Opiates inhibit neurogenesis in the adult rat hippocampus
Open accessAbstract
Recent work implicates regulation of neurogenesis as a form of plasticity in the adult rat hippocampus. Given the known effects of opiates such as morphine and heroin on hippocampal function, we examined opiate regulation of neurogenesis in this brain region. Chronic administration of morphine decreased neurogenesis by 42% in the adult rat hippocampal granule cell layer. A similar effect was seen in rats after chronic self-administration of heroin. Opiate regulation of neurogenesis was not mediated by changes in circulating levels of glucocorticoids, because similar effects were seen in rats that received adrenalectomy and corticosterone replacement. These findings suggest that opiate regulation of neurogenesis in the adult rat hippocampus may be one mechanism by which drug exposure influences hippocampal function.
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Opioids interfere with memory acquisition and retrieval.
“Critically, not only do opioids interfere with memory acquisition and retrieval, but they also interfere with hippocampal neurogenesis, where chronic administration of morphine leads to reduced hippocampal neurogenesis and cell proliferation (Eisch et al., 2000;Kahn et al., 2005;Mandyam et al., 2004).”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Eisch et al., 2000
Chronic administration of morphine leads to reduced hippocampal neurogenesis and cell proliferation.
“Critically, not only do opioids interfere with memory acquisition and retrieval, but they also interfere with hippocampal neurogenesis, where chronic administration of morphine leads to reduced hippocampal neurogenesis and cell proliferation (Eisch et al., 2000;Kahn et al., 2005;Mandyam et al., 2004).”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Eisch et al., 2000
Cites
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880 · see citing works
Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
Altman, J., & Das, G. D. (1965) · Journal of Comparative Neurology · doi:10.1002/cne.901240303 · Cited by 3,592 · see citing works
West, M. J., Slomianka, L., & Gundersen, H. J. G. (1991) · The Anatomical Record · doi:10.1002/ar.1092310411 · Cited by 2,994 · see citing works
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Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111 · see citing works
Self-citationAdult neurogenesis produces a large pool of new granule cells in the dentate gyrus
Cameron, H. A., & Mckay, R. D. G. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1040 · Cited by 1,585 · see citing works
Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495 · see citing works
Mood disorders and allostatic load
McEwen, B. S. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00177-x · Cited by 1,135 · see citing works
Adult neurogenesis: from precursors to network and physiology
Abrous, D. N., Koehl, M., & Le Moal, M. (2005) · Physiological Reviews · doi:10.1152/physrev.00055.2003 · Cited by 971 · see citing works
The role of adult hippocampal neurogenesis in brain health and disease
Toda, T., Parylak, S. L., Linker, S. B., & Gage, F. H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0036-2 · Cited by 719 · see citing works
Neurogenesis and Exercise: Past and Future Directions
van Praag, H. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8028-z · Cited by 645 · see citing works
Jiang, W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25509 · Cited by 527 · see citing works
Regulation of adult neurogenesis by antidepressant treatment
Duman, R. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00358-x · Cited by 463 · see citing works
Eisch, A. J., Bolaños, C. A., de Wit, J., Simonak, R. D., Pudiak, C. M., Barrot, M., Verhaagen, J., & Nestler, E. J. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.08.003 · Cited by 420 · see citing works
Self-citationSynaptic plasticity and mood disorders
Duman, R. S. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001016 · Cited by 363 · see citing works
Adult hippocampal neurogenesis is functionally important for stress-induced social avoidance
Lagace, D. C., Donovan, M. H., DeCarolis, N. A., Farnbauch, L. A., Malhotra, S., Berton, O., Nestler, E. J., Krishnan, V., & Eisch, A. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910072107 · Cited by 314 · see citing works
Self-citationNeuropsychological consequences of chronic opioid use: a quantitative review and meta-analysis.
