White matter impairment in heroin addicts undergoing methadone maintenance treatment and prolonged abstinence: A preliminary DTI study
Abstract
Methadone maintenance treatment (MMT) might cause the impairments of neuropsychological and neurotransmitter function in opioid addicts. Whether long-term MMT could lead to the impairment of white matter (WM) in heroin addiction brain is unclear. This study compared the WM integrity in the bilateral frontal lobe, temporal lobe, splenium and genu of corpus collasum (CC) between MMT patients (n=13), former heroin addicts (n=11) in prolonged abstinence (PA), and healthy control subjects (n=15) using diffusion tensor imaging (DTI). Fractional anisotropy (FA), apparent diffusion coefficient (ADC) and eigenvalues (λ(⊥), λ(||)) were measured. The correlation between DTI measures and accumulated former heroin dose, total methadone consumption, and PA duration were determined. Although the PA subjects showed no difference in DTI measures relative to the controls, the extensive correlations between the former heroin consumption and the DTI measures were noted. The MMT subjects showed a decreased FA values in the left genu, as well as the increased ADC and λ(⊥) values in the left splenium of CC in comparison to the controls. Compared with the PA, the MMT subjects had a significantly increased ADC value in the bilateral splenium of CC. Importantly, the methadone dosage used in the MMT group was correlated with the FA value in the left splenium of CC and in the right frontal lobe. Our preliminary results suggest that methadone plays a role in the impairment of WM integrity in heroin users…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Following prolonged abstinence, alcohol or opiate users can show white matter microstructure that is not significantly different from nonusers.
“Following prolonged abstinence, abusers of alcohol (Pfefferbaum et al., 2014) or opiates (Wang et al., 2011) have white matter microstructure that is not significantly different from nonusers.”
From Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research (2019) · cites this paper as Wang et al., 2011
Cites
Diffusion tensor imaging of the brain
Alexander, A. L., Lee, J. E., Lazar, M., & Field, A. S. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.05.011 · Cited by 2,747 · see citing works
Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water
Song, S.-K., Sun, S.-W., Ramsbottom, M. J., Chang, C., Russell, J., & Cross, A. H. (2002) · NeuroImage · doi:10.1006/nimg.2002.1267 · Cited by 2,582 · see citing works
Demyelination increases radial diffusivity in corpus callosum of mouse brain
Song, S.-K., Yoshino, J., Le, T. Q., Lin, S.-J., Sun, S.-W., Cross, A. H., & Armstrong, R. C. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.01.028 · Cited by 1,658 · see citing works
Opiates inhibit neurogenesis in the adult rat hippocampus
Eisch, A. J., Barrot, M., Schad, C. A., Self, D. W., & Nestler, E. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.120552597 · Cited by 599 · see citing works
Evidence for long-term neurotoxicity associated with methamphetamine abuse
Ernst, T., Chang, L., Leonido–Yee, M., & Speck, O. (2000) · Neurology · doi:10.1212/wnl.54.6.1344 · Cited by 373 · see citing works
Morphine induces apoptosis of human microglia and neurons
Hu, S., Sheng, W. S., Lokensgard, J. R., & Peterson, P. K. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00030-8 · Cited by 328 · see citing works
Cognitive impairment in methadone maintenance patients
Mintzer, M. Z., & Stitzer, M. L. (2002) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(02)00013-3 · Cited by 285 · see citing works
Schulte, T., Sullivan, E. V., Müller-Oehring, E. M., Adalsteinsson, E., & Pfefferbaum, A. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi020 · Cited by 275 · see citing works
Impaired response inhibition function in abstinent heroin dependents: An fMRI study
Fu, L., Bi, G., Zou, Z., Wang, Y., Ye, E., Ma, L., Ming-Fan, & Zheng, Y. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.04.033 · Cited by 226 · see citing works
Self-citationPfefferbaum, A., & Sullivan, E. V. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300623 · Cited by 225 · see citing works
Pfefferbaum, A., Adalsteinsson, E., & Sullivan, E. V. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.007 · Cited by 221 · see citing works
Lim, K. O., Choi, S. J., Pomara, N., Wolkin, A., & Rotrosen, J. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01355-5 · Cited by 191 · see citing works
Tyszka, J., Readhead, C., Bearer, E., Pautler, R., & Jacobs, R. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.08.037 · Cited by 187 · see citing works
Neuropsychological functioning in methadone maintenance patients versus abstinent heroin abusers
Verdejo‐García, A., Toribio, I., Orozco, C. E. R., Puente, K. L., & Pérez-Garcı́a, M. (2004) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2004.11.006 · Cited by 180 · see citing works
Arnone, D., Barrick, T. R., Chengappa, S., Mackay, C. E., Clark, C. A., & Abou-Saleh, M. T. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.02.064 · Cited by 178 · see citing works
Opioid abuse and cognitive performance
Mintzer, M. Z., Copersino, M. L., & Stitzer, M. L. (2004) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2004.10.008 · Cited by 155 · see citing works
Using magnetic resonance imaging and diffusion tensor imaging to assess brain damage in alcoholics.
