The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Hippocampal-dependent antidepressant-like activity of histone deacetylase inhibition
Open accessAbstract
Chronic social defeat stress in mice significantly decreases subsequent social interactions and induces other depression-like behaviors. Here we measured and manipulated levels of acetylated histone H3 (acH3), a chromatin mark of transcriptional activation, in the hippocampus and amygdala after ten continuous days of social defeat stress in male C57/Bl6J mice. This form of social stress causes a transient increase, followed by a persistent decrease, in the levels of acH3 in hippocampus. By comparison, increased acH3 in amygdala was more robust but also highly transient. The persistent decrease in acH3 in hippocampus may be pathological, since it is reversed by chronic fluoxetine administration. Consistent with this hypothesis, infusion of a histone deacetylase (HDAC) inhibitor MS-275 (100 μM) into hippocampus reverses a defeat-induced deficit in sucrose preference, although it does not restore social interaction behavior. Next, different forms of social enrichment were examined with or without hippocampal infusion of MS-275. After social stress, simple pair-housing with another male C57, or female C57, mouse does not reverse social avoidance. However, when HDAC inhibitors are infused into hippocampus during social housing with another male, social avoidance is attenuated. Interestingly, social avoidance is reversed when MS-275 is infused directly into amygdala. Together, these findings further support the antidepressant potential of HDAC inhibitors, and indicate that temporally overlapping environmental and molecular events are required to optimally reverse specific stress-induced behavioral symptoms.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Histone acetylation changes, primarily mediated by HDAC, impact the stress response, depression-like behavior, and antidepressant effects.104,127–129”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [127]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In depression-related models, reduced acetylation at sites such as H3K9ac and H4K12ac has been associated with decreased expression of key mood-regulating genes, including brain-derived neurotrophic factor (BDNF) and the serotonin transporter (SLC6A4) (Covington et al., 2011; Schroeder et al., 2007).”
From Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook (2026) · cites this paper as Covington et al., 2011
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“the injection of an HDAC inhibitor into the amygdala reversed social avoidance.127”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [127]
The cited source says what the claim attributes to it.
In the citing paper
“Transiently increased H3K14 acetylation in the amygdala of mice followed by chronic social defeat stress.”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [127]
In the citing paper
“we have shown that susceptible mice also avoid non–aggressive C57BL6/J littermates, and that such social avoidance is essentially permanent—it persists for >6 months—despite housing with non–aggressive littermates, suggesting that it does reflect a maladaptive response36, 38.”
From Neurobiology of resilience (2012) · cites this paper as [38]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?
Fanselow, M. S., & Dong, H.-W. (2010) · Neuron · doi:10.1016/j.neuron.2009.11.031 · Cited by 3,358
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307
Self-citationEssential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129
Self-citationSustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780
