Delayed melatonin administration promotes neuronal survival, neurogenesis and motor recovery, and attenuates hyperactivity and anxiety after mild focal cerebral ischemia in mice

Tissue Plasminogen Activator for Acute Ischemic Stroke

(1995) · New England Journal of Medicine · doi:10.1056/nejm199512143332401 · Cited by 11,654 · see citing works

Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials

Hacke, W., Donnan, G. A., Fieschi, C., Kaste, M., von Kummer, R., Broderick, J. P., Brott, T. G., Frankel, M., Grotta, J. C., Haley, E. C., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15692-4 · Cited by 2,561 · see citing works

One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species?

Tan, D., Manchester, L. C., Terron, M. P., Flores, L. J., & Reiter, R. J. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00407.x · Cited by 1,601 · see citing works

Transient expression of doublecortin during adult neurogenesis

Brown, J. P., Couillard‐Després, S., Cooper‐Kuhn, C. M., Winkler, J., Aigner, L., & Kuhn, H. G. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10874 · Cited by 1,494 · see citing works

1,026 Experimental treatments in acute stroke

O’Collins, V. E., Macleod, M. R., Donnan, G. A., Horky, L. L., van der Worp, H. B., & Howells, D. W. (2006) · Annals of Neurology · doi:10.1002/ana.20741 · Cited by 1,453 · see citing works

Recommendations for standards regarding preclinical neuroprotective and restorative drug development.

Roundtable, S. T. A. I. (1999) · Stroke · doi:10.1161/01.str.30.12.2752 · Cited by 1,258 · see citing works

Effects of Melatonin Treatment in Septic Newborns

Gitto, E., Karbownik‐Lewińska, M., Reiter, R. J., Tan, D. X., Cuzzocrea, S., Chiurazzi, P., Cordaro, S., Corona, G., Trimarchi, G. R., & Barberi, I. (2001) · Pediatric Research · doi:10.1203/00006450-200112000-00021 · Cited by 507 · see citing works

Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti‐apoptotic effects of melatonin

Andrabi, S. A., Sayeed, I., Siemen, D., Wolf, G. L., & Horn, T. F. W. (2004) · The FASEB Journal · doi:10.1096/fj.03-1031fje · Cited by 311 · see citing works

Future of neuroprotection for acute stroke: In the aftermath of the SAINT trials

Savitz, S. I., & Fisher, M. (2007) · Annals of Neurology · doi:10.1002/ana.21127 · Cited by 267 · see citing works

Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress‐induced apoptosis of rat brain astrocytes

Jou, M., Peng, T., Reiter, R. J., Jou, S., WU, H., & Wen, S. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00140.x · Cited by 265 · see citing works

Neurogenesis in Rats After Focal Cerebral Ischemia is Enhanced by Indomethacin

Hoehn, B. D., Palmer, T. D., & Steinberg, G. K. (2005) · Stroke · doi:10.1161/01.str.0000190020.30282.cc · Cited by 239 · see citing works

Brain‐derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK‐1/‐2 and Akt pathways

Kılıç, E., Kılıç, Ü., Soliz, J., Bassetti, C. L., Gassmann, M., & Hermann, D. M. (2005) · The FASEB Journal · doi:10.1096/fj.05-3941fje · Cited by 230 · see citing works

AFMK, a melatonin metabolite, attenuates X‐ray‐induced oxidative damage to DNA, proteins and lipids in mice

Manda, K., Ueno, M., & Anzai, K. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00432.x · Cited by 222 · see citing works

VEGF overexpression induces post-ischaemic neuroprotection, but facilitates haemodynamic steal phenomena

Wang, Y. (2004) · Brain · doi:10.1093/brain/awh325 · Cited by 221 · see citing works

The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia

Kilic, E., Kilic, Ü., Wang, Y., Bassetti, C. L., Marti, H. H., Hermann, D. M., Kilic, E., Kilic, Ü., Wang, Y., Bassetti, C. L., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-4829fje · Cited by 218 · see citing works

The utility of melatonin in reducing cerebral damage resulting from ischemia and reperfusion

Cheung, R. T. F. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.00034.x · Cited by 161 · see citing works

When Melatonin Gets on Your Nerves: Its Beneficial Actions in Experimental Models of Stroke

Reiter, R. J., Tan, D., León, J., Kılıç, Ü., & Kılıç, E. (2005) · Experimental Biology and Medicine · doi:10.1177/153537020523000205 · Cited by 160 · see citing works

Pinealectomy Aggravates and Melatonin Administration Attenuates Brain Damage in Focal Ischemia

Kılıç, E., Özdemir, Y., Bolay, H., Keleştimur, H., & Dalkara, T. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199905000-00005 · Cited by 160 · see citing works

Melatonin influences the proliferative and differentiative activity of neural stem cells

Moriya, T., Horie, N., Mitome, M., & Shinohara, K. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00435.x · Cited by 151 · see citing works

Impaired explorative behavior and neophobia in genetically modified mice lacking or overexpressing the extracellular serine protease inhibitor neuroserpin

