Oxytocin, feeding, and satiety

Sabatier, Nancy; Leng, Gareth; Menzies, John

doi:10.3389/fendo.2013.00035

Cited by 149Regulation of Appetite and ObesityNeuroendocrine regulation and behaviorNeuropeptides and Animal Physiology

Oxytocin, feeding, and satiety

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Sabatier, Nancy, Leng, Gareth, Menzies, John·2013·Frontiers in Endocrinology

DOI 10.3389/fendo.2013.00035PMC PMC3603288

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Abstract

Oxytocin neurons have a physiological role in food intake and energy balance. Central administration of oxytocin is powerfully anorexigenic, reducing food intake and meal duration. The central mechanisms underlying this effect of oxytocin have become better understood in the past few years. Parvocellular neurons of the paraventricular nucleus project to the caudal brainstem to regulate feeding via autonomic functions including the gastrointestinal vago-vagal reflex. In contrast, magnocellular neurons of the supraoptic and paraventricular nuclei release oxytocin from their dendrites to diffuse to distant hypothalamic targets involved in satiety. The ventromedial hypothalamus, for example, expresses a high density of oxytocin receptors but does not contain detectable oxytocin nerve fibers. Magnocellular neurons represent targets for the anorexigenic neuropeptide α-melanocyte stimulating hormone. In addition to homeostatic control, oxytocin may also have a role in reward-related feeding. Evidence suggests that oxytocin can selectively suppress sugar intake and that it may have a role in limiting the intake of palatable food by inhibiting the reward pathway.

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Axonal release of oxytocin from the PVN may have effects on hedonic food consumption via dopaminergic mesolimbic neurons in the ventral tegmental area (VTA).
“Axonal release of oxytocin from the PVN may also have effects on hedonic food consumption via dopaminergic mesolimbic neurons in the ventral tegmental area (VTA)(25, 26, 27).”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [25]
Oxytocin is released by dendrites of magnocellular neurons of the PVN and SON, and may reduce food intake in part via diffusion to the ventromedial nucleus, a satiety-regulating brain region rich in oxytocin receptors.
“Oxytocin is also released by dendrites of magnocellular neurons of the PVN and SON, and may reduce food intake in part via diffusion to the ventromedial nucleus, a satiety-regulating brain region rich in oxytocin receptors(25).”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [25]
Vagal nerve fibers project to the PVN.
“Additionally, it is known that vagal nerve fibers project to the PVN (Sabatier et al., 2013; Uvnas-Moberg et al., 2014), a brain region where oxytocin is produced”
From Mechanisms underlying microbial-mediated changes in social behavior in mouse models of autism spectrum disorder (2019) · cites this paper as Sabatier et al., 2013

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Authors: Sabatier, N., Leng, G., & Menzies, J.
Affiliations: University of Edinburgh (GB)
Corresponding author: Menzies, John
ORCID: Leng, Gareth
Menzies, John
Venue: Frontiers in Endocrinology
Publisher: Frontiers Media SA
Published: 2013
Volume: 4
Pages: 35-35
ISSN: 1664-2392 (ISSN-L)
DOI: 10.3389/fendo.2013.00035
PMC: PMC3603288
OpenAlex: W2131330949
Cited by: 149
References: 108
Citations by year: 2026: 4 · 2025: 6 · 2024: 6 · 2023: 8 · 2022: 13 · 2021: 17 · 2020: 9 · 2019: 17 · 2018: 15 · 2017: 15 · 2016: 15 · 2015: 16 · 2014: 7 · 2013: 1
FWCI: 7.02
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Endocrinology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
Funders: Medical Research Scotland
Biotechnology and Biological Sciences Research Council (BB/E015123/1)
FP7 Food, Agriculture and Fisheries, Biotechnology (266408, 245009)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, feeding behavior, satiety, anorectic effect, paraventricular nucleus, supraoptic nucleus, magnocellular neurons, parvocellular neurons, ventromedial hypothalamus, oxytocin receptor, alpha-melanocyte-stimulating hormone, energy balance, vago-vagal reflex, food reward, sugar consumption, palatable food intake

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Oxytocin, feeding, and satiety

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