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Cited by 11Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuropeptides and Animal Physiology

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Amyloid-β production in aged guinea pigs: atropine-induced enhancement is reversed by naloxone

Ionov, Ilya D., Pushinskaya, Irina I.·2010·Neuroscience Letters
DOI 10.1016/j.neulet.2010.06.010
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Abstract

Advanced age, cholinergic deficit, and elevated brain levels of enkephalin are associated with sporadic Alzheimer's disease. The influence of these factors on production of amyloidogenic peptides (Abeta) is uncertain. In the present experiments, the levels of 40/42 amino acid-residue Abeta were measured in the brain cortex of guinea pigs aged 15-16 weeks (young) and 25-26 months (aged). As was found, injections of atropine (21 days, 5mg/kg/day) increase Abeta levels in aged but not young animals. This atropine-induced effect was antagonized by simultaneous injections of naloxone (3mg/kg/day) whereas naloxone alone failed to affect Abeta accumulation. These results are discussed in the light of a possible "acetylcholine - Abeta" feedback loop and an influence of enkephalin on the loop function.

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Metadata

Authors
Ionov, I. D., & Pushinskaya, I. I.
Affiliations
Russian Academy of Sciences (RU)
ORCID
Ionov, Ilya D.
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2010-08
Volume
480
Issue
1
Pages
83-86
ISSN
0304-3940 (ISSN-L)
DOI
10.1016/j.neulet.2010.06.010
OpenAlex
W2064848141
Cited by
11
References
2
Citations by year
2026: 1 · 2024: 3 · 2022: 1 · 2020: 1 · 2018: 1 · 2015: 1 · 2013: 1 · 2012: 1
FWCI
0.33
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
amyloid-beta, Alzheimer's disease, aging, atropine, naloxone, cholinergic deficit, enkephalin, acetylcholine, cerebral cortex, guinea pig
MeSH terms
Aging, Animals, Atropine, Cerebral Cortex, Enkephalins, Guinea Pigs, Male, Naloxone, Narcotic Antagonists, Amyloid beta-Peptides, Muscarinic Antagonists

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