Self-citationGenetics of Mouse Behavior: Interactions with Laboratory Environment
Crabbe, J. C., Wahlsten, D., & Dudek, B. C. (1999) · Science · doi:10.1126/science.284.5420.1670 · Cited by 1,666
HDAC2 negatively regulates memory formation and synaptic plasticity
Guan, J.-S., Haggarty, S. J., Giacometti, E., Dannenberg, J.-H., Joseph, N., Gao, J., Nieland, T. J. F., Zhou, Y., Wang, X., Mazitschek, R., et al. (2009) · Nature · doi:10.1038/nature07925 · Cited by 1,644
Neurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606
LeDoux, J. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.005 · Cited by 1,281
Regulation of histone acetylation during memory formation in the hippocampus
Levenson, J. M., O'Riordan, K. J., Brown, K. D., Trinh, M. A., Molfese, D. L., & Sweatt, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402229200 · Cited by 1,131
Vecsey, C. G., Hawk, J. D., Lattal, K. M., Stein, J. M., Fabian, S., Attner, M. A., Cabrera, S. M., McDonough, C. B., Brindle, P. K., Abel, T. G., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0296-07.2007 · Cited by 854
Cited by
Sorted by citations
Items 101–178 of 178
Depressive disorder and antidepressants from an epigenetic point of view
Arčan, I. Š., Kouter, K., & Paska, A. V. (2022) · World Journal of Psychiatry · doi:10.5498/wjp.v12.i9.1150 · Cited by 27
Qian, W., Yu, C., Wang, S., Niu, A., Shi, G., Cheng, Y., Xu, N., Jin, Q., & Xu, J. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.586904 · Cited by 20
Genome and stress-reaction in animals and humans
Dyuzhikova, N. A., & Даев, Е. В. (2018) · Ecological genetics · doi:10.17816/ecogen1614-26 · Cited by 22
Chromatin Alterations in Neurological Disorders and Strategies of (Epi)Genome Rescue
Janowski, M., Milewska, M., Zare, P., & Pękowska, A. (2021) · Pharmaceuticals · doi:10.3390/ph14080765 · Cited by 21
Dynamic regulation of cerebral DNA repair genes by psychological stress
Forsberg, K., Aalling, N., Wörtwein, G., Loft, S. H., Möller, P., Hau, J., Hageman, I., Jørgensen, M. B., & Jørgensen, A. (2014) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2014.12.003 · Cited by 20
Neuroepigenetics of Neurotrophin Signaling: Neurobiology of Anxiety and Affective Disorders
Règue, M., Lanfumey, L., & Mongeau, R. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.03.002 · Cited by 22
Matsuda, Y., Ozawa, N., Shinozaki, T., Aoki, K., Nihonmatsu-Kikuchi, N., Shinba, T., & Tatebayashi, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-96094-0 · Cited by 23
Tsuji, M., Miyagawa, K., & Takeda, H. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.14r07cp · Cited by 19
Failure to detect the action of antidepressants in the forced swim test in Swiss mice
Suman, P. R., Zerbinatti, N., Theindl, L. C., Domingues, K., & de Oliveira, C. L. (2017) · Acta Neuropsychiatrica · doi:10.1017/neu.2017.33 · Cited by 19
Kalkman, H. O. (2023) · Biomedicines · doi:10.3390/biomedicines11030806 · Cited by 18
Juan, D. M.-S., Lamas, M., & Ramírez-Rodríguez, G. B. (2023) · Cells · doi:10.3390/cells12162062 · Cited by 21
Benatti, B. M., Adiletta, A., Sgadó, P., Malgaroli, A., Ferro, M., & Lamanna, J. (2024) · Behavioral Sciences · doi:10.3390/bs14100882 · Cited by 23
Stress Response and Perinatal Reprogramming: Unraveling (Mal)adaptive Strategies
Musazzi, L., & Marrocco, J. (2016) · Neural Plasticity · doi:10.1155/2016/6752193 · Cited by 18
Opposing effects of positive and negative stress on hippocampal plasticity over the lifespan
Wosiski‐Kuhn, M., & Stranahan, A. M. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.11.003 · Cited by 18
Epigenetics of amphetamine-induced sensitization: HDAC5 expression and microRNA in neural remodeling
Liu, P. K., & Liu, C. H. (2016) · Journal of Biomedical Science · doi:10.1186/s12929-016-0294-8 · Cited by 19
