Melatonin supplementation delays the decline of adult hippocampal neurogenesis during normal aging of mice

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Melatonin Modulates Cell Survival of New Neurons in the Hippocampus of Adult Mice

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The contribution of failing adult hippocampal neurogenesis to psychiatric disorders

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Natural variation and genetic covariance in adult hippocampal neurogenesis

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Melatonin treatment mimics the antidepressant action in chronic corticosterone‐treated mice

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Cerebrovascular melatonin MT1-receptor alterations in patients with Alzheimer's disease

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Melatonin improves presynaptic protein, SNAP‐25, expression and dendritic spine density and enhances functional and electrophysiological recovery following transient focal cerebral ischemia in rats

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Repetitive transcranial magnetic stimulation (rTMS) influences spatial cognition and modulates hippocampal structural synaptic plasticity in aging mice

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A novel melatonin agonist Neu-P11 facilitates memory performance and improves cognitive impairment in a rat model of Alzheimer' disease

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Melatoninergic System in Parkinson’s Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms

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Melatonin: From Neurobiology to Treatment

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Protective Effects of Melatonin on Neurogenesis Impairment in Neurological Disorders and Its Relevant Molecular Mechanisms

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Recent Advances in Neurogenic Small Molecules as Innovative Treatments for Neurodegenerative Diseases

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Protective effects of melatonin against valproic acid-induced memory impairments and reductions in adult rat hippocampal neurogenesis

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NovelN-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential

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Melatonin synergizes with citalopram to induce antidepressant‐like behavior and to promote hippocampal neurogenesis in adult mice

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Melatonin Reverses the Depression-associated Behaviour and Regulates Microglia, Fractalkine Expression and Neurogenesis in Adult Mice Exposed to Chronic Mild Stress

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Adult Neurogenesis under Control of the Circadian System

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Melatonin pretreatment prevented the effect of dexamethasone negative alterations on behavior and hippocampal neurogenesis in the mouse brain

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Piromelatine ameliorates memory deficits associated with chronic mild stress-induced anhedonia in rats

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Chronic administration of a melatonin membrane receptor antagonist, luzindole, affects hippocampal neurogenesis without changes in hopelessness-like behavior in adult mice

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TRYCAT Pathways Link Peripheral Inflammation, Nicotine, Somatization and Depression in the Etiology and Course of Parkinson’s Disease

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Prophylactic Role of Oral Melatonin Administration on Neurogenesis in Adult Balb/C Mice during REM Sleep Deprivation

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Melatonin Influences Structural Plasticity in the Axons of Granule Cells in the Dentate Gyrus of Balb/C Mice

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Melatonin ameliorates dexamethasone-induced inhibitory effects on the proliferation of cultured progenitor cells obtained from adult rat hippocampus

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The effects of agomelatine on endoplasmic reticulum stress related to mitochondrial dysfunction in hippocampus of aging rat model

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Regional upregulation of hippocampal melatonin MT2 receptors by valproic acid: Therapeutic implications for Alzheimer's disease

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Fe3O4 Nanozymes Improve Neuroblast Differentiation and Blood-Brain Barrier Integrity of the Hippocampal Dentate Gyrus in D-Galactose-Induced Aged Mice

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Benefits of the Neurogenic Potential of Melatonin for Treating Neurological and Neuropsychiatric Disorders

Potes, Y., Cachán-Vega, C., Antuña, E., García-González, C., Menéndez-Coto, N., Boga, J. A., Gutiérrez‐Rodríguez, J., Bermúdez, M., Sierra, V., Vega‐Naredo, I., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054803 · Cited by 25 · see citing works

ASMT gene expression correlates with cognitive impairment in patients with recurrent depressive disorder

Gałecki, P. (2014) · Medical Science Monitor · doi:10.12659/msm.890160 · Cited by 25 · see citing works

Melatonin Modulates Dendrite Maturation and Complexity in the Dorsal- and Ventral- Dentate Gyrus Concomitantly with Its Antidepressant-Like Effect in Male Balb/C Mice

Ramírez-Rodríguez, G. B., Palacios-Cabriales, D. M., Ortíz‐López, L., Estrada-Camarena, E. M., & Vega‐Rivera, N. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051724 · Cited by 24 · see citing works