Madani, R., Kozlov, S. V., Akhmedov, A. T., Cinelli, P., Kinter, J., Lipp, H., Sonderegger, P., & Wolfer, D. P. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00077-0 · Cited by 140 · see citing works

Systematic review and meta‐analysis of the efficacy of melatonin in experimental stroke

Macleod, M. R., O'Collins, T., Horky, L. L., Howells, D., & Donnan, G. A. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00172.x · Cited by 137 · see citing works

Signal transduction pathways involved in melatonin‐induced neuroprotection after focal cerebral ischemia in mice

Kılıç, Ü., Kılıç, E., Reiter, R. J., Bassetti, C. L., & Hermann, D. M. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00178.x · Cited by 135 · see citing works

Protective effects of melatonin in ischemic brain injury

Cuzzocrea, S., Costantino, G., Gitto, E., Mazzon, E., Fulia, F., Serraino, I., Cordaro, S., Barberi, I., Sarro, A. D., & Caputi, A. P. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-0633.2002.290404.x · Cited by 132 · see citing works

Extended analysis of path data from mutant mice using the public domain software Wintrack

Wolfer, D. P., Madani, R., Valenti, P., & Lipp, H. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00531-5 · Cited by 130 · see citing works

Neuroprotection by melatonin against ischemic neuronal injury associated with modulation of DNA damage and repair in the rat following a transient cerebral ischemia

Sun, F., Lin, X., Mao, L., Ge, W., Zhang, L., Huang, Y., & Gu, J. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2002.01891.x · Cited by 126 · see citing works

Administration of Melatonin After Onset of Ischemia Reduces the Volume of Cerebral Infarction in a Rat Middle Cerebral Artery Occlusion Stroke Model

Pei, Z., Pang, S. F., & Cheung, R. T. F. (2003) · Stroke · doi:10.1161/01.str.0000057460.14810.3e · Cited by 123 · see citing works

Pretreatment with melatonin reduces volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model

Pei, Z., Pang, S. F., & Cheung, R. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2002.1o847.x · Cited by 116 · see citing works

Adenovirus-Mediated Gene Transfer of Heparin-Binding Epidermal Growth Factor-Like Growth Factor Enhances Neurogenesis and Angiogenesis After Focal Cerebral Ischemia in Rats

Sugiura, S., Kitagawa, K., Tanaka, S., Todo, K., Omura‐Matsuoka, E., Sasaki, T., Mabuchi, T., Matsushita, K., Yagita, Y., & Hori, M. (2005) · Stroke · doi:10.1161/01.str.0000158905.22871.95 · Cited by 116 · see citing works

Melatonin: Detoxification of Oxygen And Nitrogen-Based Toxic Reactants

Reiter, R. J., Tan, D., Manchester, C., López‐Burillo, S., Sainz, R. M., & Mayo, C. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0135-0_62 · Cited by 111 · see citing works

Relationship between metabolic dysfunctions, gene responses and delayed cell death after mild focal cerebral ischemia in mice

Hermann, D. M., Kılıç, E., Hata, R., Hossmann, K., & Mies, G. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00125-7 · Cited by 111 · see citing works

Multitargeted Effects of Statin-Enhanced Thrombolytic Therapy for Stroke With Recombinant Human Tissue-Type Plasminogen Activator in the Rat

Zhang, L., Zhang, Z. G., Ding, G., Jiang, Q., Liu, X., Meng, H., Hozeska‐Solgot, A., Zhang, C., Li, L., Morris, D., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.516757 · Cited by 100 · see citing works

Anxious and Hyperactive Phenotype Following Brief Ischemic Episodes in Mice

Winter, B., Juckel, G., Viktorov, I. L., Katchanov, J., Gietz, A., Sohr, R., Balkaya, M., Hörtnagl, H., & Endres, M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.010 · Cited by 97 · see citing works

Pretreatment with melatonin exerts anti‐inflammatory effects against ischemia/reperfusion injury in a rat middle cerebral artery occlusion stroke model

Pei, Z., & Cheung, R. T. F. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00138.x · Cited by 79 · see citing works

Neurobehavioral development, adult openfield exploration and swimming navigation learning in mice with a modified β-amyloid precursor protein gene

Tremml, P., Lipp, H., Müller, U., Ricceri, L., & Wolfer, D. P. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00211-8 · Cited by 76 · see citing works

Prophylactic use of melatonin protects against focal cerebral ischemia in mice: role of endothelin converting enzyme‐1

Kılıç, E., Kılıç, Ü., Reiter, R. J., Bassetti, C. L., & Hermann, D. M. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00162.x · Cited by 73 · see citing works

Melatonin increases cell proliferation in the dentate gyrus of maternally separated rats

Kim, M., Kim, H. K., Kim, B., & Yim, S. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00157.x · Cited by 70 · see citing works

Tissue‐plasminogen activator‐induced ischemic brain injury is reversed by melatonin: role of iNOS and Akt