A life-course, epigenetic perspective on resilience in brain and body
McEwen, B. S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813983-7.00001-x · Cited by 18
Siddiqui, N., Sharma, A. K., Kesharwani, A., Anurag, & Parihar, V. K. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102282 · Cited by 16
Sokolov, A. V., & Schiöth, H. B. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02992-y · Cited by 16
The impact of antidepressants on human neurodevelopment: Brain organoids as experimental tools
Marinho, L. S. R., Chiarantin, G. M. D., Ikebara, J. M., Cardoso, D. S., de Lima-Vasconcellos, T. H., Higa, G. S. V., Ferraz, M. S. A., Pasquale, R. D., Takada, S. H., Papes, F., et al. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.09.007 · Cited by 35
Li, H., Jiang, Q., Fu, X., Jiang, X., Zhou, Q., & Qiu, H. (2017) · Neuroreport · doi:10.1097/wnr.0000000000000879 · Cited by 17
Muñoz-Cobo, I., Erburu, M. M., Zwergel, C., Cirilli, R., Mai, A., Valente, S., Puerta, E., & Tordera, R. M. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4975-8 · Cited by 15
Carboni, E., & Carta, A. R. (2022) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2105144 · Cited by 16
Pusalkar, M., Ghosh, S. K., Jaggar, M., Husain, B. F. A., Galande, S., & Vaidya, V. A. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw040 · Cited by 15
Roberson‐Nay, R., Wolen, A. R., Lapato, D. M., Lancaster, E. E., Webb, B. T., Verhulst, B., Hettema, J. M., & York, T. P. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/422345 · Cited by 14
Involvement of 5-HT1A receptor-mediated histone acetylation in the regulation of depression
Zhu, L.-J., Sun, Y.-Q., Wang, S., Shi, H.-J., & Li, N. (2021) · Neuroreport · doi:10.1097/wnr.0000000000001693 · Cited by 12
Crotonylation modification and its role in diseases
Guo, Y., Li, J., & Zhang, K. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1492212 · Cited by 15
Molecular, Cellular, and Circuit Basis of Depression Susceptibility and Resilience
Han, M., Russo, S. J., & Nestler, E. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00012-3 · Cited by 13
Self-citationDaulatzai, M. A. (2015) · Neurotoxicity Research · doi:10.1007/s12640-015-9528-x · Cited by 12
Research on Xiaoyao Powder in the treatment of depression based on epigenetics and quality markers
Wang, J., Wu, Q., Ou, C., Lu, G., & Yu, H. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1223451 · Cited by 12
Butto, T., Chongtham, M. C., Mungikar, K., Hartwich, D., Linke, M., Ruffini, N., Radyushkin, K., Schweiger, S., Winter, J., & Gerber, S. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02555-z · Cited by 12
PET ‐ MRI Applications and Future Prospects in Psychiatry
Zürcher, N. R., Chen, J. E., & Wey, H. (2024) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.29471 · Cited by 12
Epigenetic aging in major depressive disorder: Clocks, mechanisms and therapeutic perspectives
Shaikh, M., & Doshi, G. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176757 · Cited by 13
Arndt, D. L., Wukitsch, T. J., Garcia, E. J., & Cain, M. E. (2019) · Behavioral Neuroscience · doi:10.1037/bne0000333 · Cited by 12
Athira, K. V., Wahul, A. B., Soren, K., Das, T., Dey, S. K., Samudrala, P. K., Kumar, A., Lahkar, M., & Chakravarty, S. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105083 · Cited by 11
Epigenetic modulation: Research progress on histone acetylation levels in major depressive disorders
Meng, Y., Du, J., Liu, N., Qiang, Y., Xiao, L., Lan, X., Ma, L., Yang, J.-M., Yu, J., & Lu, G. (2022) · Journal of drug targeting · doi:10.1080/1061186x.2022.2125978 · Cited by 14
Circadian and epigenetic control of depression-like behaviors
