Low-grade endotoxemia in patients with severe autism

Neuroglial activation and neuroinflammation in the brain of patients with autism

Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J., Knapp, D. J., & Crews, F. T. (2007) · Glia · doi:10.1002/glia.20467 · Cited by 2,144

Elevated immune response in the brain of autistic patients

Li, X., Chauhan, A., Sheikh, A. M., Patil, S., Chauhan, V., Li, X.-M., Ji, L., Brown, T., & Malik, M. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.12.002 · Cited by 786

Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children

Parracho, H. M., Bingham, M. O., Gibson, G. R., & McCartney, A. L. (2005) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46101-0 · Cited by 784

A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation.

Erridge, C., Attina, T., Spickett, C. M., & Webb, D. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1286 · Cited by 776

Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration

Cunningham, C., Wilcockson, D. C., Campion, S., Lunnon, K., & Perry, V. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2614-05.2005 · Cited by 768

Association of endotoxemia with carotid atherosclerosis and cardiovascular disease

Wiedermann, C. J., Kiechl, S., Dunzendorfer, S., Schratzberger, P., Egger, G., Oberhollenzer, F., & Willeit, J. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00448-9 · Cited by 505

Immunity, neuroglia and neuroinflammation in autism

Pardo, C. A., Vargas, D. L., & Zimmerman, A. W. (2005) · International Review of Psychiatry · doi:10.1080/02646830500381930 · Cited by 469

Cerebrospinal Fluid and Serum Markers of Inflammation in Autism

Zimmerman, A. W., Jyonouchi, H., Comi, A. M., Connors, S. L., Milstien, S., Varsou, A., & Heyes, M. P. (2005) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2005.03.014 · Cited by 300

Modulatory effects of sCD14 and LBP on LPS-host cell interactions

Kitchens, R. L., & Thompson, P. A. (2005) · Journal of Endotoxin Research · doi:10.1179/096805105x46565 · Cited by 268

Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease

Forsyth, C. B., Shannon, K. M., Kordower, J. H., Voigt, R. M., Shaikh, M., Jaglin, J. A., Estes, J. D., Dodiya, H. B., & Keshavarzian, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028032 · Cited by 974

The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders

Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857

Intestinal Barrier Dysfunction, LPS Translocation, and Disease Development

Ghosh, S. S., Wang, J., Yannie, P. J., & Ghosh, S. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvz039 · Cited by 838

Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder

Vuong, H. E., & Hsiao, E. Y. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.08.024 · Cited by 595

Autism Spectrum Disorders and the Gut Microbiota

Fattorusso, A., Di Genova, L., Dell’Isola, G., Mencaroni, E., & Esposito, S. (2019) · Nutrients · doi:10.3390/nu11030521 · Cited by 484

The Gut Microbiota and Autism Spectrum Disorders

Li, Q., Han, Y., Dy, A. B. C., & Hagerman, R. J. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00120 · Cited by 462

The endotoxin hypothesis of neurodegeneration

Brown, G. C. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1564-7 · Cited by 457

The influence of neuroinflammation in Autism Spectrum Disorder

Matta, S. M., Hill‐Yardin, E. L., & Crack, P. J. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.04.037 · Cited by 431

Gut microbiota in autism and mood disorders

Mangiola, F. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i1.361 · Cited by 413

Role of microbiota-derived short-chain fatty acids in nervous system disorders

Mirzaei, R., Bouzari, B., Hosseini‐Fard, S. R., Mazaheri, M., Ahmadyousefi, Y., Abdi, M., Jalalifar, S., Karimitabar, Z., Teimoori, A., Keyvani, H., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111661 · Cited by 408

Stress induces endotoxemia and low-grade inflammation by increasing barrier permeability

de Punder, K., & Pruimboom, L. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00223 · Cited by 321

Cytokine dysregulation in autism spectrum disorders (ASD): Possible role of the environment

Goines, P. E., & Ashwood, P. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.07.006 · Cited by 314

The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease

Morris, G., Berk, M., Carvalho, A. F., Caso, J. R., Sanz, Y., Walder, K. R., & Maes, M. H. J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0004-2 · Cited by 318