Melatonin: a multitasking indoleamine to modulate hippocampal neurogenesis

Romero, A., Morales-Garcia, J. A., & Ramos, E. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.350189 · Cited by 23 · see citing works

Chronic Treatment with Melatonin Improves Hippocampal Neurogenesis in the Aged Brain and Under Neurodegeneration

Cachán-Vega, C., Vega‐Naredo, I., Potes, Y., Bermejo-Millo, J. C., Rubio‐González, A., García-González, C., Antuña, E., Bermúdez, M., Gutiérrez‐Rodríguez, J., Boga, J. A., et al. (2022) · Molecules · doi:10.3390/molecules27175543 · Cited by 23 · see citing works

Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties

Herrera‐Arozamena, C., Estrada, M., Pérez, C., Lagartera, L., Morales-Garcia, J. A., Pérez‐Castillo, A., Franco‐Gonzalez, J. F., Michalska, P., Duarte, P., Leon, R. M., et al. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112090 · Cited by 23 · see citing works

Melatonin and the Programming of Stem Cells

Hardeland, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23041971 · Cited by 22 · see citing works

Environmental enrichment: dissociated effects between physical activity and changing environmental complexity on anxiety and neurogenesis in adult male Balb/C mice.

Ramírez-Rodríguez, G. B., Gutiérrez-Vera, B., Ortíz‐López, L., Vega‐Rivera, N. M., Juan, D. M.-S., Granados-Juárez, A., Aquino, D. V. C.-D., Castro-García, M., & Ramos, M. F. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113878 · Cited by 22 · see citing works

5 Hz of repetitive transcranial magnetic stimulation improves cognition and induces modifications in hippocampal neurogenesis in adult female Swiss Webster mice

Ramírez-Rodríguez, G. B., Juan, D. M.-S., & Gonzalez-Olvera, J. J. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.06.001 · Cited by 17 · see citing works

Low-frequency transcranial magnetic stimulation is beneficial for enhancing synaptic plasticity in the aging brain

Ma, J., Zhang, Z., Luan, F., Xie, C.-Y., Geng, D.-D., & Wang, Y.-Y. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.158356 · Cited by 17 · see citing works

[Effects of sleep deprivation in hippocampal neurogenesis].

Lopez-Virgen, V., Zárate-López, D., Adirsch, F. L., Collas-Aguilar, J., & González-Pérez, Ó. (2015) · PubMed · Cited by 17 · see citing works

Melatonin mitigates hippocampal and cognitive impairments caused by prenatal irradiation

Pipová, N., Kisková, T., Vilhanová, K., Stafurikova, A., Jendželovský, R., Račeková, E., & Šmajda, B. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14687 · Cited by 16 · see citing works

Melatonin maintains calcium-binding calretinin-positive neurons in the dentate gyrus during aging of Balb/C mice

Ramírez-Rodríguez, G. B., Gómez‐Sánchez, A., & Ortíz‐López, L. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.10.014 · Cited by 14 · see citing works

Melatonin alters neuronal architecture and increases cysteine‐rich protein 1 signaling in the male mouse hippocampus

Ang, M. J., Kang, S., & Moon, C. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24708 · Cited by 13 · see citing works

Repetitive transcranial magnetic stimulation and fluoxetine reverse depressive-like behavior but with differential effects on Olig2-positive cells in chronically stressed mice

Ramírez-Rodríguez, G. B., Juan, D. M.-S., Rico-Becerra, A. I., Gonzalez-Olvera, J. J., & Reyes‐Galindo, V. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109567 · Cited by 11 · see citing works

Comparing the Behavioural Effects of Exogenous Growth Hormone and Melatonin in Young and Old Wistar Rats

Barceló, P., Nicolau, C., Gamundı́, A., Fiol-deRoque, M. A., Tresguerres, J. A. F., Akaârir, M., & Rial, R. V. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/5863402 · Cited by 11 · see citing works

Melatonin Prevents Depression but Not Anxiety-like Behavior Produced by the Chemotherapeutic Agent Temozolomide: Implication of Doublecortin Cells and Hilar Oligodendrocytes

