The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Low-grade endotoxemia in patients with severe autism
Abstract
The objective of this study was to examine whether levels of endotoxin and other markers of immuno-inflammatory activation are altered in adult patients with severe autism. We determined circulating serum endotoxin levels, its soluble receptor (sCD14), and markers of immuno-inflammatory activation (IL-1beta, IL-6, and IL-10) in 22 adult patients with severe autism and 28 age- and gender-matched healthy controls. Compared with healthy subjects, serum levels of endotoxin were significantly higher in autistic patients and inversely and independently correlated with Socialization scores on the Vineland Adaptive Behavior Scales (VABS) and ADI-R Domain A score (social). Whether increased endotoxin may contribute to the pathophysiology of inflammation and impaired reciprocal social interaction in autism should be further explored in future studies.
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In the citing paper
“Serum endotoxin levels are elevated in patients with severe autism [30], liver cirrhosis [11], diabetes [31], cardiovascular disease [8], chronic infection and ageing [32], amyotrophic lateral sclerosis and Alzheimer’s disease [10].”
From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [30]
In the citing paper
“Blood endotoxin levels are increased in autism [30].”
From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [30]
In the citing paper
“Excessive use of antibiotics may result in the overgrowth of Desulfovibrio, i.e., bacteria resistant to common therapy, which release LPS [244].”
From The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders (2021) · cites this paper as [244]
In the citing paper
“Deficient integrity of the gut epithelium and increased intestinal permeability are also reported (21).”
From Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder (2017) · cites this paper as [21]
In the citing paper
“Levels of the proinflammatory cytokines IL-6 and tumor necrosis factor-alpha (TNF-α), which lead to activation of the HPA axis (Dunn, 2006), have been shown to be increased in those with ASD (Ashwood et al., 2011; Emanuele et al., 2010; von Känel et al., 2005).”
From Associations between cytokines, endocrine stress response, and gastrointestinal symptoms in autism spectrum disorder (2016) · cites this paper as Emanuele et al., 2010
Citations
Cites
Neuroglial activation and neuroinflammation in the brain of patients with autism
Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149
Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J., Knapp, D. J., & Crews, F. T. (2007) · Glia · doi:10.1002/glia.20467 · Cited by 2,144
Elevated immune response in the brain of autistic patients
Li, X., Chauhan, A., Sheikh, A. M., Patil, S., Chauhan, V., Li, X.-M., Ji, L., Brown, T., & Malik, M. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.12.002 · Cited by 786
Parracho, H. M., Bingham, M. O., Gibson, G. R., & McCartney, A. L. (2005) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46101-0 · Cited by 784
Erridge, C., Attina, T., Spickett, C. M., & Webb, D. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1286 · Cited by 776
Cunningham, C., Wilcockson, D. C., Campion, S., Lunnon, K., & Perry, V. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2614-05.2005 · Cited by 768
Association of endotoxemia with carotid atherosclerosis and cardiovascular disease
Wiedermann, C. J., Kiechl, S., Dunzendorfer, S., Schratzberger, P., Egger, G., Oberhollenzer, F., & Willeit, J. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00448-9 · Cited by 505
Immunity, neuroglia and neuroinflammation in autism
Pardo, C. A., Vargas, D. L., & Zimmerman, A. W. (2005) · International Review of Psychiatry · doi:10.1080/02646830500381930 · Cited by 469
Cerebrospinal Fluid and Serum Markers of Inflammation in Autism
Zimmerman, A. W., Jyonouchi, H., Comi, A. M., Connors, S. L., Milstien, S., Varsou, A., & Heyes, M. P. (2005) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2005.03.014 · Cited by 300
Modulatory effects of sCD14 and LBP on LPS-host cell interactions
Kitchens, R. L., & Thompson, P. A. (2005) · Journal of Endotoxin Research · doi:10.1179/096805105x46565 · Cited by 268
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Items 201–225 of 225
[Diagnosis of dementia--an objective examination or a subjective evaluation?].
