leptin action
Robertson, S., Leinninger, G. M., & Myers, M. G. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.04.005 · Cited by 186 · see citing works
Leptin receptor signaling: pathways to leptin resistance
Wauman, J. (2011) · Frontiers in bioscience · doi:10.2741/3885 · Cited by 179 · see citing works
Distribution of prolactin‐responsive neurons in the mouse forebrain
Brown, R. S. E., Kokay, I. C., Herbison, A. E., & Grattan, D. R. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22208 · Cited by 174 · see citing works
The Leptin Receptor Complex: Heavier Than Expected?
Wauman, J., Zabeau, L., & Tavernier, J. H. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00030 · Cited by 178 · see citing works
Oxytocin, feeding, and satiety
Sabatier, N., Leng, G., & Menzies, J. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00035 · Cited by 149 · see citing works
Farr, O. M., Tsoukas, M. A., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.07.004 · Cited by 146 · see citing works
Wada, N., Hirako, S., Takenoya, F., Kageyama, H., Okabe, M., & Shioda, S. (2014) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2014.09.002 · Cited by 145 · see citing works
STAT3 phosphorylation in central leptin resistance
Liu, H., Du, T., Li, C., & Yang, G. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-021-00569-w · Cited by 124 · see citing works
Role of Adipokines Signaling in the Modulation of T Cells Function
Procaccini, C., Rosa, V. D., Galgani, M., Carbone, F., Rocca, C. L., Formisano, L., & Matarese, G. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00332 · Cited by 99 · see citing works
Shpakov, A. O., Derkach, K. V., & Berstein, L. M. (2015) · Future Science OA · doi:10.4155/fso.15.23 · Cited by 92 · see citing works
Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes
Bosier, B., Bellocchio, L., Metna‐Laurent, M., Gómez, E. S., Matias, I., Hébert-Chatelain, É., Cannich, A., Maître, M., Lesté-Lasserre, T., Cardinal, P., et al. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.08.001 · Cited by 88 · see citing works
Central Regulation of Metabolism by Protein Tyrosine Phosphatases
Tsou, R. C., & Bence, K. K. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00192 · Cited by 85 · see citing works
Central Leptin Receptor Action and Resistance in Obesity
Bjørbæk, C. (2009) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e3181bb0d49 · Cited by 86 · see citing works
Prolactin receptor in regulation of neuronal excitability and channels
Patil, M. J., Henry, M. A., & Akopian, A. N. (2014) · Channels · doi:10.4161/chan.28946 · Cited by 83 · see citing works
Gong, L., Yao, F., Hockman, K., Heng, H. H., Morton, G. J., Takeda, K., Akira, S., Low, M. J., Rubinstein, M., & MacKenzie, R. G. (2008) · Endocrinology · doi:10.1210/en.2007-0945 · Cited by 80 · see citing works
Ladyman, S. R., Fieldwick, D., & Grattan, D. R. (2012) · Reproduction · doi:10.1530/rep-12-0112 · Cited by 77 · see citing works
Sahu, A. (2011) · Neuroendocrinology · doi:10.1159/000326785 · Cited by 74 · see citing works
Rummel, C. D. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.09.003 · Cited by 70 · see citing works
Emerging role of leptin in rheumatoid arthritis
Tian, G., Liang, J.-N., Wang, Z.-Y., & Zhou, D. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12372 · Cited by 70 · see citing works
Roumaud, P., & Martin, L. J. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0046 · Cited by 69 · see citing works
Rummel, C. D., Inoue, W., Sachot, C., Poole, S., Hübschle, T., & Luheshi, G. N. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21850 · Cited by 66 · see citing works
Self-citationObesity impairs lactation performance in mice by inducing prolactin resistance
Buonfiglio, D. D. C., Ramos-Lobo, A. M., Freitas, V. M., Zampieri, T. T., Nagaishi, V. S., Magalhães, M., Cipolla‐Neto, J., Cella, N., & Donato, J. (2016) · Scientific Reports · doi:10.1038/srep22421 · Cited by 60 · see citing works
Singireddy, A. V., Inglis, M. A., Zuure, W. A., Kim, J. S., & Anderson, G. M. (2013) · Endocrinology · doi:10.1210/en.2013-1109 · Cited by 54 · see citing works
López, H. S., Lanuza, E., Agustín‐Pavón, C., & Martínez‐Garciá, F. (2016) · Brain Structure and Function · doi:10.1007/s00429-016-1254-5 · Cited by 54 · see citing works