Microbiota-gut-brain axis and the central nervous system

Zhu, X., Han, Y., Du, J., Liu, R., Jin, K., & Yi, W. (2017) · Oncotarget · doi:10.18632/oncotarget.17754 · Cited by 308

Microbiota regulation of the mammalian gut-brain axis

Burokas, A., Moloney, R. D., Dinan, T. G., & Cryan, J. F. (2015) · Advances in applied microbiology · doi:10.1016/bs.aambs.2015.02.001 · Cited by 300

Modulatory Effects of Gut Microbiota on the Central Nervous System: How Gut Could Play a Role in Neuropsychiatric Health and Diseases

Yarandi, S., Peterson, D. A., Treisman, G. J., Moran, T. H., & Pasricha, P. J. (2016) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm15146 · Cited by 308

Gut Microbiota Features in Young Children With Autism Spectrum Disorders

Coretti, L., Paparo, L., Riccio, M. P., Amato, F., Cuomo, M., Natale, A., Borrelli, L., Corrado, G., De Caro, C., Comegna, M., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03146 · Cited by 266

Innate immune dysfunction and neuroinflammation in autism spectrum disorder (ASD)

Hughes, H. K., Moreno, R. J., & Ashwood, P. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.12.001 · Cited by 293

Gut microbiota, immune development and function

Bengmark, S. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.09.002 · Cited by 274

Desulfovibrio in the Gut: The Enemy within?

Singh, S., Carroll‐Portillo, A., & Lin, H. C. (2023) · Microorganisms · doi:10.3390/microorganisms11071772 · Cited by 279

Plasma Cytokine Profiles in Subjects with High-Functioning Autism Spectrum Disorders

Suzuki, K., Matsuzaki, H., Iwata, K., Kameno, Y., Shimmura, C., Kawai, S., Yoshihara, Y., Wakuda, T., Takebayashi, K., Takagai, S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020470 · Cited by 252

Neonatal Cytokine Profiles Associated With Autism Spectrum Disorder

Krakowiak, P., Goines, P. E., Tancredi, D. J., Ashwood, P., Hansen, R. L., Hertz-Picciotto, I., & Van de Water, J. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.08.007 · Cited by 249

Immune Dysfunction and Autoimmunity as Pathological Mechanisms in Autism Spectrum Disorders

Hughes, H. K., Ko, E. M., Rose, D. R., & Ashwood, P. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00405 · Cited by 253

The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders

Morris, G., & Berk, M. (2015) · BMC Medicine · doi:10.1186/s12916-015-0310-y · Cited by 245

Developmental neurotoxicity of inhaled ambient ultrafine particle air pollution: Parallels with neuropathological and behavioral features of autism and other neurodevelopmental disorders

Allen, J. L., Oberdorster, G., Morris-Schaffer, K., Wong, C., Klocke, C., Sobolewski, M., Conrad, K., Mayer-Proschel, M., & Cory-Slechta, D. A. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2015.12.014 · Cited by 241

A meta-analysis of pro-inflammatory cytokines in autism spectrum disorders: Effects of age, gender, and latitude

Saghazadeh, A., Ataeinia, B., Keynejad, K., Abdolalizadeh, A., Hirbod‐Mobarakeh, A., & Rezaei, N. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.05.019 · Cited by 246

Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms

Rose, D. R., Yang, H., Serena, G., Sturgeon, C., Ma, B., Careaga, M., Hughes, H. K., Angkustsiri, K., Rose, M., Hertz-Picciotto, I., et al. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.03.025 · Cited by 227

The “psychomicrobiotic”: targeting microbiota in major psychiatric disorders: a systematic review

Fond, G., Boukouaci, W., Chevalier, G., Regnault, A., Eberl, G., Hamdani, N., Dickerson, F., Macgregor, A., Boyer, L., Dargel, A., et al. (2015) · Pathologie Biologie · doi:10.1016/j.patbio.2014.10.003 · Cited by 219