Baldacchino, A., Balfour, D. J. K., Passetti, F., Humphris, G., & Matthews, K. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.06.006 · Cited by 263 · see citing works
Perera, T. D., Dwork, A. J., Keegan, K. A., Thirumangalakudi, L., Lipira, C. M., Joyce, N., Lange, C., Higley, J. D., Rosoklija, G., Hen, R., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017600 · Cited by 244 · see citing works
Kempermann, G. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.40101.x · Cited by 231 · see citing works
Li, Y.-F., Huang, Y., Amsdell, S. L., Xiao, L., O'Donnell, J. M., & Zhang, H.-T. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.66 · Cited by 185 · see citing works
Increasing hippocampal neurogenesis: a novel mechanism for antidepressant drugs
Malberg, J., & Schechter, L. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053382223 · Cited by 167 · see citing works
The neural rejuvenation hypothesis of cocaine addiction
Dong, Y., & Nestler, E. J. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.05.005 · Cited by 163 · see citing works
Self-citationMechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148 · see citing works
Adult brain neurogenesis and depression
Jacobs, B. L. (2002) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(02)00015-6 · Cited by 147 · see citing works
Schiavon, A. P., Bonato, J. M., Milani, H., Guimarães, F. S., & Weffort de Oliveira, R. M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.06.017 · Cited by 135 · see citing works
Caldarone, B. J., Harrist, A., Cleary, M. A., Beech, R. D., King, S. L., & Picciotto, M. R. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.08.010 · Cited by 122 · see citing works
Mandyam, C. D., Norris, R. D., & Eisch, A. J. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20090 · Cited by 116 · see citing works
Self-citationVEGF and depression: A comprehensive assessment of clinical data
Clark-Raymond, A., & Halaris, A. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.04.008 · Cited by 108 · see citing works
McKinnon, M. C., Boyd, J. E., Frewen, P. A., Lanius, U. F., Jetly, R., Richardson, J. D., & Lanius, R. A. (2016) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2016.07.017 · Cited by 94 · see citing works
“…not only do opioids interfere with memory acquisition and retrieval, but they also interfere with hippocampal neurogenesis, where chronic administration of morphine leads to reduced hippocampal neurogenesis and cell proliferation (Eisch et al., 2000; Kahn et al., 2005; Mandyam et al., 2004).”
Zhang, Z., Wang, W., Zhong, P., Liu, S. J., Long, J. Z., Zhao, L., Gao, H., Cravatt, B. F., & Liu, Q. (2015) · Hippocampus · doi:10.1002/hipo.22344 · Cited by 89 · see citing works
Shors, T. J., Olson, R. L., Bates, M. E., Selby, E. A., & Alderman, B. L. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.08.012 · Cited by 69 · see citing works
Wang, Y., Li, W., Li, Q., Yang, W., Zhu, J., & Wang, W. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.02.053 · Cited by 60 · see citing works
5-HT2A/2C receptor blockade regulates progenitor cell proliferation in the adult rat hippocampus
Jha, S., Rajendran, R., Fernandes, K. A., & Vaidya, V. A. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.06.028 · Cited by 56 · see citing works
McEwen, B. S. (2004) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2004.6.2/bmcewen · Cited by 54 · see citing works
Neurobehavioral Teratogenicity of Perfluorinated Alkyls in an Avian Model
Pinkas, A., Slotkin, T. A., Brick-Turin, Y., Van der Zee, E. A., & Yanai, J. (2010) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2009.11.004 · Cited by 48 · see citing works
A role for nuclear β-catenin in SNRI antidepressant-induced hippocampal cell proliferation
Mostany, R., Valdizán, E. M., & Pazos, A. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.04.012 · Cited by 47 · see citing works
RHODIN, A., von EHREN, M., SKOTTHEIM, B., GRÖNBLADH, A., ORTIZ‐NIETO, F., RAININKO, R., GORDH, T., & NYBERG, F. (2014) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.12309 · Cited by 20 · see citing works
- Authors
- Eisch, A. J., Barrot, M., Schad, C. A., Self, D. W., & Nestler, E. J.
- Affiliations
- Yale University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2000-06-06
- Volume
- 97
- Issue
- 13
- Pages
- 7579-7584
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC16588
- OpenAlex
- W2136108338
- Cited by
- 599
- References
- 3
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 10 · 2023: 7 · 2022: 11 · 2021: 13 · 2020: 35 · 2019: 13 · 2018: 24 · 2017: 18 · 2016: 24 · 2015: 22 · 2014: 33 · 2013: 25 · 2012: 38
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- opiates, neurogenesis, hippocampus, morphine, heroin, hippocampal granule cells, glucocorticoids, adrenalectomy, corticosterone replacement, drug exposure, neuroplasticity
- MeSH terms
- Analgesics, Opioid, Animals, Cell Differentiation, Heroin, Hippocampus, Male, Morphine, Narcotics, Neurons, Rats, Sprague-Dawley, Rats
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