Sato, S., & Sassone-Corsi, P. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.05.010 · Cited by 10
Li, L., Wang, Q., Sun, X., Li, Z., Liu, S., Zhang, X., Zhou, J., Zhang, R., Liu, K., Wang, P., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123652 · Cited by 10
Kang, S., Son, Y., Lee, S., Kim, J., Kim, J.-C., Kim, J., Jung, U., Kim, S., Yang, M., & Moon, C. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.08.007 · Cited by 10
Li, N., Liu, T., Wang, Y.-Y., Xu, T., Shi, H., Chang, L., & Zhu, L. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.08.010 · Cited by 11
Contemporary Issues in Depressive Disorders
Park, S., & Kim, Y. (2019) · Psychiatry Investigation · doi:10.30773/pi.2019.09.10 · Cited by 9
Combining Psychodynamic Psychotherapy and Pharmacotherapy
Gorman, J. M. (2016) · Psychodynamic Psychiatry · doi:10.1521/pdps.2016.44.2.183 · Cited by 11
Fresh approaches to antidepressant drug discovery
Anacker, C. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.892071 · Cited by 9
Liao, L., Wang, X., Yao, X., Zhang, B., Zhou, L., & Huang, J. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.11.006 · Cited by 8
Misztak, P., Sowa-Kućma, M., Szewczyk, B., & Nowak, G. (2021) · Neurotoxicity Research · doi:10.1007/s12640-020-00317-7 · Cited by 8
Duclot, F., & Kabbaj, M. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2021_252 · Cited by 9
Epigenetic Effects of Currently Used Psychotropic Drugs
Boks, M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-417114-5.00023-1 · Cited by 8
Potential Early Effect Biomarkers for Ambient Air Pollution Related Mental Disorders
Bai, L., Wang, K., Liu, D., & Wu, S. (2024) · Toxics · doi:10.3390/toxics12070454 · Cited by 7
Histone Modifications in the Nervous System and Neuropsychiatric Disorders
Bridi, M. S., & Abel, T. G. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-391494-1.00002-1 · Cited by 8
Linking Depression to Epigenetics: Role of the Circadian Clock
Sato, S., & Sassone‐Corsi, P. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-81147-1_3 · Cited by 8
Role of histone deacetylases in neuroplasticity impairments and inflammation in major depression
Garayo, A., Azqueta, A., & Tordera, R. M. (2024) · Neuroscience Applied · doi:10.1016/j.nsa.2024.104081 · Cited by 7
Shi, Z., Wen, K., Sammudin, N. H., LoRocco, N. C., & Zhuang, X. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03013-0 · Cited by 7
Al-Kachak, A., Fulton, S. L., Salvo, G. D., Chan, J. C., Farrelly, L. A., Lepack, A. E., Bastle, R. M., Kong, L., Cathomas, F., Newman, E. L., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.04.539464 · Cited by 6
Self-citationROLE OF ENZYMES IN THE PATHOGENESIS OF DEPRESSION
Walia, V. (2016) · Journal of Critical Reviews · Cited by 5
Lv, L.-Z., Wang, Z.-D., Ren, J.-J., Li, L.-H., Liu, X.-B., Li, J.-L., Zhu, H., Jiang, B., Han, Y.-P., Zhou, X.-M., et al. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2025.1722453 · Cited by 7
Depression: epigenetics and epitranscriptomic modifications
Banerjee, S., Shrilaxmi, M. S., Banerjee, S., Prajwal, B. G., Smith, C., D’Mello, S. R., & Dastidar, S. G. (2025) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2025.2602171 · Cited by 4
Hamilton, P. J., Chen, E. Y., Tolstikov, V., Peña, C. J., Shah, P., Panagopoulos, K., Strat, A. N., Walker, D. M., Lorsch, Z. S., Mervosh, N. L., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/490748 · Cited by 4
Self-citationEpigenetic regulation of BDNF-TrkB signaling in the pathophysiology and treatment of mood disorders
Boulle, F. (2013) · Research Publications (Maastricht University) · doi:10.26481/dis.20131129fb · Cited by 4
Is a Combination of Pharmacotherapy and Psychotherapy Superior to Each Alone?