Rosenbloom, M. J., Sullivan, E. V., & Pfefferbaum, A. (2003) · PubMed · Cited by 137 · see citing works
Boronat, M. A., García-Fuster, M. J., & Garcı́a-Sevilla, J. A. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704364 · Cited by 130 · see citing works
Lyoo, I. K., Streeter, C. C., Ahn, K. H., Lee, H. K., Pollack, M. H., Silveri, M. M., Nassar, L. E., Levin, J. M., Sarid‐Segal, O., Ciraulo, D. A., et al. (2004) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2004.04.001 · Cited by 113 · see citing works
Shi, J., Zhao, L.-Y., Copersino, M. L., Fang, Y.-X., Chen, Y., Tian, J., Deng, Y., Shuai, Y., Jin, J., & Lu, L. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.09.042 · Cited by 108 · see citing works
Xie, C., Li, S., Shao, Y., Fu, L., Goveas, J. S., Ye, E., Li, W., Cohen, A. D., Chen, G., & Zhang, Z. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.09.004 · Cited by 101 · see citing works
Self-citationWhen "enough" is not enough: new perspectives on optimal methadone maintenance dose.
Leavitt, S., Shinderman, M. S., Maxwell, S., Eap, C. B., & Paris, P. (2000) · PubMed · Cited by 100 · see citing works
Liu, B., Du, L., Kong, L., Hudson, P. M., Wilson, B. C., Chang, R. C., Abel, H. H., & Hong, J. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00057-9 · Cited by 85 · see citing works
Liu, H., Li, L., Hao, Y., Cao, D., Xu, L., Rohrbaugh, R. M., Xue, Z., Hao, W., Shan, B., & Liu, Z. (2008) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990802295238 · Cited by 84 · see citing works
Methadone maintenance improves cognitive performance after two months of treatment.
Gruber, S., Tzilos, G. K., Silveri, M., Pollack, M., Renshaw, P., Kaufman, M. J., & Yurgelun-Todd, D. (2006) · Experimental and clinical psychopharmacology · doi:10.1037/1064-1297.14.2.157 · Cited by 82 · see citing works
Cerebral perfusion in early and late opiate withdrawal: a technetium-99m-HMPAO SPECT study
Rose, J. S., Branchey, M. H., Buydens‐Branchey, L., Stapleton, J. M., Chasten, K., Werrell, A., & MAAYAN, M. L. (1996) · Psychiatry Research Neuroimaging · doi:10.1016/0925-4927(96)02663-7 · Cited by 81 · see citing works
Hasan, K. M., & Narayana, P. A. (2006) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20935 · Cited by 73 · see citing works
Delayed spongiform leukoencephalopathy after heroin abuse
Rizzuto, N., Morbin, M., Ferrari, S., Cavallaro, T., Sparaco, M., Boso, G., & Gaetti, L. (1997) · Acta Neuropathologica · doi:10.1007/s004010050676 · Cited by 67 · see citing works
Histological correlation of diffusion tensor imaging metrics in experimental spinal cord injury
Herrera, J. J., Chacko, T., & Narayana, P. A. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21481 · Cited by 59 · see citing works
Lü, L., & Wang, X. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1441.025 · Cited by 55 · see citing works
Heroin-Induced Spongiform Leukoencephalopathy: Value of Diffusion MR Imaging
Chen, C., Lee, K.-W., Lee, C.-C., Chin, S.-C., Chung, H., & Zimmerman, R. A. (2000) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-200009000-00013 · Cited by 55 · see citing works
Prosser, J. M., London, E. D., & GALYNKER, I. I. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.04.022 · Cited by 54 · see citing works
Tramullas, M., Martínez‐Cué, C., & Hurlé, M. A. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0751-x · Cited by 51 · see citing works
Alterations in the processing of non-drug-related affective stimuli in abstinent heroin addicts
Wang, Z., Zhang, J. X., Wu, Q., Liu, N., Hu, X. P., Chan, R. C. K., & Xiao, Z. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.08.020 · Cited by 43 · see citing works
Reversible spongiform leucoencephalopathy after inhalation of heated heroin
Gacouin, A., Lavoué, S., Signouret, T., Person, A., Dinard, M. D., Shpak, N., & Thomas, R. (2003) · Intensive Care Medicine · doi:10.1007/s00134-003-1691-5 · Cited by 42 · see citing works
Spongiform leucoencephalopathy after inhaling heroin
Sempere, Á. P., Posada, I. J., Ramo-Tello, C. M., & Cabello, A. (1991) · The Lancet · doi:10.1016/0140-6736(91)90463-y · Cited by 41 · see citing works
Minabe, Y., Matsuno, K., & Ashby, C. R. (1999) · Synapse · doi:10.1002/(sici)1098-2396(199908)33:2 · Cited by 40 · see citing works
Spongiform encephalopathy in addicts inhaling pre-heated heroin.