Kılıç, E., Kılıç, Ü., Reiter, R. J., Bassetti, C. L., & Hermann, D. M. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00228.x · Cited by 69 · see citing works

Melatonin reduces disseminate neuronal death after mild focal ischemia in mice via inhibition of caspase‐3 and is suitable as an add‐on treatment to tissue‐plasminogen activator

Kılıç, E., Kılıç, Ü., Yuluğ, B., et al. (2004) · Journal of Pineal Research · doi:10.1046/j.1600-079x.2003.00115.x · Cited by 67 · see citing works

Implications of ATP-binding cassette transporters for brain pharmacotherapies

Hermann, D. M., & Bassetti, C. L. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.01.007 · Cited by 65 · see citing works

Melatonin reduces nitric oxide level during ischemia but not blood–brain barrier breakdown during reperfusion in a rat middle cerebral artery occlusion stroke model

Pei, Z., Fung, P. C. W., & Cheung, R. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.00014.x · Cited by 59 · see citing works

Preclinical evaluation of pharmacokinetics and safety of melatonin in propylene glycol for intravenous administration

Cheung, R. T. F., Tipoe, G. L., Tam, S., Ma, E. S. K., Zou, L. Y., & Chan, P. S. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00372.x · Cited by 59 · see citing works

Life After Cerovive

Ginsberg, M. D. (2007) · Stroke · doi:10.1161/strokeaha.106.479170 · Cited by 56 · see citing works

Aggravation of Focal Cerebral Ischemia by Tissue Plasminogen Activator Is Reversed by 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor but Does Not Depend on Endothelial NO Synthase

Kılıç, E., Kılıç, Ü., Matter, C. M., Lüscher, T. F., Bassetti, C. L., & Hermann, D. M. (2004) · Stroke · doi:10.1161/01.str.0000152273.24063.f7 · Cited by 51 · see citing works

Melatonin reduces infarction volume in a photothrombotic stroke model in the wild‐type but not cyclooxygenase‐1‐gene knockout mice

Zou, L. Y., Cheung, R. T. F., Liu, S., Li, G., & Huang, L. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00349.x · Cited by 29 · see citing works

Tissue Plasminogen Activator–Induced Reperfusion Injury After Stroke Revisited

Hermann, D. M., & Matter, C. M. (2007) · Circulation · doi:10.1161/circulationaha.107.712380 · Cited by 27 · see citing works

Reduced locomotion in the serum and glucocorticoid inducible kinase 3 knock out mouse

Lang, U. E., Wolfer, D. P., Grahammer, F., Strutz‐Seebohm, N., Seebohm, G., Lipp, H.-P., McCormick, J. A., Hellweg, R., Dawson, K., Wang, J., et al. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.08.017 · Cited by 21 · see citing works

Neuroprotection in the SAINT‐II aftermath

Hermann, D. M., & Bassetti, C. L. (2007) · Annals of Neurology · doi:10.1002/ana.21210 · Cited by 8 · see citing works

Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation

Hermann, D. M., & Chopp, M. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70039-x · Cited by 333 · see citing works

Role of Nogo-A in neuronal survival in the reperfused ischemic brain

Kilic, E., ElAli, A., Kilic, Ü., Guo, Z., Ugur, M., Uslu, U., Bassetti, C. L., Schwab, M. E., & Hermann, D. M. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.268 · Cited by 79 · see citing works

Melatonin supplementation delays the decline of adult hippocampal neurogenesis during normal aging of mice

Ramírez-Rodríguez, G., Vega-Rivera, N. M., Benítez-King, G., Castro-García, M., & Ortíz-López, L. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.09.045 · Cited by 71 · see citing works

Adult Neurogenesis in the Subventricular Zone and Its Regulation After Ischemic Stroke: Implications for Therapeutic Approaches

Dillen, Y., Kemps, H., Gervois, P., Wolfs, E., & Bronckaers, A. (2019) · Translational Stroke Research · doi:10.1007/s12975-019-00717-8 · Cited by 76 · see citing works

Neurogenesis in the Adult Subventricular Zone

Zhong, C. (2007) · Chinese Journal of Clinical Neurosciences · Cited by 2 · see citing works

Agent based deterministic model of the adult subventricular neurogenesis

Kurhekar, M. P., & Deshpande, U. A. (2015) · Nano Communication Networks · doi:10.1016/j.nancom.2015.04.005 · Cited by 1 · see citing works

L ‐lactate induces neurogenesis in the mouse ventricular‐subventricular zone via the lactate receptor HCA 1

Lambertus, M., Øverberg, L. T., Andersson, K. A., Hjelden, M. S., Hadzic, A., Haugen, Ø. P., Storm‐Mathisen, J., Bergersen, L. H., Geiseler, S. J., & Morland, C. (2020) · Acta Physiologica · doi:10.1111/apha.13587 · Cited by 62 · see citing works

Recent research on neural stem cells and neurogenesis of subventricular zone

Wu, M. (2010) · Shengming kexue