The function of gut microbiota in immune-related neurological disorders: a review

Sittipo, P., Choi, J., Lee, S., & Lee, Y. K. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02510-1 · Cited by 221

Microbiology of regressive autism

Finegold, S. M., Downes, J., & Summanen, P. H. (2012) · Anaerobe · doi:10.1016/j.anaerobe.2011.12.018 · Cited by 211

Modeling the Interplay Between Neurons and Astrocytes in Autism Using Human Induced Pluripotent Stem Cells

Russo, F. B., de Freitas, B. C. G., Pignatari, G. C., Fernandes, I. R., Sebat, J. L., Muotri, A. R., & Beltrão-Braga, P. C. B. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.09.021 · Cited by 203

Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management

de Theije, C. G. M., Wu, J., da Silva, S. L., Kamphuis, P. J. G. H., Garssen, J., Korte, S. M., & Kraneveld, A. D. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.07.013 · Cited by 212

Desulfovibrio species are potentially important in regressive autism

Finegold, S. M. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.04.032 · Cited by 197

Peripheral and central inflammation in autism spectrum disorders

Depino, A. M. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.10.003 · Cited by 189

Gastrointestinal and hepatic mechanisms limiting entry and dissemination of lipopolysaccharide into the systemic circulation

Guerville, M., & Boudry, G. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00098.2016 · Cited by 195

Sex-related alterations of gut microbiota composition in the BTBR mouse model of autism spectrum disorder

Coretti, L., Cristiano, C., Florio, E., Scala, G., Lama, A., Keller, S., Cuomo, M., Russo, R., Pero, R., Paciello, O., et al. (2017) · Scientific Reports · doi:10.1038/srep45356 · Cited by 175

The Potential Role of Probiotics in the Management of Childhood Autism Spectrum Disorders

Critchfield, J. W., van Hemert, S., Ash, M. E., Mulder, L. H. C., & Ashwood, P. (2011) · Gastroenterology Research and Practice · doi:10.1155/2011/161358 · Cited by 178

The Role of Gut Dysbiosis in the Pathophysiology of Neuropsychiatric Disorders

Anand, N., Gorantla, V. R., & Chidambaram, S. B. (2022) · Cells · doi:10.3390/cells12010054 · Cited by 194

Gut microbiota changes in patients with autism spectrum disorders

Ding, X., Xu, Y., Zhang, X., Zhang, L., Duan, G., Song, C., Li, Z., Yang, Y., Wang, Y., Wang, X., et al. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.06.032 · Cited by 166

Can probiotics benefit children with autism spectrum disorders?

Navarro, F., Liu, Y., & Rhoads, J. M. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i46.10093 · Cited by 154

Increased Serum Zonulin Levels as an Intestinal Permeability Marker in Autistic Subjects

Esnafoğlu, E., Cırrık, S., Ayyıldız, S. N., Erdil, A., Ertürk, E. Y., Dağlı, A., & Noyan, T. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.04.004 · Cited by 152

The Role of Gut Microbiota and Gut–Brain Interplay in Selected Diseases of the Central Nervous System

Doroszkiewicz, J., Groblewska, M., & Mroczko, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810028 · Cited by 166

Nutritional interventions for autism spectrum disorder

Karhu, E., Zukerman, R. J., Eshraghi, R. S., Mittal, J., Deth, R. C., Castejon, A. M., Trivedi, M. S., Mittal, R., & Eshraghi, A. A. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuz092 · Cited by 159

The Impact of Neuroimmune Alterations in Autism Spectrum Disorder

Gottfried, C., Bambini-Junior, V., Francis, F., Riesgo, R., & Savino, W. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00121 · Cited by 143

Immune Endophenotypes in Children With Autism Spectrum Disorder

Careaga, M., Rogers, S. J., Hansen, R. L., Amaral, D. G., de Water, J. V., & Ashwood, P. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.08.036 · Cited by 143

Brain IL-6 and autism

Wei, H., Alberts, I. L., & Li, X. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.025 · Cited by 139

Immune Abnormalities in Autism Spectrum Disorder—Could They Hold Promise for Causative Treatment?