Schiffer, D., Brignolio, F., Giordana, M. T., Mongini, T., Migheli, A., & Palmucci, L. (1985) · PubMed · Cited by 40 · see citing works
Neuronal depletion in the globus pallidus of heroin addicts
Pearson, J. M., Mm, B., & RICHTER, R. W. (1976) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(76)90037-5 · Cited by 39 · see citing works
Kaufman, M. J., Pollack, M. H., Villafuerte, R. A., Kukes, T. J., Rose, S. L., Mendelson, J. H., Cohen, B. M., & Renshaw, P. F. (1999) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(99)00017-7 · Cited by 35 · see citing works
Heroin Vapor Inhalation-induced Spongiform Leukoencephalopathy
Jee, R.-C., Tsao, W.-L., Shyu, W., Yen, P.-S., Hsu, Y., & Liu, S. (2009) · Journal of the Formosan Medical Association · doi:10.1016/s0929-6646(09)60101-7 · Cited by 20 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ceceli, A. O., Bradberry, C. W., & Goldstein, R. Z. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01153-9 · Cited by 150 · see citing works
Single-cell RNA-seq uncovers a robust transcriptional response to morphine by glia
Avey, D., Sankararaman, S., Yim, A. K. Y., Barve, R., Milbrandt, J., & Mitra, R. D. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.08.080 · Cited by 143 · see citing works
Seney, M. L., Kim, S.-M., Glausier, J. R., Hildebrand, M. A., Xue, X., Zong, W., Wang, J., Shelton, M. A., Phan, B. N., Srinivasan, C., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.06.007 · Cited by 133 · see citing works
Li, Q., Wang, Y., Zhang, Y., Li, W., Yang, W., Zhu, J., Wu, N., Chang, H., Zheng, Y., Qin, W., et al. (2012) · Brain Research · doi:10.1016/j.brainres.2012.06.024 · Cited by 133 · see citing works
Self-citationHampton, W. H., Hanik, I. M., & Olson, I. R. (2019) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.02.005 · Cited by 95 · see citing works
Endogenous opiates and behavior: 2006
Bodnar, R. J. (2007) · Peptides · doi:10.1016/j.peptides.2007.09.002 · Cited by 91 · see citing works
Inflammatory response in heroin addicts undergoing methadone maintenance treatment
Chan, Y.-Y., Yang, S., Lin, J., Chang, J.-L., Lin, J., & Lo, W. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2014.12.053 · Cited by 88 · see citing works
White matter impairment in chronic heroin dependence: A quantitative DTI study
Li, W., Li, Q., Zhu, J., Qin, Y., Zheng, Y., Chang, H., Zhang, D., Wang, H., Wang, L., Wang, Y., et al. (2013) · Brain Research · doi:10.1016/j.brainres.2013.07.036 · Cited by 61 · see citing works
Self-citationTolomeo, S., Gray, S., Matthews, K., Steele, J. D., & Baldacchino, A. (2016) · Psychological Medicine · doi:10.1017/s0033291716001513 · Cited by 61 · see citing works
Qiu, Y., Jiang, G., Su, H., Lv, X., Zhang, X., Tian, J., & Zhuo, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063212 · Cited by 58 · see citing works
Endogenous opiates and behavior: 2011
Bodnar, R. J. (2012) · Peptides · doi:10.1016/j.peptides.2012.09.027 · Cited by 58 · see citing works
Aberrant Default-Mode Functional and Structural Connectivity in Heroin-Dependent Individuals
Ma, X., Qiu, Y., Tian, J., Wang, J., Li, S., Zhan, W., Wang, T., Zeng, S., Jiang, G., & Xu, Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120861 · Cited by 57 · see citing works
Cognitive Control in Opioid Dependence and Methadone Maintenance Treatment
Liao, D., Huang, C.-Y., Hu, S., Fang, S., Wu, C., Chen, W., Lee, T. S., Chen, P., & Li, C.-S. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094589 · Cited by 54 · see citing works
Jiang, G., Wen, X., Qiu, Y., Zhang, R., Wang, J., Li, M., Ma, X., Tian, J., & Huang, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082715 · Cited by 53 · see citing works