Choi, K., & Kim, Y. (2017) · Springer eBooks · doi:10.1007/978-981-10-6577-4_21 · Cited by 4
Epigenetic Approaches to Define the Molecular and Genetic Risk Architectures of Schizophrenia
Kundaković, M., Peter, C. J., Roussos, P., & Akbarian, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801829-3.00013-6 · Cited by 2
Czarny, P. L., Białek, K. I., Ziółkowska, S., Talarowska, M. E., & Śliwiński, T. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817935-2.00029-5 · Cited by 2
Epigenetic effects of currently used psychotropic drugs
Peedicayil, J., & Santhosh, S. (2021) · Epigenetics in Psychiatry · doi:10.1016/b978-0-12-823577-5.00005-2
Arčan, I. Š., Kouter, K., Zupanc, T., & Paska, A. V. (2024) · Epigenomics · doi:10.2217/epi-2023-0351 · Cited by 1
Gene-Environment Interactions and Role of Epigenetics in Depression
Lin, E., & Tsai, S. (2017) · Springer eBooks · doi:10.1007/978-981-10-6580-4_3 · Cited by 1
Epigenetics of major depressive disorder
Braun, P., & Potash, J. B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823577-5.00002-7 · Cited by 1
Next Generation Antidepressants
Mignon, L., Stahl, S. M., Dremencov, E., Cremers, T. I. F. H., de Groote, L., Filip, M., McCreary, A. C., Shamy, J. L., Brickman, A. M., Griesemer, C. D., et al. (2010) · Cambridge University Press eBooks · doi:10.1017/9780511778414 · Cited by 1
Neural Mechanisms of Resiliency and Susceptibility After Repeated Social Defeat
Wayne, C. R. (2023) · Louisiana State University · doi:10.31390/gradschool_dissertations.6224 · Cited by 1
Examining Hippocampal Reelin Expression and Neural Plasticity in an Animal Model of Depression
Fenton, E. Y. (2013) · University Library - University of Saskatchewan (University of Saskatchewan)
Epigenetic alterations related to early life stressful events
Lennartsson, A. (2012) · Acta Neuropsychiatrica · doi:10.1111/acn.12012
Clinical research Epigenetic mechanisms in schizophrenia
Akbarian, S. (2014)
Histone deacetylase inhibition-mediated cytotoxicity of oligodendrocytes.
Dincman, T. A. (2011) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/351
Arndt, D. L. (2016) · K-State Research Exchange (Kansas State University)
New Approaches for Treating Depression
Nestler, E. J. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780190681425.003.0030
Self-citationPharmacoepigenetics of mood disorders
Bellia, F., Ballerini, P., & D’Addario, C. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-18722-3.00019-0
Epigenetic regulation of BDNF-TRKB signaling in the pathophysiology and treatment of mood disorders
Boulle, F. (2013) · theses.fr (ABES) · doi:10.70675/7796cc83z9f91z48c6zadb1zb6a90897b5d5
Potential muscular doping effects of anti-depressants
Tutakhail, A. (2019) · theses.fr (ABES) · doi:10.70675/f3cbba2dza035z4ef0zaebbz68fe16432b48
Zhang, L., Han, Y., Lv, D., Yao, P., Chen, L., Yuan, Y., Zhao, J., Guo, W., Guo, Z., & Ou, Y. (2026) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.70071
Epigenetic Control of Stress-Induced Depression: Emerging Roles of HDAC3 and HDAC6
Mohan, A. S., Narayanan, J., Kashid, V. A., Patel, R. J., & Prajapati, B. G. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27167313
Metadata
- Authors
- Covington, H. E., Vialou, V. F., LaPlant, Q., Ohnishi, Y. N., & Nestler, E. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Nestler, Eric J.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 493
- Issue
- 3
- Pages
- 122-126
- ISSN
- 0304-3940 (ISSN-L)
- PMC
- PMC3074929
- OpenAlex
- W2052682553
- Cited by
- 178
- References
- 25
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 15 · 2023: 12 · 2022: 6 · 2021: 17 · 2020: 10 · 2019: 16 · 2018: 13 · 2017: 15 · 2016: 14 · 2015: 10 · 2014: 15 · 2013: 16 · 2012: 8
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (P50MH066172)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- histone deacetylase inhibition, entinostat, acetylated histone H3, chronic social defeat stress, depression-like behavior, social avoidance, hippocampus, amygdala, fluoxetine, social enrichment, antidepressant effects, chromatin acetylation
- MeSH terms
- Animals, Antidepressive Agents, Benzamides, Depression, Female, Hippocampus, Histone Deacetylases, Interpersonal Relations, Male, Mice, Inbred C57BL, Motor Activity, Pyridines, Stress, Psychological, Mice, Histone Deacetylase Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