Gładysz, D., Krzywdzińska, A., & Hozyasz, K. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0822-x · Cited by 134

Autism Spectrum Disorder (ASD) with and without Mental Regression Is Associated with Changes in the Fecal Microbiota

Plaza‐Díaz, J., Gómez-Fernández, A., Chueca, N., de la Torre‐Aguilar, M. J., Gil, Á., Pérez-Navero, J. L., Flores‐Rojas, K., Martín-Borreguero, P., Solis‐Urra, P., Ruiz‐Ojeda, F. J., et al. (2019) · Nutrients · doi:10.3390/nu11020337 · Cited by 131

Microbiota, immunoregulatory old friends and psychiatric disorders

Rook, G. A. W., Raison, C. L., & Lowry, C. A. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_15 · Cited by 117

Gut microbiota profiles of autism spectrum disorder and attention deficit/hyperactivity disorder: A systematic literature review.

Bundgaard‐Nielsen, C., Knudsen, J. K., Leutscher, P. D. C., Lauritsen, M. B., Nyegaard, M., Hagstrøm, S., & Sørensen, S. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1748258 · Cited by 125

Long-term altered immune responses following fetal priming in a non-human primate model of maternal immune activation

Rose, D. R., Careaga, M., de Water, J. V., McAllister, A. K., Bauman, M. D., & Ashwood, P. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.11.020 · Cited by 119

Autism Spectrum Disorder Associated With Gut Microbiota at Immune, Metabolomic, and Neuroactive Level

García-Gutiérrez, E., Narbad, A., & Rodríguez, J. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.578666 · Cited by 118

Association of Peripheral Blood Levels of Cytokines With Autism Spectrum Disorder: A Meta-Analysis

Zhao, H., Zhang, H., Liu, S., Luo, W., Jiang, Y., & Gao, J. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.670200 · Cited by 111

Maternal immune activation, central nervous system development and behavioral phenotypes

Minakova, E., & Warner, B. B. (2018) · Birth Defects Research · doi:10.1002/bdr2.1416 · Cited by 114

Curcumin-mediated regulation of intestinal barrier function: The mechanism underlying its beneficial effects

Ghosh, S. S., He, H., Wang, J., Gehr, T. W. B., & Ghosh, S. (2018) · Tissue Barriers · doi:10.1080/21688370.2018.1425085 · Cited by 110

The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders

Fowlie, G., Cohen, N., & Ming, X. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082251 · Cited by 108

The Human Gut Microbiome as a Potential Factor in Autism Spectrum Disorder

Alharthi, A., Alhazmi, S., Alburae, N. A., & Bahieldin, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031363 · Cited by 126

The neurobiology of autism spectrum disorders

Parellada, M., Penzol, M. J., Pina‐Camacho, L., Moreno, C., González‐Vioque, E., Zalsman, G., & Arango, C. (2013) · European Psychiatry · doi:10.1016/j.eurpsy.2013.02.005 · Cited by 115

Gastrointestinal involvement of autism spectrum disorder: focus on gut microbiota

Settanni, C. R., Bibbò, S., Ianiro, G., Rinninella, E., Cintoni, M., Mele, M. C., Cammarota, G., & Gasbarrini, A. (2021) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2021.1869938 · Cited by 98

Man and the Microbiome: A New Theory of Everything?

Butler, M., Cryan, J. F., & Dinan, T. G. (2019) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050718-095432 · Cited by 96

Associations between cytokines, endocrine stress response, and gastrointestinal symptoms in autism spectrum disorder

Ferguson, B. J., Marler, S., Altstein, L. L., Lee, E. B., Mazurek, M. O., McLaughlin, A., Macklin, E. A., McDonnell, E., Davis, D. J., Belenchia, A. M., et al. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.05.009 · Cited by 89

The gut microbiome and microbial translocation in multiple sclerosis

Mirza, A., & Mao‐Draayer, Y. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.03.001 · Cited by 92

Modeling environmental risk factors of autism in mice induces IBD-related gut microbial dysbiosis and hyperserotonemia