White matter abnormalities in long-term heroin users: a preliminary neuroimaging meta-analysis
Wollman, S. C., Alhassoon, O. M., Stern, M. J., Hall, M. G., Rompogren, J., Kimmel, C. L., & Perez-Figueroa, A. M. (2015) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2014.985829 · Cited by 47 · see citing works
Chan, Y.-Y., Lo, W., Li, T., Shen, L., Yang, S.-N., Chen, Y.-H., & Lin, J. (2014) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x14500372 · Cited by 44 · see citing works
Lin, W., Chou, K. H., Chen, C.-C., Huang, C., Chen, H. L., Lu, C. H., Li, S.-H., Wang, Y., Cheng, Y., & Lin, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033809 · Cited by 45 · see citing works
Self-citationLi, W., Li, Q., Wang, Y., Zhu, J., Ye, J., Yan, X., Li, Y., Chen, J., Liu, J., Li, Z., et al. (2016) · Scientific Reports · doi:10.1038/srep19662 · Cited by 40 · see citing works
Self-citationResting-state Abnormalities in Heroin-dependent Individuals
Pandria, N., Kovatsi, L., Vivas, A. B., & Bamidis, P. D. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.11.018 · Cited by 39 · see citing works
Denier, N., Schmidt, A., Gerber, H., Schmid, O., Riecher‐Rössler, A., Wiesbeck, G. A., Huber, C. G., Lang, U. E., Radue, E. W., Walter, M., et al. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00135 · Cited by 35 · see citing works
Aberrant interhemispheric functional and structural connectivity in heroin‐dependent individuals
Qiu, Y., Jiang, G., Ma, X., Su, H., Lv, X., & Zhuo, F. (2016) · Addiction Biology · doi:10.1111/adb.12387 · Cited by 36 · see citing works
Butelman, E. R., Goldstein, R. Z., Nwaneshiudu, C. A., Girdhar, K., Roussos, P., Russo, S. J., & Alia‐Klein, N. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.07.031 · Cited by 34 · see citing works
Zhang, R., Jiang, G., Tian, J., Qiu, Y., Wen, X., Zalesky, A., Li, M., Ma, X., Wang, J., Li, S., et al. (2015) · Addiction Biology · doi:10.1111/adb.12234 · Cited by 32 · see citing works
Wei, X., Li, W., Chen, J., Li, Y., Zhu, J., Shi, H., Liu, J., Xue, J., Liu, W., Wang, F., et al. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00051-5 · Cited by 29 · see citing works
Self-citationGaudreault, P., King, S. G., Malaker, P., Nelly Alia-klein, A., & Goldstein, R. Z. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01833-y · Cited by 27 · see citing works
Chen, S., Lee, S.-Y., Tao, P., Chang, Y. H., Chen, S., Chu, C., Chen, P. S., Lee, I. H., Yeh, T. L., Yang, Y. K., et al. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9400-1 · Cited by 27 · see citing works
Current Understanding of the Neurobiology of Opioid Use Disorder: an Overview
Moningka, H., Lichenstein, S. D., & Yip, S. W. (2019) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-019-0170-4 · Cited by 24 · see citing works
Saroj, R., Ghosh, A., Subodh, B. N., Nehra, R., Mahintamani, T., Rana, D. K., & Basu, D. (2020) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2020.102181 · Cited by 23 · see citing works
Zou, Y., Murray, D. E., Durazzo, T. C., Schmidt, T. P., Murray, T. A., & Meyerhoff, D. J. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.01.032 · Cited by 22 · see citing works
Bouncing back: Brain rehabilitation amid opioid and stimulant epidemics
Stewart, J. L., May, A. C., & Paulus, M. P. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.102068 · Cited by 23 · see citing works
Imaging neuroinflammation in individuals with substance use disorders
Li, X., Ramos-Rolón, A. P., Kass, G., Pereira-Rufino, L. D. S., Shifman, N., Shi, Z., Volkow, N. D., & Wiers, C. E. (2024) · Journal of Clinical Investigation · doi:10.1172/jci172884 · Cited by 20 · see citing works