Cabrera-Muñoz, E. A., Ramírez-Rodríguez, G. B., Díaz-Yañez, L., Reyes‐Galindo, V., Juan, D. M.-S., & Vega‐Rivera, N. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713376 · Cited by 10 · see citing works

Melatonin

Sharman, E. H., & Bondy, S. C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802147-7.00036-x · Cited by 8 · see citing works

Melatonin Supplementation in Alzheimer’s disease: The Potential Role in Neurogenesis

Ebrahimi, R., Faramarzi, A., Salarvandian, S., Zarei, R., Heidari, M., Salehian, F., & Esmaeilpour, K. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05095-x · Cited by 8 · see citing works

Pretraining hippocampal stimulation of melatonin type 2 receptors can improve memory acquisition in rats

Beigi, B., Shahidi, ‬., Komaki‬, A., Sarihi, A., & Hashemi-Firouzi, N. (2018) · International Journal of Neuroscience · doi:10.1080/00207454.2018.1545770 · Cited by 8 · see citing works

Exposure to Patterned Auditory Stimuli during Acute Stress Prevents Despair-Like Behavior in Adult Mice That Were Previously Housed in an Enriched Environment in Combination with Auditory Stimuli

Flores-Gutiérrez, E. O., Cabrera-Muñoz, E. A., Vega‐Rivera, N. M., Ortíz‐López, L., & Ramírez-Rodríguez, G. B. (2018) · Neural Plasticity · doi:10.1155/2018/8205245 · Cited by 8 · see citing works

Advances in Characterizing Recently-Identified Molecular Actions of Melatonin: Clinical Implications

Reiter, R., Sharma, R., Rosales-Corral, S., Coto-Montes, A., Boga, J., & Vriend, J. (2020) · Approaching Complex Diseases · doi:10.1007/978-3-030-32857-3_14 · Cited by 3 · see citing works

Alzheimer's Disease and the Immune System

Cao, C. (2015) · SOJ Neurology · doi:10.15226/2374-6858/2/1/00112 · Cited by 5 · see citing works

Pinealectomy-Induced Melatonin Deficiency Exerts Age-Specific Effects on Sphingolipid Turnover in Rats

Tchekalarova, J. D., Georgieva, I., Vukova, T., Apostolova, S. N., & Tzoneva, R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041694 · Cited by 4 · see citing works

Age-related memory decline is accelerated by pinealectomy in young adult and middle-aged rats via BDNF / ERK / CREB signalling

Tchekalarova, J. D., Atanasova, D., Krushovlieva, D., Barbutska, D., Atanasova, M., Rashev, P., Nenchovska, Z., Mourdjeva, M., & Koeva, Y. A. (2025) · Neurochemistry International · doi:10.1016/j.neuint.2025.105960 · Cited by 4 · see citing works

Effect of Lepidium meyenii (maca) on spatial memory and brain oxidative damage of ovariectomized-rats exposed to mobile phone

Marín-Tello, C., Villafana-Medina, H., Aliaga-Arauco, J., Malpartida-Tello, V. C., Castañeda-Marín, E., Sánchez-Marín, C., & Vásquez-Kool, J. (2021) · Revista Vitae · doi:10.17533/udea.vitae.v28n1a342472 · Cited by 4 · see citing works

Melatonin and neurodegeneration: From neurotoxic environment to cell resilience

Ramos, E., Gil‐Martín, E., & Romero, A. (2019) · Advances in molecular toxicology · doi:10.1016/b978-0-444-64293-6.00003-8 · Cited by 4 · see citing works

The relevance of the endocrine condition in microglia morphology and dendrite complexity of doublecortin‐associated neurons in young adult and middle‐aged female rats exposed to acute stress

Vega‐Rivera, N. M., González‐Monroy, E., Morelos-Santana, E., & Estrada-Camarena, E. M. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15398 · Cited by 4 · see citing works

Perspective for Modulation of Hypothalamic Neurogenesis: Integrating Anatomical Insights with Exercise and Dietary Interventions

de Isla, J. C., Bández, M. J., Rosety, I., Pérez-López, I., Rosety, M. Á., Verástegui, C., Sánchez-Gomar, I., & Geribaldi‐Doldán, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262210914 · Cited by 4 · see citing works