Leptin Signaling in the Control of Metabolism and Appetite: Lessons from Animal Models
Barrios-Correa, A. A., Estrada, J. A., & Contreras, I. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1185-0 · Cited by 51 · see citing works
Leptin signaling and leptin resistance
Liu, J., Lai, F., Hou, Y., & Zheng, R. (2022) · Medical Review · doi:10.1515/mr-2022-0017 · Cited by 55 · see citing works
Signaling Pathways Induced by Leptin during Epithelial–Mesenchymal Transition in Breast Cancer
Olea‐Flores, M., Juárez-Cruz, J. C., Catalán, M. A. M., Padilla‐Benavides, T., & Navarro‐Tito, N. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113493 · Cited by 47 · see citing works
Ladyman, S. R., & Grattan, D. R. (2013) · JAK-STAT · doi:10.4161/jkst.23675 · Cited by 48 · see citing works
Brain STAT5 signaling modulates learning and memory formation
Furigo, I. C., Melo, H. M., Silva, N. M. L. E., Ramos-Lobo, A. M., Teixeira, P. D. S., Buonfiglio, D. D. C., Wasinski, F., Lima, E. R., Higuti, E., Peroni, C. N., et al. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1627-z · Cited by 41 · see citing works
New Actors Driving the Epithelial–Mesenchymal Transition in Cancer: The Role of Leptin
Olea‐Flores, M., Juárez-Cruz, J. C., Zuñiga‐Eulogio, M. D., Acosta, E., García-Rodríguez, E., Zacapala-Gómez, A. E., Catalán, M. A. M., Ortiz‐Ortiz, J., Ortuño‐Pineda, C., & Navarro‐Tito, N. (2020) · Biomolecules · doi:10.3390/biom10121676 · Cited by 39 · see citing works
Balancing STAT Activity as a Therapeutic Strategy
Polak, K. L., Chernosky, N. M., Smigiel, J. M., Tamagno, I., & Jackson, M. W. (2019) · Cancers · doi:10.3390/cancers11111716 · Cited by 30 · see citing works
Barnes, M. J., Primeaux, S. D., & Bray, G. A. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00030.2008 · Cited by 31 · see citing works
Brain STAT5 signaling and behavioral control
Furigo, I. C., Ramos-Lobo, A. M., Frazão, R., & Donato, J. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.04.019 · Cited by 29 · see citing works
Velmurugan, S., Russell, J. A., & Leng, G. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12016 · Cited by 29 · see citing works
Leptin Signaling and Action in Birds
Ohkubo, T., & Adachi, H. (2008) · The Journal of Poultry Science · doi:10.2141/jpsa.45.233 · Cited by 27 · see citing works
The role of leptin in central nervous system diseases
Li, X., Yan, H., Guo, Y., & Wang, D. (2016) · Neuroreport · doi:10.1097/wnr.0000000000000546 · Cited by 26 · see citing works
Buntin, J. D., & Buntin, L. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.02.006 · Cited by 23 · see citing works
Wołodko, K., Walewska, E., Adamowski, M., Fernandez, J. C., Kelsey, G., & Galvão, A. M. (2020) · Cellular Physiology and Biochemistry · doi:10.33594/000000228 · Cited by 20 · see citing works
Caquineau, C., Douglas, A. J., & Leng, G. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.01982.x · Cited by 19 · see citing works
Effect of leptin on cytotrophoblast proliferation and invasion
Liu, H., Wu, Y., Qiao, F., & Gong, X. (2009) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-009-0519-0 · Cited by 18 · see citing works
Severi, I., Senzacqua, M., Mondini, E., Fazioli, F., Cinti, S., & Giordano, A. (2015) · Brain Research · doi:10.1016/j.brainres.2015.06.028 · Cited by 18 · see citing works
STAT5 ablation in AgRP neurons increases female adiposity and blunts food restriction adaptations
Furigo, I. C., Teixeira, P. D. S., Quaresma, P. G. F., Mansano, N. D. S., Frazão, R., & Donato, J. (2019) · Journal of Molecular Endocrinology · doi:10.1530/jme-19-0158 · Cited by 18 · see citing works
Yan, L., & Li, J. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.04.015 · Cited by 16 · see citing works
Beall, C., Hanna, L., & Ellacott, K. L. J. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160045 · Cited by 16 · see citing works
Leptin in Tumor Microenvironment
Angelucci, A., Clementi, L., & Alesse, E. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-43093-1_6 · Cited by 15 · see citing works
PATHOGENETIC MECHANISMS OF LEPTIN RESISTANCE
Chumakova, G. A., Ott, A., Veselovskaya, N. G., Гриценко, О. В., & Shenkova, N. N. (2015) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2015-4-107-110 · Cited by 14 · see citing works