Lim, J. S., Lim, M. Y., Choi, Y., & Ko, G. (2017) · Molecular Brain · doi:10.1186/s13041-017-0292-0 · Cited by 89

Targeting gut barrier dysfunction with phytotherapies: Effective strategy against chronic diseases

Dey, P. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105135 · Cited by 86

Visceral Inflammation and Immune Activation Stress the Brain

Holzer, P., Farzi, A., Hassan, A. M., Zenz, G., Jačan, A., & Reichmann, F. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01613 · Cited by 84

The Gut Microbiome as a Regulator of the Neuroimmune Landscape

Yu, L. W., Agirman, G., & Hsiao, E. Y. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101320-014237 · Cited by 75

The combined role of serotonin and interleukin-6 as biomarker for autism

Yang, C.-J., Liu, C.-L., Sang, B., Zhu, X.-M., & Du, Y.-J. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.10.011 · Cited by 80

Microbiome, Parkinson’s Disease and Molecular Mimicry

Miraglia, F., & Colla, E. (2019) · Cells · doi:10.3390/cells8030222 · Cited by 84

Inflammatory profiles in the BTBR mouse: how relevant are they to autism spectrum disorders?

Careaga, M., Schwartzer, J., & Ashwood, P. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.006 · Cited by 77

Dietary supplementation with partially hydrolyzed guar gum helps improve constipation and gut dysbiosis symptoms and behavioral irritability in children with autism spectrum disorder

Inoüe, R., Sakaue, Y., Kawada, Y., Tamaki, R., Yasukawa, Z., Ozeki, M., Ueba, S., Sawai, C., Nonomura, K., Tsukahara, T., et al. (2019) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.18-105 · Cited by 79

The gut microbiota in neuropsychiatric disorders

Grochowska, M., Wojnar, M., & Radkowski, M. (2018) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2018-008 · Cited by 77

Anti-inflammatory cytokines in autism spectrum disorders: A systematic review and meta-analysis

Saghazadeh, A., Ataeinia, B., Keynejad, K., Abdolalizadeh, A., Hirbod‐Mobarakeh, A., & Rezaei, N. (2019) · Cytokine · doi:10.1016/j.cyto.2019.154740 · Cited by 82

The use of biomarkers associated with leaky gut as a diagnostic tool for early intervention in autism spectrum disorder: a systematic review

AL-Ayadhi, L. Y., Zayed, N., Bhat, R. S., Moubayed, N., Al-Muammar, M. N., & El-Ansary, A. (2021) · Gut Pathogens · doi:10.1186/s13099-021-00448-y · Cited by 78

Neuroimmune Alterations in Autism: A Translational Analysis Focusing on the Animal Model of Autism Induced by Prenatal Exposure to Valproic Acid

Deckmann, I., Schwingel, G. B., Fontes‐Dutra, M., Bambini-Júnior, V., & Gottfried, C. (2018) · NeuroImmunoModulation · doi:10.1159/000492113 · Cited by 69

Children and adolescents with attention deficit hyperactivity disorder and autism spectrum disorder share distinct microbiota compositions

Bundgaard‐Nielsen, C., Lauritsen, M. B., Knudsen, J. K., Rold, L. S., Larsen, M. H., Hindersson, P., Villadsen, A. B., Leutscher, P. D. C., Hagstrøm, S., Nyegaard, M., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2211923 · Cited by 69

Association of a MET genetic variant with autism-associated maternal autoantibodies to fetal brain proteins and cytokine expression

Heuer, L., Braunschweig, D., Ashwood, P., Van de Water, J., & Campbell, D. B. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.48 · Cited by 62

Imbalance in pro-inflammatory and anti-inflammatory cytokines milieu in B cells of children with autism

Nadeem, A., Ahmad, S. F., Al-Harbi, N. O., AL-Ayadhi, L. Y., Sarawi, W. S., Attia, S. M., Bakheet, S. A., Alqarni, S. A., Ali, N., & AsSobeai, H. M. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.12.009 · Cited by 79