Melatonin, a Neuroprotective Agent: Relevance for Stress-Induced Neuropsychiatric Disorders

Govitrapong, P., Ekthuwapranee, K., Ruksee, N., & Boontem, P. (2016) · Springer eBooks · doi:10.1007/978-81-322-2803-5_8 · Cited by 3 · see citing works

Disrupted Tryptophan Metabolism Mediates Manganese-Induced Neurogenesis and Neuroinflammatory Impairments: Rescue by Exogenous Melatonin

Wang, X., Ma, T., He, W., Shan, T., Zhang, G., Peng, F., Chen, L., Ma, J., Ding, C., Niu, P., et al. (2025) · Environment & Health · doi:10.1021/envhealth.5c00264 · Cited by 2 · see citing works

The Role of G-Protein-Coupled Receptors in Adult Neurogenesis

Collette, K. M., Doze, V. A., & Perez, D. M. (2013) · Methods in pharmacology and toxicology · doi:10.1007/978-1-62703-779-2_21 · Cited by 1 · see citing works

Melatonin Induces Antidepressant-Like Behavior by Promotion of Adult Hippocampal Neurogenesis

Ramírez-Rodríguez, G. B. (2016) · Springer eBooks · doi:10.1007/978-81-322-2803-5_10 · Cited by 1 · see citing works

Nutraceutical potential of melatonin on human health

Oyebanjo, O. T., Ambali, O. A., Adetuyi, B. O., Oni, P. G., Olajide, P. A., & Ogunlana, O. O. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13814-0.00018-1 · Cited by 1 · see citing works

Brain nutrition-orthomolecular aspects

Moya, R. L. (2017) · Integrative Food Nutrition and Metabolism · doi:10.15761/ifnm.1000188

Melatonin Can Ameliorate Memory Deficits Induced By Methotrexate Chemotherapy in Adult Rats

Krutsri, S., Suwannakot, K., Aranarochana, A., Chaisawang, P., Pannangrong, W., Chaijaroonkhanarak, W., & Welbat, J. U. (2018) · Srinagarind Medical Journal-ศรีนครินทร์เวชสาร

Influência da melatonina sobre a ordenação temporal diária da neurogênese e neuroinflamação em ratos espontaneamente diabéticos do tipo 2 (Goto-Kakizaki).

de Matos, R. A. (2019) · doi:10.11606/t.42.2019.tde-17062019-160518

BindingDB Entry 50046160: Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential.

BindingDB (2016) · UC San Diego · doi:10.7270/q2jm2cdg

BindingDB Entry 50013255: Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties.

BindingDB (2022) · UC San Diego · doi:10.7270/q2p272wn

Melatonin Modulates Cell Survival of New Neurons in the Hippocampus of Adult Mice

Ramírez-Rodríguez, G. B., Klempin, F., Babu, H., Benítez‐King, G., & Kempermann, G. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.46 · Cited by 229 · see citing works

Chronic Treatment with Melatonin Improves Hippocampal Neurogenesis in the Aged Brain and Under Neurodegeneration

Cachán-Vega, C., Vega‐Naredo, I., Potes, Y., Bermejo-Millo, J. C., Rubio‐González, A., García-González, C., Antuña, E., Bermúdez, M., Gutiérrez‐Rodríguez, J., Boga, J. A., et al. (2022) · Molecules · doi:10.3390/molecules27175543 · Cited by 23 · see citing works

Chronic treatment with melatonin stimulates dendrite maturation and complexity in adult hippocampal neurogenesis of mice

Ramírez-Rodríguez, G. B., Ortíz‐López, L., Domínguez-Alonso, A., Benítez‐King, G., & Kempermann, G. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00802.x · Cited by 139 · see citing works

Melatonin maintains calcium-binding calretinin-positive neurons in the dentate gyrus during aging of Balb/C mice

Ramírez-Rodríguez, G. B., Gómez‐Sánchez, A., & Ortíz‐López, L. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.10.014 · Cited by 14 · see citing works

Melatonin: a multitasking indoleamine to modulate hippocampal neurogenesis

Romero, A., Morales-Garcia, J. A., & Ramos, E. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.350189 · Cited by 23 · see citing works