Luo, J., Yang, R., Yang, W., Duan, C., Deng, Y., Zhang, J., Chen, J., & Liu, J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00492 · Cited by 20 · see citing works
Self-citationA Systematic Review of Noninvasive Brain Stimulation for Opioid Use Disorder
Ward, H. B., Mosquera, M. J., Suzuki, J., & Mariano, T. Y. (2020) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13108 · Cited by 16 · see citing works
Dwivedi, I., Caldwell, A. B., Zhou, D., Wu, W., Subramaniam, S., & Haddad, G. G. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02397-3 · Cited by 14 · see citing works
Disrupted Integrity of White Matter in Heroin-addicted Subjects at Different Abstinent Time
Shen, Y., Wang, E., Wang, X., & Lou, M. (2012) · Journal of Addiction Medicine · doi:10.1097/adm.0b013e318252db94 · Cited by 13 · see citing works
A possible biomarker for methadone related deaths
Argo, A., Spatola, G. F., Zerbo, S., Sortino, C., Lanzarone, A., Uzzo, M. L., Pitruzzella, A., Farè, F., Roda, G., Gambaro, V., et al. (2017) · Journal of Forensic and Legal Medicine · doi:10.1016/j.jflm.2017.05.010 · Cited by 12 · see citing works
Diffusivity of the uncinate fasciculus in heroin users relates to their levels of anxiety
Wong, N. M. L., Cheung, S., Chan, C. C. H., Zeng, H., Liu, Y.-P., So, K., & Lee, T. M. C. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.48 · Cited by 10 · see citing works
Ghosh, A., Basu, D., Khandelwal, N. K., Ahuja, C. K., Subodh, B. N., & Rana, D. K. (2019) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2019.02.009 · Cited by 9 · see citing works
Ivers, J., Fitzgerald, J., Whelan, C. D., Sweeney, B., Keenan, E., Fagan, A. J., McMarrow, J., Meany, J., Barry, J. M., & Frodl, T. (2016) · Addiction Biology · doi:10.1111/adb.12466 · Cited by 9 · see citing works
Roberts, D., Wolfarth, A., Sánchez, C., & Pehrson, A. L. (2018) · Progress in brain research · doi:10.1016/bs.pbr.2018.07.001 · Cited by 9 · see citing works
Navaei, F., Fathabadi, F. F., Moghaddam, M. H., Fathi, M., Vakili, K. G., Abdollahifar, M., Boroujeni, M. E., Zamani, N., Zamani, N., Norouzian, M., et al. (2022) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2022.102139 · Cited by 7 · see citing works
Early malnutrition attenuates the impairing action of naloxone on spreading depression in young rats
Guedes, R. C. A., Rocha-de-Melo, A. P., de Lima, K. R., de Albuquerque, J. D. M. S., & Francisco, E. D. S. (2013) · Nutritional Neuroscience · doi:10.1179/1476830512y.0000000046 · Cited by 7 · see citing works
Impaired Cognition Control and Inferior Frontal Cortex Modulation in Heroin Addiction
Schmidt, A., Walter, M., & Borgwardt, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800213-1.00097-3 · Cited by 8 · see citing works
Frontal White Matter Changes and Craving Recovery in Inpatients With Heroin Use Disorder
Gaudreault, P., King, S. G., Huang, Y., Ceceli, A. O., Kronberg, G., Nelly Alia-klein, A., & Goldstein, R. Z. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.51678 · Cited by 6 · see citing works
Gamito, P. S., Oliveira, J., Lopes, P., Morais, D., Cristóvão, S., Caçôete, C., Henriques, C., Silva, D., Silva, A., Rebelo, S., et al. (2013) · Proceedings of the ICTs for improving Patients Rehabilitation Research Techniques · doi:10.4108/icst.pervasivehealth.2013.252175 · Cited by 5 · see citing works
Disrupted resting-state functional connectivity of frontal network in opium use disorder
Taremian, F., Eskandari, Z., Dadashi, M., & Hosseini, S. R. (2021) · Applied Neuropsychology Adult · doi:10.1080/23279095.2021.1938051 · Cited by 4 · see citing works