Shpakov, A. O. (2016) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093016030017 · Cited by 11 · see citing works
Smiley, K. O., Dong, L., Ramakrishnan, S., & Adkins-Regan, E. (2020) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2020.113657 · Cited by 6 · see citing works
Breast feeding, obesity, and asthma association: clinical and molecular views
Kian, N., Bagheri, A., Salmanpour, F., Soltani, A., Mohajer, Z., Samieefar, N., Barekatain, B., & Kelishadi, R. (2023) · Clinical and Molecular Allergy · doi:10.1186/s12948-023-00189-0 · Cited by 10 · see citing works
Leptin: a pleitropic factor in physiology
Almabhouh, F. A., Isyraqiah, F., Ibrahim, H., & Singh, H. (2019) · Journal of Clinical and Health Sciences · doi:10.24191/jchs.v4i2.7551 · Cited by 10 · see citing works
Flurbiprofen Ameliorates Glucose Deprivation-Induced Leptin Resistance
Hosoi, T., Suyama, Y., Kayano, T., & Ozawa, K. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00354 · Cited by 8 · see citing works
Glutamatergic Activation of Neuronostatin Neurons in the Periventricular Nucleus of the Hypothalamus
Koçoğlu, S. S., Yurtseven, D. G., Çakır, C., Minbay, Z., & Eyigör, Ö. (2020) · Brain Sciences · doi:10.3390/brainsci10040217 · Cited by 8 · see citing works
Watanabe, Y., Ikegawa, M., Naruse, Y., & Tanaka, M. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07339.x · Cited by 6 · see citing works
The role of hypothalamus in the pathophysiological process of MASLD and advances in drug discovery
Wei, S., Dong, Y., Wang, Y., Li, G., Zhao, Y., & Zheng, R. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107972 · Cited by 4 · see citing works
Hristov, M., Landzhov, B. V., & YAKIMOVA, K. S. (2024) · Biotechnic & Histochemistry · doi:10.1080/10520295.2024.2335167 · Cited by 3 · see citing works
Kubota, T., Fukushima, A., Hagiwara, H., Kamiya, Y., Furuta, M., Miyazaki, T., Fujioka, H., Fujiwara, S.-E., Funabashi, T., & Akema, T. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.02.017 · Cited by 3 · see citing works
The role of AgRP neurons as a central link between leptin receptors and fertility
Egan, O. K. (2016) · Otago University Research Archive (University of Otago) · Cited by 1 · see citing works
Actions of appetite regulating peptides on supraoptic nucleus (SON) oxytocin neurones
Velmurugan, S. (2009) · ERA · Cited by 1 · see citing works
STAT5B (signal transducer and activator of transcription 5B)
Del, R. A., Bernaciak, T. M., & Silva, C. (2012) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/46938
Unraveling Novel Leptin-Dependent Signaling Pathways in the Basomedial Hypothalamus.
Villanueva, E. C. (2010) · Deep Blue (University of Michigan)
One Receptor for Multiple Pathways: Focus on Leptin Signaling
Gómez, R., Conde, J., Scotece, M., & Gualillo, O. (2011) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781849733434-00044
Beall, C., Hanna, L., & Ellacott, K. L. J. (2017) · Comprehensive physiology · doi:10.1002/j.2040-4603.2017.tb00781.x
Hypothalamic Regulation of the Gonadal Axis and Roles of Leptin and Insulin in It
Zorina, I. I., Derkach, K. V., & Shpakov, A. O. (2026) · Biochemistry (Moscow) · doi:10.1134/s0006297926600353
Metabolic Effects of Neural and Pancreatic Shp2
He, Z., Zhang, S. S., Yu, J., & Feng, G. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7855-3_9
- Authors
- Mütze, J., Roth, J., Gerstberger, R., & Hübschle, T.
- Affiliations
- Justus-Liebig-Universität Gießen (DE)
- Corresponding author
- Roth, Joachim
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 417
- Issue
- 3
- Pages
- 286-291
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1970705566
- Cited by
- 71
- References
- 23
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 9 · 2012: 2
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin, STAT5, nuclear translocation, hypothalamus, arcuate nucleus, ventral premammillary nucleus, supraoptic nucleus, JAK/STAT signaling, leptin receptor, astrocytes, neurons, rat brain
- MeSH terms
- Animals, Appetite Regulation, Arcuate Nucleus of Hypothalamus, Astrocytes, Body Weight, Cell Nucleus, Hypothalamus, Injections, Intraperitoneal, Male, Neurons, Supraoptic Nucleus, Signal Transduction, Rats, Wistar, Leptin, Active Transport, Cell Nucleus, STAT5 Transcription Factor, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review