Cytokine Profile in Autism Spectrum Disorders in Children

Bryn, V., Aass, H. C. D., Skjeldal, O. H., Isaksen, J., Saugstad, O. D., & Ormstad, H. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0847-z · Cited by 61

A quasi-paired cohort strategy reveals the impaired detoxifying function of microbes in the gut of autistic children

Zhang, M., Chu, Y., Meng, Q., Ding, R., Shi, X., Wang, Z., He, Y., Zhang, J., Liu, J., Zhang, J., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba3760 · Cited by 58

Microbiota-derived short chain fatty acids in pediatric health and diseases: from gut development to neuroprotection

Hsu, C., Khachatryan, L., Younis, N. K., Mustafa, M. A., Ahmad, N., Athab, Z. H., Валерьевна, П. А., Викторовна, К. Е., Mirzaei, R., & Karampoor, S. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1456793 · Cited by 71

Microbiota‐gut‐brain axis: Interaction of gut microbes and their metabolites with host epithelial barriers

Bhattarai, Y. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13366 · Cited by 61

Autism Spectrum Disorder: Signaling Pathways and Prospective Therapeutic Targets

Baranova, J., Dragunas, G., Botelho, M. C. S., Ayub, A. L. P., Bueno-Alves, R., Alencar, R. R., Papaiz, D. D., Sogayar, M. C., Ulrich, H., & Correa, R. G. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00882-7 · Cited by 63

Randomized Double-Blind Crossover Study for Evaluating a Probiotic Mixture on Gastrointestinal and Behavioral Symptoms of Autistic Children

Guidetti, C., Salvini, E., Viri, M., Deidda, F., Amoruso, A., Visciglia, A., Drago, L., Calgaro, M., Vitulo, N., Pane, M., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11185263 · Cited by 54

The Gut-Brain-Immune Axis in Autism Spectrum Disorders: A State-of-Art Report

Puricelli, C., Rolla, R., Gigliotti, C. L., Boggio, E. M., Beltrami, E., Dianzani, U., & Keller, R. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.755171 · Cited by 64

Comparing the Gut Microbiome in Autism and Preclinical Models: A Systematic Review

Alamoudi, M. U. A., Hosie, S., Shindler, A. E., Wood, J. L., Franks, A. E., & Hill‐Yardin, E. L. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.905841 · Cited by 59

Leaky Gut Plays a Critical Role in the Pathophysiology of Autism in Mice by Activating the Lipopolysaccharide-Mediated Toll-Like Receptor 4–Myeloid Differentiation Factor 88–Nuclear Factor Kappa B Signaling Pathway

Li, F., Ke, H., Wang, S., Mao, W., Fu, C., Chen, X. X., Fu, Q., Qin, X., Huang, Y., Li, B., et al. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00993-9 · Cited by 61

The chemistry of gut microbiome in health and diseases

Lau, A., Tan, L. T., Mutalib, N. A., Wong, S. H., Letchumanan, V., & Lee, L. (2021) · Progress In Microbes & Molecular Biology · doi:10.36877/pmmb.a0000175 · Cited by 55

The Battle of LPS Clearance in Host Defense vs. Inflammatory Signaling

Kumar, P., Schroder, E. A., Rajaram, M. V. S., Harris, E. N., & Ganesan, L. P. (2024) · Cells · doi:10.3390/cells13181590 · Cited by 52

Gut-to-Brain Axis in Autism Spectrum Disorders

Kraneveld, A. D., Szklany, K., de Theije, C. G. M., & Garssen, J. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.09.001 · Cited by 47

Dietary Fatty Acids and Microbiota-Brain Communication in Neuropsychiatric Diseases

Marrone, M. C., & Coccurello, R. (2019) · Biomolecules · doi:10.3390/biom10010012 · Cited by 48

Dysregulated gene expression associated with inflammatory and translation pathways in activated monocytes from children with autism spectrum disorder

Hughes, H. K., Rowland, M. E., Onore, C. E., Rogers, S. J., Ciernia, A. V., & Ashwood, P. (2022) · Translational Psychiatry · doi:10.1038/s41398-021-01766-0 · Cited by 51