Vaselbehagh, M., Sadegh, M., Karami, H., Babaie, S., & Sakhaie, M. H. (2021) · PubMed Central · doi:10.22074/cellj.2021.7384 · Cited by 4 · see citing works
Gaudreault, P., King, S. G., Malaker, P., Nelly Alia-klein, A., & Goldstein, R. Z. (2022) · medRxiv · doi:10.1101/2022.03.22.22272765 · Cited by 3 · see citing works
FRONTAL WHITE MATTER CHANGES INDICATE RECOVERY WITH INPATIENT TREATMENT IN HEROIN ADDICTIONPreprint
Gaudreault, P., King, S. G., Huang, Y., Ceceli, A. O., Kronberg, G., Nelly Alia-klein, A., & Goldstein, R. Z. (2024) · medRxiv · doi:10.1101/2024.06.10.24308719 · Cited by 3 · see citing works
Focused Ultrasound Combined With Microbubbles Attenuate Symptoms in Heroin-Addicted Mice
Feng, Y., Sun, J., Wang, T., Yu, Z., Zhao, Y., Li, Y., Lai, S., Xu, Y., & Zhu, M. (2024) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2024.06.014 · Cited by 2 · see citing works
Agunbiade, K., Fonville, L., McGonigle, J., Elliott, R., Ersche, K. D., Flechais, R., Orbán, C., Murphy, A., Smith, D. G., John Suckling, A., et al. (2022) · Addiction Biology · doi:10.1111/adb.13207 · Cited by 2 · see citing works
Mahoney, J. J., Bryant, K. R., & Haut, M. W. (2019) · Springer eBooks · doi:10.1007/978-3-030-14895-9_32 · Cited by 2 · see citing works
Single Cell RNAseq Uncovers a Robust Transcriptional Response to Morphine by OligodendrocytesPreprint
Avey, D. R., Sankararaman, S., Yim, A. K., Barve, R. A., Mitra, R. D., & Milbrandt, J. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/306944 · Cited by 2 · see citing works
Brain Imaging and Substance Use Disorders: Focus on White Matter Microstructural Integrity
Rossetti, M. G., Crisanti, C., Brambilla, P., & Lorenzetti, V. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819641-0.00117-1 · Cited by 2 · see citing works
Leventelis, C., Veskoukis, A. S., Gil, A. P. R., Papadopoulos, P., Garderi, M., Angeli, A., Kampitsi, A., & Tsironi, M. (2025) · Pharmacy · doi:10.3390/pharmacy13020040 · Cited by 2 · see citing works
Effects of Alcohol and Opioids on Neuroregeneration
Zolali, E., McMahon, L. R., & Obeng, S. (2025) · Springer eBooks · doi:10.1007/978-3-031-93677-7_12 · Cited by 1 · see citing works
Caulkins, J. P., Pérez-Dávila, S., Kilmer, B., Poser, J., & Reuter, P. (2025) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2025.2504147 · Cited by 1 · see citing works
Ghosh, A., Verma, A., Kaur, S., Ahuja, C. K., Nehra, R., Singh, P., Modi, M., Kumaran, S. S., & Basu, D. (2025) · Indian Journal of Psychological Medicine · doi:10.1177/02537176251388698
Kaur, S., Verma, A., Ghosh, A., Salan, T., Ahuja, C. K., Singh, P., Modi, M., Nehra, R., Basu, D., & Govind, V. (2026) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2026.112248
- Authors
- Wang, Y., Li, W., Li, Q., Yang, W., Zhu, J., & Wang, W.
- Affiliations
- Tang Du Hospital (CN)
- Corresponding author
- Wang, Wei
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 494
- Issue
- 1
- Pages
- 49-53
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2018398784
- Cited by
- 60
- References
- 41
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 6 · 2015: 5 · 2014: 3 · 2013: 6 · 2012: 5
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- methadone maintenance treatment, heroin addiction, white matter integrity, corpus callosum, splenium, genu, fractional anisotropy, apparent diffusion coefficient, long-term abstinence, methadone dose, opioid use disorder, diffusion tensor imaging
- MeSH terms
- Adult, Brain, Heroin, Heroin Dependence, Humans, Male, Methadone, Middle Aged, Narcotics, Nerve Fibers, Myelinated, Regression Analysis, Anisotropy, Diffusion Tensor Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review