Tybjerg, J., & Sørensen, L. U. (1994) · PubMed · Cited by 1
de Jesus, A. J. B. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.10.2020.tde-27082020-174347 · Cited by 1
Mott, M. C. (2011) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/1016
Bobylova, M. Y., Винярская, И. В., Быстрова, К. Ю., & Narovatkina, Y. K. (2015) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.17650/2073-8803-2014-9-1-42-51
A Role for the Microbiota in Neurodevelopmental Disorders
Yano, J. M., & Hsiao, E. Y. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802304-4.00014-1
Fond, G. B., Boukouaci, W., Chevalier, G., Regnault, A., Eberl, G., Hamdani, N., Dickerson, F., Macgregor, A., Boyer, L., Dargél, A., et al. (2014)
Environmental Pressures on Transgenerational Epigenetic Inheritance
Adhya, D., Massrali, A., Paul, A., Kotter, M., Carroll, J. S., Srivastava, D. P., Price, J., & Baron‐Cohen, S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108131797.010
Serum Zonulin Levels and Social Cognition in Children with Attention Deficit Hyperactivity Disorder
Yurteri, N., & ŞAHİN, İ. E. (2020) · Düzce Tıp Fakültesi Dergisi · doi:10.18678/dtfd.779517
Brain-gut axis: From the conditioned reflex to the microbiota-gut-brain communication system
Gyires, K. (2020) · Integrative Physiology · doi:10.33910/2687-1270-2020-1-4-266-276
The Potential Role of Probiotics in theManagement of Childhood Autism SpectrumDisorders
Critchfield, J. W., van Hemert, S., Ash, M. E., & Ashwood, P. (2014)
(2020) · Archivos Argentinos de Pediatria · doi:10.5546/aap.2020.e271
Complementary and Alternative Therapies
Guiot, C., Grasso, F., Rocchetti, M., & Brondino, N. (2022) · Autism and child psychopathology series · doi:10.1007/978-3-030-88538-0_64
Self-citationThe Issue of Monocyte Activation in ASD: Troubles with Translation
Moreno, R. J., & Ashwood, P. (2022) · Journal of Cellular Immunology · doi:10.33696/immunology.4.146
Efeitos do estresse oxidativo no transtorno do espectro autista: uma revisão de literatura
Freitas, M. C., Vasconcelos, I. K. M., de Freitas, R. F., Fontenele, D. R., do Nascimento, V. E. G., Holanda, B. F., & Aragão, G. F. (2024) · doi:10.22491/9786584884359/cap8
Impact of COVID-19 on behavior in autism spectrum disorder
Antolini, G., & Colizzi, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95650-5.00005-7
Inflammatory Impact on Sleep, Schizophrenia, and Autism Spectrum Disorder
Kamijo, S., & Miwa, H. (2024) · Progress in inflammation research · doi:10.1007/978-3-031-74744-1_7
Gut Microbiota Alterations in Patients with Panic Disorder: A Case-Control Study
Grąźlewski, T., Kucharska–Mazur, J., Samochowiec, J., Reginia, A., Liśkiewicz, P., Michalczyk, A., Misiak, B., Kaczmarczyk, M., & Stachowska, E. (2025) · Nutrients · doi:10.3390/nu17172772
Environmental Risk Factors Link Autism to Many Other Outcomes
Waterhouse, L. H. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-415961-7.00005-8 · Cited by 1
AL-Ayadhi, L. Y., Zayed, N., Bhat, R. S., Moubayed, N. M. S., Al-Muammar, M. N., & El-Ansary, A. (2021) · Figshare · doi:10.6084/m9.figshare.16614539
Scenna, M. S., Bej, E., Cesare, P., Persichitti, I., Cimini, A., d’Angelo, M., & Castelli, V. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1783888 · Cited by 1
Ikehara, M., Ishida, R., Yamamuro, K., Kashida, N., Takeda, T., Toritsuka, M., & Makinodan, M. (2026) · Neuropsychopharmacology Reports · doi:10.1002/npr2.70138
O’Brien, K., & Blair, P. (2026) · Springer eBooks · doi:10.1007/978-3-032-14521-5_10
Kong, W., Qiu, H., Jiang, Y., Ge, H., Wu, W., Huang, L., Chu, L., & Ge, L. (2026) · Biomolecules · doi:10.3390/biom16091321
Kaur, M. K. K., Allahbadia, M. G., & MD, D. M. S. (2025) · Obesity Research - Open Journal · doi:10.17140/oroj.2025.v11.i01.pp19-45.1417
Metadata
- Authors
- Emanuele, E., Orsi, P., Boso, M., Broglia, D., Brondino, N., Barale, F., di Nemi, S. U., & Politi, P.
- Affiliations
- University of Pavia (IT)
- Corresponding author
- Emanuele, Enzo
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 471
- Issue
- 3
- Pages
- 162-165
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1974864175
- Cited by
- 225
- References
- 18
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 18 · 2023: 12 · 2022: 30 · 2021: 22 · 2020: 28 · 2019: 20 · 2018: 15 · 2017: 12 · 2016: 12 · 2015: 13 · 2014: 9 · 2013: 3 · 2012: 6
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- autism spectrum disorder, endotoxemia, endotoxin, soluble CD14, IL-1β, interleukin-6, IL-10, neuroinflammation, adaptive behavior, social interaction, autistic adults
- MeSH terms
- Adolescent, Adult, Autistic Disorder, Endotoxins, Female, Humans, Immunity, Innate, Male, Severity of Illness Index, Social Behavior, Interleukin-6, Interleukin-10, Lipopolysaccharide Receptors, Endotoxemia, Interleukin-1beta, Young Adult
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