Intestinal barrier function and metabolic/liver diseases

Ghosh, S. S., Wang, J., Yannie, P. J., & Ghosh, S. (2020) · Liver Research · doi:10.1016/j.livres.2020.03.002 · Cited by 49

A Pilot Study on Covid and Autism: Prevalence, Clinical Presentation and Vaccine Side Effects

Brondino, N., Bertoglio, F., Forneris, F., Faravelli, S., Borghesi, A., Damiani, S., Provenzani, U., Nola, M., Olivola, M., Caviglia, M., et al. (2021) · Brain Sciences · doi:10.3390/brainsci11070860 · Cited by 45

Between Dysbiosis, Maternal Immune Activation and Autism: Is There a Common Pathway?

Suprunowicz, M., Tomaszek, N., Urbaniak, A., Zackiewicz, K., Modzelewski, S., & Waszkiewicz, N. (2024) · Nutrients · doi:10.3390/nu16040549 · Cited by 44

Gut Microbiota and Neurologic Diseases and Injuries

Patterson, T. T., & Grandhi, R. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-2385-4_6 · Cited by 46

Intestinal Permeability and Its Significance in Psychiatric Disorders—A Narrative Review and Future Perspectives

Wasiak, J., & Gawlik-Kotelnicka, O. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114459 · Cited by 47

The link between autism spectrum disorder and gut microbiota: A scoping review

Nitschke, A. S., Deonandan, R., & Konkle, A. T. M. (2020) · Autism · doi:10.1177/1362361320913364 · Cited by 46

Prebiotic, Probiotic, and Synbiotic Consumption Alter Behavioral Variables and Intestinal Permeability and Microbiota in BTBR Mice

Nettleton, J. E., Klančič, T., Schick, A., Choo, A. C., Cheng, N., Shearer, J., Borgland, S. L., Rho, J. M., & Reimer, R. A. (2021) · Microorganisms · doi:10.3390/microorganisms9091833 · Cited by 43

Microbiota, Immune System and Autism Spectrum Disorders: An Integrative Model towards Novel Treatment Options

Carpita, B., Marazziti, D., Palego, L., Giannaccini, G., Betti, L., & Dell’Osso, L. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190328151539 · Cited by 42

Treating Autism Spectrum Disorder with Gluten-Free and Casein-Free Diet: The Underlying Microbiota-Gut-Brain Axis Mechanisms

Savelkoul, H. F. J. (2017) · Clinical Immunolgy & Immunotherapy · doi:10.24966/ciit-8844/100009 · Cited by 40

Role of serum levels of neurotensin in children with autism spectrum disorder

Bashir, S., & AL-Ayadhi, L. Y. (2013) · Neurology Psychiatry and Brain Research · doi:10.1016/j.npbr.2013.04.002 · Cited by 4

Tumor necrosis factor-alpha expression in peripheral blood mononuclear cells correlates with early childhood social interaction in autism spectrum disorder

Makinodan, M., Iwata, K., Ikawa, D., Yamashita, Y., Yamamuro, K., Toritsuka, M., Kimoto, S., Okumura, K., Yamauchi, T., Yoshino, H., et al. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.12.005 · Cited by 14

Pro-inflammatory cytokines in autistic children in central Saudi Arabia

AL-Ayadhi, L. Y. (2005) · Neurosciences · doi:10.17712/1658-3183.1339 · Cited by 37

Serum levels of P-selectin in men with high-functioning autism

Iwata, Y., Tsuchiya, K. J., Mikawa, S., Nakamura, K., Takai, Y., Suda, S., Sekine, Y., Suzuki, K., Kawai, M., Sugihara, G., et al. (2008) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.107.043497 · Cited by 18

Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders

Gülöksüz, S. A., Abalı, O., Çetin, E. A., Gazioğlu, S. B., Deniz, G., Yildirim, A., Kawiková, I., Gülöksüz, S., & Leckman, J. F. (2017) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2015-1843 · Cited by 59